Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NAC3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory . Required for normal oligodendrocyte differentiation and for normal myelination (PubMed). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NAC3_HUMAN
GO:0046872 metal ion binding 63.6364 4 yes
GO:0008324 cation transmembrane transporter activity 36.3636 4 yes
GO:0005432 calcium:sodium antiporter activity 27.2727 7 yes
GO:0015081 sodium ion transmembrane transporter activity 27.2727 6 yes
GO:0015085 calcium ion transmembrane transporter activity 27.2727 6 yes
GO:0015291 secondary active transmembrane transporter activity 27.2727 4 yes
GO:0015297 antiporter activity 27.2727 5 yes
GO:0015298 solute:cation antiporter activity 27.2727 5 yes
GO:0015368 calcium:cation antiporter activity 27.2727 7 yes
GO:0022853 active ion transmembrane transporter activity 27.2727 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 27.2727 4 yes
GO:0046873 metal ion transmembrane transporter activity 27.2727 5 yes
GO:0140828 metal cation:monoatomic cation antiporter activity 27.2727 6 yes
GO:0004674 protein serine/threonine kinase activity 27.2727 4 no
GO:0004690 cyclic nucleotide-dependent protein kinase activity 27.2727 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 27.2727 4 no
GO:0005524 ATP binding 27.2727 5 no
GO:0016301 kinase activity 27.2727 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 27.2727 4 no
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0030554 adenyl nucleotide binding 27.2727 5 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0106310 protein serine kinase activity 27.2727 4 no
GO:0005509 calcium ion binding 27.2727 5 no
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential 18.1818 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NAC3_HUMAN
GO:0010646 regulation of cell communication 63.6364 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 yes
GO:0060255 regulation of macromolecule metabolic process 63.6364 4 yes
GO:0080090 regulation of primary metabolic process 63.6364 4 yes
GO:0031323 regulation of cellular metabolic process 54.5455 4 yes
GO:0048523 negative regulation of cellular process 54.5455 4 yes
GO:0048878 chemical homeostasis 54.5455 4 yes
GO:0051246 regulation of protein metabolic process 54.5455 5 yes
GO:0010468 regulation of gene expression 54.5455 5 no
GO:0009966 regulation of signal transduction 45.4545 4 yes
GO:0048522 positive regulation of cellular process 45.4545 4 yes
GO:0006796 phosphate-containing compound metabolic process 45.4545 4 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0006873 cellular ion homeostasis 36.3636 4 yes
GO:0006874 cellular calcium ion homeostasis 36.3636 7 yes
GO:0006875 cellular metal ion homeostasis 36.3636 6 yes
GO:0008016 regulation of heart contraction 36.3636 6 yes
GO:0030003 cellular cation homeostasis 36.3636 5 yes
GO:0044057 regulation of system process 36.3636 4 yes
GO:0050801 ion homeostasis 36.3636 5 yes
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 yes
GO:0055065 metal ion homeostasis 36.3636 7 yes
GO:0055074 calcium ion homeostasis 36.3636 8 yes
GO:0055080 cation homeostasis 36.3636 6 yes
GO:0072503 cellular divalent inorganic cation homeostasis 36.3636 6 yes
GO:0072507 divalent inorganic cation homeostasis 36.3636 7 yes
GO:0098657 import into cell 36.3636 4 yes
GO:0098771 inorganic ion homeostasis 36.3636 6 yes
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 yes
GO:1903522 regulation of blood circulation 36.3636 5 yes
GO:1903779 regulation of cardiac conduction 36.3636 4 yes
GO:0006468 protein phosphorylation 36.3636 5 no
GO:0016310 phosphorylation 36.3636 5 no
GO:0036211 protein modification process 36.3636 4 no
GO:0043412 macromolecule modification 36.3636 4 no
GO:0048585 negative regulation of response to stimulus 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 27.2727 7 yes
GO:0006811 ion transport 27.2727 4 yes
GO:0006812 cation transport 27.2727 5 yes
GO:0006814 sodium ion transport 27.2727 7 yes
GO:0006816 calcium ion transport 27.2727 7 yes
GO:0006937 regulation of muscle contraction 27.2727 6 yes
GO:0006942 regulation of striated muscle contraction 27.2727 7 yes
GO:0007612 learning 27.2727 4 yes
GO:0007613 memory 27.2727 4 yes
GO:0009892 negative regulation of metabolic process 27.2727 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 27.2727 5 yes
GO:0010647 positive regulation of cell communication 27.2727 5 yes
GO:0019220 regulation of phosphate metabolic process 27.2727 6 yes
GO:0023056 positive regulation of signaling 27.2727 4 yes
GO:0030001 metal ion transport 27.2727 6 yes
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 yes
GO:0031399 regulation of protein modification process 27.2727 6 yes
GO:0035725 sodium ion transmembrane transport 27.2727 6 yes
GO:0036293 response to decreased oxygen levels 27.2727 4 yes
GO:0036294 cellular response to decreased oxygen levels 27.2727 5 yes
GO:0042325 regulation of phosphorylation 27.2727 7 yes
GO:0043549 regulation of kinase activity 27.2727 5 yes
GO:0045859 regulation of protein kinase activity 27.2727 6 yes
GO:0050890 cognition 27.2727 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 27.2727 5 yes
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 yes
GO:0051248 negative regulation of protein metabolic process 27.2727 6 yes
GO:0051338 regulation of transferase activity 27.2727 4 yes
GO:0070588 calcium ion transmembrane transport 27.2727 6 yes
GO:0071453 cellular response to oxygen levels 27.2727 4 yes
GO:0071456 cellular response to hypoxia 27.2727 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 27.2727 7 yes
GO:0090257 regulation of muscle system process 27.2727 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 27.2727 7 yes
GO:0098655 cation transmembrane transport 27.2727 4 yes
GO:0098659 inorganic cation import across plasma membrane 27.2727 5 yes
GO:0098660 inorganic ion transmembrane transport 27.2727 4 yes
GO:0098662 inorganic cation transmembrane transport 27.2727 5 yes
GO:0098703 calcium ion import across plasma membrane 27.2727 6 yes
GO:0099587 inorganic ion import across plasma membrane 27.2727 4 yes
GO:0043269 regulation of ion transport 27.2727 5 no
GO:0003018 vascular process in circulatory system 27.2727 4 no
GO:0009743 response to carbohydrate 27.2727 4 no
GO:0009746 response to hexose 27.2727 6 no
GO:0009749 response to glucose 27.2727 7 no
GO:0019722 calcium-mediated signaling 27.2727 5 no
GO:0019932 second-messenger-mediated signaling 27.2727 4 no
GO:0034284 response to monosaccharide 27.2727 5 no
GO:0071310 cellular response to organic substance 27.2727 4 no
GO:1901701 cellular response to oxygen-containing compound 27.2727 4 no
GO:0009968 negative regulation of signal transduction 27.2727 5 no
GO:0010648 negative regulation of cell communication 27.2727 5 no
GO:0023057 negative regulation of signaling 27.2727 4 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0051128 regulation of cellular component organization 27.2727 4 no
GO:0051223 regulation of protein transport 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0070201 regulation of establishment of protein localization 27.2727 6 no
GO:0001933 negative regulation of protein phosphorylation 18.1818 8 yes
GO:0006469 negative regulation of protein kinase activity 18.1818 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 18.1818 6 yes
GO:0031400 negative regulation of protein modification process 18.1818 7 yes
GO:0031644 regulation of nervous system process 18.1818 5 yes
GO:0033673 negative regulation of kinase activity 18.1818 6 yes
GO:0034330 cell junction organization 18.1818 4 yes
GO:0042326 negative regulation of phosphorylation 18.1818 8 yes
GO:0043086 negative regulation of catalytic activity 18.1818 4 yes
GO:0045936 negative regulation of phosphate metabolic process 18.1818 7 yes
GO:0050806 positive regulation of synaptic transmission 18.1818 5 yes
GO:0050808 synapse organization 18.1818 5 yes
GO:0051348 negative regulation of transferase activity 18.1818 5 yes
GO:0060291 long-term synaptic potentiation 18.1818 4 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 18.1818 8 yes
GO:0098815 modulation of excitatory postsynaptic potential 18.1818 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
CXA8_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
CGAT2_HUMAN [view interactions] High throughput no yes
PDE3B_HUMAN [view interactions] High throughput no no
TMM43_HUMAN [view interactions] High throughput no no
EMC7_HUMAN [view interactions] High throughput no yes
NAC2_HUMAN [view entry] [view interactions] High throughput yes no
REEP4_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
AKAP1_HUMAN [view entry] [view interactions] Computational yes yes
NAC1_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
KGP1_HUMAN [view interactions] Computational no yes
KAPCG_HUMAN [view interactions] Computational no no