ADDA_HUMAN
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ADDA_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 37.8049 | 4 | no |
GO:0000166 | nucleotide binding | 36.5854 | 4 | no |
GO:0017076 | purine nucleotide binding | 36.5854 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 36.5854 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.3659 | 4 | no |
GO:0043169 | cation binding | 29.2683 | 4 | no |
GO:0046872 | metal ion binding | 29.2683 | 5 | no |
GO:0003779 | actin binding | 28.0488 | 4 | yes |
GO:0019900 | kinase binding | 28.0488 | 4 | no |
GO:0019901 | protein kinase binding | 26.8293 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 21.9512 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.9512 | 5 | no |
GO:0005524 | ATP binding | 20.7317 | 5 | no |
GO:0045296 | cadherin binding | 12.1951 | 4 | yes |
GO:0003723 | RNA binding | 10.9756 | 4 | yes |
GO:0042803 | protein homodimerization activity | 7.3171 | 4 | yes |
GO:0046982 | protein heterodimerization activity | 7.3171 | 4 | yes |
GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 4.8780 | 5 | yes |
GO:0140297 | DNA-binding transcription factor binding | 4.8780 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ADDA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 62.1951 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 52.4390 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
GO:0006996 | organelle organization | 45.1220 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 45.1220 | 4 | no |
GO:0008104 | protein localization | 43.9024 | 4 | no |
GO:0010646 | regulation of cell communication | 43.9024 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 43.9024 | 4 | no |
GO:0022607 | cellular component assembly | 42.6829 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 37.8049 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 36.5854 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.5854 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 35.3659 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.3659 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.1463 | 5 | no |
GO:0007010 | cytoskeleton organization | 32.9268 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 32.9268 | 4 | no |
GO:0033043 | regulation of organelle organization | 31.7073 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.7073 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 31.7073 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 31.7073 | 4 | no |
GO:0010468 | regulation of gene expression | 30.4878 | 6 | no |
GO:0051246 | regulation of protein metabolic process | 30.4878 | 5 | no |
GO:0051049 | regulation of transport | 29.2683 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.0488 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 26.8293 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 26.8293 | 6 | yes |
GO:0051129 | negative regulation of cellular component organization | 25.6098 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 25.6098 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.6098 | 4 | no |
GO:0043933 | protein-containing complex organization | 25.6098 | 4 | no |
GO:0071702 | organic substance transport | 25.6098 | 4 | no |
GO:0030030 | cell projection organization | 25.6098 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 24.3902 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 24.3902 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 24.3902 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 24.3902 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.3902 | 6 | no |
GO:0031399 | regulation of protein modification process | 24.3902 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.3902 | 5 | no |
GO:0071705 | nitrogen compound transport | 24.3902 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.1707 | 6 | no |
GO:0141124 | intracellular signaling cassette | 23.1707 | 4 | no |
GO:2000145 | regulation of cell motility | 23.1707 | 4 | no |
GO:0060341 | regulation of cellular localization | 23.1707 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 21.9512 | 5 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 21.9512 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 21.9512 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.9512 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 21.9512 | 6 | no |
GO:0042325 | regulation of phosphorylation | 21.9512 | 7 | no |
GO:0032880 | regulation of protein localization | 21.9512 | 5 | no |
GO:0030334 | regulation of cell migration | 21.9512 | 5 | no |
GO:0007015 | actin filament organization | 20.7317 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 20.7317 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 20.7317 | 7 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.7317 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 20.7317 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 20.7317 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 20.7317 | 5 | no |
GO:0043254 | regulation of protein-containing complex assembly | 18.2927 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 17.0732 | 4 | yes |
GO:0010639 | negative regulation of organelle organization | 15.8537 | 6 | yes |
GO:0060284 | regulation of cell development | 15.8537 | 5 | yes |
GO:0032271 | regulation of protein polymerization | 14.6341 | 6 | yes |
GO:0032535 | regulation of cellular component size | 14.6341 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 14.6341 | 4 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 14.6341 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 14.6341 | 6 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 13.4146 | 6 | yes |
GO:2000026 | regulation of multicellular organismal development | 13.4146 | 4 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 12.1951 | 6 | yes |
GO:0030832 | regulation of actin filament length | 12.1951 | 5 | yes |
GO:0030833 | regulation of actin filament polymerization | 10.9756 | 7 | yes |
GO:0030834 | regulation of actin filament depolymerization | 10.9756 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 10.9756 | 7 | yes |
GO:0032272 | negative regulation of protein polymerization | 10.9756 | 7 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 10.9756 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 10.9756 | 5 | yes |
GO:1901879 | regulation of protein depolymerization | 10.9756 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 10.9756 | 7 | yes |
GO:0010038 | response to metal ion | 9.7561 | 4 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 9.7561 | 7 | yes |
GO:0045597 | positive regulation of cell differentiation | 9.7561 | 5 | yes |
GO:0051693 | actin filament capping | 9.7561 | 8 | yes |
GO:0010720 | positive regulation of cell development | 8.5366 | 6 | yes |
GO:0043393 | regulation of protein binding | 8.5366 | 4 | yes |
GO:0051592 | response to calcium ion | 7.3171 | 5 | yes |
GO:0032092 | positive regulation of protein binding | 6.0976 | 5 | yes |
GO:0051099 | positive regulation of binding | 6.0976 | 4 | yes |
GO:0071241 | cellular response to inorganic substance | 6.0976 | 4 | yes |
GO:0071248 | cellular response to metal ion | 6.0976 | 5 | yes |
GO:0030856 | regulation of epithelial cell differentiation | 4.8780 | 5 | yes |
GO:0051016 | barbed-end actin filament capping | 4.8780 | 9 | yes |
GO:0051017 | actin filament bundle assembly | 4.8780 | 5 | yes |
GO:0061572 | actin filament bundle organization | 4.8780 | 6 | yes |
GO:0045601 | regulation of endothelial cell differentiation | 3.6585 | 6 | yes |
GO:0071277 | cellular response to calcium ion | 3.6585 | 6 | yes |
GO:1901550 | regulation of endothelial cell development | 3.6585 | 6 | yes |
GO:1903140 | regulation of establishment of endothelial barrier | 3.6585 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MYO10_HUMAN | [view interactions] | Low throughput | no | no |
SPTB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDK1_HUMAN | [view interactions] | Low throughput | no | no |
RFX1_HUMAN | [view interactions] | Low throughput | no | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS105_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRWD1_HUMAN | [view interactions] | High throughput | no | no |
ADDG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SVIL_HUMAN | [view interactions] | High throughput | no | yes |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBIA1_HUMAN | [view interactions] | High throughput | no | no |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBP2_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
RN138_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
R144A_HUMAN | [view interactions] | High throughput | no | yes |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CIC_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
RIGI_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND3_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TLS1_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
GCSP_HUMAN | [view interactions] | High throughput | no | yes |
UBP11_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTPN_HUMAN | [view interactions] | High throughput | no | yes |
NDC80_HUMAN | [view interactions] | High throughput | no | no |
ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASML_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HEXA_HUMAN | [view interactions] | High throughput | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO5_HUMAN | [view interactions] | High throughput | no | yes |
TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RN183_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
TNR6_HUMAN | [view interactions] | High throughput | no | no |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
ARL14_HUMAN | [view interactions] | High throughput | no | no |
ARL15_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GEMI7_HUMAN | [view interactions] | High throughput | no | no |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
KITH_HUMAN | [view interactions] | High throughput | no | yes |
PGBM_HUMAN | [view interactions] | High throughput | no | no |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUP54_HUMAN | [view interactions] | High throughput | no | yes |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ST17B_HUMAN | [view interactions] | High throughput | no | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIM3_HUMAN | [view interactions] | High throughput | no | no |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MD13L_HUMAN | [view interactions] | High throughput | no | no |
CP135_HUMAN | [view interactions] | High throughput | no | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
CRYAA_HUMAN | [view interactions] | High throughput | no | no |
PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DRC5_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
HM20A_HUMAN | [view interactions] | High throughput | no | yes |
ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLH42_HUMAN | [view interactions] | High throughput | no | yes |
AIRIM_HUMAN | [view interactions] | High throughput | no | yes |
HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
FOXP3_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MMS19_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
FA78A_HUMAN | [view interactions] | High throughput | no | yes |
DPPA4_HUMAN | [view interactions] | High throughput | no | no |
ANR29_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
IF16_HUMAN | [view interactions] | High throughput | no | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEST_HUMAN | [view interactions] | High throughput | no | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CARF_HUMAN | [view interactions] | High throughput | no | yes |