AP180_HUMAN
Evidence for PS localization
Functions
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000299 | LIG_AP2alpha_1 | LIG | 440 | 444 | - |
| ELMI000300 | LIG_AP2alpha_1 | LIG | 564 | 568 | - |
| ELMI000301 | LIG_AP2alpha_1 | LIG | 642 | 646 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP180_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 23.0769 | 4 | yes |
| GO:0003779 | actin binding | 20.5128 | 4 | no |
| GO:0019901 | protein kinase binding | 17.9487 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 12.8205 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 12.8205 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 10.2564 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 7.6923 | 4 | yes |
| GO:0005545 | 1-phosphatidylinositol binding | 5.1282 | 5 | yes |
| GO:0032050 | clathrin heavy chain binding | 5.1282 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP180_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.9744 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 51.2821 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.2821 | 4 | yes |
| GO:0006897 | endocytosis | 46.1538 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 43.5897 | 4 | no |
| GO:0006996 | organelle organization | 43.5897 | 4 | yes |
| GO:0008104 | protein localization | 41.0256 | 4 | yes |
| GO:0051049 | regulation of transport | 41.0256 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.0256 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.8974 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.8974 | 4 | no |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | yes |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0015031 | protein transport | 30.7692 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.7692 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 28.2051 | 5 | yes |
| GO:0032880 | regulation of protein localization | 28.2051 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.2051 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.2051 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.2051 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.2051 | 5 | no |
| GO:0030030 | cell projection organization | 28.2051 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.2051 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 28.2051 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 25.6410 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.6410 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.6410 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.6410 | 4 | no |
| GO:0030100 | regulation of endocytosis | 23.0769 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 23.0769 | 7 | yes |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:0023056 | positive regulation of signaling | 23.0769 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0034330 | cell junction organization | 23.0769 | 4 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | no |
| GO:0061024 | membrane organization | 20.5128 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 20.5128 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:0048488 | synaptic vesicle endocytosis | 20.5128 | 5 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 20.5128 | 5 | no |
| GO:0140238 | presynaptic endocytosis | 20.5128 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.5128 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5128 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.5128 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.5128 | 6 | no |
| GO:0010468 | regulation of gene expression | 20.5128 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.5128 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5128 | 5 | no |
| GO:0016050 | vesicle organization | 15.3846 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 15.3846 | 6 | yes |
| GO:0048268 | clathrin coat assembly | 15.3846 | 6 | yes |
| GO:2000369 | regulation of clathrin-dependent endocytosis | 7.6923 | 7 | yes |
| GO:0006900 | vesicle budding from membrane | 7.6923 | 5 | yes |
| GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane | 5.1282 | 7 | yes |
| GO:0070142 | synaptic vesicle budding | 5.1282 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCJ_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| MELPH_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI44_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | Computational | yes | no |