LMTK3_HUMAN
Evidence for PS localization
Functions
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LMTK3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 39.5349 | 4 | yes |
| GO:0046872 | metal ion binding | 39.5349 | 5 | yes |
| GO:0000166 | nucleotide binding | 37.2093 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 34.8837 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.5581 | 4 | yes |
| GO:0043168 | anion binding | 32.5581 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.2326 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.9070 | 6 | yes |
| GO:0003723 | RNA binding | 27.9070 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.5814 | 5 | yes |
| GO:0005524 | ATP binding | 23.2558 | 5 | yes |
| GO:0016301 | kinase activity | 11.6279 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 9.3023 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LMTK3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.8140 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.4884 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.1628 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.8372 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.8372 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.5116 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.8605 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.8605 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.5349 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 34.8837 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.8837 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.8837 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.8837 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.8837 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.8837 | 4 | no |
| GO:0006996 | organelle organization | 30.2326 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.2326 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.2326 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.9070 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 27.9070 | 4 | no |
| GO:0051049 | regulation of transport | 27.9070 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.9070 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.9070 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.9070 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.5814 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.5814 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.5814 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5814 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.5814 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.5814 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5814 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.5814 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.5814 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.2558 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.2558 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.2558 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 23.2558 | 4 | no |
| GO:0022607 | cellular component assembly | 23.2558 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.9302 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 20.9302 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.9302 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.9302 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.9302 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.9302 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 20.9302 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.9302 | 6 | no |
| GO:0016310 | phosphorylation | 6.9767 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK098_HUMAN | [view interactions] | High throughput | no | no |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| PHF6_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| DDX47_HUMAN | [view interactions] | High throughput | no | yes |
| APT_HUMAN | [view interactions] | High throughput | no | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| DDX56_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| NSA2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1C_HUMAN | [view interactions] | High throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| PWP1_HUMAN | [view interactions] | High throughput | no | no |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| EBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |