ARF1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [ARF1_HUMAN]
Isoform [A0A8V8TQC0] alignment
Isoform [A0A8V8TQP8] alignment
Isoform [A0A8V8TP92] alignment
Isoform [A0A8V8TP99] alignment
Isoform [A0A8V8TPG9] alignment
Isoform [A0A8V8TNZ0] alignment
Isoform [A0A8V8TNZ5] alignment
LOADING 42%
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 35 | Tyr | His | Periventricularnodularheterotopia8(PVNH8) | - |
| 127 | Lys | Glu | Periventricularnodularheterotopia8(PVNH8) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002321 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI002321 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARF1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.6780 | 4 | yes |
| GO:0000166 | nucleotide binding | 37.2881 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.4407 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.5932 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.7458 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 27.9661 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.9661 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.9661 | 6 | yes |
| GO:0003924 | GTPase activity | 24.5763 | 7 | yes |
| GO:0005525 | GTP binding | 24.5763 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 24.5763 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 24.5763 | 5 | yes |
| GO:0003723 | RNA binding | 23.7288 | 4 | yes |
| GO:0043169 | cation binding | 19.4915 | 4 | yes |
| GO:0046872 | metal ion binding | 16.9492 | 5 | yes |
| GO:0000287 | magnesium ion binding | 2.5424 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARF1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 50.8475 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 46.6102 | 4 | no |
| GO:0071702 | organic substance transport | 40.6780 | 4 | yes |
| GO:0006996 | organelle organization | 39.8305 | 4 | no |
| GO:0071705 | nitrogen compound transport | 38.9831 | 4 | yes |
| GO:0015031 | protein transport | 37.2881 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 37.2881 | 4 | yes |
| GO:0010646 | regulation of cell communication | 34.7458 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 33.8983 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.8983 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.3559 | 4 | yes |
| GO:0051049 | regulation of transport | 30.5085 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 30.5085 | 4 | no |
| GO:0006886 | intracellular protein transport | 28.8136 | 4 | yes |
| GO:0022607 | cellular component assembly | 28.8136 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.8136 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.1186 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.2712 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4237 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.5763 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5763 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.7288 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.7288 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.1864 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 21.1864 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| ADCK5_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1S3_HUMAN | [view interactions] | Low throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3S2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP4E1_HUMAN | [view interactions] | Low throughput | no | no |
| AP4M1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |