Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

REV3L_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3-5 exonuclease activity and thus has no proofreading function. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in REV3L_HUMAN
GO:0046872 metal ion binding 33.3333 4 yes
GO:0005524 ATP binding 33.3333 5 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0003677 DNA binding 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in REV3L_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0090304 nucleic acid metabolic process 58.3333 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.6667 5 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.6667 5 no
GO:0006259 DNA metabolic process 33.3333 4 yes
GO:0006281 DNA repair 33.3333 5 yes
GO:0006974 cellular response to DNA damage stimulus 33.3333 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 33.3333 4 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0006301 postreplication repair 25.0000 6 yes
GO:0009059 macromolecule biosynthetic process 25.0000 4 yes
GO:0018130 heterocycle biosynthetic process 25.0000 4 yes
GO:0019438 aromatic compound biosynthetic process 25.0000 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 25.0000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 25.0000 4 yes
GO:0031396 regulation of protein ubiquitination 25.0000 8 no
GO:0031398 positive regulation of protein ubiquitination 25.0000 9 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 7 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 no
GO:0010564 regulation of cell cycle process 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0070848 response to growth factor 25.0000 4 no
GO:0071363 cellular response to growth factor stimulus 25.0000 5 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1901987 regulation of cell cycle phase transition 25.0000 6 no
GO:1901990 regulation of mitotic cell cycle phase transition 25.0000 6 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 no
GO:0000724 double-strand break repair via homologous recombination 16.6667 7 yes
GO:0000725 recombinational repair 16.6667 6 yes
GO:0006260 DNA replication 16.6667 5 yes
GO:0006261 DNA-templated DNA replication 16.6667 6 yes
GO:0006302 double-strand break repair 16.6667 6 yes
GO:0006310 DNA recombination 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CHK2_HUMAN [view interactions] Low throughput no yes
MD2L2_HUMAN [view interactions] Low throughput no yes
HDAC4_HUMAN [view interactions] Low throughput no yes
MD2L1_HUMAN [view interactions] Low throughput no no
REV1_HUMAN [view interactions] Low throughput no yes
SCAI_HUMAN [view entry] [view interactions] Low throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
CBX1_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
GPR27_HUMAN [view interactions] High throughput no yes
RIR1_HUMAN [view entry] [view interactions] High throughput yes yes
CFLAR_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
CCR6_HUMAN [view interactions] High throughput no no
CAC1A_HUMAN [view interactions] High throughput no no
COPZ1_HUMAN [view interactions] High throughput no no
CDY1_HUMAN [view interactions] High throughput no no
CSAD_HUMAN [view interactions] High throughput no yes
A1BG_HUMAN [view interactions] High throughput no no
THIO_HUMAN [view interactions] High throughput no yes
MOT10_HUMAN [view interactions] High throughput no yes
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
RFXAP_HUMAN [view interactions] High throughput no no
F107A_HUMAN [view entry] [view interactions] High throughput yes no
P53_HUMAN [view interactions] High throughput no no
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
PIGB_HUMAN [view interactions] High throughput no yes
POLH_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DPOD2_HUMAN [view interactions] High throughput no no
H15_HUMAN [view interactions] High throughput no no
H33_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
SLTM_HUMAN [view interactions] High throughput no yes
MEF2A_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PMS1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
ST17B_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
DPOLM_HUMAN [view interactions] Computational no no
DPOLL_HUMAN [view interactions] Computational no no
EXO1_HUMAN [view interactions] Computational no no
UB2V2_HUMAN [view entry] [view interactions] Computational yes no
XPA_HUMAN [view interactions] Computational no yes
POLK_HUMAN [view interactions] Computational no no
DPOE1_HUMAN [view interactions] Computational no no
DPOD4_HUMAN [view interactions] Computational no no
UBE2N_HUMAN [view entry] [view interactions] Computational yes yes
FEN1_HUMAN [view interactions] Computational no yes
FANCM_HUMAN [view interactions] Computational no no
DPOG1_HUMAN [view interactions] Computational no yes
CHRC1_HUMAN [view interactions] Computational no no
DCR1A_HUMAN [view interactions] Computational no yes
RFA1_HUMAN [view interactions] Computational no yes
DPOG2_HUMAN [view interactions] Computational no yes
ATR_HUMAN [view interactions] Computational no no
MCM3_HUMAN [view interactions] Computational no no
DPOD3_HUMAN [view interactions] Computational no yes
FACD2_HUMAN [view interactions] Computational no no
PRI1_HUMAN [view interactions] Computational no no
DPOD1_HUMAN [view interactions] Computational no yes
RAD52_HUMAN [view interactions] Computational no no
RFC1_HUMAN [view interactions] Computational no yes
XRCC3_HUMAN [view interactions] Computational no no
RAD18_HUMAN [view interactions] Computational no yes
HLTF_HUMAN [view interactions] Computational no no
RAD51_HUMAN [view interactions] Computational no yes
DPOLN_HUMAN [view interactions] Computational no no
XPF_HUMAN [view interactions] Computational no yes
MUS81_HUMAN [view interactions] Computational no no
RPC9_HUMAN [view interactions] Computational no yes
PRI2_HUMAN [view interactions] Computational no no
DPOLA_HUMAN [view interactions] Computational no yes
DPOA2_HUMAN [view interactions] Computational no yes
ERCC1_HUMAN [view interactions] Computational no yes
POLI_HUMAN [view interactions] Computational no yes
DPOE2_HUMAN [view interactions] Computational no no
PCNA_HUMAN [view interactions] Computational no no
DPOE3_HUMAN [view interactions] Computational no yes
DPOE4_HUMAN [view interactions] Computational no no