AT1A2_HUMAN
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AT1A2_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 40.6250 | 4 | yes |
GO:0008324 | cation transmembrane transporter activity | 37.5000 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 37.5000 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 31.2500 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 31.2500 | 5 | yes |
GO:0015399 | primary active transmembrane transporter activity | 28.1250 | 4 | yes |
GO:0017076 | purine nucleotide binding | 28.1250 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 28.1250 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.1250 | 4 | yes |
GO:0005524 | ATP binding | 25.0000 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | yes |
GO:0015662 | P-type ion transporter activity | 21.8750 | 4 | yes |
GO:0005509 | calcium ion binding | 21.8750 | 5 | no |
GO:0019900 | kinase binding | 21.8750 | 4 | no |
GO:0015079 | potassium ion transmembrane transporter activity | 18.7500 | 6 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 18.7500 | 6 | yes |
GO:0005391 | P-type sodium:potassium-exchanging transporter activity | 15.6250 | 5 | yes |
GO:0008554 | P-type sodium transporter activity | 15.6250 | 4 | yes |
GO:0008556 | P-type potassium transmembrane transporter activity | 15.6250 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 12.5000 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 12.5000 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 12.5000 | 6 | yes |
GO:0046982 | protein heterodimerization activity | 12.5000 | 4 | yes |
GO:0016887 | ATP hydrolysis activity | 9.3750 | 7 | yes |
GO:0016791 | phosphatase activity | 6.2500 | 5 | yes |
GO:0030955 | potassium ion binding | 6.2500 | 6 | yes |
GO:0031402 | sodium ion binding | 6.2500 | 6 | yes |
GO:0031420 | alkali metal ion binding | 6.2500 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 6.2500 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AT1A2_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 56.2500 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 53.1250 | 4 | no |
GO:0030003 | cellular cation homeostasis | 46.8750 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 46.8750 | 4 | yes |
GO:0048878 | chemical homeostasis | 46.8750 | 4 | yes |
GO:0050801 | ion homeostasis | 46.8750 | 5 | yes |
GO:0055065 | metal ion homeostasis | 46.8750 | 7 | yes |
GO:0055080 | cation homeostasis | 46.8750 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 46.8750 | 6 | yes |
GO:0006812 | cation transport | 46.8750 | 5 | yes |
GO:0006873 | cellular ion homeostasis | 46.8750 | 4 | yes |
GO:0006875 | cellular metal ion homeostasis | 46.8750 | 6 | yes |
GO:0030001 | metal ion transport | 40.6250 | 6 | yes |
GO:0051128 | regulation of cellular component organization | 40.6250 | 4 | no |
GO:0022607 | cellular component assembly | 40.6250 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | no |
GO:0010646 | regulation of cell communication | 37.5000 | 4 | yes |
GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
GO:0098655 | cation transmembrane transport | 37.5000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 37.5000 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 37.5000 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
GO:0006996 | organelle organization | 34.3750 | 4 | no |
GO:0043269 | regulation of ion transport | 31.2500 | 5 | yes |
GO:0071310 | cellular response to organic substance | 31.2500 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 31.2500 | 4 | no |
GO:0010959 | regulation of metal ion transport | 28.1250 | 6 | yes |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 28.1250 | 6 | yes |
GO:0044057 | regulation of system process | 28.1250 | 4 | yes |
GO:0055067 | monovalent inorganic cation homeostasis | 28.1250 | 7 | yes |
GO:0009892 | negative regulation of metabolic process | 28.1250 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 28.1250 | 4 | no |
GO:0010468 | regulation of gene expression | 28.1250 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | yes |
GO:0090257 | regulation of muscle system process | 25.0000 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
GO:0006937 | regulation of muscle contraction | 25.0000 | 6 | yes |
GO:0030007 | cellular potassium ion homeostasis | 21.8750 | 7 | yes |
GO:0035725 | sodium ion transmembrane transport | 21.8750 | 6 | yes |
GO:0036376 | sodium ion export across plasma membrane | 21.8750 | 4 | yes |
GO:0055075 | potassium ion homeostasis | 21.8750 | 8 | yes |
GO:0055078 | sodium ion homeostasis | 21.8750 | 8 | yes |
GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 21.8750 | 4 | yes |
GO:0098657 | import into cell | 21.8750 | 4 | yes |
GO:0098659 | inorganic cation import across plasma membrane | 21.8750 | 5 | yes |
GO:0099587 | inorganic ion import across plasma membrane | 21.8750 | 4 | yes |
GO:1903522 | regulation of blood circulation | 21.8750 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 21.8750 | 6 | yes |
GO:0033043 | regulation of organelle organization | 21.8750 | 5 | no |
GO:0043933 | protein-containing complex organization | 21.8750 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 21.8750 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.8750 | 5 | no |
GO:0030030 | cell projection organization | 21.8750 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.8750 | 5 | no |
GO:0006813 | potassium ion transport | 21.8750 | 7 | yes |
GO:0006814 | sodium ion transport | 21.8750 | 7 | yes |
GO:0006883 | cellular sodium ion homeostasis | 21.8750 | 7 | yes |
GO:0008016 | regulation of heart contraction | 18.7500 | 6 | yes |
GO:0014070 | response to organic cyclic compound | 18.7500 | 4 | yes |
GO:0019722 | calcium-mediated signaling | 18.7500 | 5 | yes |
GO:0019932 | second-messenger-mediated signaling | 18.7500 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 18.7500 | 5 | yes |
GO:0051924 | regulation of calcium ion transport | 18.7500 | 7 | yes |
GO:0071407 | cellular response to organic cyclic compound | 18.7500 | 5 | yes |
GO:0071805 | potassium ion transmembrane transport | 18.7500 | 6 | yes |
GO:0090075 | relaxation of muscle | 18.7500 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 18.7500 | 4 | yes |
GO:1902600 | proton transmembrane transport | 18.7500 | 6 | yes |
GO:1990573 | potassium ion import across plasma membrane | 18.7500 | 6 | yes |
GO:0003018 | vascular process in circulatory system | 18.7500 | 4 | yes |
GO:0006942 | regulation of striated muscle contraction | 15.6250 | 7 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 15.6250 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 15.6250 | 5 | yes |
GO:0032870 | cellular response to hormone stimulus | 15.6250 | 4 | yes |
GO:0033993 | response to lipid | 15.6250 | 4 | yes |
GO:0048545 | response to steroid hormone | 15.6250 | 4 | yes |
GO:0055119 | relaxation of cardiac muscle | 15.6250 | 5 | yes |
GO:0071396 | cellular response to lipid | 15.6250 | 5 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 15.6250 | 7 | yes |
GO:0002028 | regulation of sodium ion transport | 15.6250 | 7 | yes |
GO:0006940 | regulation of smooth muscle contraction | 12.5000 | 7 | yes |
GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 12.5000 | 6 | yes |
GO:0035150 | regulation of tube size | 12.5000 | 4 | yes |
GO:0035296 | regulation of tube diameter | 12.5000 | 5 | yes |
GO:0050890 | cognition | 12.5000 | 4 | yes |
GO:0055117 | regulation of cardiac muscle contraction | 12.5000 | 7 | yes |
GO:0071383 | cellular response to steroid hormone stimulus | 12.5000 | 5 | yes |
GO:0086009 | membrane repolarization | 12.5000 | 4 | yes |
GO:0097746 | blood vessel diameter maintenance | 12.5000 | 5 | yes |
GO:0006936 | muscle contraction | 12.5000 | 4 | yes |
GO:0006941 | striated muscle contraction | 9.3750 | 5 | yes |
GO:0010232 | vascular transport | 9.3750 | 4 | yes |
GO:0019229 | regulation of vasoconstriction | 9.3750 | 6 | yes |
GO:0032970 | regulation of actin filament-based process | 9.3750 | 4 | yes |
GO:0045822 | negative regulation of heart contraction | 9.3750 | 6 | yes |
GO:0045823 | positive regulation of heart contraction | 9.3750 | 6 | yes |
GO:0045932 | negative regulation of muscle contraction | 9.3750 | 5 | yes |
GO:0051051 | negative regulation of transport | 9.3750 | 4 | yes |
GO:0051282 | regulation of sequestering of calcium ion | 9.3750 | 4 | yes |
GO:0060048 | cardiac muscle contraction | 9.3750 | 6 | yes |
GO:0150104 | transport across blood-brain barrier | 9.3750 | 5 | yes |
GO:1902305 | regulation of sodium ion transmembrane transport | 9.3750 | 7 | yes |
GO:1903416 | response to glycoside | 9.3750 | 4 | yes |
GO:1903523 | negative regulation of blood circulation | 9.3750 | 5 | yes |
GO:1903524 | positive regulation of blood circulation | 9.3750 | 5 | yes |
GO:0007612 | learning | 6.2500 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 6.2500 | 5 | yes |
GO:0009141 | nucleoside triphosphate metabolic process | 6.2500 | 5 | yes |
GO:0009144 | purine nucleoside triphosphate metabolic process | 6.2500 | 6 | yes |
GO:0009150 | purine ribonucleotide metabolic process | 6.2500 | 6 | yes |
GO:0009199 | ribonucleoside triphosphate metabolic process | 6.2500 | 6 | yes |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 6.2500 | 7 | yes |
GO:0009259 | ribonucleotide metabolic process | 6.2500 | 5 | yes |
GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 6.2500 | 6 | yes |
GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 6.2500 | 7 | yes |
GO:0019693 | ribose phosphate metabolic process | 6.2500 | 4 | yes |
GO:0034763 | negative regulation of transmembrane transport | 6.2500 | 5 | yes |
GO:0034766 | negative regulation of ion transmembrane transport | 6.2500 | 6 | yes |
GO:0043271 | negative regulation of ion transport | 6.2500 | 5 | yes |
GO:0044070 | regulation of anion transport | 6.2500 | 6 | yes |
GO:0046034 | ATP metabolic process | 6.2500 | 7 | yes |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 6.2500 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 6.2500 | 5 | yes |
GO:0051899 | membrane depolarization | 6.2500 | 4 | yes |
GO:0051926 | negative regulation of calcium ion transport | 6.2500 | 6 | yes |
GO:0072521 | purine-containing compound metabolic process | 6.2500 | 4 | yes |
GO:0086010 | membrane depolarization during action potential | 6.2500 | 5 | yes |
GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 6.2500 | 6 | yes |
GO:1901019 | regulation of calcium ion transmembrane transporter activity | 6.2500 | 6 | yes |
GO:1903170 | negative regulation of calcium ion transmembrane transport | 6.2500 | 7 | yes |
GO:1903279 | regulation of calcium:sodium antiporter activity | 6.2500 | 7 | yes |
GO:1903959 | regulation of anion transmembrane transport | 6.2500 | 6 | yes |
GO:1904063 | negative regulation of cation transmembrane transport | 6.2500 | 7 | yes |
GO:2000649 | regulation of sodium ion transmembrane transporter activity | 6.2500 | 6 | yes |
GO:0006163 | purine nucleotide metabolic process | 6.2500 | 5 | yes |
GO:0006753 | nucleoside phosphate metabolic process | 6.2500 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 6.2500 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ZNRF2_HUMAN | [view interactions] | Low throughput | no | yes |
NAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCD21_HUMAN | [view interactions] | Low throughput | no | no |
KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
FBX25_HUMAN | [view interactions] | High throughput | no | no |
ZNRF1_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
STB5L_HUMAN | [view interactions] | High throughput | no | no |
DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
TPX2_HUMAN | [view interactions] | High throughput | no | yes |
IL2RA_HUMAN | [view interactions] | High throughput | no | no |
CNGA4_HUMAN | [view interactions] | High throughput | no | no |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LIMK1_HUMAN | [view interactions] | High throughput | no | yes |
CC062_HUMAN | [view interactions] | High throughput | no | no |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
AQP5_HUMAN | [view interactions] | High throughput | no | no |
VPP4_HUMAN | [view interactions] | High throughput | no | no |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPPA3_HUMAN | [view interactions] | High throughput | no | no |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBRAP_HUMAN | [view interactions] | High throughput | no | no |
H4_HUMAN | [view interactions] | High throughput | no | yes |
ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P2RY8_HUMAN | [view interactions] | High throughput | no | no |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
APBB1_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCN1A_HUMAN | [view interactions] | Computational | no | no |
XLRS1_HUMAN | [view interactions] | Computational | no | no |
AT1B3_HUMAN | [view interactions] | Computational | no | yes |
PLM_HUMAN | [view interactions] | Computational | no | no |
AT1A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PPLA_HUMAN | [view interactions] | Computational | no | no |
AT1B4_HUMAN | [view interactions] | Computational | no | no |
ATNG_HUMAN | [view interactions] | Computational | no | no |
AT2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CAC1A_HUMAN | [view interactions] | Computational | no | no |