VTI1B_HUMAN
Evidence for PS localization
Functions
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VTI1B_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.3509 | 4 | no |
| GO:0000166 | nucleotide binding | 35.0877 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.0877 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.0877 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.0877 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 31.5789 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.5789 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.5789 | 6 | no |
| GO:0005525 | GTP binding | 26.3158 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 26.3158 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 26.3158 | 5 | no |
| GO:0003924 | GTPase activity | 24.5614 | 7 | no |
| GO:0008200 | ion channel inhibitor activity | 7.0175 | 5 | yes |
| GO:0016248 | channel inhibitor activity | 7.0175 | 4 | yes |
| GO:0099106 | ion channel regulator activity | 7.0175 | 4 | yes |
| GO:0017081 | chloride channel regulator activity | 5.2632 | 5 | yes |
| GO:0019869 | chloride channel inhibitor activity | 5.2632 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VTI1B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 59.6491 | 4 | yes |
| GO:0071702 | organic substance transport | 54.3860 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 52.6316 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.6316 | 4 | no |
| GO:0015031 | protein transport | 50.8772 | 4 | yes |
| GO:0006996 | organelle organization | 49.1228 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.8596 | 4 | no |
| GO:0051049 | regulation of transport | 42.1053 | 4 | no |
| GO:0006886 | intracellular protein transport | 40.3509 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.3509 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.3509 | 4 | no |
| GO:0061024 | membrane organization | 38.5965 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 36.8421 | 4 | no |
| GO:0022607 | cellular component assembly | 35.0877 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.5789 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.8246 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.8246 | 4 | no |
| GO:0016050 | vesicle organization | 28.0702 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.0702 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.3158 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.3158 | 5 | no |
| GO:0051046 | regulation of secretion | 26.3158 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 26.3158 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.5614 | 5 | yes |
| GO:0010468 | regulation of gene expression | 24.5614 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.5614 | 4 | no |
| GO:0017157 | regulation of exocytosis | 24.5614 | 5 | no |
| GO:0061025 | membrane fusion | 22.8070 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 22.8070 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.8070 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.8070 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 21.0526 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | no |
| GO:1903305 | regulation of regulated secretory pathway | 21.0526 | 6 | no |
| GO:0048284 | organelle fusion | 19.2982 | 5 | yes |
| GO:0006906 | vesicle fusion | 17.5439 | 6 | yes |
| GO:0090174 | organelle membrane fusion | 17.5439 | 6 | yes |
| GO:0007034 | vacuolar transport | 14.0351 | 4 | yes |
| GO:0048278 | vesicle docking | 14.0351 | 4 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 12.2807 | 4 | yes |
| GO:0016482 | cytosolic transport | 10.5263 | 4 | yes |
| GO:0007030 | Golgi organization | 8.7719 | 5 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 8.7719 | 7 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 8.7719 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.7719 | 6 | yes |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 7.0175 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 7.0175 | 4 | yes |
| GO:0006896 | Golgi to vacuole transport | 5.2632 | 5 | yes |
| GO:0016236 | macroautophagy | 5.2632 | 4 | yes |
| GO:0048280 | vesicle fusion with Golgi apparatus | 3.5088 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTN9_HUMAN | [view interactions] | Low throughput | no | yes |
| STX8_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GOGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| MCP_HUMAN | [view interactions] | High throughput | no | no |
| CRUM3_HUMAN | [view interactions] | High throughput | no | no |
| ASGR2_HUMAN | [view interactions] | High throughput | no | no |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| STXB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| STX10_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| HAUS7_HUMAN | [view interactions] | High throughput | no | no |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| STXB6_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| TNF12_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| VTI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTTG_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| TRDN_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASC3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| PR15B_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| CL12A_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| TRI59_HUMAN | [view interactions] | High throughput | no | no |
| SYNE4_HUMAN | [view interactions] | High throughput | no | yes |
| KASH5_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| TM234_HUMAN | [view interactions] | High throughput | no | yes |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| RNK_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MANBL_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| FCGR1_HUMAN | [view interactions] | High throughput | no | no |