Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATP4A_HUMAN

GO
G2C
SynGO

The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell . Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 . Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state . [View more on UniProt]

01002003004005006007008009001,000
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%

Interacting region for partners were not defined.

ATP4A_HUMAN has binary interactions with 37 proteins

ATP4A_HUMANGNAI1_HUMANS12A2_HUMANRB11A_HUMANVAT1_HUMANSTX12_HUMANAHNK_HUMANSTX7_HUMANSC22B_HUMANCLH1_HUMANVAMP3_HUMANANXA7_HUMANANXA6_HUMANVATA_HUMANGBG2_HUMANAT1A2_HUMANCTND1_HUMANRAB1A_HUMANANX11_HUMANANXA1_HUMANBASI_HUMANAT1B1_HUMANRAB10_HUMANANXA2_HUMANGPM6A_HUMANAPBB1_HUMANPTN1_HUMANRAB7A_HUMANRB11B_HUMANRAB5C_HUMANAT1A1_HUMANVAMP2_HUMANGNAI2_HUMANGNAQ_HUMANSTX3_HUMANAT1A3_HUMANSNAA_HUMANATP4A_HUMANATP4A_HUMANGNAI1_HUMANS12A2_HUMANRB11A_HUMANVAT1_HUMANSTX12_HUMANAHNK_HUMANSTX7_HUMANSC22B_HUMANCLH1_HUMANVAMP3_HUMANANXA7_HUMANANXA6_HUMANVATA_HUMANGBG2_HUMANAT1A2_HUMANCTND1_HUMANRAB1A_HUMANANX11_HUMANANXA1_HUMANBASI_HUMANAT1B1_HUMANRAB10_HUMANANXA2_HUMANGPM6A_HUMANAPBB1_HUMANPTN1_HUMANRAB7A_HUMANRB11B_HUMANRAB5C_HUMANAT1A1_HUMANVAMP2_HUMANGNAI2_HUMANGNAQ_HUMANSTX3_HUMANAT1A3_HUMANSNAA_HUMANATP4A_HUMAN
Download full PS network for entry.
01002003004005006007008009001,000
Interacting regions
Canonical [ATP4A_HUMAN]
Isoform [M0R249] alignment
LOADING 80%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

[GDPR]

By using PSINDB you accept the Privacy Notice in compliance with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Read the

Privacy notes
Understood