Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PP2BB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed, PubMed). Dephosphorylates and activates transcription factor NFATC1 (PubMed). Dephosphorylates and inactivates transcription factor ELK1 (PubMed). Dephosphorylates DARPP32 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PP2BB_HUMAN
GO:0043169 cation binding 45.0000 4 yes
GO:0046872 metal ion binding 45.0000 5 yes
GO:0019900 kinase binding 27.5000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0019902 phosphatase binding 22.5000 4 yes
GO:0000166 nucleotide binding 22.5000 4 no
GO:0017076 purine nucleotide binding 22.5000 5 no
GO:0032555 purine ribonucleotide binding 22.5000 4 no
GO:0043168 anion binding 22.5000 4 no
GO:0005509 calcium ion binding 17.5000 6 yes
GO:0019903 protein phosphatase binding 17.5000 5 yes
GO:0042578 phosphoric ester hydrolase activity 15.0000 4 yes
GO:0004722 protein serine/threonine phosphatase activity 12.5000 4 yes
GO:0016791 phosphatase activity 12.5000 5 yes
GO:0017018 myosin phosphatase activity 10.0000 5 yes
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 7.5000 5 yes
GO:0030346 protein phosphatase 2B binding 5.0000 6 yes
GO:0033192 calmodulin-dependent protein phosphatase activity 5.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PP2BB_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 65.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.0000 4 yes
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0048523 negative regulation of cellular process 52.5000 4 yes
GO:0009893 positive regulation of metabolic process 47.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 47.5000 5 yes
GO:0051246 regulation of protein metabolic process 47.5000 5 no
GO:1902531 regulation of intracellular signal transduction 45.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.5000 5 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0051128 regulation of cellular component organization 40.0000 4 yes
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 yes
GO:0023056 positive regulation of signaling 37.5000 4 yes
GO:0048584 positive regulation of response to stimulus 37.5000 4 yes
GO:0141124 intracellular signaling cassette 37.5000 4 yes
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010468 regulation of gene expression 35.0000 6 yes
GO:0034762 regulation of transmembrane transport 35.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 32.5000 5 yes
GO:0099177 regulation of trans-synaptic signaling 32.5000 4 yes
GO:0001932 regulation of protein phosphorylation 32.5000 7 no
GO:0006996 organelle organization 32.5000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 32.5000 6 no
GO:0045937 positive regulation of phosphate metabolic process 32.5000 7 no
GO:0051247 positive regulation of protein metabolic process 32.5000 6 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 yes
GO:0009967 positive regulation of signal transduction 30.0000 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 30.0000 5 yes
GO:0043269 regulation of monoatomic ion transport 30.0000 5 yes
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0010959 regulation of metal ion transport 27.5000 6 yes
GO:0051130 positive regulation of cellular component organization 27.5000 5 yes
GO:0051924 regulation of calcium ion transport 27.5000 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 27.5000 7 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 27.5000 6 yes
GO:0031401 positive regulation of protein modification process 27.5000 7 no
GO:0044057 regulation of system process 27.5000 4 no
GO:0051248 negative regulation of protein metabolic process 27.5000 6 no
GO:0051338 regulation of transferase activity 27.5000 4 no
GO:0036211 protein modification process 25.0000 4 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0050848 regulation of calcium-mediated signaling 25.0000 6 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0008104 protein localization 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0050890 cognition 22.5000 4 yes
GO:0060341 regulation of cellular localization 22.5000 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 22.5000 6 no
GO:0042326 negative regulation of phosphorylation 22.5000 8 no
GO:0043085 positive regulation of catalytic activity 22.5000 4 no
GO:0045859 regulation of protein kinase activity 22.5000 6 no
GO:0045936 negative regulation of phosphate metabolic process 22.5000 7 no
GO:0051347 positive regulation of transferase activity 22.5000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.0000 5 yes
GO:0034764 positive regulation of transmembrane transport 20.0000 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 20.0000 6 yes
GO:0043270 positive regulation of monoatomic ion transport 20.0000 5 yes
GO:0051050 positive regulation of transport 20.0000 4 yes
GO:0051051 negative regulation of transport 20.0000 4 yes
GO:0009891 positive regulation of biosynthetic process 17.5000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 17.5000 6 yes
GO:0016310 phosphorylation 17.5000 5 yes
GO:0019722 calcium-mediated signaling 17.5000 5 yes
GO:0023057 negative regulation of signaling 17.5000 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 17.5000 6 yes
GO:0032880 regulation of protein localization 17.5000 5 yes
GO:0033043 regulation of organelle organization 17.5000 5 yes
GO:0034763 negative regulation of transmembrane transport 17.5000 5 yes
GO:0048585 negative regulation of response to stimulus 17.5000 4 yes
GO:0051252 regulation of RNA metabolic process 17.5000 5 yes
GO:0051928 positive regulation of calcium ion transport 17.5000 6 yes
GO:1902533 positive regulation of intracellular signal transduction 17.5000 6 yes
GO:1904064 positive regulation of cation transmembrane transport 17.5000 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 17.5000 7 yes
GO:0006468 protein phosphorylation 15.0000 5 yes
GO:0007612 learning 15.0000 4 yes
GO:0007613 memory 15.0000 4 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 15.0000 6 yes
GO:0043271 negative regulation of monoatomic ion transport 15.0000 5 yes
GO:0050776 regulation of immune response 15.0000 4 yes
GO:0051926 negative regulation of calcium ion transport 15.0000 6 yes
GO:0060627 regulation of vesicle-mediated transport 15.0000 4 yes
GO:0070201 regulation of establishment of protein localization 15.0000 6 yes
GO:0106056 regulation of calcineurin-mediated signaling 15.0000 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 15.0000 7 yes
GO:1904063 negative regulation of cation transmembrane transport 15.0000 7 yes
GO:0006355 regulation of DNA-templated transcription 12.5000 7 yes
GO:0010638 positive regulation of organelle organization 12.5000 6 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 12.5000 8 yes
GO:0090279 regulation of calcium ion import 12.5000 8 yes
GO:1903829 positive regulation of protein localization 12.5000 5 yes
GO:1905664 regulation of calcium ion import across plasma membrane 12.5000 8 yes
GO:2001141 regulation of RNA biosynthetic process 12.5000 6 yes
GO:0002683 negative regulation of immune system process 10.0000 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 10.0000 8 yes
GO:0006470 protein dephosphorylation 10.0000 5 yes
GO:0016311 dephosphorylation 10.0000 5 yes
GO:0030100 regulation of endocytosis 10.0000 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 10.0000 5 yes
GO:0050850 positive regulation of calcium-mediated signaling 10.0000 7 yes
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 10.0000 9 yes
GO:0090280 positive regulation of calcium ion import 10.0000 7 yes
GO:0106058 positive regulation of calcineurin-mediated signaling 10.0000 8 yes
GO:1904951 positive regulation of establishment of protein localization 10.0000 6 yes
GO:1905665 positive regulation of calcium ion import across plasma membrane 10.0000 8 yes
GO:0033173 calcineurin-NFAT signaling cascade 7.5000 7 yes
GO:0034097 response to cytokine 7.5000 4 yes
GO:0045893 positive regulation of DNA-templated transcription 7.5000 8 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 7.5000 9 yes
GO:0051223 regulation of protein transport 7.5000 5 yes
GO:0051254 positive regulation of RNA metabolic process 7.5000 6 yes
GO:0055001 muscle cell development 7.5000 4 yes
GO:0090281 negative regulation of calcium ion import 7.5000 7 yes
GO:0097720 calcineurin-mediated signaling 7.5000 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 7.5000 7 yes
GO:1905949 negative regulation of calcium ion import across plasma membrane 7.5000 8 yes
GO:0002791 regulation of peptide secretion 5.0000 6 yes
GO:0007507 heart development 5.0000 4 yes
GO:0014904 myotube cell development 5.0000 5 yes
GO:0042110 T cell activation 5.0000 4 yes
GO:0046883 regulation of hormone secretion 5.0000 4 yes
GO:0048741 skeletal muscle fiber development 5.0000 6 yes
GO:0050708 regulation of protein secretion 5.0000 5 yes
GO:0050777 negative regulation of immune response 5.0000 5 yes
GO:0050796 regulation of insulin secretion 5.0000 6 yes
GO:0051046 regulation of secretion 5.0000 5 yes
GO:0051047 positive regulation of secretion 5.0000 5 yes
GO:0051222 positive regulation of protein transport 5.0000 5 yes
GO:0090087 regulation of peptide transport 5.0000 5 yes
GO:0090276 regulation of peptide hormone secretion 5.0000 5 yes
GO:1900180 regulation of protein localization to nucleus 5.0000 6 yes
GO:1903530 regulation of secretion by cell 5.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TB10C_HUMAN [view interactions] Low throughput no no
AKAP6_HUMAN [view interactions] Low throughput no no
CAC1H_HUMAN [view entry] [view interactions] Low throughput yes yes
TFEB_HUMAN [view interactions] Low throughput no no
NAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
NAC3_HUMAN [view entry] [view interactions] Low throughput yes no
NAC2_HUMAN [view entry] [view interactions] Low throughput yes no
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
ATOH8_HUMAN [view interactions] Low throughput no no
NFAC1_HUMAN [view interactions] Low throughput no no
MARH7_HUMAN [view interactions] Low throughput no yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
IRF2_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
RSRC1_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
PHF5A_HUMAN [view interactions] High throughput no yes
SPF45_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
RCAN1_HUMAN [view interactions] High throughput no yes
FXL17_HUMAN [view interactions] High throughput no yes
SPAG6_HUMAN [view interactions] High throughput no no
MLH1_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP76_HUMAN [view interactions] High throughput no yes
GCP3_HUMAN [view interactions] High throughput no yes
RASF2_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
RCAN3_HUMAN [view interactions] High throughput no no
PP2BC_HUMAN [view interactions] High throughput no yes
RCAN2_HUMAN [view interactions] High throughput no yes
PPR3A_HUMAN [view interactions] High throughput no no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ARMT1_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
LBH_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
T200A_HUMAN [view interactions] High throughput no yes
DEF1_HUMAN [view interactions] High throughput no no
KLRG2_HUMAN [view interactions] High throughput no no
CDR2_HUMAN [view interactions] High throughput no yes
CRTC2_HUMAN [view interactions] High throughput no yes
TRI16_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MAGA3_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
SPT33_HUMAN [view interactions] High throughput no no
F163B_HUMAN [view interactions] High throughput no yes
PAR3L_HUMAN [view interactions] High throughput no yes
PMEPA_HUMAN [view interactions] High throughput no no
HXC5_HUMAN [view interactions] High throughput no no
TENS4_HUMAN [view interactions] High throughput no no
KCNKI_HUMAN [view interactions] High throughput no no
CANB2_HUMAN [view interactions] High throughput no no
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
RBM39_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
SRSF5_HUMAN [view interactions] High throughput no yes
VPS25_HUMAN [view interactions] High throughput no yes
VPS36_HUMAN [view interactions] High throughput no yes
WDR12_HUMAN [view interactions] High throughput no yes
DAA10_HUMAN [view interactions] High throughput no yes
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
ADSSP_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1RB_HUMAN [view interactions] High throughput no yes
IPP2_HUMAN [view interactions] High throughput no no
IPP2B_HUMAN [view interactions] High throughput no no
WDR82_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no