ADDA_HUMAN
Evidence for PS localization
Functions
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADDA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.8788 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.8788 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.8788 | 4 | no |
| GO:0003779 | actin binding | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 24.2424 | 4 | no |
| GO:0019900 | kinase binding | 24.2424 | 4 | no |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 21.2121 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.2121 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.2121 | 6 | no |
| GO:0045296 | cadherin binding | 13.6364 | 4 | yes |
| GO:0003723 | RNA binding | 9.0909 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 9.0909 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 7.5758 | 4 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 4.5455 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 4.5455 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADDA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.0909 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.0303 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0006996 | organelle organization | 48.4848 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0022607 | cellular component assembly | 43.9394 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.3939 | 4 | no |
| GO:0008104 | protein localization | 39.3939 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.8788 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 34.8485 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 34.8485 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.8485 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.8485 | 4 | no |
| GO:0051049 | regulation of transport | 34.8485 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 31.8182 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 31.8182 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.8182 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 30.3030 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.3030 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.7879 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.7879 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 27.2727 | 4 | yes |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.7576 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.7576 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.7576 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.7576 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.7576 | 4 | no |
| GO:0007015 | actin filament organization | 24.2424 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 24.2424 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 24.2424 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
| GO:0010468 | regulation of gene expression | 24.2424 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.7273 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 22.7273 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.7273 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:2000145 | regulation of cell motility | 22.7273 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.7273 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.7273 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.7273 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 21.2121 | 5 | yes |
| GO:0015031 | protein transport | 21.2121 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.2121 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.2121 | 4 | no |
| GO:0032271 | regulation of protein polymerization | 19.6970 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 19.6970 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 19.6970 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 18.1818 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 18.1818 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 18.1818 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 16.6667 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 16.6667 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 16.6667 | 4 | yes |
| GO:0030833 | regulation of actin filament polymerization | 15.1515 | 7 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 15.1515 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 15.1515 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 15.1515 | 6 | yes |
| GO:0032272 | negative regulation of protein polymerization | 15.1515 | 7 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 15.1515 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 15.1515 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 15.1515 | 4 | yes |
| GO:1901879 | regulation of protein depolymerization | 15.1515 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 15.1515 | 7 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 13.6364 | 7 | yes |
| GO:0051693 | actin filament capping | 13.6364 | 8 | yes |
| GO:0060284 | regulation of cell development | 13.6364 | 5 | yes |
| GO:0010038 | response to metal ion | 12.1212 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.1212 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 10.6061 | 6 | yes |
| GO:0051099 | positive regulation of binding | 10.6061 | 4 | yes |
| GO:0051592 | response to calcium ion | 10.6061 | 5 | yes |
| GO:0043393 | regulation of protein binding | 7.5758 | 4 | yes |
| GO:0051017 | actin filament bundle assembly | 7.5758 | 5 | yes |
| GO:0061572 | actin filament bundle organization | 7.5758 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 7.5758 | 4 | yes |
| GO:0032092 | positive regulation of protein binding | 6.0606 | 5 | yes |
| GO:0051016 | barbed-end actin filament capping | 6.0606 | 9 | yes |
| GO:0071241 | cellular response to inorganic substance | 6.0606 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 6.0606 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 4.5455 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ADDA_HUMAN |
|---|---|---|---|---|
| DOID:0080000 | muscular disease | 3.0303 | 3 | no |
| DOID:3191 | nemaline myopathy | 3.0303 | 7 | no |
| DOID:422 | congenital structural myopathy | 3.0303 | 6 | no |
| DOID:423 | myopathy | 3.0303 | 5 | no |
| DOID:66 | muscle tissue disease | 3.0303 | 4 | no |
| DOID:331 | central nervous system disease | 3.0303 | 3 | no |
| DOID:936 | brain disease | 3.0303 | 4 | no |
| DOID:0050700 | cardiomyopathy | 3.0303 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.0303 | 5 | no |
| DOID:114 | heart disease | 3.0303 | 3 | no |
| DOID:2843 | long QT syndrome | 3.0303 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SPTB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFX1_HUMAN | [view interactions] | Low throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMCA4_HUMAN | [view interactions] | Low throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | Low throughput | no | yes |
| SIN3A_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGBM_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST17B_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| CA109_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| FA78A_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| ANR29_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARF_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRWD1_HUMAN | [view interactions] | High throughput | no | no |
| ADDG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RN138_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| ACE_HUMAN | [view interactions] | Computational | no | no |
| CASP3_HUMAN | [view interactions] | Computational | no | yes |
| XBP1_HUMAN | [view interactions] | Computational | no | no |
| DEMA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |