AMPH_HUMAN
Evidence for PS localization
Functions
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000296 | LIG_AP2alpha_1 | LIG | 324 | 328 | - |
| ELMI000628 | LIG_Clathr_ClatBox_1 | LIG | 118 | 122 | - |
| ELMI000450 | LIG_Clathr_ClatBox_1 | LIG | 351 | 355 | - |
| ELMI000453 | LIG_Clathr_ClatBox_2 | LIG | 380 | 385 | - |
| ELMI003660 | MOD_DYRK1A_RPxSP_1 | MOD | 290 | 294 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AMPH_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 31.3725 | 5 | no |
| GO:0046872 | metal ion binding | 23.5294 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AMPH_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 54.9020 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.9020 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.9020 | 4 | no |
| GO:0006897 | endocytosis | 50.9804 | 5 | yes |
| GO:0051049 | regulation of transport | 49.0196 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | no |
| GO:0008104 | protein localization | 43.1373 | 4 | no |
| GO:0022607 | cellular component assembly | 43.1373 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.2549 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 37.2549 | 4 | no |
| GO:0043933 | protein-containing complex organization | 37.2549 | 4 | no |
| GO:0051050 | positive regulation of transport | 35.2941 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.2941 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.2941 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 35.2941 | 6 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 31.3725 | 5 | no |
| GO:0030030 | cell projection organization | 29.4118 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.4510 | 4 | no |
| GO:0030100 | regulation of endocytosis | 27.4510 | 5 | no |
| GO:0048488 | synaptic vesicle endocytosis | 25.4902 | 5 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 25.4902 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 25.4902 | 4 | yes |
| GO:0006886 | intracellular protein transport | 25.4902 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.4902 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.4902 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.4902 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.4902 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.4902 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.4902 | 6 | no |
| GO:0009966 | regulation of signal transduction | 25.4902 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.4902 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 23.5294 | 7 | no |
| GO:0031175 | neuron projection development | 23.5294 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.5686 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.5686 | 5 | no |
| GO:0036211 | protein modification process | 21.5686 | 4 | no |
| GO:0043412 | macromolecule modification | 21.5686 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.5686 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.5686 | 6 | no |
| GO:0031399 | regulation of protein modification process | 21.5686 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.5686 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.5686 | 5 | no |
| GO:0061024 | membrane organization | 21.5686 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 9.8039 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 9.8039 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 9.8039 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AMPH_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 3.9216 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.9216 | 5 | no |
| DOID:114 | heart disease | 3.9216 | 3 | no |
| DOID:2843 | long QT syndrome | 3.9216 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRGP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | Low throughput | no | no |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN2_HUMAN | [view interactions] | Low throughput | no | no |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
| CD5R1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CABIN_HUMAN | [view interactions] | Low throughput | no | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYNEM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MANEA_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EH1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VTNC_HUMAN | [view interactions] | Low throughput | no | no |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| LGMN_HUMAN | [view interactions] | Low throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| PROP1_HUMAN | [view interactions] | High throughput | no | no |
| BIN2_HUMAN | [view interactions] | High throughput | no | no |
| AAGAB_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PP2BC_HUMAN | [view interactions] | High throughput | no | yes |
| DEUP1_HUMAN | [view interactions] | High throughput | no | no |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGF_HUMAN | [view interactions] | Computational | no | no |
| PNMA2_HUMAN | [view interactions] | Computational | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EGFR_HUMAN | [view interactions] | Computational | no | no |
| FES_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| DPYL5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |