F107A_HUMAN
Evidence for PS localization
Functions
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory . Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed, PubMed). May play a role in tumor development (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in F107A_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 37.5000 | 4 | no |
| GO:0003723 | RNA binding | 31.2500 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.2500 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.2500 | 4 | no |
| GO:0043168 | anion binding | 31.2500 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0003779 | actin binding | 12.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in F107A_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 56.2500 | 4 | yes |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | yes |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 31.2500 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 31.2500 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 31.2500 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 31.2500 | 4 | yes |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 18.7500 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 18.7500 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 18.7500 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 18.7500 | 6 | yes |
| GO:0051726 | regulation of cell cycle | 18.7500 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 12.5000 | 5 | yes |
| GO:0010948 | negative regulation of cell cycle process | 12.5000 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 12.5000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 12.5000 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 12.5000 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 12.5000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 12.5000 | 4 | yes |
| GO:0033993 | response to lipid | 12.5000 | 4 | yes |
| GO:0045786 | negative regulation of cell cycle | 12.5000 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 12.5000 | 5 | yes |
| GO:0071396 | cellular response to lipid | 12.5000 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 12.5000 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 12.5000 | 4 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 12.5000 | 6 | yes |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 12.5000 | 6 | yes |
| GO:1902806 | regulation of cell cycle G1/S phase transition | 12.5000 | 7 | yes |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 12.5000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| COMD1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| CC136_HUMAN | [view interactions] | High throughput | no | yes |
| LDOC1_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN4_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| BEGIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| HFM1_HUMAN | [view interactions] | High throughput | no | no |
| MTREX_HUMAN | [view interactions] | High throughput | no | yes |
| IQUB_HUMAN | [view interactions] | High throughput | no | no |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF3_HUMAN | [view interactions] | High throughput | no | yes |
| RNLS_HUMAN | [view interactions] | High throughput | no | no |
| AZI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDAH_HUMAN | [view interactions] | High throughput | no | no |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| MEIOB_HUMAN | [view interactions] | High throughput | no | no |
| SPT22_HUMAN | [view interactions] | High throughput | no | no |
| BIRC8_HUMAN | [view interactions] | High throughput | no | no |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| HTRA1_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| CC125_HUMAN | [view interactions] | High throughput | no | yes |
| ERR3_HUMAN | [view interactions] | High throughput | no | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |