EI2BB_HUMAN
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EI2BB_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 27.2727 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | yes |
GO:0003723 | RNA binding | 27.2727 | 4 | no |
GO:0005524 | ATP binding | 24.2424 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 24.2424 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 24.2424 | 5 | yes |
GO:0003743 | translation initiation factor activity | 12.1212 | 4 | yes |
GO:0005525 | GTP binding | 9.0909 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 9.0909 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 9.0909 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EI2BB_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 54.5455 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.5152 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 51.5152 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 48.4848 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 42.4242 | 4 | no |
GO:0006996 | organelle organization | 36.3636 | 4 | no |
GO:0010468 | regulation of gene expression | 36.3636 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | yes |
GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.3030 | 5 | yes |
GO:0051049 | regulation of transport | 30.3030 | 4 | no |
GO:0036211 | protein modification process | 30.3030 | 4 | no |
GO:0043412 | macromolecule modification | 30.3030 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
GO:0008104 | protein localization | 27.2727 | 4 | no |
GO:0010941 | regulation of cell death | 27.2727 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.2727 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.2424 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.2424 | 4 | no |
GO:0009894 | regulation of catabolic process | 24.2424 | 4 | no |
GO:0010608 | post-transcriptional regulation of gene expression | 24.2424 | 6 | yes |
GO:0048584 | positive regulation of response to stimulus | 24.2424 | 4 | yes |
GO:0023056 | positive regulation of signaling | 24.2424 | 4 | no |
GO:0071702 | organic substance transport | 21.2121 | 4 | no |
GO:0071705 | nitrogen compound transport | 21.2121 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 21.2121 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | no |
GO:0042981 | regulation of apoptotic process | 21.2121 | 6 | no |
GO:0043067 | regulation of programmed cell death | 21.2121 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 21.2121 | 5 | no |
GO:0002684 | positive regulation of immune system process | 21.2121 | 4 | yes |
GO:0006417 | regulation of translation | 21.2121 | 6 | yes |
GO:0034248 | regulation of cellular amide metabolic process | 21.2121 | 5 | yes |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 21.2121 | 6 | yes |
GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
GO:0032880 | regulation of protein localization | 21.2121 | 5 | no |
GO:0006446 | regulation of translational initiation | 15.1515 | 7 | yes |
GO:0010243 | response to organonitrogen compound | 12.1212 | 4 | yes |
GO:0021782 | glial cell development | 12.1212 | 4 | yes |
GO:0050776 | regulation of immune response | 12.1212 | 4 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 9.0909 | 4 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 9.0909 | 4 | yes |
GO:0050778 | positive regulation of immune response | 9.0909 | 5 | yes |
GO:0050851 | antigen receptor-mediated signaling pathway | 9.0909 | 5 | yes |
GO:0050852 | T cell receptor signaling pathway | 9.0909 | 6 | yes |
GO:1901652 | response to peptide | 9.0909 | 4 | yes |
GO:0007417 | central nervous system development | 6.0606 | 4 | yes |
GO:0009743 | response to carbohydrate | 6.0606 | 4 | yes |
GO:0009746 | response to hexose | 6.0606 | 6 | yes |
GO:0009749 | response to glucose | 6.0606 | 7 | yes |
GO:0014003 | oligodendrocyte development | 6.0606 | 5 | yes |
GO:0034284 | response to monosaccharide | 6.0606 | 5 | yes |
GO:0042552 | myelination | 6.0606 | 4 | yes |
GO:0043434 | response to peptide hormone | 6.0606 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EI2BG_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BA_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BE_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BD_HUMAN | [view interactions] | Low throughput | no | yes |
IF2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IF2G_HUMAN | [view interactions] | Low throughput | no | yes |
IF2B_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FUBP2_HUMAN | [view interactions] | Low throughput | no | yes |
SIGL1_HUMAN | [view interactions] | High throughput | no | no |
EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
PE2R3_HUMAN | [view interactions] | High throughput | no | no |
CAH14_HUMAN | [view interactions] | High throughput | no | yes |
GP183_HUMAN | [view interactions] | High throughput | no | yes |
EXOG_HUMAN | [view interactions] | High throughput | no | yes |
B3GL2_HUMAN | [view interactions] | High throughput | no | yes |
MFS4B_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NTCP7_HUMAN | [view interactions] | High throughput | no | no |
RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S27A2_HUMAN | [view interactions] | High throughput | no | no |
SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NECT4_HUMAN | [view interactions] | High throughput | no | no |
OPN3_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TN13B_HUMAN | [view interactions] | High throughput | no | no |
DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMRE_HUMAN | [view interactions] | High throughput | no | yes |
MCU_HUMAN | [view interactions] | High throughput | no | yes |
5MP1_HUMAN | [view interactions] | High throughput | no | no |
MR1L1_HUMAN | [view interactions] | High throughput | no | no |
PCGF6_HUMAN | [view interactions] | High throughput | no | no |
TET2_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P2RX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEUK_HUMAN | [view interactions] | High throughput | no | no |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGF14_HUMAN | [view interactions] | High throughput | no | no |
CD226_HUMAN | [view interactions] | High throughput | no | yes |
CC018_HUMAN | [view interactions] | High throughput | no | yes |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
PCDH9_HUMAN | [view interactions] | High throughput | no | no |
TACD2_HUMAN | [view interactions] | High throughput | no | no |
BTC_HUMAN | [view interactions] | High throughput | no | no |
PACC1_HUMAN | [view interactions] | High throughput | no | no |
CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
GPR17_HUMAN | [view interactions] | High throughput | no | no |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TM164_HUMAN | [view interactions] | High throughput | no | yes |
EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
SELT_HUMAN | [view interactions] | High throughput | no | yes |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
PP4P1_HUMAN | [view interactions] | High throughput | no | yes |
NEUA_HUMAN | [view interactions] | High throughput | no | yes |
UT14A_HUMAN | [view interactions] | High throughput | no | yes |
PP4P2_HUMAN | [view interactions] | High throughput | no | yes |
TNR5_HUMAN | [view interactions] | High throughput | no | no |
ZN326_HUMAN | [view interactions] | High throughput | no | yes |
CD70_HUMAN | [view interactions] | High throughput | no | no |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
GOLM2_HUMAN | [view interactions] | High throughput | no | yes |
ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
AGO1_HUMAN | [view interactions] | High throughput | no | no |
IF5_HUMAN | [view interactions] | High throughput | no | yes |
NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
RACK1_HUMAN | [view interactions] | High throughput | no | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
RTCB_HUMAN | [view interactions] | High throughput | no | yes |
NELFB_HUMAN | [view interactions] | High throughput | no | no |
YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
DIM1_HUMAN | [view interactions] | High throughput | no | yes |
EDC4_HUMAN | [view interactions] | High throughput | no | yes |
FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
IF2B3_HUMAN | [view interactions] | High throughput | no | no |
ILF2_HUMAN | [view interactions] | High throughput | no | yes |
MRE11_HUMAN | [view interactions] | High throughput | no | yes |
NMT1_HUMAN | [view interactions] | High throughput | no | yes |
PTBP1_HUMAN | [view interactions] | High throughput | no | no |
SYQ_HUMAN | [view interactions] | High throughput | no | yes |
RFC4_HUMAN | [view interactions] | High throughput | no | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
CI072_HUMAN | [view interactions] | High throughput | no | no |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP72_HUMAN | [view interactions] | High throughput | no | yes |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLPB_HUMAN | [view interactions] | High throughput | no | no |
EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4G2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF2GL_HUMAN | [view interactions] | Computational | no | no |
E2AK4_HUMAN | [view interactions] | Computational | no | yes |