STX3_HUMAN
Evidence for PS localization
Functions
Potentially involved in docking of synaptic vesicles at presynaptic active zones. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in STX3_HUMAN |
|---|---|---|---|---|
| GO:0019905 | syntaxin binding | 32.0755 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.3019 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.3019 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.3019 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 20.7547 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.7547 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.7547 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in STX3_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 58.4906 | 4 | yes |
| GO:0008104 | protein localization | 56.6038 | 4 | yes |
| GO:0006996 | organelle organization | 50.9434 | 4 | yes |
| GO:0015031 | protein transport | 50.9434 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.9434 | 4 | yes |
| GO:0071702 | organic substance transport | 50.9434 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.9434 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.1698 | 4 | no |
| GO:0051049 | regulation of transport | 47.1698 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.2830 | 4 | yes |
| GO:0061024 | membrane organization | 39.6226 | 4 | yes |
| GO:0006886 | intracellular protein transport | 35.8491 | 4 | yes |
| GO:0046903 | secretion | 35.8491 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 35.8491 | 4 | no |
| GO:0006887 | exocytosis | 33.9623 | 4 | yes |
| GO:0032880 | regulation of protein localization | 33.9623 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 33.9623 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.9623 | 4 | no |
| GO:0016050 | vesicle organization | 32.0755 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 32.0755 | 4 | no |
| GO:0023056 | positive regulation of signaling | 30.1887 | 4 | yes |
| GO:0061025 | membrane fusion | 30.1887 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 30.1887 | 4 | no |
| GO:0051046 | regulation of secretion | 30.1887 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 30.1887 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.3019 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.3019 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 28.3019 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.4151 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 26.4151 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.4151 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.4151 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.4151 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.4151 | 4 | no |
| GO:0006906 | vesicle fusion | 24.5283 | 6 | yes |
| GO:0048278 | vesicle docking | 24.5283 | 4 | yes |
| GO:0048284 | organelle fusion | 24.5283 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 24.5283 | 6 | yes |
| GO:0051223 | regulation of protein transport | 24.5283 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 24.5283 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.5283 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 24.5283 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 24.5283 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 22.6415 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 22.6415 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 22.6415 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 22.6415 | 5 | no |
| GO:0017157 | regulation of exocytosis | 22.6415 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.6415 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | no |
| GO:0072657 | protein localization to membrane | 20.7547 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.7547 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.7547 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.7547 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 20.7547 | 5 | no |
| GO:2000145 | regulation of cell motility | 20.7547 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 15.0943 | 5 | yes |
| GO:0030030 | cell projection organization | 15.0943 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 15.0943 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 15.0943 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 13.2075 | 4 | yes |
| GO:0040017 | positive regulation of locomotion | 13.2075 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 13.2075 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 13.2075 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 13.2075 | 6 | yes |
| GO:0031175 | neuron projection development | 11.3208 | 6 | yes |
| GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 11.3208 | 4 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 11.3208 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 9.4340 | 4 | yes |
| GO:0045785 | positive regulation of cell adhesion | 9.4340 | 5 | yes |
| GO:0060291 | long-term synaptic potentiation | 9.4340 | 4 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 9.4340 | 7 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 7.5472 | 5 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 7.5472 | 6 | yes |
| GO:0050920 | regulation of chemotaxis | 5.6604 | 4 | yes |
| GO:0050921 | positive regulation of chemotaxis | 5.6604 | 5 | yes |
| GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 5.6604 | 4 | yes |
| GO:1903078 | positive regulation of protein localization to plasma membrane | 5.6604 | 7 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 5.6604 | 6 | yes |
| GO:2000008 | regulation of protein localization to cell surface | 3.7736 | 6 | yes |
| GO:2000010 | positive regulation of protein localization to cell surface | 3.7736 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in STX3_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.6604 | 3 | no |
| DOID:1289 | neurodegenerative disease | 3.7736 | 4 | no |
| DOID:231 | motor neuron disease | 3.7736 | 5 | no |
| DOID:332 | amyotrophic lateral sclerosis | 3.7736 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNP23_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZFYV9_HUMAN | [view interactions] | Low throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STXB2_HUMAN | [view interactions] | Low throughput | no | no |
| SYTL4_HUMAN | [view interactions] | Low throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | Low throughput | no | yes |
| TBC30_HUMAN | [view interactions] | Low throughput | no | yes |
| EVI5_HUMAN | [view interactions] | Low throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PI3R6_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| CPLX4_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CY561_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| MANBL_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| MSMO1_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| STX10_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| TR10B_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| L2GL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K2_HUMAN | [view interactions] | High throughput | no | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| MYEF2_HUMAN | [view interactions] | High throughput | no | no |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| ZN526_HUMAN | [view interactions] | High throughput | no | yes |
| KRBX4_HUMAN | [view interactions] | High throughput | no | no |
| BUB1B_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC20_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| KIF19_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
| STXB6_HUMAN | [view interactions] | High throughput | no | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| EDAR_HUMAN | [view interactions] | High throughput | no | yes |
| LSME2_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYJ2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX3_HUMAN | [view interactions] | Computational | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VTI1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP1_HUMAN | [view interactions] | Computational | no | no |
| CPLX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |