Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AZI2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AZI2_HUMAN
GO:0004842 ubiquitin-protein transferase activity 41.6667 4 no
GO:0016755 aminoacyltransferase activity 41.6667 4 no
GO:0061630 ubiquitin protein ligase activity 41.6667 5 no
GO:0061659 ubiquitin-like protein ligase activity 41.6667 4 no
GO:0008270 zinc ion binding 33.3333 7 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0046914 transition metal ion binding 33.3333 6 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AZI2_HUMAN
GO:0048522 positive regulation of cellular process 58.3333 4 no
GO:0010646 regulation of cell communication 58.3333 4 no
GO:0051246 regulation of protein metabolic process 58.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0016567 protein ubiquitination 41.6667 8 no
GO:0032446 protein modification by small protein conjugation 41.6667 7 no
GO:0043687 post-translational protein modification 41.6667 5 no
GO:0070647 protein modification by small protein conjugation or removal 41.6667 6 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0009894 regulation of catabolic process 41.6667 4 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0019221 cytokine-mediated signaling pathway 33.3333 4 yes
GO:0051607 defense response to virus 33.3333 4 yes
GO:0060337 type I interferon-mediated signaling pathway 33.3333 6 yes
GO:0140546 defense response to symbiont 33.3333 4 yes
GO:0140888 interferon-mediated signaling pathway 33.3333 5 yes
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0007249 canonical NF-kappaB signal transduction 25.0000 5 yes
GO:0032943 mononuclear cell proliferation 25.0000 4 yes
GO:0044565 dendritic cell proliferation 25.0000 5 yes
GO:0141124 intracellular signaling cassette 25.0000 4 yes
GO:0006508 proteolysis 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0032479 regulation of type I interferon production 25.0000 5 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 25.0000 6 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031398 positive regulation of protein ubiquitination 25.0000 10 no
GO:0032006 regulation of TOR signaling 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1901875 positive regulation of post-translational protein modification 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:1903432 regulation of TORC1 signaling 25.0000 7 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0002521 leukocyte differentiation 16.6667 4 yes
GO:0042110 T cell activation 16.6667 4 yes
GO:0097028 dendritic cell differentiation 16.6667 6 yes
GO:1903131 mononuclear cell differentiation 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CACO2_HUMAN [view interactions] Low throughput no yes
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
IKKE_HUMAN [view interactions] Low throughput no yes
AZI2_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI38_HUMAN [view interactions] Low throughput no yes
TAXB1_HUMAN [view interactions] Low throughput no yes
RBCC1_HUMAN [view interactions] Low throughput no no
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
GBRL1_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF31_HUMAN [view interactions] High throughput no yes
N4BP1_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
PAPD1_HUMAN [view interactions] High throughput no yes
APBA3_HUMAN [view interactions] High throughput no yes
TXLNA_HUMAN [view interactions] High throughput no yes
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
MIB2_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
BODG_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
F107A_HUMAN [view entry] [view interactions] High throughput yes no
TXLNG_HUMAN [view interactions] High throughput no no
TBKB1_HUMAN [view interactions] High throughput no no
HIF1N_HUMAN [view interactions] High throughput no yes
CI072_HUMAN [view entry] [view interactions] High throughput yes no
CEBPB_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
KR197_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
NAA10_HUMAN [view interactions] High throughput no yes
PIP_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CEMIP_HUMAN [view interactions] High throughput no no
ATG3_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes