Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DYST_HUMAN

regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI001286 LIG_SxIP_EBH_1 LIG 7545 7558 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DYST_HUMAN
GO:0017076 purine nucleotide binding 31.3953 4 no
GO:0032555 purine ribonucleotide binding 31.3953 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.3953 4 no
GO:0019900 kinase binding 30.2326 4 no
GO:0019901 protein kinase binding 30.2326 5 no
GO:0003779 actin binding 20.9302 4 yes
GO:0046872 metal ion binding 19.7674 4 yes
GO:0015631 tubulin binding 15.1163 4 yes
GO:0005509 calcium ion binding 11.6279 5 yes
GO:0008017 microtubule binding 11.6279 5 yes
GO:0042803 protein homodimerization activity 8.1395 4 yes
GO:0051010 microtubule plus-end binding 6.9767 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DYST_HUMAN
GO:0048522 positive regulation of cellular process 68.6047 4 no
GO:0051128 regulation of cellular component organization 60.4651 4 no
GO:0048523 negative regulation of cellular process 51.1628 4 no
GO:0060255 regulation of macromolecule metabolic process 51.1628 4 no
GO:0080090 regulation of primary metabolic process 48.8372 4 no
GO:0006996 organelle organization 47.6744 4 yes
GO:0031323 regulation of cellular metabolic process 46.5116 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.5116 4 no
GO:0009893 positive regulation of metabolic process 45.3488 4 no
GO:0010646 regulation of cell communication 45.3488 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.0233 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.8605 5 no
GO:0022607 cellular component assembly 40.6977 4 yes
GO:0051049 regulation of transport 39.5349 4 no
GO:0008104 protein localization 39.5349 4 no
GO:0009966 regulation of signal transduction 38.3721 4 no
GO:0051246 regulation of protein metabolic process 38.3721 5 no
GO:0030030 cell projection organization 36.0465 4 no
GO:0051247 positive regulation of protein metabolic process 34.8837 6 no
GO:0010468 regulation of gene expression 34.8837 5 no
GO:0007010 cytoskeleton organization 33.7209 5 yes
GO:0031325 positive regulation of cellular metabolic process 32.5581 5 no
GO:0044087 regulation of cellular component biogenesis 32.5581 4 no
GO:0033043 regulation of organelle organization 31.3953 5 no
GO:0120036 plasma membrane bounded cell projection organization 30.2326 5 no
GO:0048584 positive regulation of response to stimulus 30.2326 4 no
GO:1902531 regulation of intracellular signal transduction 29.0698 5 no
GO:0071310 cellular response to organic substance 29.0698 4 no
GO:0051130 positive regulation of cellular component organization 29.0698 5 no
GO:0031399 regulation of protein modification process 27.9070 6 no
GO:0010647 positive regulation of cell communication 27.9070 5 no
GO:0023056 positive regulation of signaling 27.9070 4 no
GO:0051050 positive regulation of transport 26.7442 4 no
GO:0031344 regulation of cell projection organization 26.7442 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.7442 6 no
GO:0009967 positive regulation of signal transduction 25.5814 5 no
GO:0071702 organic substance transport 25.5814 4 no
GO:0009892 negative regulation of metabolic process 24.4186 4 no
GO:0019220 regulation of phosphate metabolic process 24.4186 6 no
GO:0051174 regulation of phosphorus metabolic process 24.4186 5 no
GO:0060341 regulation of cellular localization 24.4186 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.4186 4 no
GO:0036211 protein modification process 24.4186 4 no
GO:0043412 macromolecule modification 24.4186 4 no
GO:0001932 regulation of protein phosphorylation 23.2558 7 no
GO:0010605 negative regulation of macromolecule metabolic process 23.2558 5 no
GO:0031401 positive regulation of protein modification process 23.2558 7 no
GO:0042325 regulation of phosphorylation 23.2558 7 no
GO:0016192 vesicle-mediated transport 23.2558 4 no
GO:0009889 regulation of biosynthetic process 23.2558 4 no
GO:0031326 regulation of cellular biosynthetic process 23.2558 5 no
GO:0032880 regulation of protein localization 23.2558 5 no
GO:0045595 regulation of cell differentiation 23.2558 4 no
GO:0051493 regulation of cytoskeleton organization 23.2558 6 no
GO:0071705 nitrogen compound transport 23.2558 4 no
GO:0097435 supramolecular fiber organization 22.0930 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 20.9302 5 no
GO:0051094 positive regulation of developmental process 20.9302 4 no
GO:0060627 regulation of vesicle-mediated transport 20.9302 4 no
GO:0051240 positive regulation of multicellular organismal process 20.9302 4 no
GO:0034330 cell junction organization 18.6047 4 yes
GO:0034329 cell junction assembly 11.6279 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 9.3023 4 yes
GO:0099111 microtubule-based transport 9.3023 4 yes
GO:0010970 transport along microtubule 8.1395 4 yes
GO:0007229 integrin-mediated signaling pathway 6.9767 4 yes
GO:0031122 cytoplasmic microtubule organization 5.8140 4 yes
GO:0008088 axo-dendritic transport 4.6512 5 yes
GO:0042060 wound healing 4.6512 4 yes
GO:0098930 axonal transport 4.6512 6 yes
GO:0007044 cell-substrate junction assembly 3.4884 6 yes
GO:0008090 retrograde axonal transport 3.4884 7 yes
GO:0031581 hemidesmosome assembly 3.4884 7 yes
GO:0150115 cell-substrate junction organization 3.4884 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in DYST_HUMAN
DOID:0050700 cardiomyopathy 3.4884 4 no
DOID:0060036 intrinsic cardiomyopathy 3.4884 5 no
DOID:114 heart disease 3.4884 3 no
DOID:331 central nervous system disease 2.3256 3 no
DOID:0111962 combined immunodeficiency 2.3256 4 no
DOID:612 primary immunodeficiency disease 2.3256 3 no
DOID:0050686 organ system cancer 2.3256 3 no
DOID:10534 stomach cancer 2.3256 5 no
DOID:3119 gastrointestinal system cancer 2.3256 4 no
DOID:2843 long QT syndrome 2.3256 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] Low throughput yes yes
COHA1_HUMAN [view interactions] Low throughput no no
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
DYST_HUMAN [view entry] [view interactions] Low throughput yes yes
PERI_HUMAN [view entry] [view interactions] Low throughput yes no
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
NFH_HUMAN [view entry] [view interactions] Low throughput yes yes
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
ALDR_HUMAN [view interactions] High throughput no no
PUF60_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
INSR_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
MK06_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
PE2R4_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
STK3_HUMAN [view interactions] High throughput no yes
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CSAG2_HUMAN [view interactions] High throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
ANKR1_HUMAN [view interactions] High throughput no no
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
C1T9A_HUMAN [view interactions] High throughput no no
CLIP4_HUMAN [view interactions] High throughput no yes
MYPC2_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
FERM2_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
3BP5_HUMAN [view interactions] High throughput no yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
CHP3_HUMAN [view interactions] High throughput no yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
PEBB_HUMAN [view interactions] High throughput no no
MOB1A_HUMAN [view interactions] High throughput no yes
MOB1B_HUMAN [view interactions] High throughput no yes
DRC5_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
MED4_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
EPHA1_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
EPHA3_HUMAN [view interactions] High throughput no yes
FGFR2_HUMAN [view interactions] High throughput no yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view interactions] High throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
AAKB2_HUMAN [view interactions] High throughput no yes
ECM29_HUMAN [view interactions] High throughput no no
4ET_HUMAN [view interactions] High throughput no yes
RT31_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
PPP6_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
TTC23_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
SOCS6_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
H4_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
ID2_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
TXLNA_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
CEA16_HUMAN [view interactions] High throughput no no
COQ4_HUMAN [view interactions] High throughput no yes
ACHA_HUMAN [view entry] [view interactions] High throughput yes no
NGN3_HUMAN [view interactions] High throughput no no
ISL2_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
RB40B_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOQ_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
CLMN_HUMAN [view entry] [view interactions] High throughput yes no
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MICA2_HUMAN [view interactions] High throughput no yes
KLHL1_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
GOGA1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LMAN1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
CELR3_HUMAN [view interactions] High throughput no no
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD2_HUMAN [view interactions] High throughput no yes
SMAD9_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
MIPT3_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
TCPR2_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MAGA1_HUMAN [view interactions] High throughput no no
CSN7B_HUMAN [view interactions] High throughput no yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
RL1D1_HUMAN [view interactions] High throughput no yes
AT1A2_HUMAN [view entry] [view interactions] High throughput yes yes
CSTF3_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
VSX1_HUMAN [view interactions] High throughput no no