S29A1_HUMAN
Evidence for PS localization
Functions
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S29A1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 56.7568 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 56.7568 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 56.7568 | 4 | no |
| GO:0003924 | GTPase activity | 48.6486 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 48.6486 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 48.6486 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 48.6486 | 6 | no |
| GO:0005525 | GTP binding | 45.9459 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 45.9459 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 45.9459 | 5 | no |
| GO:0019900 | kinase binding | 29.7297 | 4 | no |
| GO:0019901 | protein kinase binding | 29.7297 | 5 | no |
| GO:0019003 | GDP binding | 29.7297 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 18.9189 | 4 | yes |
| GO:0008509 | anion transmembrane transporter activity | 8.1081 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S29A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.8649 | 4 | no |
| GO:0006996 | organelle organization | 54.0541 | 4 | no |
| GO:0051049 | regulation of transport | 51.3514 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.6486 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.9459 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.9459 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.2432 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.2432 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.2432 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 43.2432 | 4 | no |
| GO:0071702 | organic substance transport | 40.5405 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.5405 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.5405 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.5405 | 4 | no |
| GO:0007010 | cytoskeleton organization | 40.5405 | 5 | no |
| GO:0071705 | nitrogen compound transport | 37.8378 | 4 | yes |
| GO:0008104 | protein localization | 37.8378 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 37.8378 | 4 | no |
| GO:0071310 | cellular response to organic substance | 35.1351 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.1351 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.1351 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 35.1351 | 4 | no |
| GO:0030334 | regulation of cell migration | 35.1351 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:2000145 | regulation of cell motility | 35.1351 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.1351 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 32.4324 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.4324 | 4 | no |
| GO:0032880 | regulation of protein localization | 32.4324 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.4324 | 5 | no |
| GO:0060341 | regulation of cellular localization | 32.4324 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.4324 | 5 | no |
| GO:0030030 | cell projection organization | 32.4324 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 32.4324 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.4324 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.4324 | 6 | no |
| GO:0010468 | regulation of gene expression | 29.7297 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 29.7297 | 4 | no |
| GO:0010941 | regulation of cell death | 29.7297 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 29.7297 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 29.7297 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 29.7297 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.7297 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.7297 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.7297 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.7297 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 29.7297 | 5 | no |
| GO:0051050 | positive regulation of transport | 29.7297 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.7297 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 27.0270 | 4 | yes |
| GO:0007015 | actin filament organization | 27.0270 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.0270 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.0270 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.0270 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 27.0270 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.0270 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.0270 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 27.0270 | 5 | no |
| GO:0007265 | Ras protein signal transduction | 27.0270 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.0270 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.0270 | 4 | no |
| GO:0015031 | protein transport | 27.0270 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 27.0270 | 5 | no |
| GO:0051046 | regulation of secretion | 27.0270 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.3243 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 24.3243 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 24.3243 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.3243 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.3243 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.3243 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.3243 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.3243 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.3243 | 7 | no |
| GO:0002684 | positive regulation of immune system process | 24.3243 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 24.3243 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 24.3243 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 24.3243 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3243 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.3243 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 24.3243 | 6 | no |
| GO:1903530 | regulation of secretion by cell | 24.3243 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.6216 | 8 | no |
| GO:0010632 | regulation of epithelial cell migration | 21.6216 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.6216 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.6216 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.6216 | 7 | no |
| GO:0043086 | negative regulation of catalytic activity | 21.6216 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.6216 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.6216 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.6216 | 4 | no |
| GO:1904375 | regulation of protein localization to cell periphery | 21.6216 | 6 | no |
| GO:1905475 | regulation of protein localization to membrane | 21.6216 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.6216 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 21.6216 | 4 | no |
| GO:0030865 | cortical cytoskeleton organization | 21.6216 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.6216 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 21.6216 | 4 | no |
| GO:0061024 | membrane organization | 21.6216 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
| GO:0031175 | neuron projection development | 21.6216 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.6216 | 4 | no |
| GO:0030031 | cell projection assembly | 21.6216 | 5 | no |
| GO:0050776 | regulation of immune response | 21.6216 | 4 | no |
| GO:0060491 | regulation of cell projection assembly | 21.6216 | 5 | no |
| GO:0046903 | secretion | 16.2162 | 4 | yes |
| GO:0048878 | chemical homeostasis | 16.2162 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 13.5135 | 4 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 10.8108 | 5 | yes |
| GO:0071453 | cellular response to oxygen levels | 10.8108 | 4 | yes |
| GO:0071456 | cellular response to hypoxia | 10.8108 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 10.8108 | 4 | yes |
| GO:0098657 | import into cell | 8.1081 | 4 | yes |
| GO:0009743 | response to carbohydrate | 8.1081 | 4 | yes |
| GO:0034284 | response to monosaccharide | 5.4054 | 5 | yes |
| GO:0150104 | transport across blood-brain barrier | 5.4054 | 5 | yes |
| GO:0006836 | neurotransmitter transport | 5.4054 | 4 | yes |
| GO:0007589 | body fluid secretion | 5.4054 | 4 | yes |
| GO:0009746 | response to hexose | 5.4054 | 6 | yes |
| GO:0009749 | response to glucose | 5.4054 | 7 | yes |
| GO:0010232 | vascular transport | 5.4054 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STK19_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| GPR21_HUMAN | [view interactions] | High throughput | no | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S22AG_HUMAN | [view interactions] | High throughput | no | yes |
| PI2R_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S39AC_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPT3_HUMAN | [view interactions] | High throughput | no | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| O10H2_HUMAN | [view interactions] | High throughput | no | no |
| X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4A15_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| NMUR2_HUMAN | [view interactions] | High throughput | no | yes |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| CD3D_HUMAN | [view interactions] | High throughput | no | no |
| O10H1_HUMAN | [view interactions] | High throughput | no | no |
| NAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| TM2D2_HUMAN | [view interactions] | High throughput | no | yes |
| TM169_HUMAN | [view interactions] | High throughput | no | yes |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| SCN4A_HUMAN | [view interactions] | High throughput | no | no |
| NCKX3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| AGRL4_HUMAN | [view interactions] | High throughput | no | no |
| CD47_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |