NAC2_HUMAN
Evidence for PS localization
Functions
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NAC2_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 60.0000 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 60.0000 | 6 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 60.0000 | 4 | yes |
| GO:0043169 | cation binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 60.0000 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 60.0000 | 5 | yes |
| GO:0005432 | calcium:sodium antiporter activity | 40.0000 | 7 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 40.0000 | 6 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 40.0000 | 4 | yes |
| GO:0015297 | antiporter activity | 40.0000 | 5 | yes |
| GO:0015368 | calcium:monoatomic cation antiporter activity | 40.0000 | 6 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 40.0000 | 4 | yes |
| GO:0140828 | metal cation:monoatomic cation antiporter activity | 40.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NAC2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0007612 | learning | 60.0000 | 4 | yes |
| GO:0007613 | memory | 60.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 60.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 60.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 60.0000 | 5 | yes |
| GO:0050808 | synapse organization | 60.0000 | 5 | yes |
| GO:0050890 | cognition | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 60.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 40.0000 | 7 | yes |
| GO:0006811 | monoatomic ion transport | 40.0000 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 40.0000 | 5 | yes |
| GO:0006814 | sodium ion transport | 40.0000 | 7 | yes |
| GO:0006816 | calcium ion transport | 40.0000 | 7 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 40.0000 | 4 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 40.0000 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 40.0000 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 40.0000 | 6 | yes |
| GO:0030001 | metal ion transport | 40.0000 | 6 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 40.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | yes |
| GO:0031644 | regulation of nervous system process | 40.0000 | 5 | yes |
| GO:0035725 | sodium ion transmembrane transport | 40.0000 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 40.0000 | 7 | yes |
| GO:0043549 | regulation of kinase activity | 40.0000 | 5 | yes |
| GO:0044057 | regulation of system process | 40.0000 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 40.0000 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 40.0000 | 5 | yes |
| GO:0050848 | regulation of calcium-mediated signaling | 40.0000 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 40.0000 | 4 | yes |
| GO:0055074 | calcium ion homeostasis | 40.0000 | 4 | yes |
| GO:0055080 | monoatomic cation homeostasis | 40.0000 | 4 | yes |
| GO:0060291 | long-term synaptic potentiation | 40.0000 | 4 | yes |
| GO:0070509 | calcium ion import | 40.0000 | 8 | yes |
| GO:0070588 | calcium ion transmembrane transport | 40.0000 | 5 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 40.0000 | 7 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 40.0000 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 40.0000 | 4 | yes |
| GO:0098657 | import into cell | 40.0000 | 4 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 40.0000 | 5 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 40.0000 | 4 | yes |
| GO:0098703 | calcium ion import across plasma membrane | 40.0000 | 6 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 40.0000 | 4 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 40.0000 | 4 | yes |
| GO:0106056 | regulation of calcineurin-mediated signaling | 40.0000 | 7 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | yes |
| GO:1902656 | calcium ion import into cytosol | 40.0000 | 8 | yes |
| GO:1903522 | regulation of blood circulation | 40.0000 | 5 | yes |
| GO:1903779 | regulation of cardiac conduction | 40.0000 | 7 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0036211 | protein modification process | 40.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |