WNK1_HUMAN
Evidence for PS localization
Functions
Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002834 | DEG_Kelch_KLHL3_1 | DEG | 628 | 637 | - |
| ELMI001487 | DOC_SPAK_OSR1_1 | DOC | 1257 | 1261 | - |
| ELMI001489 | DOC_SPAK_OSR1_1 | DOC | 1859 | 1863 | - |
| ELMI001488 | DOC_SPAK_OSR1_1 | DOC | 1945 | 1949 | - |
| ELMI001490 | DOC_SPAK_OSR1_1 | DOC | 1957 | 1961 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WNK1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 29.6875 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.1250 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.5625 | 5 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 23.4375 | 4 | yes |
| GO:0045296 | cadherin binding | 23.4375 | 4 | no |
| GO:0019901 | protein kinase binding | 21.8750 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.8750 | 5 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 21.8750 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.8750 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.3125 | 4 | yes |
| GO:0005524 | ATP binding | 18.7500 | 5 | yes |
| GO:0019887 | protein kinase regulator activity | 17.1875 | 4 | yes |
| GO:0019209 | kinase activator activity | 10.9375 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 10.9375 | 5 | yes |
| GO:0004860 | protein kinase inhibitor activity | 9.3750 | 5 | yes |
| GO:0016301 | kinase activity | 9.3750 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 9.3750 | 4 | yes |
| GO:0019210 | kinase inhibitor activity | 9.3750 | 4 | yes |
| GO:0019902 | phosphatase binding | 9.3750 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.8125 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 7.8125 | 4 | yes |
| GO:0008200 | ion channel inhibitor activity | 7.8125 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.8125 | 4 | yes |
| GO:0015459 | potassium channel regulator activity | 6.2500 | 4 | yes |
| GO:0017081 | chloride channel regulator activity | 3.1250 | 4 | yes |
| GO:0019869 | chloride channel inhibitor activity | 3.1250 | 5 | yes |
| GO:0019870 | potassium channel inhibitor activity | 3.1250 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WNK1_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 57.8125 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.8125 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.8125 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.6875 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.4375 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.1875 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.6250 | 5 | no |
| GO:0051049 | regulation of transport | 39.0625 | 4 | yes |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.8125 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.8125 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.8125 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.8125 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.8125 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 31.2500 | 4 | no |
| GO:0022607 | cellular component assembly | 31.2500 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.6875 | 5 | no |
| GO:0071705 | nitrogen compound transport | 29.6875 | 4 | no |
| GO:0006996 | organelle organization | 29.6875 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.6875 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6875 | 5 | no |
| GO:0015031 | protein transport | 28.1250 | 4 | no |
| GO:0071702 | organic substance transport | 28.1250 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.5625 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.5625 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.5625 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.5625 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5625 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.5625 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5625 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.4375 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 23.4375 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 23.4375 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4375 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.4375 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 23.4375 | 4 | yes |
| GO:0036211 | protein modification process | 23.4375 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.8750 | 4 | yes |
| GO:0032880 | regulation of protein localization | 21.8750 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.8750 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.8750 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.8750 | 5 | yes |
| GO:0043269 | regulation of ion transport | 20.3125 | 5 | yes |
| GO:0010941 | regulation of cell death | 20.3125 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3125 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.3125 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.3125 | 5 | no |
| GO:0051051 | negative regulation of transport | 15.6250 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 15.6250 | 4 | yes |
| GO:0016310 | phosphorylation | 15.6250 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.6250 | 4 | yes |
| GO:0051046 | regulation of secretion | 14.0625 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 14.0625 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 14.0625 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 14.0625 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 14.0625 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 14.0625 | 5 | yes |
| GO:0043270 | positive regulation of ion transport | 12.5000 | 5 | yes |
| GO:0048878 | chemical homeostasis | 12.5000 | 4 | yes |
| GO:0006468 | protein phosphorylation | 12.5000 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 12.5000 | 4 | yes |
| GO:0043271 | negative regulation of ion transport | 10.9375 | 5 | yes |
| GO:0044057 | regulation of system process | 10.9375 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 10.9375 | 5 | yes |
| GO:0034097 | response to cytokine | 10.9375 | 4 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 9.3750 | 7 | yes |
| GO:0030155 | regulation of cell adhesion | 9.3750 | 4 | yes |
| GO:0032411 | positive regulation of transporter activity | 9.3750 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 9.3750 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 9.3750 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 9.3750 | 6 | yes |
| GO:0050776 | regulation of immune response | 7.8125 | 4 | yes |
| GO:0050801 | ion homeostasis | 7.8125 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 7.8125 | 4 | yes |
| GO:0055080 | cation homeostasis | 7.8125 | 6 | yes |
| GO:2000145 | regulation of cell motility | 7.8125 | 4 | yes |
| GO:0002028 | regulation of sodium ion transport | 7.8125 | 7 | yes |
| GO:0006811 | ion transport | 7.8125 | 4 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 7.8125 | 5 | yes |
| GO:0030334 | regulation of cell migration | 7.8125 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 6.2500 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 6.2500 | 7 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 6.2500 | 6 | yes |
| GO:0072676 | lymphocyte migration | 6.2500 | 4 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 6.2500 | 7 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 6.2500 | 7 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 6.2500 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 6.2500 | 5 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 6.2500 | 6 | yes |
| GO:0002684 | positive regulation of immune system process | 6.2500 | 4 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 6.2500 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 6.2500 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 6.2500 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 6.2500 | 4 | yes |
| GO:0040017 | positive regulation of locomotion | 6.2500 | 4 | yes |
| GO:0048666 | neuron development | 4.6875 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 4.6875 | 5 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 4.6875 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 4.6875 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 4.6875 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 4.6875 | 5 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 4.6875 | 7 | yes |
| GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 4.6875 | 7 | yes |
| GO:1990868 | response to chemokine | 4.6875 | 5 | yes |
| GO:1990869 | cellular response to chemokine | 4.6875 | 6 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 4.6875 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 4.6875 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 4.6875 | 5 | yes |
| GO:0010766 | negative regulation of sodium ion transport | 4.6875 | 6 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 4.6875 | 6 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 4.6875 | 6 | yes |
| GO:0043268 | positive regulation of potassium ion transport | 3.1250 | 6 | yes |
| GO:0044058 | regulation of digestive system process | 3.1250 | 5 | yes |
| GO:0045777 | positive regulation of blood pressure | 3.1250 | 4 | yes |
| GO:0050920 | regulation of chemotaxis | 3.1250 | 4 | yes |
| GO:0050921 | positive regulation of chemotaxis | 3.1250 | 5 | yes |
| GO:0060457 | negative regulation of digestive system process | 3.1250 | 5 | yes |
| GO:0070098 | chemokine-mediated signaling pathway | 3.1250 | 5 | yes |
| GO:0070587 | regulation of cell-cell adhesion involved in gastrulation | 3.1250 | 6 | yes |
| GO:0071675 | regulation of mononuclear cell migration | 3.1250 | 5 | yes |
| GO:0071677 | positive regulation of mononuclear cell migration | 3.1250 | 6 | yes |
| GO:0090186 | regulation of pancreatic juice secretion | 3.1250 | 4 | yes |
| GO:0090188 | negative regulation of pancreatic juice secretion | 3.1250 | 5 | yes |
| GO:0097021 | lymphocyte migration into lymphoid organs | 3.1250 | 5 | yes |
| GO:0097022 | lymphocyte migration into lymph node | 3.1250 | 6 | yes |
| GO:0140131 | positive regulation of lymphocyte chemotaxis | 3.1250 | 7 | yes |
| GO:1901381 | positive regulation of potassium ion transmembrane transport | 3.1250 | 7 | yes |
| GO:1901623 | regulation of lymphocyte chemotaxis | 3.1250 | 6 | yes |
| GO:1902307 | positive regulation of sodium ion transmembrane transport | 3.1250 | 7 | yes |
| GO:1903286 | regulation of potassium ion import | 3.1250 | 8 | yes |
| GO:1903288 | positive regulation of potassium ion import across plasma membrane | 3.1250 | 8 | yes |
| GO:2000401 | regulation of lymphocyte migration | 3.1250 | 6 | yes |
| GO:2000403 | positive regulation of lymphocyte migration | 3.1250 | 7 | yes |
| GO:2000404 | regulation of T cell migration | 3.1250 | 7 | yes |
| GO:2000406 | positive regulation of T cell migration | 3.1250 | 8 | yes |
| GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 3.1250 | 6 | yes |
| GO:0002685 | regulation of leukocyte migration | 3.1250 | 4 | yes |
| GO:0002687 | positive regulation of leukocyte migration | 3.1250 | 5 | yes |
| GO:0002688 | regulation of leukocyte chemotaxis | 3.1250 | 5 | yes |
| GO:0002690 | positive regulation of leukocyte chemotaxis | 3.1250 | 6 | yes |
| GO:0003084 | positive regulation of systemic arterial blood pressure | 3.1250 | 5 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 3.1250 | 6 | yes |
| GO:0010819 | regulation of T cell chemotaxis | 3.1250 | 7 | yes |
| GO:0010820 | positive regulation of T cell chemotaxis | 3.1250 | 8 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 3.1250 | 6 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 3.1250 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 3.1250 | 5 | yes |
| GO:0018209 | peptidyl-serine modification | 3.1250 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 3.1250 | 6 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 3.1250 | 5 | yes |
| GO:0033628 | regulation of cell adhesion mediated by integrin | 3.1250 | 5 | yes |
| GO:0033629 | negative regulation of cell adhesion mediated by integrin | 3.1250 | 6 | yes |
| GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 3.1250 | 6 | yes |
| GO:0033633 | negative regulation of cell-cell adhesion mediated by integrin | 3.1250 | 7 | yes |
| GO:0034114 | regulation of heterotypic cell-cell adhesion | 3.1250 | 6 | yes |
| GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 3.1250 | 7 | yes |
| GO:0034260 | negative regulation of GTPase activity | 3.1250 | 4 | yes |
| GO:0038116 | chemokine (C-C motif) ligand 21 signaling pathway | 3.1250 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in WNK1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.2500 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.2500 | 5 | no |
| DOID:114 | heart disease | 6.2500 | 3 | no |
| DOID:0080000 | muscular disease | 4.6875 | 3 | no |
| DOID:423 | myopathy | 4.6875 | 5 | no |
| DOID:66 | muscle tissue disease | 4.6875 | 4 | no |
| DOID:2843 | long QT syndrome | 3.1250 | 6 | no |
| DOID:9884 | muscular dystrophy | 3.1250 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OXSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYT9_HUMAN | [view interactions] | Low throughput | no | no |
| SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLIS2_HUMAN | [view interactions] | Low throughput | no | no |
| NED4L_HUMAN | [view interactions] | Low throughput | no | yes |
| WNK2_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| KLHL3_HUMAN | [view interactions] | Low throughput | no | no |
| KLHL2_HUMAN | [view interactions] | Low throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| METL6_HUMAN | [view interactions] | High throughput | no | yes |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT1_HUMAN | [view interactions] | High throughput | no | no |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| HAOX2_HUMAN | [view interactions] | High throughput | no | no |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| MOG1_HUMAN | [view interactions] | High throughput | no | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| ITB2_HUMAN | [view interactions] | High throughput | no | no |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPL1_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANRA2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| KS6A6_HUMAN | [view interactions] | High throughput | no | yes |
| MAOM_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN839_HUMAN | [view interactions] | High throughput | no | yes |
| FA13B_HUMAN | [view interactions] | High throughput | no | yes |
| RIPR2_HUMAN | [view interactions] | High throughput | no | no |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| CGNL1_HUMAN | [view interactions] | High throughput | no | no |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHOD1_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC9_HUMAN | [view interactions] | High throughput | no | yes |
| ZEP2_HUMAN | [view interactions] | High throughput | no | no |
| K0232_HUMAN | [view interactions] | High throughput | no | yes |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| IRAG2_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP9_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSL2_HUMAN | [view interactions] | High throughput | no | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
| TENS1_HUMAN | [view interactions] | High throughput | no | no |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIMC1_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| RASL3_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP8_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SL9A1_HUMAN | [view interactions] | High throughput | no | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN106_HUMAN | [view interactions] | High throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| SCNNG_HUMAN | [view interactions] | Computational | no | no |
| SCNNB_HUMAN | [view interactions] | Computational | no | yes |
| LIGO1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| S12A3_HUMAN | [view interactions] | Computational | no | no |
| SCNND_HUMAN | [view interactions] | Computational | no | yes |
| STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCNJ1_HUMAN | [view interactions] | Computational | no | no |
| S12A1_HUMAN | [view interactions] | Computational | no | no |
| SCNNA_HUMAN | [view interactions] | Computational | no | yes |
| RETR1_HUMAN | [view interactions] | Computational | no | no |