RAB6A_HUMAN
Evidence for PS localization
Functions
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB6A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | yes |
| GO:0005525 | GTP binding | 34.5455 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 34.5455 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 34.5455 | 5 | yes |
| GO:0003924 | GTPase activity | 32.7273 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 32.7273 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.7273 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.7273 | 6 | yes |
| GO:0017022 | myosin binding | 12.7273 | 4 | yes |
| GO:0031489 | myosin V binding | 10.9091 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB6A_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 63.6364 | 4 | yes |
| GO:0015031 | protein transport | 54.5455 | 4 | yes |
| GO:0071702 | organic substance transport | 54.5455 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 54.5455 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 47.2727 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 43.6364 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.1818 | 4 | no |
| GO:0006886 | intracellular protein transport | 36.3636 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:0006996 | organelle organization | 34.5455 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.9091 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.0909 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 29.0909 | 4 | no |
| GO:0033365 | protein localization to organelle | 27.2727 | 5 | yes |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.4545 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.4545 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.4545 | 5 | no |
| GO:0016197 | endosomal transport | 23.6364 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 23.6364 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 21.8182 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.8182 | 5 | no |
| GO:0036211 | protein modification process | 20.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
| GO:0016482 | cytosolic transport | 18.1818 | 4 | yes |
| GO:0048193 | Golgi vesicle transport | 16.3636 | 5 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 14.5455 | 5 | yes |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 7.2727 | 6 | yes |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 7.2727 | 6 | yes |
| GO:0010970 | transport along microtubule | 7.2727 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 7.2727 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 7.2727 | 4 | yes |
| GO:0099111 | microtubule-based transport | 7.2727 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 5.4545 | 4 | yes |
| GO:0006479 | protein methylation | 3.6364 | 4 | yes |
| GO:0008213 | protein alkylation | 3.6364 | 5 | yes |
| GO:0018125 | peptidyl-cysteine methylation | 3.6364 | 5 | yes |
| GO:0018198 | peptidyl-cysteine modification | 3.6364 | 6 | yes |
| GO:0034067 | protein localization to Golgi apparatus | 3.6364 | 6 | yes |
| GO:0034498 | early endosome to Golgi transport | 3.6364 | 6 | yes |
| GO:0072385 | minus-end-directed organelle transport along microtubule | 3.6364 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RAB6A_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 3.6364 | 4 | no |
| DOID:331 | central nervous system disease | 3.6364 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ECHP_HUMAN | [view interactions] | Low throughput | no | no |
| BICD1_HUMAN | [view interactions] | Low throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | Low throughput | no | yes |
| RBGP1_HUMAN | [view interactions] | Low throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAE1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAE2_HUMAN | [view interactions] | Low throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FKBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| GOGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TYRO_HUMAN | [view interactions] | Low throughput | no | no |
| RAB6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | Low throughput | no | yes |
| BICL1_HUMAN | [view interactions] | Low throughput | no | yes |
| BICD2_HUMAN | [view interactions] | Low throughput | no | yes |
| DEN5A_HUMAN | [view interactions] | Low throughput | no | yes |
| SYTL5_HUMAN | [view interactions] | Low throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| GCC2_HUMAN | [view interactions] | Low throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHG30_HUMAN | [view interactions] | High throughput | no | no |
| PAR16_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2B_HUMAN | [view interactions] | High throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CI072_HUMAN | [view interactions] | High throughput | no | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TRML2_HUMAN | [view interactions] | High throughput | no | no |
| RNF26_HUMAN | [view interactions] | High throughput | no | yes |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN131_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| I5P2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| AQP9_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST1_HUMAN | [view interactions] | High throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP1_HUMAN | [view interactions] | High throughput | no | no |
| VP26B_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| ABCD2_HUMAN | [view interactions] | High throughput | no | no |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S12A6_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | Computational | no | yes |
| VP13B_HUMAN | [view interactions] | Computational | no | no |
| VPS39_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VAMP4_HUMAN | [view interactions] | Computational | no | yes |
| RIC1_HUMAN | [view interactions] | Computational | no | no |
| RGP1_HUMAN | [view interactions] | Computational | no | yes |
| RAB43_HUMAN | [view interactions] | Computational | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX6_HUMAN | [view interactions] | Computational | no | yes |
| VPS51_HUMAN | [view interactions] | Computational | no | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GCC1_HUMAN | [view interactions] | Computational | no | yes |
| COG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYS1_HUMAN | [view interactions] | Computational | no | yes |
| NOTC2_HUMAN | [view interactions] | Computational | no | yes |
| ARL1_HUMAN | [view interactions] | Computational | no | yes |
| NOTC4_HUMAN | [view interactions] | Computational | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VPS53_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GOGA4_HUMAN | [view interactions] | Computational | no | yes |
| NOTC3_HUMAN | [view interactions] | Computational | no | yes |
| VPS54_HUMAN | [view interactions] | Computational | no | no |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COG8_HUMAN | [view interactions] | Computational | no | no |
| GOGB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VTI1A_HUMAN | [view interactions] | Computational | no | yes |
| APBA3_HUMAN | [view interactions] | Computational | no | yes |
| TMF1_HUMAN | [view interactions] | Computational | no | yes |
| STX16_HUMAN | [view interactions] | Computational | no | yes |