ATP4A_HUMAN
Evidence for PS localization
Functions
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell . Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 . Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state . [View more on UniProt]
Protein features

Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
ATP4A_HUMAN has binary interactions with 37 proteins
Isoforms

Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ATP4A_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 47.3684 | 4 | yes |
GO:0000166 | nucleotide binding | 42.1053 | 4 | yes |
GO:0017076 | purine nucleotide binding | 42.1053 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 42.1053 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 42.1053 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 39.4737 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 39.4737 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 39.4737 | 6 | yes |
GO:0043169 | cation binding | 39.4737 | 4 | yes |
GO:0046872 | metal ion binding | 39.4737 | 5 | yes |
GO:0008324 | monoatomic cation transmembrane transporter activity | 28.9474 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 28.9474 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 26.3158 | 5 | yes |
GO:0005525 | GTP binding | 26.3158 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 26.3158 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 26.3158 | 5 | no |
GO:0003924 | GTPase activity | 23.6842 | 7 | no |
GO:0045296 | cadherin binding | 23.6842 | 4 | no |
GO:0022853 | active monoatomic ion transmembrane transporter activity | 21.0526 | 4 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 18.4211 | 6 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 18.4211 | 6 | yes |
GO:0015399 | primary active transmembrane transporter activity | 18.4211 | 4 | yes |
GO:0005391 | P-type sodium:potassium-exchanging transporter activity | 15.7895 | 5 | yes |
GO:0005524 | ATP binding | 15.7895 | 5 | yes |
GO:0008554 | P-type sodium transporter activity | 15.7895 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ATP4A_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 47.3684 | 4 | yes |
GO:0008104 | protein localization | 44.7368 | 4 | no |
GO:0048522 | positive regulation of cellular process | 44.7368 | 4 | no |
GO:0071705 | nitrogen compound transport | 44.7368 | 4 | no |
GO:0015031 | protein transport | 42.1053 | 4 | no |
GO:0071702 | organic substance transport | 42.1053 | 4 | no |
GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 39.4737 | 4 | no |
GO:0098657 | import into cell | 36.8421 | 4 | yes |
GO:0006996 | organelle organization | 34.2105 | 4 | no |
GO:0051128 | regulation of cellular component organization | 34.2105 | 4 | no |
GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
GO:0060341 | regulation of cellular localization | 31.5789 | 4 | no |
GO:0006811 | monoatomic ion transport | 28.9474 | 4 | yes |
GO:0010646 | regulation of cell communication | 28.9474 | 4 | no |
GO:0032880 | regulation of protein localization | 28.9474 | 5 | no |
GO:0061024 | membrane organization | 28.9474 | 4 | no |
GO:0071310 | cellular response to organic substance | 28.9474 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 28.9474 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 28.9474 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 28.9474 | 4 | no |
GO:0006812 | monoatomic cation transport | 26.3158 | 5 | yes |
GO:0006873 | intracellular monoatomic ion homeostasis | 26.3158 | 4 | yes |
GO:0030003 | intracellular monoatomic cation homeostasis | 26.3158 | 5 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
3BHS2_HUMAN | [view interactions] | High throughput | no | no |
ACSL1_HUMAN | [view interactions] | High throughput | no | no |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIRE_HUMAN | [view interactions] | High throughput | no | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AOC3_HUMAN | [view interactions] | High throughput | no | no |
APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOA1_HUMAN | [view interactions] | High throughput | no | no |
APOH_HUMAN | [view interactions] | High throughput | no | no |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATP4B_HUMAN | [view interactions] | High throughput | no | no |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BOREA_HUMAN | [view interactions] | High throughput | no | yes |