ACM4_HUMAN
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACM4_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 34.3750 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 34.3750 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 34.3750 | 4 | no |
GO:0003924 | GTPase activity | 21.8750 | 7 | no |
GO:0016462 | pyrophosphatase activity | 21.8750 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.8750 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.8750 | 6 | no |
GO:0004930 | G protein-coupled receptor activity | 6.2500 | 4 | yes |
GO:0004993 | G protein-coupled serotonin receptor activity | 6.2500 | 5 | yes |
GO:0008227 | G protein-coupled amine receptor activity | 6.2500 | 5 | yes |
GO:0015464 | acetylcholine receptor activity | 6.2500 | 4 | yes |
GO:0016907 | G protein-coupled acetylcholine receptor activity | 6.2500 | 5 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 6.2500 | 4 | yes |
GO:0099528 | G protein-coupled neurotransmitter receptor activity | 6.2500 | 4 | yes |
GO:0099589 | serotonin receptor activity | 6.2500 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACM4_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 28.1250 | 4 | no |
GO:0048522 | positive regulation of cellular process | 28.1250 | 4 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0008104 | protein localization | 21.8750 | 4 | no |
GO:0071310 | cellular response to organic substance | 21.8750 | 4 | no |
GO:0051128 | regulation of cellular component organization | 21.8750 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 21.8750 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 21.8750 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 21.8750 | 4 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 18.7500 | 4 | yes |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 12.5000 | 5 | yes |
GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 12.5000 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 12.5000 | 6 | yes |
GO:0095500 | acetylcholine receptor signaling pathway | 12.5000 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 12.5000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 12.5000 | 4 | yes |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 6.2500 | 4 | yes |
GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 6.2500 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NGF_HUMAN | [view interactions] | Low throughput | no | no |
ACM4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KNTC1_HUMAN | [view interactions] | High throughput | no | no |
ZW10_HUMAN | [view interactions] | High throughput | no | yes |
INT5_HUMAN | [view interactions] | High throughput | no | no |
UBP24_HUMAN | [view interactions] | High throughput | no | yes |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIGM_HUMAN | [view interactions] | High throughput | no | no |
ALG8_HUMAN | [view interactions] | High throughput | no | yes |
YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
GCP2_HUMAN | [view interactions] | High throughput | no | yes |
CND3_HUMAN | [view interactions] | High throughput | no | yes |
S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO6_HUMAN | [view interactions] | High throughput | no | yes |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
GCN1_HUMAN | [view interactions] | High throughput | no | yes |
CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL10_HUMAN | [view interactions] | High throughput | no | yes |
DAAF5_HUMAN | [view interactions] | High throughput | no | no |
HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CERS6_HUMAN | [view interactions] | High throughput | no | yes |
SARM1_HUMAN | [view interactions] | High throughput | no | yes |
BRAT1_HUMAN | [view interactions] | High throughput | no | yes |
MBOA5_HUMAN | [view interactions] | High throughput | no | no |
RINT1_HUMAN | [view interactions] | High throughput | no | yes |
F91A1_HUMAN | [view interactions] | High throughput | no | yes |
LPCT4_HUMAN | [view interactions] | High throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
PR15B_HUMAN | [view interactions] | High throughput | no | no |
COG2_HUMAN | [view interactions] | High throughput | no | no |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTA_HUMAN | [view interactions] | High throughput | no | no |
TTK_HUMAN | [view interactions] | High throughput | no | yes |
GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB3B_HUMAN | [view interactions] | High throughput | no | no |
ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
ST17B_HUMAN | [view interactions] | High throughput | no | yes |
FANCA_HUMAN | [view interactions] | High throughput | no | no |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
TSN7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
CD59_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
METL9_HUMAN | [view interactions] | High throughput | no | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD81_HUMAN | [view interactions] | High throughput | no | no |
SMIM7_HUMAN | [view interactions] | High throughput | no | yes |
B2MG_HUMAN | [view interactions] | High throughput | no | yes |
ERG24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCL1_HUMAN | [view interactions] | High throughput | no | yes |
QSOX1_HUMAN | [view interactions] | High throughput | no | no |
MTG16_HUMAN | [view interactions] | High throughput | no | yes |
SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDS5B_HUMAN | [view interactions] | High throughput | no | yes |
PDXD1_HUMAN | [view interactions] | High throughput | no | no |
CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
THADA_HUMAN | [view interactions] | High throughput | no | yes |
IPO11_HUMAN | [view interactions] | High throughput | no | yes |
EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
MRP7_HUMAN | [view interactions] | High throughput | no | yes |
VEZA_HUMAN | [view interactions] | High throughput | no | yes |
ADCK1_HUMAN | [view interactions] | High throughput | no | no |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
RIF1_HUMAN | [view interactions] | High throughput | no | yes |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCP4_HUMAN | [view interactions] | High throughput | no | yes |
COG1_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CA112_HUMAN | [view interactions] | High throughput | no | yes |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
MIGA1_HUMAN | [view interactions] | High throughput | no | yes |
XPO4_HUMAN | [view interactions] | High throughput | no | no |
COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COG4_HUMAN | [view interactions] | High throughput | no | no |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IPO4_HUMAN | [view interactions] | High throughput | no | no |
T179B_HUMAN | [view interactions] | High throughput | no | no |
GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |