ATP4A_HUMAN
Evidence for PS localization
Functions
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell . Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 . Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ATP4A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 47.3684 | 4 | yes |
| GO:0000166 | nucleotide binding | 42.1053 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.1053 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 42.1053 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.1053 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 39.4737 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 39.4737 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 39.4737 | 6 | yes |
| GO:0043169 | cation binding | 39.4737 | 4 | yes |
| GO:0046872 | metal ion binding | 39.4737 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 28.9474 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 28.9474 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 26.3158 | 5 | yes |
| GO:0005525 | GTP binding | 26.3158 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 26.3158 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 26.3158 | 5 | no |
| GO:0003924 | GTPase activity | 23.6842 | 7 | no |
| GO:0045296 | cadherin binding | 23.6842 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 21.0526 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 18.4211 | 6 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 18.4211 | 6 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 18.4211 | 4 | yes |
| GO:0005391 | P-type sodium:potassium-exchanging transporter activity | 15.7895 | 5 | yes |
| GO:0005524 | ATP binding | 15.7895 | 5 | yes |
| GO:0008554 | P-type sodium transporter activity | 15.7895 | 4 | yes |
| GO:0008556 | P-type potassium transmembrane transporter activity | 15.7895 | 4 | yes |
| GO:0015662 | P-type ion transporter activity | 15.7895 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 15.7895 | 7 | yes |
| GO:0030554 | adenyl nucleotide binding | 15.7895 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 15.7895 | 5 | yes |
| GO:0030955 | potassium ion binding | 10.5263 | 7 | yes |
| GO:0031420 | alkali metal ion binding | 10.5263 | 6 | yes |
| GO:0000287 | magnesium ion binding | 7.8947 | 6 | yes |
| GO:0015078 | proton transmembrane transporter activity | 7.8947 | 5 | yes |
| GO:0008553 | P-type proton-exporting transporter activity | 5.2632 | 4 | yes |
| GO:0008900 | P-type potassium:proton transporter activity | 5.2632 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ATP4A_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 47.3684 | 4 | yes |
| GO:0008104 | protein localization | 44.7368 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.7368 | 4 | no |
| GO:0071705 | nitrogen compound transport | 44.7368 | 4 | no |
| GO:0015031 | protein transport | 42.1053 | 4 | no |
| GO:0071702 | organic substance transport | 42.1053 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.4737 | 4 | no |
| GO:0098657 | import into cell | 36.8421 | 4 | yes |
| GO:0006996 | organelle organization | 34.2105 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.2105 | 4 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.5789 | 4 | no |
| GO:0006811 | monoatomic ion transport | 28.9474 | 4 | yes |
| GO:0010646 | regulation of cell communication | 28.9474 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.9474 | 5 | no |
| GO:0061024 | membrane organization | 28.9474 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.9474 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.9474 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.9474 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 28.9474 | 4 | no |
| GO:0006812 | monoatomic cation transport | 26.3158 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 26.3158 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 26.3158 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 26.3158 | 4 | yes |
| GO:0006886 | intracellular protein transport | 26.3158 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 26.3158 | 4 | no |
| GO:0030001 | metal ion transport | 23.6842 | 6 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 23.6842 | 5 | yes |
| GO:0016050 | vesicle organization | 23.6842 | 5 | no |
| GO:0051046 | regulation of secretion | 23.6842 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 23.6842 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.6842 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 23.6842 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.6842 | 5 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 21.0526 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 21.0526 | 4 | yes |
| GO:0046903 | secretion | 21.0526 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.0526 | 4 | no |
| GO:0061025 | membrane fusion | 21.0526 | 5 | no |
| GO:0072657 | protein localization to membrane | 21.0526 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | no |
| GO:0006813 | potassium ion transport | 18.4211 | 7 | yes |
| GO:0006814 | sodium ion transport | 18.4211 | 7 | yes |
| GO:0006883 | intracellular sodium ion homeostasis | 18.4211 | 5 | yes |
| GO:0030007 | intracellular potassium ion homeostasis | 18.4211 | 5 | yes |
| GO:0035725 | sodium ion transmembrane transport | 18.4211 | 5 | yes |
| GO:0055075 | potassium ion homeostasis | 18.4211 | 4 | yes |
| GO:0055078 | sodium ion homeostasis | 18.4211 | 4 | yes |
| GO:0071805 | potassium ion transmembrane transport | 18.4211 | 5 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 18.4211 | 5 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 18.4211 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 18.4211 | 5 | yes |
| GO:1990573 | potassium ion import across plasma membrane | 18.4211 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.7895 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 15.7895 | 5 | yes |
| GO:0036376 | sodium ion export across plasma membrane | 15.7895 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 15.7895 | 6 | yes |
| GO:0010155 | regulation of proton transport | 5.2632 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAL2_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| SYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNG2_HUMAN | [view interactions] | High throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP1_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPRA1_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| APOH_HUMAN | [view interactions] | High throughput | no | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| AOC3_HUMAN | [view interactions] | High throughput | no | no |
| HYEP_HUMAN | [view interactions] | High throughput | no | no |
| FAM3B_HUMAN | [view interactions] | High throughput | no | yes |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| IF_HUMAN | [view interactions] | High throughput | no | yes |
| LIPF_HUMAN | [view interactions] | High throughput | no | no |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP4B_HUMAN | [view interactions] | High throughput | no | no |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| C163A_HUMAN | [view interactions] | High throughput | no | no |
| MRC1_HUMAN | [view interactions] | High throughput | no | no |
| MPRD_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| PEPC_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S26A9_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS2_HUMAN | [view interactions] | High throughput | no | no |
| TFR2_HUMAN | [view interactions] | High throughput | no | no |
| KCNE2_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| KLK8_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1B_HUMAN | [view interactions] | High throughput | no | yes |
| LIPC_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |