VTI1B_HUMAN
Evidence for PS localization
Functions
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VTI1B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.0345 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.0345 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.0345 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.8621 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.8621 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.8621 | 6 | no |
| GO:0005525 | GTP binding | 24.1379 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 24.1379 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 24.1379 | 5 | no |
| GO:0003924 | GTPase activity | 22.4138 | 7 | no |
| GO:0017081 | chloride channel regulator activity | 5.1724 | 4 | yes |
| GO:0019869 | chloride channel inhibitor activity | 5.1724 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VTI1B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 67.2414 | 4 | yes |
| GO:0071702 | organic substance transport | 62.0690 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 60.3448 | 4 | yes |
| GO:0015031 | protein transport | 58.6207 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 58.6207 | 4 | yes |
| GO:0006996 | organelle organization | 55.1724 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.4483 | 4 | no |
| GO:0051049 | regulation of transport | 44.8276 | 4 | no |
| GO:0006886 | intracellular protein transport | 43.1034 | 4 | yes |
| GO:0061024 | membrane organization | 43.1034 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.3793 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.6552 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.9310 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 36.2069 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.4828 | 4 | no |
| GO:0022607 | cellular component assembly | 34.4828 | 4 | no |
| GO:0016050 | vesicle organization | 32.7586 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 32.7586 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.0345 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.0345 | 4 | no |
| GO:0061025 | membrane fusion | 29.3103 | 5 | yes |
| GO:0051046 | regulation of secretion | 29.3103 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 29.3103 | 4 | no |
| GO:0048284 | organelle fusion | 27.5862 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.5862 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.8621 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 25.8621 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 25.8621 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.8621 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.8621 | 5 | no |
| GO:0006906 | vesicle fusion | 24.1379 | 6 | yes |
| GO:0048193 | Golgi vesicle transport | 24.1379 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 24.1379 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 24.1379 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.1379 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.1379 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.1379 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4138 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.4138 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.4138 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.4138 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.6897 | 4 | no |
| GO:1903305 | regulation of regulated secretory pathway | 20.6897 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.6897 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.6897 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.6897 | 5 | no |
| GO:0007034 | vacuolar transport | 15.5172 | 4 | yes |
| GO:0048278 | vesicle docking | 15.5172 | 4 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 13.7931 | 6 | yes |
| GO:0016197 | endosomal transport | 13.7931 | 4 | yes |
| GO:0016482 | cytosolic transport | 12.0690 | 4 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 10.3448 | 7 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 10.3448 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 10.3448 | 6 | yes |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 8.6207 | 6 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 8.6207 | 5 | yes |
| GO:0007030 | Golgi organization | 6.8966 | 5 | yes |
| GO:0016236 | macroautophagy | 5.1724 | 4 | yes |
| GO:0006896 | Golgi to vacuole transport | 3.4483 | 5 | yes |
| GO:0048280 | vesicle fusion with Golgi apparatus | 3.4483 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VTI1B_HUMAN |
|---|---|---|---|---|
| DOID:440 | neuromuscular disease | 5.1724 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.1724 | 3 | no |
| DOID:870 | neuropathy | 5.1724 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.4483 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.4483 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | Low throughput | no | yes |
| GOGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| STX8_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| PR15B_HUMAN | [view interactions] | High throughput | no | no |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| CASC3_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| CL12A_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| SYNE4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI59_HUMAN | [view interactions] | High throughput | no | no |
| KASH5_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| TM234_HUMAN | [view interactions] | High throughput | no | yes |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| RNK_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MANBL_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| FCGR1_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| MCP_HUMAN | [view interactions] | High throughput | no | no |
| CRUM3_HUMAN | [view interactions] | High throughput | no | no |
| ASGR2_HUMAN | [view interactions] | High throughput | no | no |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| STXB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| STX10_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| HAUS7_HUMAN | [view interactions] | High throughput | no | no |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| STXB6_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| TNF12_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| VTI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTTG_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| TRDN_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| VPS41_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| S29A3_HUMAN | [view interactions] | Computational | no | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX16_HUMAN | [view interactions] | Computational | no | yes |
| GOSR2_HUMAN | [view interactions] | Computational | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| YKT6_HUMAN | [view interactions] | Computational | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VP33A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VAMP1_HUMAN | [view interactions] | Computational | no | no |