EI2BB_HUMAN
Evidence for PS localization
Functions
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EI2BB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.2857 | 4 | yes |
| GO:0000166 | nucleotide binding | 31.4286 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.7143 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.7143 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.7143 | 4 | yes |
| GO:0003723 | RNA binding | 25.7143 | 4 | no |
| GO:0005524 | ATP binding | 22.8571 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.8571 | 5 | yes |
| GO:0043169 | cation binding | 22.8571 | 4 | no |
| GO:0046872 | metal ion binding | 22.8571 | 5 | no |
| GO:0003743 | translation initiation factor activity | 8.5714 | 4 | yes |
| GO:0005525 | GTP binding | 8.5714 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 8.5714 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 8.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EI2BB_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 54.2857 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.2857 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.4286 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.5714 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.7143 | 4 | no |
| GO:0006996 | organelle organization | 45.7143 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.1429 | 6 | yes |
| GO:0022607 | cellular component assembly | 37.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.2857 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2857 | 5 | no |
| GO:0008104 | protein localization | 34.2857 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.4286 | 4 | no |
| GO:0051049 | regulation of transport | 31.4286 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.4286 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.7143 | 4 | no |
| GO:0036211 | protein modification process | 25.7143 | 4 | no |
| GO:0043412 | macromolecule modification | 25.7143 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.7143 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.7143 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.7143 | 6 | no |
| GO:0033043 | regulation of organelle organization | 22.8571 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 4 | no |
| GO:0051046 | regulation of secretion | 22.8571 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
| GO:0071702 | organic substance transport | 22.8571 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.8571 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8571 | 5 | no |
| GO:0002684 | positive regulation of immune system process | 20.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0006417 | regulation of translation | 17.1429 | 6 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 17.1429 | 7 | yes |
| GO:0007417 | central nervous system development | 14.2857 | 4 | yes |
| GO:0050776 | regulation of immune response | 14.2857 | 4 | yes |
| GO:0006446 | regulation of translational initiation | 11.4286 | 7 | yes |
| GO:0021782 | glial cell development | 11.4286 | 4 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 8.5714 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 8.5714 | 4 | yes |
| GO:0043434 | response to peptide hormone | 8.5714 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 8.5714 | 5 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 8.5714 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 8.5714 | 6 | yes |
| GO:0009743 | response to carbohydrate | 5.7143 | 4 | yes |
| GO:0009746 | response to hexose | 5.7143 | 6 | yes |
| GO:0009749 | response to glucose | 5.7143 | 7 | yes |
| GO:0014003 | oligodendrocyte development | 5.7143 | 5 | yes |
| GO:0034284 | response to monosaccharide | 5.7143 | 5 | yes |
| GO:0042552 | myelination | 5.7143 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FUBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BA_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BD_HUMAN | [view interactions] | Low throughput | no | yes |
| IF2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CI072_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTCP7_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MFS4B_HUMAN | [view interactions] | High throughput | no | yes |
| B3GL2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOG_HUMAN | [view interactions] | High throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECT4_HUMAN | [view interactions] | High throughput | no | no |
| OPN3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EMRE_HUMAN | [view interactions] | High throughput | no | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| 5MP1_HUMAN | [view interactions] | High throughput | no | no |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| PCGF6_HUMAN | [view interactions] | High throughput | no | no |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEUK_HUMAN | [view interactions] | High throughput | no | no |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGF14_HUMAN | [view interactions] | High throughput | no | no |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| PCDH9_HUMAN | [view interactions] | High throughput | no | no |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| BTC_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SELT_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| PP4P1_HUMAN | [view interactions] | High throughput | no | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| PP4P2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM2_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| NELFB_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DIM1_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RFC4_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| OGFR_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |