Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DMD_HUMAN

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. [View more on UniProt]

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Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
54 Leu Arg Duchennemusculardystrophy(DMD) -
168 Ala Asp Beckermusculardystrophy(BMD) -
231 Tyr Asn Beckermusculardystrophy(BMD) -
773 Lys Glu Duchennemusculardystrophy(DMD) -
2921 His Arg Beckermusculardystrophy(BMD) -
3421 Ala Val Beckermusculardystrophy(BMD) -
18 Lys Asn Cardiomyopathy,dilated,3B(CMD3B) -
171 Ala Pro Beckermusculardystrophy(BMD) -
279 Thr Ala Cardiomyopathy,dilated,3B(CMD3B) -
645 Asp Gly Duchennemusculardystrophy(DMD) -
3228 Phe Leu Cardiomyopathy,dilated,3B(CMD3B) -
3313 Cys Phe Duchennemusculardystrophy(DMD) -
3335 Asp His Duchennemusculardystrophy(DMD) -
3340 Cys Tyr Duchennemusculardystrophy(DMD) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DMD_HUMAN
GO:0043169 cation binding 39.4366 4 yes
GO:0046872 metal ion binding 39.4366 5 yes
GO:0003779 actin binding 25.3521 4 yes
GO:0003723 RNA binding 21.1268 4 no
GO:0046914 transition metal ion binding 18.3099 6 yes
GO:0008270 zinc ion binding 14.0845 7 yes
GO:0017166 vinculin binding 7.0423 4 yes
GO:0050998 nitric-oxide synthase binding 4.2254 4 yes
GO:0017022 myosin binding 2.8169 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DMD_HUMAN
GO:0048522 positive regulation of cellular process 54.9296 4 yes
GO:0060255 regulation of macromolecule metabolic process 46.4789 4 yes
GO:0010646 regulation of cell communication 45.0704 4 no
GO:0048523 negative regulation of cellular process 45.0704 4 yes
GO:0080090 regulation of primary metabolic process 43.6620 4 yes
GO:0051128 regulation of cellular component organization 42.2535 4 yes
GO:0031323 regulation of cellular metabolic process 40.8451 4 yes
GO:0051049 regulation of transport 40.8451 4 yes
GO:0009966 regulation of signal transduction 38.0282 4 no
GO:0022607 cellular component assembly 36.6197 4 yes
GO:0009889 regulation of biosynthetic process 33.8028 4 no
GO:0010468 regulation of gene expression 33.8028 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.8028 5 no
GO:0031326 regulation of cellular biosynthetic process 33.8028 5 no
GO:0009893 positive regulation of metabolic process 30.9859 4 no
GO:0051246 regulation of protein metabolic process 30.9859 5 yes
GO:0006996 organelle organization 29.5775 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 28.1690 5 no
GO:0008104 protein localization 28.1690 4 yes
GO:0030030 cell projection organization 28.1690 4 yes
GO:0051130 positive regulation of cellular component organization 26.7606 5 yes
GO:0120036 plasma membrane bounded cell projection organization 26.7606 5 yes
GO:0031325 positive regulation of cellular metabolic process 25.3521 5 no
GO:1902531 regulation of intracellular signal transduction 25.3521 5 no
GO:0048584 positive regulation of response to stimulus 23.9437 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.9437 5 no
GO:0051252 regulation of RNA metabolic process 23.9437 5 no
GO:0031399 regulation of protein modification process 23.9437 6 yes
GO:0010647 positive regulation of cell communication 22.5352 5 no
GO:0023056 positive regulation of signaling 22.5352 4 no
GO:0051240 positive regulation of multicellular organismal process 22.5352 4 no
GO:0006355 regulation of DNA-templated transcription 22.5352 7 no
GO:2001141 regulation of RNA biosynthetic process 22.5352 6 no
GO:0009892 negative regulation of metabolic process 22.5352 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 22.5352 5 yes
GO:0043933 protein-containing complex organization 22.5352 4 yes
GO:0051094 positive regulation of developmental process 22.5352 4 yes
GO:0009967 positive regulation of signal transduction 21.1268 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.1268 4 no
GO:0007010 cytoskeleton organization 21.1268 5 no
GO:0060341 regulation of cellular localization 21.1268 4 no
GO:0001932 regulation of protein phosphorylation 21.1268 7 yes
GO:0019220 regulation of phosphate metabolic process 21.1268 6 yes
GO:0031324 negative regulation of cellular metabolic process 21.1268 5 yes
GO:0034762 regulation of transmembrane transport 21.1268 4 yes
GO:0042325 regulation of phosphorylation 21.1268 7 yes
GO:0043269 regulation of monoatomic ion transport 21.1268 5 yes
GO:0051174 regulation of phosphorus metabolic process 21.1268 5 yes
GO:0010959 regulation of metal ion transport 19.7183 6 yes
GO:0031344 regulation of cell projection organization 19.7183 5 yes
GO:0051050 positive regulation of transport 19.7183 4 yes
GO:0065003 protein-containing complex assembly 19.7183 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.7183 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 18.3099 5 yes
GO:0045595 regulation of cell differentiation 18.3099 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 16.9014 6 yes
GO:0010975 regulation of neuron projection development 16.9014 7 yes
GO:0044057 regulation of system process 16.9014 4 yes
GO:0006936 muscle contraction 14.0845 4 yes
GO:0051248 negative regulation of protein metabolic process 14.0845 6 yes
GO:0141124 intracellular signaling cassette 14.0845 4 yes
GO:1903522 regulation of blood circulation 12.6761 5 yes
GO:0022898 regulation of transmembrane transporter activity 12.6761 4 yes
GO:0031346 positive regulation of cell projection organization 12.6761 6 yes
GO:0031400 negative regulation of protein modification process 12.6761 7 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 12.6761 5 yes
GO:0045597 positive regulation of cell differentiation 12.6761 5 yes
GO:0051924 regulation of calcium ion transport 12.6761 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 11.2676 7 yes
GO:0002028 regulation of sodium ion transport 11.2676 7 yes
GO:0010976 positive regulation of neuron projection development 11.2676 7 yes
GO:0099536 synaptic signaling 11.2676 4 yes
GO:1902305 regulation of sodium ion transmembrane transport 9.8592 7 yes
GO:0001933 negative regulation of protein phosphorylation 9.8592 8 yes
GO:0008016 regulation of heart contraction 9.8592 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 9.8592 6 yes
GO:0030031 cell projection assembly 9.8592 5 yes
GO:0042326 negative regulation of phosphorylation 9.8592 8 yes
GO:0045936 negative regulation of phosphate metabolic process 9.8592 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 9.8592 6 yes
GO:2001257 regulation of cation channel activity 8.4507 6 yes
GO:0006941 striated muscle contraction 8.4507 5 yes
GO:0007517 muscle organ development 8.4507 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 8.4507 5 yes
GO:0051282 regulation of sequestering of calcium ion 8.4507 4 yes
GO:0055001 muscle cell development 8.4507 4 yes
GO:0070925 organelle assembly 8.4507 5 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 7.0423 6 yes
GO:0006937 regulation of muscle contraction 7.0423 6 yes
GO:0006942 regulation of striated muscle contraction 7.0423 7 yes
GO:0019722 calcium-mediated signaling 7.0423 5 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 7.0423 8 yes
GO:0034764 positive regulation of transmembrane transport 7.0423 5 yes
GO:0045664 regulation of neuron differentiation 7.0423 5 yes
GO:0055117 regulation of cardiac muscle contraction 7.0423 7 yes
GO:0090257 regulation of muscle system process 7.0423 5 yes
GO:0090287 regulation of cellular response to growth factor stimulus 7.0423 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 7.0423 6 yes
GO:0001894 tissue homeostasis 5.6338 4 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 5.6338 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 5.6338 7 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 5.6338 6 yes
GO:0035994 response to muscle stretch 5.6338 4 yes
GO:0043270 positive regulation of monoatomic ion transport 5.6338 5 yes
GO:0044782 cilium organization 5.6338 5 yes
GO:0060271 cilium assembly 5.6338 6 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 5.6338 6 yes
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation 4.2254 8 yes
GO:1902307 positive regulation of sodium ion transmembrane transport 4.2254 7 yes
GO:1904064 positive regulation of cation transmembrane transport 4.2254 7 yes
GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 4.2254 7 yes
GO:0001508 action potential 4.2254 4 yes
GO:0010765 positive regulation of sodium ion transport 4.2254 6 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 4.2254 6 yes
GO:0035633 maintenance of blood-brain barrier 4.2254 5 yes
GO:0060048 cardiac muscle contraction 4.2254 6 yes
GO:0060537 muscle tissue development 4.2254 4 yes
GO:0086001 cardiac muscle cell action potential 4.2254 5 yes
GO:1901385 regulation of voltage-gated calcium channel activity 4.2254 7 yes
GO:2000651 positive regulation of sodium ion transmembrane transporter activity 2.8169 6 yes
GO:0007519 skeletal muscle tissue development 2.8169 5 yes
GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling 2.8169 6 yes
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 2.8169 7 yes
GO:0014819 regulation of skeletal muscle contraction 2.8169 8 yes
GO:0032411 positive regulation of transporter activity 2.8169 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 2.8169 5 yes
GO:0033137 negative regulation of peptidyl-serine phosphorylation 2.8169 9 yes
GO:0043043 peptide biosynthetic process 2.8169 4 yes
GO:0044458 motile cilium assembly 2.8169 7 yes
GO:0045666 positive regulation of neuron differentiation 2.8169 6 yes
GO:0048666 neuron development 2.8169 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DTNA_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] Low throughput yes no
SNTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] Low throughput yes no
NDE1_HUMAN [view interactions] Low throughput no yes
CTNL1_HUMAN [view interactions] Low throughput no no
K2C8_HUMAN [view interactions] Low throughput no no
K1C19_HUMAN [view interactions] Low throughput no no
DTNB_HUMAN [view entry] [view interactions] Low throughput yes no
DTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAV3_HUMAN [view interactions] Low throughput no no
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
EGFLA_HUMAN [view interactions] Low throughput no no
IQEC3_HUMAN [view entry] [view interactions] Low throughput yes no
SNTG1_HUMAN [view interactions] Low throughput no no
SNTG2_HUMAN [view interactions] Low throughput no no
PGM5_HUMAN [view interactions] Low throughput no no
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
MARK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
SGCZ_HUMAN [view interactions] Low throughput no no
PAK5_HUMAN [view interactions] Low throughput no yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI63_HUMAN [view interactions] Low throughput no no
ACTS_HUMAN [view interactions] Low throughput no no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
ELF1_HUMAN [view interactions] Low throughput no yes
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
PSB5_HUMAN [view interactions] High throughput no yes
NUP58_HUMAN [view interactions] High throughput no yes
KIF15_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
LPAR6_HUMAN [view interactions] High throughput no no
LRC8E_HUMAN [view interactions] High throughput no no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI41_HUMAN [view interactions] High throughput no yes
HAUS1_HUMAN [view interactions] High throughput no yes
OSBL1_HUMAN [view interactions] High throughput no yes
WDR54_HUMAN [view interactions] High throughput no no
PALS2_HUMAN [view interactions] High throughput no yes
IFIT5_HUMAN [view interactions] High throughput no no
ABCA1_HUMAN [view interactions] High throughput no yes
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
TENS2_HUMAN [view interactions] High throughput no no
TENS3_HUMAN [view interactions] High throughput no no
TENS1_HUMAN [view interactions] High throughput no no
GLU2B_HUMAN [view interactions] High throughput no yes
SF3B2_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
KCJ10_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
ADA1D_HUMAN [view interactions] High throughput no no
ITB4_HUMAN [view entry] [view interactions] High throughput yes yes
SHC2_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
KCNQ1_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
PSA2_HUMAN [view interactions] High throughput no yes
KAD1_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
AK1A1_HUMAN [view entry] [view interactions] High throughput yes no
CATD_HUMAN [view interactions] High throughput no yes
FLIP1_HUMAN [view entry] [view interactions] High throughput yes no
ARGI1_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
PRDX4_HUMAN [view interactions] High throughput no yes
DNPEP_HUMAN [view interactions] High throughput no yes
CO3_HUMAN [view entry] [view interactions] High throughput yes no
CLU_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
SPTN4_HUMAN [view entry] [view interactions] High throughput yes no
SPTA1_HUMAN [view interactions] High throughput no no
FYCO1_HUMAN [view interactions] High throughput no no
DEUP1_HUMAN [view interactions] High throughput no no
DNSL2_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
TLN2_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIFCL_HUMAN [view interactions] High throughput no yes
STRN3_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C40_HUMAN [view interactions] High throughput no no
RMXL1_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
MYPC3_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
SATB2_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
MPIP1_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
M3K5_HUMAN [view interactions] High throughput no yes
ZGPAT_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
MIPT3_HUMAN [view interactions] High throughput no yes
HNF4A_HUMAN [view interactions] High throughput no no
KCJ12_HUMAN [view interactions] High throughput no no
KCNJ4_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
NFX1_HUMAN [view interactions] High throughput no yes
SGCD_HUMAN [view entry] [view interactions] High throughput yes no
SGCA_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
SGCB_HUMAN [view interactions] High throughput no no
SGCG_HUMAN [view interactions] High throughput no no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
LDB3_HUMAN [view interactions] High throughput no no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
GAN_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
LONF3_HUMAN [view interactions] High throughput no no
HAUS4_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
SIR2_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
REST_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TNIP1_HUMAN [view interactions] High throughput no yes
PAGE1_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA4_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA2_HUMAN [view interactions] High throughput no no
SIR5_HUMAN [view interactions] High throughput no yes
TRM2A_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ZDH15_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
CHIO_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
DRP2_HUMAN [view entry] [view interactions] High throughput yes no
FCHO2_HUMAN [view interactions] High throughput no yes
LHX3_HUMAN [view interactions] High throughput no no
LHX5_HUMAN [view interactions] High throughput no no
LMA1L_HUMAN [view interactions] High throughput no no
LMAN2_HUMAN [view interactions] High throughput no yes
LMA2L_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
STA13_HUMAN [view interactions] High throughput no yes
STRP2_HUMAN [view interactions] High throughput no yes
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE2_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes