EXOC6_HUMAN
Evidence for PS localization
Functions
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC6_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 26.1905 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.1905 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.1905 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 26.1905 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 26.1905 | 5 | no |
| GO:0003924 | GTPase activity | 26.1905 | 7 | no |
| GO:0005525 | GTP binding | 26.1905 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC6_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 71.4286 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 64.2857 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 64.2857 | 4 | yes |
| GO:0015031 | protein transport | 61.9048 | 4 | yes |
| GO:0046903 | secretion | 47.6190 | 4 | yes |
| GO:0006996 | organelle organization | 47.6190 | 4 | no |
| GO:0006887 | exocytosis | 42.8571 | 4 | yes |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.0952 | 4 | no |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 35.7143 | 4 | yes |
| GO:0030030 | cell projection organization | 35.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.7143 | 4 | no |
| GO:0051049 | regulation of transport | 35.7143 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.9524 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 28.5714 | 6 | yes |
| GO:0048193 | Golgi vesicle transport | 28.5714 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0006886 | intracellular protein transport | 28.5714 | 4 | yes |
| GO:0072657 | protein localization to membrane | 26.1905 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 26.1905 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.1905 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.1905 | 4 | no |
| GO:0061024 | membrane organization | 26.1905 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.1905 | 6 | no |
| GO:1990778 | protein localization to cell periphery | 23.8095 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0016050 | vesicle organization | 23.8095 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0051046 | regulation of secretion | 23.8095 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 23.8095 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.8095 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.8095 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.8095 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.8095 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.8095 | 4 | no |
| GO:0006893 | Golgi to plasma membrane transport | 21.4286 | 5 | yes |
| GO:0033365 | protein localization to organelle | 21.4286 | 5 | no |
| GO:0031175 | neuron projection development | 21.4286 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0099022 | vesicle tethering | 9.5238 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB3I_HUMAN | [view interactions] | Low throughput | no | no |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| GCDH_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2C8_HUMAN | [view interactions] | High throughput | no | no |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC30_HUMAN | [view interactions] | High throughput | no | yes |
| CAR19_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| ULA1_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOQ_HUMAN | [view interactions] | Computational | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FUT2_HUMAN | [view interactions] | Computational | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| C2CD5_HUMAN | [view interactions] | Computational | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |