ACM4_HUMAN
Evidence for PS localization
Functions
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACM4_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 38.2353 | 4 | no |
| GO:0017076 | purine nucleotide binding | 38.2353 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.2941 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.2941 | 4 | no |
| GO:0043168 | anion binding | 35.2941 | 4 | no |
| GO:0043169 | cation binding | 26.4706 | 4 | no |
| GO:0046872 | metal ion binding | 26.4706 | 5 | no |
| GO:0005525 | GTP binding | 20.5882 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.5882 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5882 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5882 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 20.5882 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.5882 | 5 | no |
| GO:0004930 | G protein-coupled receptor activity | 5.8824 | 4 | yes |
| GO:0004993 | G protein-coupled serotonin receptor activity | 5.8824 | 6 | yes |
| GO:0008227 | G protein-coupled amine receptor activity | 5.8824 | 5 | yes |
| GO:0015464 | acetylcholine receptor activity | 5.8824 | 4 | yes |
| GO:0016907 | G protein-coupled acetylcholine receptor activity | 5.8824 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 5.8824 | 4 | yes |
| GO:0099528 | G protein-coupled neurotransmitter receptor activity | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACM4_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 29.4118 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 26.4706 | 4 | no |
| GO:0008104 | protein localization | 26.4706 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.4706 | 4 | no |
| GO:0071702 | organic substance transport | 26.4706 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.4706 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.4706 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 23.5294 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 20.5882 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 20.5882 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0051049 | regulation of transport | 20.5882 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.5882 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.5882 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.5882 | 4 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 11.7647 | 5 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 11.7647 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 11.7647 | 7 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 11.7647 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 11.7647 | 6 | yes |
| GO:0099536 | synaptic signaling | 11.7647 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 11.7647 | 5 | yes |
| GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 5.8824 | 4 | yes |
| GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NGF_HUMAN | [view interactions] | Low throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FANCA_HUMAN | [view interactions] | High throughput | no | no |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| ST17B_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG2_HUMAN | [view interactions] | High throughput | no | no |
| PR15B_HUMAN | [view interactions] | High throughput | no | no |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| LPCT4_HUMAN | [view interactions] | High throughput | no | yes |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| MBOA5_HUMAN | [view interactions] | High throughput | no | no |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| BRAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SARM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| XPO6_HUMAN | [view interactions] | High throughput | no | yes |
| S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| GCP2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| PIGM_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| UBP24_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TSN7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| METL9_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD59_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B2MG_HUMAN | [view interactions] | High throughput | no | yes |
| SMIM7_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| QSOX1_HUMAN | [view interactions] | High throughput | no | no |
| MCL1_HUMAN | [view interactions] | High throughput | no | yes |
| ERG24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PDS5B_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THADA_HUMAN | [view interactions] | High throughput | no | yes |
| IPO11_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| MRP7_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| COG1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIRRM_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| MIGA1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG4_HUMAN | [view interactions] | High throughput | no | no |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| T179B_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |