SPTB1_HUMAN
Evidence for PS localization
Functions
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SPTB1_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 30.0000 | 4 | no |
| GO:0003779 | actin binding | 25.0000 | 4 | yes |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0030506 | ankyrin binding | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SPTB1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 35.0000 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 35.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 35.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.0000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 25.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 20.0000 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.0000 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.0000 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 15.0000 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 15.0000 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 15.0000 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 15.0000 | 7 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 15.0000 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 15.0000 | 7 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 15.0000 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 15.0000 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 15.0000 | 6 | yes |
| GO:0032272 | negative regulation of protein polymerization | 15.0000 | 7 | yes |
| GO:0032535 | regulation of cellular component size | 15.0000 | 4 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 15.0000 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 15.0000 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 15.0000 | 5 | yes |
| GO:0050808 | synapse organization | 15.0000 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 15.0000 | 7 | yes |
| GO:0051693 | actin filament capping | 15.0000 | 8 | yes |
| GO:0110053 | regulation of actin filament organization | 15.0000 | 6 | yes |
| GO:1901879 | regulation of protein depolymerization | 15.0000 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 15.0000 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 15.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CSRP3_HUMAN | [view interactions] | Low throughput | no | no |
| SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADDA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| B3AT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| SH22A_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RB40L_HUMAN | [view interactions] | High throughput | no | no |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| GLBL2_HUMAN | [view interactions] | High throughput | no | no |
| CPLX4_HUMAN | [view interactions] | High throughput | no | no |
| CRP_HUMAN | [view interactions] | High throughput | no | no |
| ZBT12_HUMAN | [view interactions] | High throughput | no | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| NMNA3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CSTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| O13C5_HUMAN | [view interactions] | High throughput | no | no |
| F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CABP4_HUMAN | [view interactions] | High throughput | no | no |
| RN145_HUMAN | [view interactions] | High throughput | no | yes |
| C2AIL_HUMAN | [view interactions] | High throughput | no | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| PAPOG_HUMAN | [view interactions] | High throughput | no | yes |
| CJ053_HUMAN | [view interactions] | High throughput | no | no |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| MTURN_HUMAN | [view interactions] | High throughput | no | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| RPRD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| CHTOP_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| IL13_HUMAN | [view interactions] | High throughput | no | no |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| BOLA1_HUMAN | [view interactions] | High throughput | no | yes |
| MTFR2_HUMAN | [view interactions] | High throughput | no | no |
| ACOT6_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM5_HUMAN | [view interactions] | High throughput | no | no |
| RASA3_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |