ADA10_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 28%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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ADA10_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ADA10_HUMAN]
Isoform [C9J9B4] alignment
Isoform [O14672-2] alignment
Isoform [H0YNC5] alignment
Isoform [H0YK32] alignment
Isoform [H0YK87] alignment
Isoform [H3BS53] alignment
Isoform [B5MC71] alignment
Isoform [A0A087WYG1] alignment
LOADING 6%
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002078 | TRG_ER_diArg_1 | TRG | 723 | 725 | - |
| ELMI002078 | TRG_ER_diArg_1 | TRG | 723 | 725 | - |
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADA10_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 28.0423 | 4 | no |
| GO:0000166 | nucleotide binding | 25.9259 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.9259 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.8677 | 4 | no |
| GO:0043169 | cation binding | 23.2804 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.2804 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2804 | 4 | no |
| GO:0046872 | metal ion binding | 22.7513 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 20.6349 | 5 | no |
| GO:0019900 | kinase binding | 14.2857 | 4 | yes |
| GO:0019901 | protein kinase binding | 13.2275 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 10.0529 | 4 | yes |
| GO:0017124 | SH3 domain binding | 4.7619 | 4 | yes |
| GO:0004175 | endopeptidase activity | 2.6455 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADA10_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6190 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.7989 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.5079 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 36.5079 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.9206 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 32.2751 | 4 | yes |
| GO:0006996 | organelle organization | 32.2751 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.6878 | 4 | no |
| GO:0008104 | protein localization | 30.1587 | 4 | no |
| GO:0051049 | regulation of transport | 29.1005 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.0423 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0423 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 27.5132 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.4550 | 5 | yes |
| GO:0010468 | regulation of gene expression | 25.3968 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 24.8677 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | yes |
| GO:0030030 | cell projection organization | 22.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0023056 | positive regulation of signaling | 21.1640 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.6349 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 20.6349 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.6349 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| ADA33_HUMAN | [view interactions] | High throughput | no | yes |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA4_HUMAN | [view interactions] | High throughput | no | no |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |