Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RX4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RX4_HUMAN
GO:0000166 nucleotide binding 75.0000 4 yes
GO:0005524 ATP binding 75.0000 5 yes
GO:0017076 purine nucleotide binding 75.0000 5 yes
GO:0030554 adenyl nucleotide binding 75.0000 6 yes
GO:0032555 purine ribonucleotide binding 75.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 75.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 75.0000 4 yes
GO:0043168 anion binding 75.0000 4 yes
GO:0001614 purinergic nucleotide receptor activity 50.0000 5 yes
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity 50.0000 7 yes
GO:0005216 monoatomic ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 50.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 50.0000 7 yes
GO:0005261 monoatomic cation channel activity 50.0000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 50.0000 4 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 50.0000 5 yes
GO:0016502 nucleotide receptor activity 50.0000 4 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0035381 ATP-gated ion channel activity 50.0000 7 yes
GO:0099094 ligand-gated monoatomic cation channel activity 50.0000 6 yes
GO:0005262 calcium channel activity 25.0000 6 yes
GO:0005507 copper ion binding 25.0000 7 yes
GO:0008270 zinc ion binding 25.0000 7 yes
GO:0015085 calcium ion transmembrane transporter activity 25.0000 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 yes
GO:0043169 cation binding 25.0000 4 yes
GO:0045296 cadherin binding 25.0000 4 yes
GO:0046872 metal ion binding 25.0000 5 yes
GO:0046873 metal ion transmembrane transporter activity 25.0000 5 yes
GO:0046914 transition metal ion binding 25.0000 6 yes
GO:0099604 ligand-gated calcium channel activity 25.0000 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in P2RX4_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0048584 positive regulation of response to stimulus 62.5000 4 yes
GO:0051049 regulation of transport 62.5000 4 yes
GO:0051050 positive regulation of transport 62.5000 4 yes
GO:0007600 sensory perception 62.5000 4 yes
GO:0010243 response to organonitrogen compound 62.5000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0014070 response to organic cyclic compound 50.0000 4 yes
GO:0014074 response to purine-containing compound 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0030001 metal ion transport 50.0000 6 yes
GO:0033198 response to ATP 50.0000 4 yes
GO:0046683 response to organophosphorus 50.0000 4 yes
GO:0050954 sensory perception of mechanical stimulus 50.0000 5 yes
GO:0060341 regulation of cellular localization 50.0000 4 yes
GO:0070588 calcium ion transmembrane transport 50.0000 5 yes
GO:0098655 monoatomic cation transmembrane transport 50.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 yes
GO:0006811 monoatomic ion transport 50.0000 4 yes
GO:0006812 monoatomic cation transport 50.0000 5 yes
GO:0006816 calcium ion transport 50.0000 7 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0010632 regulation of epithelial cell migration 37.5000 4 yes
GO:0010634 positive regulation of epithelial cell migration 37.5000 5 yes
GO:0010959 regulation of metal ion transport 37.5000 6 yes
GO:0030334 regulation of cell migration 37.5000 5 yes
GO:0030335 positive regulation of cell migration 37.5000 6 yes
GO:0032101 regulation of response to external stimulus 37.5000 4 yes
GO:0032103 positive regulation of response to external stimulus 37.5000 5 yes
GO:0034762 regulation of transmembrane transport 37.5000 4 yes
GO:0034764 positive regulation of transmembrane transport 37.5000 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 37.5000 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 37.5000 6 yes
GO:0040017 positive regulation of locomotion 37.5000 4 yes
GO:0043269 regulation of monoatomic ion transport 37.5000 5 yes
GO:0043270 positive regulation of monoatomic ion transport 37.5000 5 yes
GO:0043535 regulation of blood vessel endothelial cell migration 37.5000 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 37.5000 7 yes
GO:0044057 regulation of system process 37.5000 4 yes
GO:0050848 regulation of calcium-mediated signaling 37.5000 6 yes
GO:0050850 positive regulation of calcium-mediated signaling 37.5000 7 yes
GO:0050920 regulation of chemotaxis 37.5000 4 yes
GO:0050921 positive regulation of chemotaxis 37.5000 5 yes
GO:0051046 regulation of secretion 37.5000 5 yes
GO:0051047 positive regulation of secretion 37.5000 5 yes
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 37.5000 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 37.5000 7 yes
GO:0051924 regulation of calcium ion transport 37.5000 7 yes
GO:0051928 positive regulation of calcium ion transport 37.5000 6 yes
GO:0141124 intracellular signaling cassette 37.5000 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 37.5000 7 yes
GO:1903530 regulation of secretion by cell 37.5000 4 yes
GO:1903532 positive regulation of secretion by cell 37.5000 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 37.5000 6 yes
GO:1904064 positive regulation of cation transmembrane transport 37.5000 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 37.5000 7 yes
GO:2000145 regulation of cell motility 37.5000 4 yes
GO:2000147 positive regulation of cell motility 37.5000 5 yes
GO:2001026 regulation of endothelial cell chemotaxis 37.5000 5 yes
GO:2001028 positive regulation of endothelial cell chemotaxis 37.5000 6 yes
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0002684 positive regulation of immune system process 37.5000 4 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 yes
GO:0010524 positive regulation of calcium ion transport into cytosol 37.5000 4 yes
GO:0010594 regulation of endothelial cell migration 37.5000 5 yes
GO:0010595 positive regulation of endothelial cell migration 37.5000 6 yes
GO:0010614 negative regulation of cardiac muscle hypertrophy 25.0000 6 yes
GO:0014741 negative regulation of muscle hypertrophy 25.0000 5 yes
GO:0014743 regulation of muscle hypertrophy 25.0000 6 yes
GO:0019228 neuronal action potential 25.0000 5 yes
GO:0019233 sensory perception of pain 25.0000 5 yes
GO:0019722 calcium-mediated signaling 25.0000 5 yes
GO:0032303 regulation of icosanoid secretion 25.0000 6 yes
GO:0032305 positive regulation of icosanoid secretion 25.0000 6 yes
GO:0032306 regulation of prostaglandin secretion 25.0000 5 yes
GO:0032308 positive regulation of prostaglandin secretion 25.0000 6 yes
GO:0032368 regulation of lipid transport 25.0000 5 yes
GO:0032370 positive regulation of lipid transport 25.0000 5 yes
GO:0032890 regulation of organic acid transport 25.0000 5 yes
GO:0032892 positive regulation of organic acid transport 25.0000 5 yes
GO:0035590 purinergic nucleotide receptor signaling pathway 25.0000 4 yes
GO:0043502 regulation of muscle adaptation 25.0000 4 yes
GO:0045428 regulation of nitric oxide biosynthetic process 25.0000 5 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 25.0000 6 yes
GO:0048678 response to axon injury 25.0000 4 yes
GO:0050975 sensory perception of touch 25.0000 6 yes
GO:0051899 membrane depolarization 25.0000 4 yes
GO:0055117 regulation of cardiac muscle contraction 25.0000 7 yes
GO:0055119 relaxation of cardiac muscle 25.0000 5 yes
GO:0071241 cellular response to inorganic substance 25.0000 4 yes
GO:0071248 cellular response to metal ion 25.0000 5 yes
GO:0071294 cellular response to zinc ion 25.0000 6 yes
GO:0071310 cellular response to organic substance 25.0000 4 yes
GO:0071318 cellular response to ATP 25.0000 5 yes
GO:0071407 cellular response to organic cyclic compound 25.0000 5 yes
GO:0071417 cellular response to organonitrogen compound 25.0000 4 yes
GO:0071675 regulation of mononuclear cell migration 25.0000 5 yes
GO:0071677 positive regulation of mononuclear cell migration 25.0000 6 yes
GO:0080164 regulation of nitric oxide metabolic process 25.0000 4 yes
GO:0090075 relaxation of muscle 25.0000 4 yes
GO:0090257 regulation of muscle system process 25.0000 5 yes
GO:1901699 cellular response to nitrogen compound 25.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 yes
GO:1903522 regulation of blood circulation 25.0000 5 yes
GO:1903975 regulation of glial cell migration 25.0000 6 yes
GO:1903977 positive regulation of glial cell migration 25.0000 7 yes
GO:1904139 regulation of microglial cell migration 25.0000 7 yes
GO:1904141 positive regulation of microglial cell migration 25.0000 8 yes
GO:1904407 positive regulation of nitric oxide metabolic process 25.0000 5 yes
GO:1905521 regulation of macrophage migration 25.0000 6 yes
GO:1905523 positive regulation of macrophage migration 25.0000 7 yes
GO:1905952 regulation of lipid localization 25.0000 4 yes
GO:1905954 positive regulation of lipid localization 25.0000 4 yes
GO:2000191 regulation of fatty acid transport 25.0000 6 yes
GO:2000193 positive regulation of fatty acid transport 25.0000 6 yes
GO:0009743 response to carbohydrate 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0007605 sensory perception of sound 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0006936 muscle contraction 25.0000 4 no
GO:0001508 action potential 25.0000 4 yes
GO:0001894 tissue homeostasis 25.0000 4 yes
GO:0002028 regulation of sodium ion transport 25.0000 7 yes
GO:0002685 regulation of leukocyte migration 25.0000 4 yes
GO:0002687 positive regulation of leukocyte migration 25.0000 5 yes
GO:0006937 regulation of muscle contraction 25.0000 6 yes
GO:0006942 regulation of striated muscle contraction 25.0000 7 yes
GO:0008016 regulation of heart contraction 25.0000 6 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 yes
GO:0010038 response to metal ion 25.0000 4 yes
GO:0010043 response to zinc ion 25.0000 5 yes
GO:0010611 regulation of cardiac muscle hypertrophy 25.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P2RX2_HUMAN [view entry] [view interactions] Low throughput yes no
P2RX6_HUMAN [view entry] [view interactions] Low throughput yes no
P2RX4_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH5_HUMAN [view interactions] Low throughput no yes
P2RX7_HUMAN [view interactions] Low throughput no yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
CGAT2_HUMAN [view interactions] High throughput no yes
SPP2B_HUMAN [view interactions] High throughput no yes
ORC4_HUMAN [view interactions] High throughput no yes
XYLK_HUMAN [view interactions] High throughput no yes
GALT1_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
EI2BA_HUMAN [view interactions] High throughput no yes
PIGH_HUMAN [view interactions] High throughput no yes
KCNJ8_HUMAN [view interactions] High throughput no yes
GL8D1_HUMAN [view interactions] High throughput no yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
CYBC1_HUMAN [view interactions] High throughput no yes
EMC7_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
WNT4_HUMAN [view interactions] High throughput no no
KRA59_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
DAAF6_HUMAN [view interactions] High throughput no no
NT2NC_HUMAN [view interactions] High throughput no no
KRA11_HUMAN [view interactions] High throughput no no
KR123_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
FDFT_HUMAN [view interactions] High throughput no yes
ARMX3_HUMAN [view interactions] High throughput no no
SPTC2_HUMAN [view interactions] High throughput no no
PGAP4_HUMAN [view interactions] High throughput no no
HS2ST_HUMAN [view interactions] High throughput no yes
TNPO3_HUMAN [view interactions] High throughput no yes
COQ8B_HUMAN [view interactions] High throughput no yes
EI2BD_HUMAN [view interactions] High throughput no yes
SAAL1_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
PLD6_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
OPRX_HUMAN [view interactions] High throughput no no
B3GT5_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
GLT14_HUMAN [view interactions] High throughput no no
THEM6_HUMAN [view interactions] High throughput no no
LRC8E_HUMAN [view interactions] High throughput no no
LRP10_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes