Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADDA_HUMAN

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ADDA_HUMAN
GO:0043168 anion binding 37.8049 4 no
GO:0000166 nucleotide binding 36.5854 4 no
GO:0017076 purine nucleotide binding 36.5854 5 no
GO:0032555 purine ribonucleotide binding 36.5854 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.3659 4 no
GO:0043169 cation binding 29.2683 4 no
GO:0046872 metal ion binding 29.2683 5 no
GO:0003779 actin binding 28.0488 4 yes
GO:0019900 kinase binding 28.0488 4 no
GO:0019901 protein kinase binding 26.8293 5 no
GO:0030554 adenyl nucleotide binding 21.9512 6 no
GO:0032559 adenyl ribonucleotide binding 21.9512 5 no
GO:0005524 ATP binding 20.7317 5 no
GO:0045296 cadherin binding 12.1951 4 yes
GO:0003723 RNA binding 10.9756 4 yes
GO:0042803 protein homodimerization activity 7.3171 4 yes
GO:0046982 protein heterodimerization activity 7.3171 4 yes
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 4.8780 5 yes
GO:0140297 DNA-binding transcription factor binding 4.8780 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADDA_HUMAN
GO:0048522 positive regulation of cellular process 62.1951 4 yes
GO:0048523 negative regulation of cellular process 52.4390 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0006996 organelle organization 45.1220 4 yes
GO:0060255 regulation of macromolecule metabolic process 45.1220 4 no
GO:0008104 protein localization 43.9024 4 no
GO:0010646 regulation of cell communication 43.9024 4 no
GO:0031323 regulation of cellular metabolic process 43.9024 4 no
GO:0022607 cellular component assembly 42.6829 4 yes
GO:0080090 regulation of primary metabolic process 37.8049 4 no
GO:0009893 positive regulation of metabolic process 36.5854 4 no
GO:0009966 regulation of signal transduction 36.5854 4 no
GO:0044087 regulation of cellular component biogenesis 35.3659 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 35.3659 5 no
GO:0031325 positive regulation of cellular metabolic process 34.1463 5 no
GO:0007010 cytoskeleton organization 32.9268 5 yes
GO:0009889 regulation of biosynthetic process 32.9268 4 no
GO:0033043 regulation of organelle organization 31.7073 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 31.7073 5 no
GO:0031326 regulation of cellular biosynthetic process 31.7073 5 no
GO:0048584 positive regulation of response to stimulus 31.7073 4 no
GO:0010468 regulation of gene expression 30.4878 6 no
GO:0051246 regulation of protein metabolic process 30.4878 5 no
GO:0051049 regulation of transport 29.2683 4 no
GO:1902531 regulation of intracellular signal transduction 28.0488 5 no
GO:0032970 regulation of actin filament-based process 26.8293 4 yes
GO:0051493 regulation of cytoskeleton organization 26.8293 6 yes
GO:0051129 negative regulation of cellular component organization 25.6098 5 yes
GO:0010647 positive regulation of cell communication 25.6098 5 no
GO:0023056 positive regulation of signaling 25.6098 4 no
GO:0043933 protein-containing complex organization 25.6098 4 no
GO:0071702 organic substance transport 25.6098 4 no
GO:0030030 cell projection organization 25.6098 4 no
GO:0032956 regulation of actin cytoskeleton organization 24.3902 5 yes
GO:0097435 supramolecular fiber organization 24.3902 4 yes
GO:0009891 positive regulation of biosynthetic process 24.3902 5 no
GO:0009967 positive regulation of signal transduction 24.3902 5 no
GO:0019220 regulation of phosphate metabolic process 24.3902 6 no
GO:0031399 regulation of protein modification process 24.3902 6 no
GO:0051174 regulation of phosphorus metabolic process 24.3902 5 no
GO:0071705 nitrogen compound transport 24.3902 4 no
GO:0051247 positive regulation of protein metabolic process 23.1707 6 no
GO:0141124 intracellular signaling cassette 23.1707 4 no
GO:2000145 regulation of cell motility 23.1707 4 no
GO:0060341 regulation of cellular localization 23.1707 4 no
GO:0051130 positive regulation of cellular component organization 21.9512 5 yes
GO:1902903 regulation of supramolecular fiber organization 21.9512 5 yes
GO:0009892 negative regulation of metabolic process 21.9512 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.9512 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.9512 6 no
GO:0042325 regulation of phosphorylation 21.9512 7 no
GO:0032880 regulation of protein localization 21.9512 5 no
GO:0030334 regulation of cell migration 21.9512 5 no
GO:0007015 actin filament organization 20.7317 5 yes
GO:0110053 regulation of actin filament organization 20.7317 6 yes
GO:0001932 regulation of protein phosphorylation 20.7317 7 no
GO:0010605 negative regulation of macromolecule metabolic process 20.7317 5 no
GO:0043085 positive regulation of catalytic activity 20.7317 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.7317 4 no
GO:0031324 negative regulation of cellular metabolic process 20.7317 5 no
GO:0043254 regulation of protein-containing complex assembly 18.2927 5 yes
GO:0045595 regulation of cell differentiation 17.0732 4 yes
GO:0010639 negative regulation of organelle organization 15.8537 6 yes
GO:0060284 regulation of cell development 15.8537 5 yes
GO:0032271 regulation of protein polymerization 14.6341 6 yes
GO:0032535 regulation of cellular component size 14.6341 4 yes
GO:0051094 positive regulation of developmental process 14.6341 4 yes
GO:0051494 negative regulation of cytoskeleton organization 14.6341 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 14.6341 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 13.4146 6 yes
GO:2000026 regulation of multicellular organismal development 13.4146 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 12.1951 6 yes
GO:0030832 regulation of actin filament length 12.1951 5 yes
GO:0030833 regulation of actin filament polymerization 10.9756 7 yes
GO:0030834 regulation of actin filament depolymerization 10.9756 7 yes
GO:0030835 negative regulation of actin filament depolymerization 10.9756 7 yes
GO:0032272 negative regulation of protein polymerization 10.9756 7 yes
GO:0043242 negative regulation of protein-containing complex disassembly 10.9756 6 yes
GO:0043244 regulation of protein-containing complex disassembly 10.9756 5 yes
GO:1901879 regulation of protein depolymerization 10.9756 6 yes
GO:1901880 negative regulation of protein depolymerization 10.9756 7 yes
GO:0010038 response to metal ion 9.7561 4 yes
GO:0030837 negative regulation of actin filament polymerization 9.7561 7 yes
GO:0045597 positive regulation of cell differentiation 9.7561 5 yes
GO:0051693 actin filament capping 9.7561 8 yes
GO:0010720 positive regulation of cell development 8.5366 6 yes
GO:0043393 regulation of protein binding 8.5366 4 yes
GO:0051592 response to calcium ion 7.3171 5 yes
GO:0032092 positive regulation of protein binding 6.0976 5 yes
GO:0051099 positive regulation of binding 6.0976 4 yes
GO:0071241 cellular response to inorganic substance 6.0976 4 yes
GO:0071248 cellular response to metal ion 6.0976 5 yes
GO:0030856 regulation of epithelial cell differentiation 4.8780 5 yes
GO:0051016 barbed-end actin filament capping 4.8780 9 yes
GO:0051017 actin filament bundle assembly 4.8780 5 yes
GO:0061572 actin filament bundle organization 4.8780 6 yes
GO:0045601 regulation of endothelial cell differentiation 3.6585 6 yes
GO:0071277 cellular response to calcium ion 3.6585 6 yes
GO:1901550 regulation of endothelial cell development 3.6585 6 yes
GO:1903140 regulation of establishment of endothelial barrier 3.6585 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYO10_HUMAN [view interactions] Low throughput no no
SPTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
RFX1_HUMAN [view interactions] Low throughput no yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
HS105_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATLA2_HUMAN [view entry] [view interactions] High throughput yes yes
LRWD1_HUMAN [view interactions] High throughput no no
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
UBIA1_HUMAN [view interactions] High throughput no no
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
GBP2_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
RN138_HUMAN [view entry] [view interactions] High throughput yes no
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
R144A_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
VATD_HUMAN [view entry] [view interactions] High throughput yes yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
GCSP_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
MTPN_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
ASML_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
HEXA_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
NUBP1_HUMAN [view interactions] High throughput no yes
PLCB3_HUMAN [view entry] [view interactions] High throughput yes no
NSUN2_HUMAN [view interactions] High throughput no yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO5_HUMAN [view interactions] High throughput no yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
DYLT1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RN183_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
TNR6_HUMAN [view interactions] High throughput no no
AR13B_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
ARL15_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI7_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
PGBM_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NUP54_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ZBT18_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
ST17B_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PIM3_HUMAN [view interactions] High throughput no no
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
CDKL2_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
MD13L_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
CRYAA_HUMAN [view interactions] High throughput no no
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
DRC5_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
HM20A_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
KLH42_HUMAN [view interactions] High throughput no yes
AIRIM_HUMAN [view interactions] High throughput no yes
HSF2B_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
FA78A_HUMAN [view interactions] High throughput no yes
DPPA4_HUMAN [view interactions] High throughput no no
ANR29_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
NEST_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CARF_HUMAN [view interactions] High throughput no yes