Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NAC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NAC2_HUMAN
GO:0046872 metal ion binding 66.6667 4 yes
GO:0008324 cation transmembrane transporter activity 44.4444 4 yes
GO:0015085 calcium ion transmembrane transporter activity 44.4444 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 44.4444 4 yes
GO:0046873 metal ion transmembrane transporter activity 44.4444 5 yes
GO:0005432 calcium:sodium antiporter activity 33.3333 7 yes
GO:0015081 sodium ion transmembrane transporter activity 33.3333 6 yes
GO:0015291 secondary active transmembrane transporter activity 33.3333 4 yes
GO:0015297 antiporter activity 33.3333 5 yes
GO:0015298 solute:cation antiporter activity 33.3333 5 yes
GO:0015368 calcium:cation antiporter activity 33.3333 7 yes
GO:0022853 active ion transmembrane transporter activity 33.3333 4 yes
GO:0140828 metal cation:monoatomic cation antiporter activity 33.3333 6 yes
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0004690 cyclic nucleotide-dependent protein kinase activity 33.3333 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration 22.2222 8 yes
GO:0005509 calcium ion binding 22.2222 5 no
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential 22.2222 6 no
GO:0000287 magnesium ion binding 22.2222 5 no
GO:0004679 AMP-activated protein kinase activity 22.2222 5 no
GO:0004691 cAMP-dependent protein kinase activity 22.2222 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in NAC2_HUMAN
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0036211 protein modification process 55.5556 4 no
GO:0043412 macromolecule modification 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0010468 regulation of gene expression 55.5556 5 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 yes
GO:0048878 chemical homeostasis 55.5556 4 yes
GO:0051246 regulation of protein metabolic process 55.5556 5 yes
GO:0072503 cellular divalent inorganic cation homeostasis 44.4444 6 yes
GO:0072507 divalent inorganic cation homeostasis 44.4444 7 yes
GO:0098771 inorganic ion homeostasis 44.4444 6 yes
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 yes
GO:1903522 regulation of blood circulation 44.4444 5 yes
GO:1903779 regulation of cardiac conduction 44.4444 4 yes
GO:0006468 protein phosphorylation 44.4444 5 no
GO:0006796 phosphate-containing compound metabolic process 44.4444 4 no
GO:0016310 phosphorylation 44.4444 5 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0006873 cellular ion homeostasis 44.4444 4 yes
GO:0006874 cellular calcium ion homeostasis 44.4444 7 yes
GO:0006875 cellular metal ion homeostasis 44.4444 6 yes
GO:0008016 regulation of heart contraction 44.4444 6 yes
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0030003 cellular cation homeostasis 44.4444 5 yes
GO:0044057 regulation of system process 44.4444 4 yes
GO:0050801 ion homeostasis 44.4444 5 yes
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 yes
GO:0055065 metal ion homeostasis 44.4444 7 yes
GO:0055074 calcium ion homeostasis 44.4444 8 yes
GO:0055080 cation homeostasis 44.4444 6 yes
GO:0070588 calcium ion transmembrane transport 33.3333 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 yes
GO:0097553 calcium ion transmembrane import into cytosol 33.3333 7 yes
GO:0098655 cation transmembrane transport 33.3333 4 yes
GO:0098657 import into cell 33.3333 4 yes
GO:0098659 inorganic cation import across plasma membrane 33.3333 5 yes
GO:0098660 inorganic ion transmembrane transport 33.3333 4 yes
GO:0098662 inorganic cation transmembrane transport 33.3333 5 yes
GO:0098703 calcium ion import across plasma membrane 33.3333 6 yes
GO:0099587 inorganic ion import across plasma membrane 33.3333 4 yes
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0006937 regulation of muscle contraction 33.3333 6 no
GO:0006942 regulation of striated muscle contraction 33.3333 7 no
GO:0019722 calcium-mediated signaling 33.3333 5 no
GO:0019932 second-messenger-mediated signaling 33.3333 4 no
GO:0090257 regulation of muscle system process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0006811 ion transport 33.3333 4 yes
GO:0006812 cation transport 33.3333 5 yes
GO:0006814 sodium ion transport 33.3333 7 yes
GO:0006816 calcium ion transport 33.3333 7 yes
GO:0007612 learning 33.3333 4 yes
GO:0007613 memory 33.3333 4 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0030001 metal ion transport 33.3333 6 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0034330 cell junction organization 33.3333 4 yes
GO:0035725 sodium ion transmembrane transport 33.3333 6 yes
GO:0042325 regulation of phosphorylation 33.3333 7 yes
GO:0043549 regulation of kinase activity 33.3333 5 yes
GO:0045859 regulation of protein kinase activity 33.3333 6 yes
GO:0050808 synapse organization 33.3333 5 yes
GO:0050890 cognition 33.3333 4 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0060291 long-term synaptic potentiation 22.2222 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 22.2222 4 yes
GO:0008104 protein localization 22.2222 4 no
GO:0018105 peptidyl-serine phosphorylation 22.2222 6 no
GO:0018193 peptidyl-amino acid modification 22.2222 5 no
GO:0018209 peptidyl-serine modification 22.2222 6 no
GO:0046777 protein autophosphorylation 22.2222 6 no
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0006469 negative regulation of protein kinase activity 22.2222 7 no
GO:0009743 response to carbohydrate 22.2222 4 no
GO:0009746 response to hexose 22.2222 6 no
GO:0009749 response to glucose 22.2222 7 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 22.2222 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 22.2222 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 22.2222 6 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0033673 negative regulation of kinase activity 22.2222 6 no
GO:0034284 response to monosaccharide 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0036293 response to decreased oxygen levels 22.2222 4 no
GO:0036294 cellular response to decreased oxygen levels 22.2222 5 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 22.2222 5 no
GO:0051282 regulation of sequestering of calcium ion 22.2222 4 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0055117 regulation of cardiac muscle contraction 22.2222 7 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0071453 cellular response to oxygen levels 22.2222 4 no
GO:0071456 cellular response to hypoxia 22.2222 4 no
GO:0071901 negative regulation of protein serine/threonine kinase activity 22.2222 8 no
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 22.2222 4 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1903169 regulation of calcium ion transmembrane transport 22.2222 7 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0001843 neural tube closure 22.2222 5 no
GO:0003091 renal water homeostasis 22.2222 4 no
GO:0008589 regulation of smoothened signaling pathway 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0010737 protein kinase A signaling 22.2222 4 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0030104 water homeostasis 22.2222 5 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0034380 high-density lipoprotein particle assembly 22.2222 4 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0045879 negative regulation of smoothened signaling pathway 22.2222 6 no
GO:0060606 tube closure 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0065005 protein-lipid complex assembly 22.2222 6 no
GO:0070613 regulation of protein processing 22.2222 7 no
GO:0071825 protein-lipid complex subunit organization 22.2222 5 no
GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 22.2222 6 no
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 22.2222 7 no
GO:1903317 regulation of protein maturation 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0003018 vascular process in circulatory system 22.2222 4 yes
GO:0009893 positive regulation of metabolic process 22.2222 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 yes
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 yes
GO:0031644 regulation of nervous system process 22.2222 5 yes
GO:0050806 positive regulation of synaptic transmission 22.2222 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 22.2222 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
GPR37_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NAC3_HUMAN [view entry] [view interactions] High throughput yes no
DDX58_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
KGP1_HUMAN [view interactions] Computational no yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
NAC1_HUMAN [view entry] [view interactions] Computational yes yes