EXOC6_HUMAN
Evidence for PS localization
Functions
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC6_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 25.7143 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC6_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 60.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 60.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 60.0000 | 4 | yes |
| GO:0015031 | protein transport | 54.2857 | 4 | yes |
| GO:0061024 | membrane organization | 45.7143 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.7143 | 4 | no |
| GO:0046903 | secretion | 42.8571 | 4 | yes |
| GO:0048278 | vesicle docking | 37.1429 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.1429 | 4 | no |
| GO:0006996 | organelle organization | 34.2857 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 34.2857 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.4286 | 4 | no |
| GO:0000281 | mitotic cytokinesis | 28.5714 | 4 | yes |
| GO:0006886 | intracellular protein transport | 28.5714 | 4 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 28.5714 | 4 | yes |
| GO:0090148 | membrane fission | 28.5714 | 5 | yes |
| GO:0099022 | vesicle tethering | 28.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 25.7143 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 25.7143 | 4 | no |
| GO:0022607 | cellular component assembly | 25.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.7143 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.7143 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.7143 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.7143 | 4 | no |
| GO:0006893 | Golgi to plasma membrane transport | 22.8571 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 22.8571 | 4 | no |
| GO:0030030 | cell projection organization | 22.8571 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.8571 | 5 | no |
| GO:0016050 | vesicle organization | 22.8571 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB3I_HUMAN | [view interactions] | Low throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC30_HUMAN | [view interactions] | High throughput | no | yes |
| CAR19_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ULA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS1_HUMAN | [view interactions] | High throughput | no | yes |
| GCDH_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2C8_HUMAN | [view interactions] | High throughput | no | no |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |