Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATP4A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell . Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 . Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ATP4A_HUMAN
GO:0017076 purine nucleotide binding 43.2432 4 yes
GO:0032555 purine ribonucleotide binding 43.2432 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.2432 4 yes
GO:0046872 metal ion binding 37.8378 4 yes
GO:0008324 cation transmembrane transporter activity 29.7297 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 29.7297 4 yes
GO:0046873 metal ion transmembrane transporter activity 27.0270 5 yes
GO:0005525 GTP binding 27.0270 5 no
GO:0019001 guanyl nucleotide binding 27.0270 5 no
GO:0032561 guanyl ribonucleotide binding 27.0270 5 no
GO:0003924 GTPase activity 24.3243 7 no
GO:0016462 pyrophosphatase activity 24.3243 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.3243 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.3243 6 no
GO:0022853 active ion transmembrane transporter activity 21.6216 4 yes
GO:0045296 cadherin binding 21.6216 4 no
GO:0015079 potassium ion transmembrane transporter activity 18.9189 6 yes
GO:0015081 sodium ion transmembrane transporter activity 18.9189 6 yes
GO:0015399 primary active transmembrane transporter activity 18.9189 4 yes
GO:0005391 P-type sodium:potassium-exchanging transporter activity 16.2162 5 yes
GO:0005524 ATP binding 16.2162 5 yes
GO:0008554 P-type sodium transporter activity 16.2162 4 yes
GO:0008556 P-type potassium transmembrane transporter activity 16.2162 4 yes
GO:0015662 P-type ion transporter activity 16.2162 4 yes
GO:0030554 adenyl nucleotide binding 16.2162 5 yes
GO:0032559 adenyl ribonucleotide binding 16.2162 5 yes
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 10.8108 5 yes
GO:0015078 proton transmembrane transporter activity 10.8108 5 yes
GO:0000287 magnesium ion binding 8.1081 5 yes
GO:0008553 P-type proton-exporting transporter activity 8.1081 4 yes
GO:0008900 P-type potassium:proton transporter activity 8.1081 5 yes
GO:0030955 potassium ion binding 8.1081 6 yes
GO:0031420 alkali metal ion binding 8.1081 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ATP4A_HUMAN
GO:0008104 protein localization 48.6486 4 no
GO:0071705 nitrogen compound transport 48.6486 4 no
GO:0015031 protein transport 45.9459 4 no
GO:0071702 organic substance transport 45.9459 4 no
GO:0051049 regulation of transport 43.2432 4 no
GO:0048522 positive regulation of cellular process 43.2432 4 no
GO:0016192 vesicle-mediated transport 40.5405 4 no
GO:0060255 regulation of macromolecule metabolic process 37.8378 4 no
GO:0006811 ion transport 35.1351 4 yes
GO:0022607 cellular component assembly 32.4324 4 no
GO:0048523 negative regulation of cellular process 32.4324 4 no
GO:0051128 regulation of cellular component organization 32.4324 4 no
GO:0006996 organelle organization 32.4324 4 no
GO:0006812 cation transport 29.7297 5 yes
GO:0006873 cellular ion homeostasis 29.7297 4 yes
GO:0030003 cellular cation homeostasis 29.7297 5 yes
GO:0048878 chemical homeostasis 29.7297 4 yes
GO:0050801 ion homeostasis 29.7297 5 yes
GO:0055080 cation homeostasis 29.7297 6 yes
GO:0098771 inorganic ion homeostasis 29.7297 6 yes
GO:0080090 regulation of primary metabolic process 29.7297 4 no
GO:0031323 regulation of cellular metabolic process 29.7297 4 no
GO:0061024 membrane organization 29.7297 4 no
GO:0006875 cellular metal ion homeostasis 27.0270 6 yes
GO:0030001 metal ion transport 27.0270 6 yes
GO:0055065 metal ion homeostasis 27.0270 7 yes
GO:0006886 intracellular protein transport 27.0270 4 no
GO:0060627 regulation of vesicle-mediated transport 27.0270 4 no
GO:0010646 regulation of cell communication 27.0270 4 no
GO:0071310 cellular response to organic substance 24.3243 4 no
GO:0051171 regulation of nitrogen compound metabolic process 24.3243 4 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0009893 positive regulation of metabolic process 24.3243 4 no
GO:0016050 vesicle organization 24.3243 5 no
GO:0051046 regulation of secretion 24.3243 5 no
GO:1903530 regulation of secretion by cell 24.3243 4 no
GO:0051050 positive regulation of transport 24.3243 4 no
GO:0030004 cellular monovalent inorganic cation homeostasis 21.6216 6 yes
GO:0055067 monovalent inorganic cation homeostasis 21.6216 7 yes
GO:0098655 cation transmembrane transport 21.6216 4 yes
GO:0098657 import into cell 21.6216 4 yes
GO:0098660 inorganic ion transmembrane transport 21.6216 4 yes
GO:0098662 inorganic cation transmembrane transport 21.6216 5 yes
GO:0009892 negative regulation of metabolic process 21.6216 4 no
GO:0032880 regulation of protein localization 21.6216 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.6216 5 no
GO:0061025 membrane fusion 21.6216 5 no
GO:0010468 regulation of gene expression 21.6216 5 no
GO:0046903 secretion 21.6216 4 no
GO:0072657 protein localization to membrane 21.6216 4 no
GO:0006813 potassium ion transport 18.9189 7 yes
GO:0006814 sodium ion transport 18.9189 7 yes
GO:0006883 cellular sodium ion homeostasis 18.9189 7 yes
GO:0030007 cellular potassium ion homeostasis 18.9189 7 yes
GO:0035725 sodium ion transmembrane transport 18.9189 6 yes
GO:0055075 potassium ion homeostasis 18.9189 8 yes
GO:0055078 sodium ion homeostasis 18.9189 8 yes
GO:0071805 potassium ion transmembrane transport 18.9189 6 yes
GO:0098659 inorganic cation import across plasma membrane 18.9189 5 yes
GO:0099587 inorganic ion import across plasma membrane 18.9189 4 yes
GO:1990573 potassium ion import across plasma membrane 18.9189 6 yes
GO:0036376 sodium ion export across plasma membrane 16.2162 4 yes
GO:1902600 proton transmembrane transport 16.2162 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NUFP1_HUMAN [view interactions] High throughput no yes
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
LIPC_HUMAN [view interactions] High throughput no no
ERO1B_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
APBB1_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
UFL1_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
MAL2_HUMAN [view interactions] High throughput no no
PRAF3_HUMAN [view interactions] High throughput no yes
SYPL1_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RAB25_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
SCAM2_HUMAN [view interactions] High throughput no no
SCAM3_HUMAN [view interactions] High throughput no no
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
SNG2_HUMAN [view interactions] High throughput no no
STX3_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
VAT1_HUMAN [view entry] [view interactions] High throughput yes no
VAMP1_HUMAN [view interactions] High throughput no no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
VAMP5_HUMAN [view interactions] High throughput no no
VAMP8_HUMAN [view interactions] High throughput no no
LMAN2_HUMAN [view interactions] High throughput no yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
TPRA1_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
APOA1_HUMAN [view interactions] High throughput no no
APOH_HUMAN [view interactions] High throughput no no
BAP31_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CAH9_HUMAN [view interactions] High throughput no no
CBPD_HUMAN [view interactions] High throughput no yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
AOC3_HUMAN [view interactions] High throughput no no
HYEP_HUMAN [view interactions] High throughput no no
FAM3B_HUMAN [view interactions] High throughput no yes
FAM3C_HUMAN [view interactions] High throughput no yes
LG3BP_HUMAN [view interactions] High throughput no no
IF_HUMAN [view interactions] High throughput no yes
LIPG_HUMAN [view interactions] High throughput no no
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
ATP4B_HUMAN [view interactions] High throughput no no
LSS_HUMAN [view interactions] High throughput no yes
ACSL1_HUMAN [view interactions] High throughput no no
C163A_HUMAN [view interactions] High throughput no no
MRC1_HUMAN [view interactions] High throughput no no
MPRD_HUMAN [view interactions] High throughput no yes
GANAB_HUMAN [view interactions] High throughput no yes
AIRE_HUMAN [view interactions] High throughput no no
PEPC_HUMAN [view interactions] High throughput no no
KCNQ1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
S26A9_HUMAN [view interactions] High throughput no no
3BHS2_HUMAN [view interactions] High throughput no no
TFR2_HUMAN [view entry] [view interactions] High throughput yes no
KCNE2_HUMAN [view interactions] High throughput no no
LGR4_HUMAN [view interactions] High throughput no yes
KLK8_HUMAN [view interactions] High throughput no no
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
UBXN8_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SKP2_HUMAN [view interactions] High throughput no yes
CLK1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
VATB1_HUMAN [view interactions] Computational no no
IPYR2_HUMAN [view interactions] Computational no yes
HRH2_HUMAN [view interactions] Computational no no
GAST_HUMAN [view interactions] Computational no no
LHPP_HUMAN [view interactions] Computational no yes
CP2CJ_HUMAN [view interactions] Computational no no
AT12A_HUMAN [view entry] [view interactions] Computational yes no
IPYR_HUMAN [view interactions] Computational no yes