Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STXB5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in STXB5_HUMAN
GO:0019905 syntaxin binding 40.9091 4 yes
GO:0019900 kinase binding 27.2727 4 no
GO:0017076 purine nucleotide binding 22.7273 4 no
GO:0019901 protein kinase binding 22.7273 5 no
GO:0032555 purine ribonucleotide binding 22.7273 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.7273 4 no
GO:0017075 syntaxin-1 binding 18.1818 5 yes
GO:0017022 myosin binding 13.6364 4 yes
GO:0005096 GTPase activator activity 9.0909 4 yes
GO:0030695 GTPase regulator activity 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STXB5_HUMAN
GO:0006996 organelle organization 77.2727 4 no
GO:0008104 protein localization 72.7273 4 yes
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0071702 organic substance transport 72.7273 4 yes
GO:0071705 nitrogen compound transport 72.7273 4 yes
GO:0061024 membrane organization 72.7273 4 no
GO:0010646 regulation of cell communication 68.1818 4 yes
GO:0015031 protein transport 68.1818 4 yes
GO:0016192 vesicle-mediated transport 68.1818 4 yes
GO:0022607 cellular component assembly 63.6364 4 no
GO:0051049 regulation of transport 59.0909 4 yes
GO:0051128 regulation of cellular component organization 59.0909 4 yes
GO:0061025 membrane fusion 59.0909 5 no
GO:0016050 vesicle organization 54.5455 5 no
GO:0006906 vesicle fusion 50.0000 6 no
GO:0048284 organelle fusion 50.0000 5 no
GO:0090174 organelle membrane fusion 50.0000 6 no
GO:0010647 positive regulation of cell communication 45.4545 5 no
GO:0023056 positive regulation of signaling 45.4545 4 no
GO:0006886 intracellular protein transport 45.4545 4 no
GO:0006887 exocytosis 40.9091 4 yes
GO:0032880 regulation of protein localization 40.9091 5 yes
GO:0046903 secretion 40.9091 4 yes
GO:0050804 modulation of chemical synaptic transmission 40.9091 5 yes
GO:0051046 regulation of secretion 40.9091 5 yes
GO:0060341 regulation of cellular localization 40.9091 4 yes
GO:0060627 regulation of vesicle-mediated transport 40.9091 4 yes
GO:0099177 regulation of trans-synaptic signaling 40.9091 4 yes
GO:1903530 regulation of secretion by cell 40.9091 4 yes
GO:0009966 regulation of signal transduction 40.9091 4 no
GO:0048584 positive regulation of response to stimulus 40.9091 4 no
GO:0060255 regulation of macromolecule metabolic process 40.9091 4 no
GO:0044087 regulation of cellular component biogenesis 36.3636 4 yes
GO:0051050 positive regulation of transport 36.3636 4 yes
GO:0043933 protein-containing complex organization 36.3636 4 no
GO:0048278 vesicle docking 36.3636 4 no
GO:0065003 protein-containing complex assembly 36.3636 5 no
GO:0017157 regulation of exocytosis 31.8182 5 yes
GO:0009893 positive regulation of metabolic process 31.8182 4 no
GO:0010468 regulation of gene expression 31.8182 5 no
GO:0010604 positive regulation of macromolecule metabolic process 31.8182 5 no
GO:0048523 negative regulation of cellular process 31.8182 4 no
GO:0043254 regulation of protein-containing complex assembly 27.2727 5 yes
GO:0051047 positive regulation of secretion 27.2727 5 yes
GO:1903532 positive regulation of secretion by cell 27.2727 5 yes
GO:0023061 signal release 27.2727 4 no
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 27.2727 4 no
GO:0048499 synaptic vesicle membrane organization 27.2727 5 no
GO:0050806 positive regulation of synaptic transmission 27.2727 5 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0048193 Golgi vesicle transport 22.7273 5 no
GO:1903076 regulation of protein localization to plasma membrane 22.7273 7 no
GO:1904375 regulation of protein localization to cell periphery 22.7273 6 no
GO:1905475 regulation of protein localization to membrane 22.7273 6 no
GO:0051223 regulation of protein transport 22.7273 5 yes
GO:0070201 regulation of establishment of protein localization 22.7273 6 yes
GO:0006897 endocytosis 22.7273 5 no
GO:0016079 synaptic vesicle exocytosis 22.7273 4 no
GO:0031344 regulation of cell projection organization 22.7273 5 no
GO:0045055 regulated exocytosis 22.7273 5 no
GO:0099003 vesicle-mediated transport in synapse 22.7273 5 no
GO:0099643 signal release from synapse 22.7273 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.7273 6 no
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0010648 negative regulation of cell communication 22.7273 5 no
GO:0023057 negative regulation of signaling 22.7273 4 no
GO:0031323 regulation of cellular metabolic process 22.7273 4 no
GO:0042127 regulation of cell population proliferation 22.7273 4 no
GO:0051171 regulation of nitrogen compound metabolic process 22.7273 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.7273 5 no
GO:0071310 cellular response to organic substance 22.7273 4 no
GO:1902531 regulation of intracellular signal transduction 22.7273 5 no
GO:0010807 regulation of synaptic vesicle priming 18.1818 6 yes
GO:0045921 positive regulation of exocytosis 18.1818 6 yes
GO:0046928 regulation of neurotransmitter secretion 18.1818 4 yes
GO:0050708 regulation of protein secretion 18.1818 5 yes
GO:0051588 regulation of neurotransmitter transport 18.1818 5 yes
GO:1903305 regulation of regulated secretory pathway 13.6364 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in STXB5_HUMAN
DOID:1826 epilepsy 9.0909 5 no
DOID:331 central nervous system disease 9.0909 3 no
DOID:936 brain disease 9.0909 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
STX4_HUMAN [view entry] [view interactions] Low throughput yes no
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO2_HUMAN [view interactions] Low throughput no yes
SUMO3_HUMAN [view interactions] Low throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KGP1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB1_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX3_HUMAN [view entry] [view interactions] High throughput yes no
STX19_HUMAN [view interactions] High throughput no yes
STX11_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
S10A6_HUMAN [view interactions] High throughput no yes
KXDL1_HUMAN [view interactions] High throughput no yes
STX8_HUMAN [view interactions] High throughput no yes
SEGN_HUMAN [view interactions] High throughput no no
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
SYBU_HUMAN [view interactions] Computational no yes
VAMP2_HUMAN [view entry] [view interactions] Computational yes no
STX1B_HUMAN [view entry] [view interactions] Computational yes yes
VAMP8_HUMAN [view interactions] Computational no no
VAMP4_HUMAN [view interactions] Computational no yes
STX5_HUMAN [view interactions] Computational no yes
STX2_HUMAN [view interactions] Computational no no
CPLX1_HUMAN [view entry] [view interactions] Computational yes yes
VTI1A_HUMAN [view interactions] Computational no yes