Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PP2BB_HUMAN

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed, PubMed). Dephosphorylates and activates transcription factor NFATC1 (PubMed). Dephosphorylates and inactivates transcription factor ELK1 (PubMed). Dephosphorylates DARPP32 (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PP2BB_HUMAN
GO:0046872 metal ion binding 39.3443 4 yes
GO:0019900 kinase binding 29.5082 4 no
GO:0019901 protein kinase binding 27.8689 5 no
GO:0019902 phosphatase binding 18.0328 4 yes
GO:0042578 phosphoric ester hydrolase activity 16.3934 4 yes
GO:0005509 calcium ion binding 14.7541 5 yes
GO:0016791 phosphatase activity 14.7541 5 yes
GO:0019903 protein phosphatase binding 14.7541 5 yes
GO:0004722 protein serine/threonine phosphatase activity 13.1148 4 yes
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4.9180 5 yes
GO:0030346 protein phosphatase 2B binding 4.9180 6 yes
GO:0033192 calmodulin-dependent protein phosphatase activity 3.2787 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PP2BB_HUMAN
GO:0048522 positive regulation of cellular process 70.4918 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.2131 4 yes
GO:0080090 regulation of primary metabolic process 65.5738 4 yes
GO:0031323 regulation of cellular metabolic process 63.9344 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.2951 4 yes
GO:0010646 regulation of cell communication 54.0984 4 yes
GO:0051246 regulation of protein metabolic process 52.4590 5 no
GO:0048523 negative regulation of cellular process 50.8197 4 yes
GO:0009893 positive regulation of metabolic process 47.5410 4 yes
GO:0009966 regulation of signal transduction 45.9016 4 no
GO:0031325 positive regulation of cellular metabolic process 44.2623 5 yes
GO:0051049 regulation of transport 44.2623 4 yes
GO:0019220 regulation of phosphate metabolic process 44.2623 6 no
GO:0051174 regulation of phosphorus metabolic process 44.2623 5 no
GO:0010604 positive regulation of macromolecule metabolic process 42.6230 5 yes
GO:0010468 regulation of gene expression 40.9836 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.9836 5 yes
GO:0051128 regulation of cellular component organization 39.3443 4 yes
GO:0009892 negative regulation of metabolic process 39.3443 4 no
GO:0010605 negative regulation of macromolecule metabolic process 39.3443 5 no
GO:0031399 regulation of protein modification process 39.3443 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.7049 5 no
GO:0042325 regulation of phosphorylation 37.7049 7 no
GO:0043085 positive regulation of catalytic activity 37.7049 4 no
GO:0006996 organelle organization 37.7049 4 no
GO:0051247 positive regulation of protein metabolic process 36.0656 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.7869 5 yes
GO:0031324 negative regulation of cellular metabolic process 32.7869 5 no
GO:0010562 positive regulation of phosphorus metabolic process 32.7869 6 no
GO:0045937 positive regulation of phosphate metabolic process 32.7869 7 no
GO:1902531 regulation of intracellular signal transduction 32.7869 5 no
GO:0006796 phosphate-containing compound metabolic process 32.7869 4 yes
GO:0009889 regulation of biosynthetic process 32.7869 4 yes
GO:0031326 regulation of cellular biosynthetic process 31.1475 5 yes
GO:0036211 protein modification process 31.1475 4 yes
GO:0043412 macromolecule modification 31.1475 4 yes
GO:0001932 regulation of protein phosphorylation 31.1475 7 no
GO:0051248 negative regulation of protein metabolic process 31.1475 6 no
GO:0050804 modulation of chemical synaptic transmission 29.5082 5 yes
GO:0099177 regulation of trans-synaptic signaling 29.5082 4 yes
GO:0042327 positive regulation of phosphorylation 29.5082 8 no
GO:0060341 regulation of cellular localization 27.8689 4 yes
GO:0051338 regulation of transferase activity 27.8689 4 no
GO:0022607 cellular component assembly 27.8689 4 no
GO:0016192 vesicle-mediated transport 26.2295 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.2295 5 yes
GO:0051050 positive regulation of transport 26.2295 4 yes
GO:0044057 regulation of system process 26.2295 4 no
GO:0031401 positive regulation of protein modification process 26.2295 7 no
GO:0010647 positive regulation of cell communication 24.5902 5 yes
GO:0023056 positive regulation of signaling 24.5902 4 yes
GO:0051252 regulation of RNA metabolic process 24.5902 5 yes
GO:0008104 protein localization 24.5902 4 no
GO:0010563 negative regulation of phosphorus metabolic process 24.5902 6 no
GO:0043549 regulation of kinase activity 24.5902 5 no
GO:0045936 negative regulation of phosphate metabolic process 24.5902 7 no
GO:0010941 regulation of cell death 24.5902 4 no
GO:0019932 second-messenger-mediated signaling 22.9508 4 yes
GO:0045595 regulation of cell differentiation 22.9508 4 no
GO:0051130 positive regulation of cellular component organization 22.9508 5 no
GO:0001934 positive regulation of protein phosphorylation 22.9508 8 no
GO:0031400 negative regulation of protein modification process 22.9508 7 no
GO:0051347 positive regulation of transferase activity 22.9508 5 no
GO:0051336 regulation of hydrolase activity 22.9508 4 no
GO:0034762 regulation of transmembrane transport 22.9508 4 no
GO:0043269 regulation of ion transport 22.9508 5 no
GO:0032880 regulation of protein localization 21.3115 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 21.3115 7 yes
GO:2001141 regulation of RNA biosynthetic process 21.3115 6 yes
GO:0048584 positive regulation of response to stimulus 21.3115 4 no
GO:0071310 cellular response to organic substance 21.3115 4 no
GO:0033674 positive regulation of kinase activity 21.3115 6 no
GO:0043933 protein-containing complex organization 21.3115 4 no
GO:0034765 regulation of ion transmembrane transport 21.3115 5 no
GO:0042981 regulation of apoptotic process 21.3115 6 no
GO:0043067 regulation of programmed cell death 21.3115 5 no
GO:0006355 regulation of DNA-templated transcription 21.3115 6 yes
GO:0050890 cognition 19.6721 4 yes
GO:0060627 regulation of vesicle-mediated transport 18.0328 4 yes
GO:0019722 calcium-mediated signaling 16.3934 5 yes
GO:0048585 negative regulation of response to stimulus 16.3934 4 yes
GO:1903829 positive regulation of protein localization 16.3934 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 14.7541 6 yes
GO:0016310 phosphorylation 14.7541 5 yes
GO:0016311 dephosphorylation 14.7541 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 14.7541 6 yes
GO:0070201 regulation of establishment of protein localization 14.7541 6 yes
GO:0006468 protein phosphorylation 14.7541 5 yes
GO:0009891 positive regulation of biosynthetic process 14.7541 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 13.1148 6 yes
GO:0051223 regulation of protein transport 13.1148 5 yes
GO:0006470 protein dephosphorylation 13.1148 5 yes
GO:0007612 learning 13.1148 4 yes
GO:0030100 regulation of endocytosis 11.4754 5 yes
GO:0045893 positive regulation of DNA-templated transcription 11.4754 7 yes
GO:0051046 regulation of secretion 11.4754 5 yes
GO:0051222 positive regulation of protein transport 11.4754 5 yes
GO:0051254 positive regulation of RNA metabolic process 11.4754 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.4754 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 11.4754 8 yes
GO:1903530 regulation of secretion by cell 11.4754 4 yes
GO:1904951 positive regulation of establishment of protein localization 11.4754 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 11.4754 7 yes
GO:0007613 memory 9.8361 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 8.1967 8 yes
GO:0050708 regulation of protein secretion 6.5574 5 yes
GO:0050776 regulation of immune response 6.5574 4 yes
GO:0051047 positive regulation of secretion 6.5574 5 yes
GO:1903532 positive regulation of secretion by cell 6.5574 5 yes
GO:0033173 calcineurin-NFAT signaling cascade 4.9180 6 yes
GO:0034097 response to cytokine 4.9180 4 yes
GO:0046883 regulation of hormone secretion 4.9180 4 yes
GO:0048016 inositol phosphate-mediated signaling 4.9180 5 yes
GO:0050714 positive regulation of protein secretion 4.9180 6 yes
GO:0050796 regulation of insulin secretion 4.9180 6 yes
GO:0090087 regulation of peptide transport 4.9180 5 yes
GO:0090276 regulation of peptide hormone secretion 4.9180 5 yes
GO:0097720 calcineurin-mediated signaling 4.9180 6 yes
GO:1900242 regulation of synaptic vesicle endocytosis 4.9180 6 yes
GO:1903421 regulation of synaptic vesicle recycling 4.9180 5 yes
GO:0002683 negative regulation of immune system process 4.9180 4 yes
GO:0002791 regulation of peptide secretion 4.9180 6 yes
GO:0032024 positive regulation of insulin secretion 3.2787 7 yes
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3.2787 8 yes
GO:0042110 T cell activation 3.2787 4 yes
GO:0046887 positive regulation of hormone secretion 3.2787 5 yes
GO:0048872 homeostasis of number of cells 3.2787 4 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 3.2787 7 yes
GO:0090277 positive regulation of peptide hormone secretion 3.2787 6 yes
GO:0002793 positive regulation of peptide secretion 3.2787 6 yes
GO:0007507 heart development 3.2787 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PP2BB_HUMAN
DOID:0050700 cardiomyopathy 3.2787 4 no
DOID:0060036 intrinsic cardiomyopathy 3.2787 5 no
DOID:114 heart disease 3.2787 3 no
DOID:2843 long QT syndrome 3.2787 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TB10C_HUMAN [view interactions] Low throughput no no
AKAP6_HUMAN [view interactions] Low throughput no no
CAC1H_HUMAN [view entry] [view interactions] Low throughput yes yes
TFEB_HUMAN [view interactions] Low throughput no no
NAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
NAC3_HUMAN [view entry] [view interactions] Low throughput yes no
NAC2_HUMAN [view entry] [view interactions] Low throughput yes no
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
ATOH8_HUMAN [view interactions] Low throughput no no
NFAC1_HUMAN [view interactions] Low throughput no no
MARH7_HUMAN [view interactions] Low throughput no yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
IRF2_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
SPF45_HUMAN [view interactions] High throughput no yes
PHF5A_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
RSRC1_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
FXL17_HUMAN [view interactions] High throughput no yes
MLH1_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP76_HUMAN [view interactions] High throughput no yes
GCP3_HUMAN [view interactions] High throughput no yes
RASF2_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
RCAN3_HUMAN [view interactions] High throughput no no
PP2BC_HUMAN [view interactions] High throughput no yes
RCAN2_HUMAN [view interactions] High throughput no yes
PPR3A_HUMAN [view interactions] High throughput no no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ARMT1_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
LBH_HUMAN [view interactions] High throughput no yes
RCAN1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
T200A_HUMAN [view interactions] High throughput no yes
DEF1_HUMAN [view interactions] High throughput no no
KLRG2_HUMAN [view interactions] High throughput no no
CDR2_HUMAN [view interactions] High throughput no yes
CRTC2_HUMAN [view interactions] High throughput no yes
TRI16_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
SPT33_HUMAN [view interactions] High throughput no no
F163B_HUMAN [view interactions] High throughput no yes
PAR3L_HUMAN [view interactions] High throughput no yes
PMEPA_HUMAN [view interactions] High throughput no no
HXC5_HUMAN [view interactions] High throughput no no
TENS4_HUMAN [view interactions] High throughput no no
KCNKI_HUMAN [view interactions] High throughput no no
CANB2_HUMAN [view interactions] High throughput no no
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
RBM39_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
SRSF5_HUMAN [view interactions] High throughput no yes
VPS25_HUMAN [view interactions] High throughput no yes
VPS36_HUMAN [view interactions] High throughput no yes
WDR12_HUMAN [view interactions] High throughput no yes
DAA10_HUMAN [view interactions] High throughput no yes
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
CT027_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1RB_HUMAN [view interactions] High throughput no yes
IPP2B_HUMAN [view interactions] High throughput no no
IPP2_HUMAN [view interactions] High throughput no no
WDR82_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
NOS1_HUMAN [view entry] [view interactions] Computational yes yes
EPN1_HUMAN [view entry] [view interactions] Computational yes yes
SODC_HUMAN [view interactions] Computational no yes
NFAC3_HUMAN [view interactions] Computational no no
PP2AB_HUMAN [view interactions] Computational no yes
CYC_HUMAN [view entry] [view interactions] Computational yes yes
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
EPS15_HUMAN [view entry] [view interactions] Computational yes yes
CAC1D_HUMAN [view interactions] Computational no yes
PPR1B_HUMAN [view entry] [view interactions] Computational yes yes
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
MEF2A_HUMAN [view interactions] Computational no yes
PPIA_HUMAN [view entry] [view interactions] Computational yes yes
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
AP2A1_HUMAN [view entry] [view interactions] Computational yes yes
PR15B_HUMAN [view interactions] Computational no no
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
BAD_HUMAN [view entry] [view interactions] Computational yes yes
2AAA_HUMAN [view entry] [view interactions] Computational yes no
2A5G_HUMAN [view interactions] Computational no yes
NFAC4_HUMAN [view interactions] Computational no yes
AP2M1_HUMAN [view entry] [view interactions] Computational yes yes
NEB2_HUMAN [view entry] [view interactions] Computational yes yes
TADBP_HUMAN [view interactions] Computational no yes
NEPR1_HUMAN [view interactions] Computational no yes
FKB1A_HUMAN [view interactions] Computational no yes
PP4R2_HUMAN [view interactions] Computational no yes
SHOC2_HUMAN [view interactions] Computational no yes
2A5A_HUMAN [view interactions] Computational no yes
TOX4_HUMAN [view interactions] Computational no yes
MEF2D_HUMAN [view interactions] Computational no yes
2ABA_HUMAN [view interactions] Computational no yes
PLCG2_HUMAN [view interactions] Computational no yes
CABIN_HUMAN [view interactions] Computational no yes
2ABD_HUMAN [view interactions] Computational no yes
MYPT1_HUMAN [view entry] [view interactions] Computational yes yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
CNEP1_HUMAN [view interactions] Computational no yes
PPR1A_HUMAN [view interactions] Computational no yes
PP4R4_HUMAN [view interactions] Computational no yes
MEF2C_HUMAN [view interactions] Computational no yes
PTPA_HUMAN [view interactions] Computational no yes
SYNJ2_HUMAN [view entry] [view interactions] Computational yes yes
NFAC2_HUMAN [view interactions] Computational no yes
BIN1_HUMAN [view entry] [view interactions] Computational yes yes
PP4R1_HUMAN [view interactions] Computational no yes