S29A1_HUMAN
Evidence for PS localization
Functions
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S29A1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 53.8462 | 4 | no |
| GO:0017076 | purine nucleotide binding | 53.8462 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 53.8462 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 53.8462 | 4 | no |
| GO:0043168 | anion binding | 53.8462 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 48.7179 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 48.7179 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 48.7179 | 6 | no |
| GO:0003924 | GTPase activity | 46.1538 | 7 | no |
| GO:0005525 | GTP binding | 43.5897 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 43.5897 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 43.5897 | 5 | no |
| GO:0019003 | GDP binding | 25.6410 | 5 | no |
| GO:0019900 | kinase binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 17.9487 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 15.3846 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 15.3846 | 5 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 10.2564 | 4 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 7.6923 | 6 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 7.6923 | 4 | yes |
| GO:0015293 | symporter activity | 5.1282 | 5 | yes |
| GO:0015294 | solute:monoatomic cation symporter activity | 5.1282 | 5 | yes |
| GO:0015370 | solute:sodium symporter activity | 5.1282 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S29A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.1026 | 4 | no |
| GO:0006996 | organelle organization | 48.7179 | 4 | no |
| GO:0051049 | regulation of transport | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.5897 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.5897 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.5897 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0256 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0030334 | regulation of cell migration | 38.4615 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
| GO:2000145 | regulation of cell motility | 38.4615 | 4 | no |
| GO:0060341 | regulation of cellular localization | 38.4615 | 4 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | no |
| GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 35.8974 | 4 | no |
| GO:0032880 | regulation of protein localization | 35.8974 | 5 | no |
| GO:0071702 | organic substance transport | 35.8974 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 35.8974 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 33.3333 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:2000147 | positive regulation of cell motility | 33.3333 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 33.3333 | 4 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 30.7692 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.7692 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0033043 | regulation of organelle organization | 30.7692 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 28.2051 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.2051 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2051 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.2051 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.2051 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.2051 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.2051 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.2051 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 28.2051 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 28.2051 | 5 | no |
| GO:0098657 | import into cell | 28.2051 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 25.6410 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.6410 | 5 | no |
| GO:0030030 | cell projection organization | 25.6410 | 4 | no |
| GO:0051046 | regulation of secretion | 25.6410 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.6410 | 6 | no |
| GO:0015031 | protein transport | 25.6410 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.6410 | 4 | no |
| GO:0007015 | actin filament organization | 25.6410 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 23.0769 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:1903530 | regulation of secretion by cell | 23.0769 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0060491 | regulation of cell projection assembly | 23.0769 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 20.5128 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0017157 | regulation of exocytosis | 20.5128 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5128 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.5128 | 4 | no |
| GO:0043086 | negative regulation of catalytic activity | 20.5128 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 20.5128 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0050776 | regulation of immune response | 20.5128 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.5128 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.5128 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.5128 | 5 | no |
| GO:0010632 | regulation of epithelial cell migration | 20.5128 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.5128 | 5 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 20.5128 | 6 | no |
| GO:0006886 | intracellular protein transport | 20.5128 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.5128 | 5 | no |
| GO:1904375 | regulation of protein localization to cell periphery | 20.5128 | 6 | no |
| GO:1905475 | regulation of protein localization to membrane | 20.5128 | 6 | no |
| GO:0046903 | secretion | 17.9487 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 10.2564 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 10.2564 | 4 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 10.2564 | 5 | yes |
| GO:0071453 | cellular response to oxygen levels | 10.2564 | 4 | yes |
| GO:0071456 | cellular response to hypoxia | 10.2564 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 7.6923 | 4 | yes |
| GO:0001504 | neurotransmitter uptake | 5.1282 | 5 | yes |
| GO:0007589 | body fluid secretion | 5.1282 | 4 | yes |
| GO:0009743 | response to carbohydrate | 5.1282 | 4 | yes |
| GO:0010232 | vascular transport | 5.1282 | 4 | yes |
| GO:0150104 | transport across blood-brain barrier | 5.1282 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STK19_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| GPR21_HUMAN | [view interactions] | High throughput | no | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S22AG_HUMAN | [view interactions] | High throughput | no | yes |
| PI2R_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S39AC_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPT3_HUMAN | [view interactions] | High throughput | no | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| O10H2_HUMAN | [view interactions] | High throughput | no | no |
| X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4A15_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| NMUR2_HUMAN | [view interactions] | High throughput | no | yes |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| CD3D_HUMAN | [view interactions] | High throughput | no | no |
| O10H1_HUMAN | [view interactions] | High throughput | no | no |
| NAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| TM2D2_HUMAN | [view interactions] | High throughput | no | yes |
| TM169_HUMAN | [view interactions] | High throughput | no | yes |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| SCN4A_HUMAN | [view interactions] | High throughput | no | no |
| NCKX3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| AGRL4_HUMAN | [view interactions] | High throughput | no | no |
| CD47_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |