AP180_HUMAN
Evidence for PS localization
Functions
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000299 | LIG_AP2alpha_1 | LIG | 440 | 444 | - |
| ELMI000300 | LIG_AP2alpha_1 | LIG | 564 | 568 | - |
| ELMI000301 | LIG_AP2alpha_1 | LIG | 642 | 646 | - |
| ELMI000299 | LIG_AP2alpha_1 | LIG | 440 | 444 | - |
| ELMI000300 | LIG_AP2alpha_1 | LIG | 564 | 568 | - |
| ELMI000301 | LIG_AP2alpha_1 | LIG | 642 | 646 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP180_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 33.3333 | 4 | yes |
| GO:0019901 | protein kinase binding | 27.7778 | 5 | yes |
| GO:0043168 | anion binding | 27.7778 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 11.1111 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 11.1111 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 8.3333 | 6 | yes |
| GO:0005545 | 1-phosphatidylinositol binding | 5.5556 | 5 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 5.5556 | 5 | yes |
| GO:0032050 | clathrin heavy chain binding | 5.5556 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP180_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 55.5556 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 47.2222 | 4 | yes |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0098657 | import into cell | 41.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
| GO:0030030 | cell projection organization | 36.1111 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 30.5556 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 30.5556 | 4 | yes |
| GO:0051049 | regulation of transport | 30.5556 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.5556 | 5 | no |
| GO:0036211 | protein modification process | 30.5556 | 4 | no |
| GO:0043412 | macromolecule modification | 30.5556 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.5556 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.5556 | 6 | no |
| GO:0034330 | cell junction organization | 30.5556 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.5556 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 30.5556 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.7778 | 4 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.7778 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.7778 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 22.2222 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 22.2222 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0050807 | regulation of synapse organization | 22.2222 | 5 | no |
| GO:0050808 | synapse organization | 22.2222 | 5 | no |
| GO:1905475 | regulation of protein localization to membrane | 22.2222 | 6 | no |
| GO:0051093 | negative regulation of developmental process | 22.2222 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0030100 | regulation of endocytosis | 16.6667 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.6667 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 16.6667 | 5 | yes |
| GO:0016050 | vesicle organization | 13.8889 | 5 | yes |
| GO:0061024 | membrane organization | 13.8889 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 11.1111 | 6 | yes |
| GO:0048268 | clathrin coat assembly | 11.1111 | 6 | yes |
| GO:0006900 | vesicle budding from membrane | 8.3333 | 5 | yes |
| GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane | 5.5556 | 7 | yes |
| GO:0070142 | synaptic vesicle budding | 5.5556 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCJ_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| MELPH_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI44_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |