Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA10_HUMAN

(Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI002078 TRG_ER_diArg_1 TRG 723 725 -

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA10_HUMAN
GO:0045296 cadherin binding 27.4194 4 no
GO:0046872 metal ion binding 24.1935 4 yes
GO:0019900 kinase binding 22.5806 4 yes
GO:0019901 protein kinase binding 22.5806 5 yes
GO:0017076 purine nucleotide binding 22.5806 4 no
GO:0032555 purine ribonucleotide binding 22.5806 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.9677 4 no
GO:0004175 endopeptidase activity 8.0645 4 yes
GO:0017124 SH3 domain binding 8.0645 4 yes
GO:0042803 protein homodimerization activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADA10_HUMAN
GO:0048523 negative regulation of cellular process 58.0645 4 yes
GO:0048522 positive regulation of cellular process 56.4516 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0009966 regulation of signal transduction 45.1613 4 yes
GO:0051128 regulation of cellular component organization 41.9355 4 yes
GO:0060255 regulation of macromolecule metabolic process 41.9355 4 yes
GO:0080090 regulation of primary metabolic process 38.7097 4 no
GO:0022607 cellular component assembly 37.0968 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 37.0968 4 no
GO:0051049 regulation of transport 37.0968 4 no
GO:0031323 regulation of cellular metabolic process 35.4839 4 no
GO:0010468 regulation of gene expression 33.8710 5 yes
GO:0048584 positive regulation of response to stimulus 33.8710 4 yes
GO:0009893 positive regulation of metabolic process 33.8710 4 no
GO:1902531 regulation of intracellular signal transduction 33.8710 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.2581 5 no
GO:0048585 negative regulation of response to stimulus 32.2581 4 no
GO:0036211 protein modification process 30.6452 4 yes
GO:0043412 macromolecule modification 30.6452 4 yes
GO:0010941 regulation of cell death 30.6452 4 no
GO:0042127 regulation of cell population proliferation 29.0323 4 yes
GO:0006996 organelle organization 29.0323 4 no
GO:0010647 positive regulation of cell communication 29.0323 5 no
GO:0023056 positive regulation of signaling 29.0323 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.0323 5 no
GO:0016192 vesicle-mediated transport 29.0323 4 no
GO:0032880 regulation of protein localization 27.4194 5 yes
GO:0060341 regulation of cellular localization 27.4194 4 yes
GO:0009889 regulation of biosynthetic process 27.4194 4 no
GO:0009967 positive regulation of signal transduction 27.4194 5 no
GO:0031325 positive regulation of cellular metabolic process 27.4194 5 no
GO:0031326 regulation of cellular biosynthetic process 27.4194 5 no
GO:0043085 positive regulation of catalytic activity 27.4194 4 no
GO:0051246 regulation of protein metabolic process 27.4194 5 no
GO:0071310 cellular response to organic substance 27.4194 4 no
GO:0051130 positive regulation of cellular component organization 27.4194 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.8065 5 no
GO:0042981 regulation of apoptotic process 25.8065 6 no
GO:0043067 regulation of programmed cell death 25.8065 5 no
GO:0030030 cell projection organization 25.8065 4 no
GO:0030155 regulation of cell adhesion 24.1935 4 yes
GO:2000145 regulation of cell motility 24.1935 4 yes
GO:0031399 regulation of protein modification process 24.1935 6 no
GO:0051252 regulation of RNA metabolic process 24.1935 5 no
GO:0008104 protein localization 24.1935 4 no
GO:0051050 positive regulation of transport 24.1935 4 no
GO:0010243 response to organonitrogen compound 24.1935 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.5806 6 no
GO:0030334 regulation of cell migration 22.5806 5 yes
GO:0006355 regulation of DNA-templated transcription 22.5806 6 no
GO:0009968 negative regulation of signal transduction 22.5806 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.5806 5 no
GO:0010648 negative regulation of cell communication 22.5806 5 no
GO:0023057 negative regulation of signaling 22.5806 4 no
GO:0051247 positive regulation of protein metabolic process 22.5806 6 no
GO:1902533 positive regulation of intracellular signal transduction 22.5806 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.5806 7 no
GO:2001141 regulation of RNA biosynthetic process 22.5806 6 no
GO:0006897 endocytosis 22.5806 5 no
GO:0080134 regulation of response to stress 22.5806 4 no
GO:0060548 negative regulation of cell death 22.5806 5 no
GO:0031344 regulation of cell projection organization 22.5806 5 no
GO:0032101 regulation of response to external stimulus 20.9677 4 yes
GO:0034330 cell junction organization 20.9677 4 yes
GO:0043933 protein-containing complex organization 20.9677 4 yes
GO:0007010 cytoskeleton organization 20.9677 5 no
GO:0033043 regulation of organelle organization 20.9677 5 no
GO:0019220 regulation of phosphate metabolic process 20.9677 6 no
GO:0031401 positive regulation of protein modification process 20.9677 7 no
GO:0042325 regulation of phosphorylation 20.9677 7 no
GO:0051174 regulation of phosphorus metabolic process 20.9677 5 no
GO:0022603 regulation of anatomical structure morphogenesis 20.9677 4 no
GO:0051094 positive regulation of developmental process 20.9677 4 no
GO:1901701 cellular response to oxygen-containing compound 20.9677 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.9677 4 no
GO:0009892 negative regulation of metabolic process 19.3548 4 yes
GO:0002684 positive regulation of immune system process 17.7419 4 yes
GO:0006508 proteolysis 17.7419 4 yes
GO:0008284 positive regulation of cell population proliferation 17.7419 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 17.7419 5 yes
GO:0030335 positive regulation of cell migration 17.7419 6 yes
GO:0040017 positive regulation of locomotion 17.7419 4 yes
GO:0065003 protein-containing complex assembly 17.7419 5 yes
GO:2000147 positive regulation of cell motility 17.7419 5 yes
GO:0045216 cell-cell junction organization 16.1290 5 yes
GO:1905475 regulation of protein localization to membrane 16.1290 6 yes
GO:2000026 regulation of multicellular organismal development 16.1290 4 yes
GO:0006796 phosphate-containing compound metabolic process 14.5161 4 yes
GO:0006468 protein phosphorylation 12.9032 5 yes
GO:0007162 negative regulation of cell adhesion 12.9032 5 yes
GO:0016310 phosphorylation 12.9032 5 yes
GO:0032103 positive regulation of response to external stimulus 12.9032 5 yes
GO:0007229 integrin-mediated signaling pathway 9.6774 4 yes
GO:0010629 negative regulation of gene expression 9.6774 6 yes
GO:0034097 response to cytokine 9.6774 4 yes
GO:1904375 regulation of protein localization to cell periphery 9.6774 6 yes
GO:0001558 regulation of cell growth 8.0645 4 yes
GO:1901342 regulation of vasculature development 8.0645 5 yes
GO:0001701 in utero embryonic development 6.4516 6 yes
GO:0002685 regulation of leukocyte migration 6.4516 4 yes
GO:0007219 Notch signaling pathway 6.4516 4 yes
GO:0009792 embryo development ending in birth or egg hatching 6.4516 4 yes
GO:0030198 extracellular matrix organization 6.4516 5 yes
GO:0034332 adherens junction organization 6.4516 6 yes
GO:0042982 amyloid precursor protein metabolic process 6.4516 4 yes
GO:0043009 chordate embryonic development 6.4516 5 yes
GO:0043062 extracellular structure organization 6.4516 4 yes
GO:0045229 external encapsulating structure organization 6.4516 4 yes
GO:0050920 regulation of chemotaxis 6.4516 4 yes
GO:0050921 positive regulation of chemotaxis 6.4516 5 yes
GO:0099173 postsynapse organization 6.4516 4 yes
GO:0006509 membrane protein ectodomain proteolysis 4.8387 6 yes
GO:0016485 protein processing 4.8387 5 yes
GO:0022411 cellular component disassembly 4.8387 4 yes
GO:0030307 positive regulation of cell growth 4.8387 5 yes
GO:0033619 membrane protein proteolysis 4.8387 5 yes
GO:0042987 amyloid precursor protein catabolic process 4.8387 5 yes
GO:0045927 positive regulation of growth 4.8387 4 yes
GO:0051604 protein maturation 4.8387 4 yes
GO:0071675 regulation of mononuclear cell migration 4.8387 5 yes
GO:2000401 regulation of lymphocyte migration 4.8387 6 yes
GO:2000404 regulation of T cell migration 4.8387 7 yes
GO:0002687 positive regulation of leukocyte migration 3.2258 5 yes
GO:0002688 regulation of leukocyte chemotaxis 3.2258 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 3.2258 6 yes
GO:0008593 regulation of Notch signaling pathway 3.2258 5 yes
GO:0071677 positive regulation of mononuclear cell migration 3.2258 6 yes
GO:1902473 regulation of protein localization to synapse 3.2258 6 yes
GO:2000403 positive regulation of lymphocyte migration 3.2258 7 yes
GO:2000406 positive regulation of T cell migration 3.2258 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in ADA10_HUMAN
DOID:0111962 combined immunodeficiency 3.2258 4 no
DOID:612 primary immunodeficiency disease 3.2258 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
TSN5_HUMAN [view interactions] Low throughput no no
TSN15_HUMAN [view interactions] Low throughput no yes
TSN14_HUMAN [view interactions] Low throughput no no
TSN33_HUMAN [view interactions] Low throughput no no
TSN12_HUMAN [view interactions] Low throughput no yes
BACE1_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
EPHA3_HUMAN [view interactions] Low throughput no yes
CD81_HUMAN [view interactions] Low throughput no no
EFNA2_HUMAN [view interactions] Low throughput no no
MD2L1_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
NOTC1_HUMAN [view interactions] Low throughput no yes
NEP_HUMAN [view interactions] Low throughput no no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMB2_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK2_HUMAN [view entry] [view interactions] High throughput yes no
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
TSN17_HUMAN [view interactions] High throughput no yes
TSN10_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NICA_HUMAN [view interactions] High throughput no yes
PEN2_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
APH1A_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
HCK_HUMAN [view entry] [view interactions] High throughput yes no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
GRAP_HUMAN [view interactions] High throughput no no
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
ITK_HUMAN [view interactions] High throughput no no
NCF1_HUMAN [view interactions] High throughput no no
PPIP1_HUMAN [view interactions] High throughput no no
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
SNX33_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
MMP14_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
CTL1_HUMAN [view interactions] High throughput no no
IGSF8_HUMAN [view entry] [view interactions] High throughput yes no
TSN9_HUMAN [view interactions] High throughput no yes
S39AE_HUMAN [view interactions] High throughput no yes
BCAM_HUMAN [view interactions] High throughput no yes
4F2_HUMAN [view entry] [view interactions] High throughput yes no
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
TFR1_HUMAN [view interactions] High throughput no yes
APMAP_HUMAN [view interactions] High throughput no yes
TEN3_HUMAN [view interactions] High throughput no yes
MFGM_HUMAN [view interactions] High throughput no no
FPRP_HUMAN [view interactions] High throughput no yes
ITA6_HUMAN [view interactions] High throughput no yes
ITA3_HUMAN [view entry] [view interactions] High throughput yes yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
CD82_HUMAN [view interactions] High throughput no no
TBCD9_HUMAN [view interactions] High throughput no yes
PGFRB_HUMAN [view interactions] High throughput no yes
CSPG4_HUMAN [view interactions] High throughput no yes
CD63_HUMAN [view interactions] High throughput no no
CD151_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
TAZ_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
MPPE1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
APEX1_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
ADA33_HUMAN [view interactions] High throughput no yes
TMPSD_HUMAN [view interactions] High throughput no no
HFE_HUMAN [view interactions] High throughput no yes
TMPS3_HUMAN [view interactions] High throughput no no
EXTL3_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
CL12B_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
LRAD1_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CRLF2_HUMAN [view interactions] High throughput no no
CD1E_HUMAN [view interactions] High throughput no yes
LYAG_HUMAN [view interactions] High throughput no yes
SIRPD_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
HLAG_HUMAN [view interactions] High throughput no no
PTPRN_HUMAN [view interactions] High throughput no yes
NAAA_HUMAN [view interactions] High throughput no yes
B3GT4_HUMAN [view interactions] High throughput no yes
KLRD1_HUMAN [view interactions] High throughput no no
IL5RA_HUMAN [view interactions] High throughput no no
ECEL1_HUMAN [view interactions] High throughput no yes
T106A_HUMAN [view interactions] High throughput no no
BTNL2_HUMAN [view interactions] High throughput no no
ASIC4_HUMAN [view interactions] High throughput no no
CNTP3_HUMAN [view interactions] High throughput no yes
B3GN3_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
ADA30_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
PRTN3_HUMAN [view interactions] High throughput no no
DNJB9_HUMAN [view interactions] High throughput no yes
UD17_HUMAN [view interactions] High throughput no no
BRID5_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
OR4S2_HUMAN [view interactions] High throughput no no
MSRB2_HUMAN [view interactions] High throughput no no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
T106B_HUMAN [view interactions] High throughput no yes
ZDHC6_HUMAN [view interactions] High throughput no no
HCLS1_HUMAN [view interactions] High throughput no no
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
OTOR_HUMAN [view interactions] High throughput no no
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
SH321_HUMAN [view interactions] High throughput no yes
RUSC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARH38_HUMAN [view interactions] High throughput no no
PACN3_HUMAN [view interactions] High throughput no yes
GRAP2_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX18_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
ARHGJ_HUMAN [view interactions] High throughput no no
PEX13_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGG_HUMAN [view interactions] High throughput no yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG4_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
RIM3A_HUMAN [view interactions] High throughput no no
RHG33_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO7A_HUMAN [view interactions] High throughput no yes
SPTA1_HUMAN [view interactions] High throughput no no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SH319_HUMAN [view interactions] High throughput no no
RL40_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
PKHA7_HUMAN [view interactions] Computational no yes
ADA17_HUMAN [view interactions] Computational no yes
NOTC2_HUMAN [view interactions] Computational no yes
VGFR2_HUMAN [view interactions] Computational no no
EPHA1_HUMAN [view interactions] Computational no yes
NOTC3_HUMAN [view interactions] Computational no yes
CADH1_HUMAN [view entry] [view interactions] Computational yes no
EGF_HUMAN [view interactions] Computational no no
DTX1_HUMAN [view interactions] Computational no yes
DLL4_HUMAN [view interactions] Computational no no
JAG1_HUMAN [view interactions] Computational no no
DLL1_HUMAN [view interactions] Computational no no
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
TIMP1_HUMAN [view interactions] Computational no no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
PSN2_HUMAN [view entry] [view interactions] Computational yes no
CTND1_HUMAN [view entry] [view interactions] Computational yes no
NOTC4_HUMAN [view interactions] Computational no no
JAG2_HUMAN [view interactions] Computational no yes
EFNA5_HUMAN [view interactions] Computational no yes
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
EGFR_HUMAN [view interactions] Computational no no
HBEGF_HUMAN [view interactions] Computational no no
CADH2_HUMAN [view entry] [view interactions] Computational yes no