REV3L_HUMAN
Evidence for PS localization
Functions
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3-5 exonuclease activity and thus has no proofreading function. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in REV3L_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 40.0000 | 4 | yes |
| GO:0003677 | DNA binding | 30.0000 | 4 | yes |
| GO:0005524 | ATP binding | 30.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
| GO:0043168 | anion binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in REV3L_HUMAN |
|---|---|---|---|---|
| GO:0009059 | macromolecule biosynthetic process | 50.0000 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 30.0000 | 4 | yes |
| GO:0141187 | nucleic acid biosynthetic process | 30.0000 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 30.0000 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 30.0000 | 4 | no |
| GO:0016070 | RNA metabolic process | 30.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.0000 | 4 | no |
| GO:0007346 | regulation of mitotic cell cycle | 30.0000 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 30.0000 | 4 | no |
| GO:1901987 | regulation of cell cycle phase transition | 30.0000 | 6 | no |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 30.0000 | 6 | no |
| GO:0030334 | regulation of cell migration | 30.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 30.0000 | 4 | no |
| GO:0050890 | cognition | 30.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
| GO:0000731 | DNA synthesis involved in DNA repair | 20.0000 | 6 | yes |
| GO:0006259 | DNA metabolic process | 20.0000 | 5 | yes |
| GO:0006260 | DNA replication | 20.0000 | 6 | yes |
| GO:0006261 | DNA-templated DNA replication | 20.0000 | 7 | yes |
| GO:0006281 | DNA repair | 20.0000 | 5 | yes |
| GO:0006974 | DNA damage response | 20.0000 | 4 | yes |
| GO:0071897 | DNA biosynthetic process | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MD2L2_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | Low throughput | no | no |
| REV1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | Low throughput | no | yes |
| DPOD2_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| MEF2A_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| ST17B_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| GPR27_HUMAN | [view interactions] | High throughput | no | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFLAR_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| CDY1_HUMAN | [view interactions] | High throughput | no | no |
| CSAD_HUMAN | [view interactions] | High throughput | no | yes |
| A1BG_HUMAN | [view interactions] | High throughput | no | no |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| MOT10_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFXAP_HUMAN | [view interactions] | High throughput | no | no |
| F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGB_HUMAN | [view interactions] | High throughput | no | yes |
| POLH_HUMAN | [view interactions] | High throughput | no | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |