Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NAC3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory . Required for normal oligodendrocyte differentiation and for normal myelination (PubMed). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NAC3_HUMAN
GO:0043169 cation binding 66.6667 4 yes
GO:0046872 metal ion binding 66.6667 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 50.0000 4 yes
GO:0015081 sodium ion transmembrane transporter activity 50.0000 6 yes
GO:0015291 secondary active transmembrane transporter activity 50.0000 4 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 50.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 yes
GO:0005432 calcium:sodium antiporter activity 33.3333 7 yes
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 yes
GO:0015297 antiporter activity 33.3333 5 yes
GO:0015368 calcium:monoatomic cation antiporter activity 33.3333 6 yes
GO:0140828 metal cation:monoatomic cation antiporter activity 33.3333 5 yes
GO:0005509 calcium ion binding 33.3333 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in NAC3_HUMAN
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0007612 learning 50.0000 4 yes
GO:0007613 memory 50.0000 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0050890 cognition 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0098657 import into cell 50.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0050848 regulation of calcium-mediated signaling 33.3333 6 no
GO:0106056 regulation of calcineurin-mediated signaling 33.3333 7 no
GO:0150104 transport across blood-brain barrier 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0046903 secretion 33.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0002683 negative regulation of immune system process 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051051 negative regulation of transport 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:1900180 regulation of protein localization to nucleus 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0006811 monoatomic ion transport 33.3333 4 yes
GO:0006812 monoatomic cation transport 33.3333 5 yes
GO:0006814 sodium ion transport 33.3333 7 yes
GO:0006816 calcium ion transport 33.3333 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 33.3333 4 yes
GO:0006874 intracellular calcium ion homeostasis 33.3333 5 yes
GO:0008016 regulation of heart contraction 33.3333 6 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0030001 metal ion transport 33.3333 6 yes
GO:0030003 intracellular monoatomic cation homeostasis 33.3333 5 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0031644 regulation of nervous system process 33.3333 5 yes
GO:0034330 cell junction organization 33.3333 4 yes
GO:0035725 sodium ion transmembrane transport 33.3333 5 yes
GO:0036293 response to decreased oxygen levels 33.3333 4 yes
GO:0036294 cellular response to decreased oxygen levels 33.3333 5 yes
GO:0042325 regulation of phosphorylation 33.3333 7 yes
GO:0043549 regulation of kinase activity 33.3333 5 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0045859 regulation of protein kinase activity 33.3333 6 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0050808 synapse organization 33.3333 5 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0051248 negative regulation of protein metabolic process 33.3333 6 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0055074 calcium ion homeostasis 33.3333 4 yes
GO:0055080 monoatomic cation homeostasis 33.3333 4 yes
GO:0060291 long-term synaptic potentiation 33.3333 4 yes
GO:0070509 calcium ion import 33.3333 8 yes
GO:0070588 calcium ion transmembrane transport 33.3333 5 yes
GO:0071453 cellular response to oxygen levels 33.3333 4 yes
GO:0071456 cellular response to hypoxia 33.3333 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 yes
GO:0097553 calcium ion transmembrane import into cytosol 33.3333 6 yes
GO:0098655 monoatomic cation transmembrane transport 33.3333 4 yes
GO:0098659 inorganic cation import across plasma membrane 33.3333 5 yes
GO:0098662 inorganic cation transmembrane transport 33.3333 4 yes
GO:0098703 calcium ion import across plasma membrane 33.3333 6 yes
GO:0098815 modulation of excitatory postsynaptic potential 33.3333 4 yes
GO:0099587 inorganic ion import across plasma membrane 33.3333 4 yes
GO:1902656 calcium ion import into cytosol 33.3333 8 yes
GO:1903522 regulation of blood circulation 33.3333 5 yes
GO:1903779 regulation of cardiac conduction 33.3333 7 yes
GO:0003018 vascular process in circulatory system 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010232 vascular transport 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
CXA8_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
CGAT2_HUMAN [view interactions] High throughput no yes
PDE3B_HUMAN [view interactions] High throughput no no
TMM43_HUMAN [view interactions] High throughput no no
EMC7_HUMAN [view interactions] High throughput no yes
NAC2_HUMAN [view entry] [view interactions] High throughput yes no
REEP4_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes