AK1A1_HUMAN
Evidence for PS localization
Functions
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein . Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed, PubMed). Displays no reductase activity towards retinoids . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AK1A1_HUMAN |
|---|---|---|---|---|
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 13.0435 | 4 | yes |
| GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | 8.6957 | 7 | yes |
| GO:0004033 | aldo-keto reductase (NADP) activity | 8.6957 | 5 | yes |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | 8.6957 | 6 | yes |
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | 8.6957 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AK1A1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.8261 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 39.1304 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.4348 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 26.0870 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 26.0870 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 26.0870 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010646 | regulation of cell communication | 26.0870 | 4 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0016310 | phosphorylation | 26.0870 | 5 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0010941 | regulation of cell death | 21.7391 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.7391 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 5 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.7391 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.7391 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.7391 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.7391 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 21.7391 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0007010 | cytoskeleton organization | 21.7391 | 5 | no |
| GO:0034308 | primary alcohol metabolic process | 17.3913 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 17.3913 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 17.3913 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 17.3913 | 4 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 13.0435 | 4 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 13.0435 | 4 | yes |
| GO:0016137 | glycoside metabolic process | 8.6957 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 8.6957 | 4 | yes |
| GO:0030647 | aminoglycoside antibiotic metabolic process | 8.6957 | 6 | yes |
| GO:0046185 | aldehyde catabolic process | 8.6957 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 8.6957 | 4 | yes |
| GO:1901657 | glycosyl compound metabolic process | 8.6957 | 4 | yes |
| GO:1901661 | quinone metabolic process | 8.6957 | 4 | yes |
| GO:1902644 | tertiary alcohol metabolic process | 8.6957 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOS4_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| IGHG2_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| MFTC_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| MOT5_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| POTEF_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK2_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| GNPI2_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDCD6_HUMAN | [view interactions] | High throughput | no | no |
| AL3B1_HUMAN | [view interactions] | Computational | no | yes |
| AL3B2_HUMAN | [view interactions] | Computational | no | yes |
| GLPK2_HUMAN | [view interactions] | Computational | no | no |
| CRYL1_HUMAN | [view interactions] | Computational | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KLOT_HUMAN | [view interactions] | Computational | no | no |
| AL3A1_HUMAN | [view interactions] | Computational | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MIOX_HUMAN | [view interactions] | Computational | no | no |
| AL9A1_HUMAN | [view interactions] | Computational | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ARK72_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL1B1_HUMAN | [view interactions] | Computational | no | yes |
| AOFB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GLPK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BGLR_HUMAN | [view interactions] | Computational | no | yes |