LMTK3_HUMAN
Evidence for PS localization
Functions
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LMTK3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 41.0256 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.2051 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | yes |
| GO:0005524 | ATP binding | 20.5128 | 5 | yes |
| GO:0003723 | RNA binding | 20.5128 | 4 | no |
| GO:0016301 | kinase activity | 12.8205 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 10.2564 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 5.1282 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LMTK3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.2821 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.1538 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.5897 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0256 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8974 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.7692 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.2051 | 4 | yes |
| GO:0010468 | regulation of gene expression | 28.2051 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0036211 | protein modification process | 25.6410 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.6410 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.6410 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.6410 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.6410 | 6 | no |
| GO:0006996 | organelle organization | 25.6410 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0051049 | regulation of transport | 23.0769 | 4 | no |
| GO:0010941 | regulation of cell death | 20.5128 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.5128 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5128 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.5128 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5128 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5128 | 5 | no |
| GO:0008104 | protein localization | 20.5128 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.5128 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5128 | 5 | no |
| GO:0016310 | phosphorylation | 12.8205 | 5 | yes |
| GO:0006468 | protein phosphorylation | 7.6923 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LMTK3_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.6923 | 3 | no |
| DOID:0050700 | cardiomyopathy | 5.1282 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.1282 | 5 | no |
| DOID:114 | heart disease | 5.1282 | 3 | no |
| DOID:2843 | long QT syndrome | 5.1282 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK098_HUMAN | [view interactions] | High throughput | no | no |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBP2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAZ1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| PWP1_HUMAN | [view interactions] | High throughput | no | no |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1C_HUMAN | [view interactions] | High throughput | no | no |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSA2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX56_HUMAN | [view interactions] | High throughput | no | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| APT_HUMAN | [view interactions] | High throughput | no | yes |
| DDX47_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| PHF6_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |