SPTB1_HUMAN
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SPTB1_HUMAN |
---|---|---|---|---|
GO:0045296 | cadherin binding | 30.0000 | 4 | no |
GO:0003779 | actin binding | 25.0000 | 4 | yes |
GO:0046872 | metal ion binding | 25.0000 | 4 | no |
GO:0042803 | protein homodimerization activity | 25.0000 | 4 | no |
GO:0030506 | ankyrin binding | 10.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SPTB1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 45.0000 | 4 | yes |
GO:0006996 | organelle organization | 40.0000 | 4 | yes |
GO:0007010 | cytoskeleton organization | 35.0000 | 5 | yes |
GO:0033043 | regulation of organelle organization | 35.0000 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 35.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 35.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 35.0000 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 30.0000 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 30.0000 | 6 | yes |
GO:0008104 | protein localization | 30.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
GO:0010639 | negative regulation of organelle organization | 25.0000 | 6 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 25.0000 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
GO:0051049 | regulation of transport | 25.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
GO:0008064 | regulation of actin polymerization or depolymerization | 20.0000 | 6 | yes |
GO:0030832 | regulation of actin filament length | 20.0000 | 5 | yes |
GO:0032535 | regulation of cellular component size | 20.0000 | 4 | yes |
GO:0110053 | regulation of actin filament organization | 20.0000 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 15.0000 | 7 | yes |
GO:0030834 | regulation of actin filament depolymerization | 15.0000 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 15.0000 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 15.0000 | 7 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 15.0000 | 6 | yes |
GO:0032271 | regulation of protein polymerization | 15.0000 | 6 | yes |
GO:0032272 | negative regulation of protein polymerization | 15.0000 | 7 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 15.0000 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 15.0000 | 5 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 15.0000 | 5 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 15.0000 | 7 | yes |
GO:0051693 | actin filament capping | 15.0000 | 8 | yes |
GO:1901879 | regulation of protein depolymerization | 15.0000 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 15.0000 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 15.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CSRP3_HUMAN | [view interactions] | Low throughput | no | no |
SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ADDA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPB41_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
B3AT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
SH22A_HUMAN | [view interactions] | High throughput | no | no |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RB40L_HUMAN | [view interactions] | High throughput | no | no |
TXND5_HUMAN | [view interactions] | High throughput | no | yes |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
GLBL2_HUMAN | [view interactions] | High throughput | no | no |
CPLX4_HUMAN | [view interactions] | High throughput | no | no |
CRP_HUMAN | [view interactions] | High throughput | no | no |
ZBT12_HUMAN | [view interactions] | High throughput | no | yes |
RM38_HUMAN | [view interactions] | High throughput | no | yes |
NMNA3_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
CSTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPB1_HUMAN | [view interactions] | High throughput | no | yes |
O13C5_HUMAN | [view interactions] | High throughput | no | no |
F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CABP4_HUMAN | [view interactions] | High throughput | no | no |
RN145_HUMAN | [view interactions] | High throughput | no | yes |
C2AIL_HUMAN | [view interactions] | High throughput | no | yes |
SLU7_HUMAN | [view interactions] | High throughput | no | yes |
PAPOG_HUMAN | [view interactions] | High throughput | no | yes |
CJ053_HUMAN | [view interactions] | High throughput | no | no |
ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GARS_HUMAN | [view interactions] | High throughput | no | yes |
MTURN_HUMAN | [view interactions] | High throughput | no | no |
DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
RPRD2_HUMAN | [view interactions] | High throughput | no | yes |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
CHTOP_HUMAN | [view interactions] | High throughput | no | yes |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
IL13_HUMAN | [view interactions] | High throughput | no | no |
SPB4_HUMAN | [view interactions] | High throughput | no | no |
BOLA1_HUMAN | [view interactions] | High throughput | no | yes |
MTFR2_HUMAN | [view interactions] | High throughput | no | no |
ACOT6_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSM5_HUMAN | [view interactions] | High throughput | no | no |
RASA3_HUMAN | [view interactions] | High throughput | no | yes |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |