Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYO5A_HUMAN

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI003866 LIG_CaM_IQ_9 LIG 770 786 -
ELMI003867 LIG_CaM_IQ_9 LIG 793 808 -
ELMI003868 LIG_CaM_IQ_9 LIG 818 834 -
ELMI003869 LIG_CaM_IQ_9 LIG 841 856 -
ELMI003870 LIG_CaM_IQ_9 LIG 866 881 -
ELMI003871 LIG_CaM_IQ_9 LIG 889 905 -

Molecular function

Term Name % Distance from the top of the tree Annotated in MYO5A_HUMAN
GO:0017076 purine nucleotide binding 32.2917 4 yes
GO:0032555 purine ribonucleotide binding 31.2500 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.2083 4 yes
GO:0003779 actin binding 27.0833 4 yes
GO:0046872 metal ion binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 22.9167 5 yes
GO:0032559 adenyl ribonucleotide binding 21.8750 5 yes
GO:0005524 ATP binding 20.8333 5 yes
GO:0051020 GTPase binding 17.7083 4 yes
GO:0031267 small GTPase binding 16.6667 5 yes
GO:0003723 RNA binding 11.4583 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYO5A_HUMAN
GO:0048522 positive regulation of cellular process 57.2917 4 no
GO:0006996 organelle organization 51.0417 4 no
GO:0008104 protein localization 47.9167 4 yes
GO:0031323 regulation of cellular metabolic process 46.8750 4 no
GO:0010646 regulation of cell communication 44.7917 4 no
GO:0060255 regulation of macromolecule metabolic process 44.7917 4 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:0048523 negative regulation of cellular process 42.7083 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0071702 organic substance transport 36.4583 4 yes
GO:0051049 regulation of transport 36.4583 4 no
GO:0016192 vesicle-mediated transport 35.4167 4 yes
GO:0071705 nitrogen compound transport 35.4167 4 yes
GO:0022607 cellular component assembly 35.4167 4 no
GO:0051246 regulation of protein metabolic process 34.3750 5 no
GO:0015031 protein transport 33.3333 4 yes
GO:0030030 cell projection organization 32.2917 4 no
GO:0009893 positive regulation of metabolic process 30.2083 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.2083 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.1250 5 no
GO:0120036 plasma membrane bounded cell projection organization 26.0417 5 no
GO:0007010 cytoskeleton organization 26.0417 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 23.9583 5 no
GO:0099177 regulation of trans-synaptic signaling 23.9583 4 no
GO:0031399 regulation of protein modification process 23.9583 6 no
GO:0048584 positive regulation of response to stimulus 23.9583 4 no
GO:0051050 positive regulation of transport 22.9167 4 no
GO:0019220 regulation of phosphate metabolic process 22.9167 6 no
GO:0031325 positive regulation of cellular metabolic process 22.9167 5 no
GO:0042325 regulation of phosphorylation 22.9167 7 no
GO:0051174 regulation of phosphorus metabolic process 22.9167 5 no
GO:0036211 protein modification process 22.9167 4 no
GO:0043412 macromolecule modification 22.9167 4 no
GO:0071310 cellular response to organic substance 21.8750 4 yes
GO:0072657 protein localization to membrane 21.8750 4 yes
GO:0001932 regulation of protein phosphorylation 21.8750 7 no
GO:0022603 regulation of anatomical structure morphogenesis 21.8750 4 no
GO:0051130 positive regulation of cellular component organization 21.8750 5 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0010243 response to organonitrogen compound 18.7500 4 yes
GO:0097435 supramolecular fiber organization 18.7500 4 yes
GO:1901699 cellular response to nitrogen compound 17.7083 4 yes
GO:1901701 cellular response to oxygen-containing compound 16.6667 4 yes
GO:1990778 protein localization to cell periphery 16.6667 5 yes
GO:0071417 cellular response to organonitrogen compound 15.6250 4 yes
GO:0007015 actin filament organization 13.5417 5 yes
GO:0072659 protein localization to plasma membrane 12.5000 5 yes
GO:0051650 establishment of vesicle localization 11.4583 4 yes
GO:0048193 Golgi vesicle transport 10.4167 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 9.3750 6 yes
GO:0030705 cytoskeleton-dependent intracellular transport 9.3750 4 yes
GO:1901652 response to peptide 9.3750 4 yes
GO:0043434 response to peptide hormone 8.3333 4 yes
GO:0099518 vesicle cytoskeletal trafficking 8.3333 5 yes
GO:1901653 cellular response to peptide 8.3333 5 yes
GO:0032868 response to insulin 7.2917 5 yes
GO:0032869 cellular response to insulin stimulus 7.2917 6 yes
GO:0032870 cellular response to hormone stimulus 7.2917 4 yes
GO:0071375 cellular response to peptide hormone stimulus 7.2917 5 yes
GO:0030050 vesicle transport along actin filament 5.2083 4 yes
GO:0099515 actin filament-based transport 5.2083 5 yes
GO:0032400 melanosome localization 3.1250 5 yes
GO:0032401 establishment of melanosome localization 3.1250 6 yes
GO:0032402 melanosome transport 3.1250 5 yes
GO:0051875 pigment granule localization 3.1250 4 yes
GO:0051904 pigment granule transport 3.1250 4 yes
GO:0051905 establishment of pigment granule localization 3.1250 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in MYO5A_HUMAN
DOID:114 heart disease 5.2083 3 no
DOID:0050700 cardiomyopathy 4.1667 4 no
DOID:0060036 intrinsic cardiomyopathy 4.1667 5 no
DOID:2843 long QT syndrome 3.1250 6 no
DOID:0050155 sensory system disease 2.0833 3 no
DOID:0050563 nonsyndromic deafness 2.0833 5 no
DOID:0050564 autosomal dominant nonsyndromic deafness 2.0833 6 no
DOID:2742 auditory system disease 2.0833 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RIPL2_HUMAN [view interactions] Low throughput no yes
SPIR2_HUMAN [view interactions] Low throughput no yes
MICA1_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
S17A9_HUMAN [view interactions] Low throughput no no
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DYL2_HUMAN [view entry] [view interactions] Low throughput yes no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
MELPH_HUMAN [view interactions] Low throughput no yes
RB27A_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
GFAP_HUMAN [view entry] [view interactions] Low throughput yes no
BMF_HUMAN [view interactions] Low throughput no yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
NPHP4_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
WRP73_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
KPCD1_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CSF1_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
MK07_HUMAN [view interactions] High throughput no yes
CDK13_HUMAN [view interactions] High throughput no no
MYLK_HUMAN [view interactions] High throughput no no
PKN3_HUMAN [view interactions] High throughput no yes
TBCK_HUMAN [view interactions] High throughput no yes
KPSH2_HUMAN [view interactions] High throughput no no
RPKL1_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
SMAD2_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
DCP1A_HUMAN [view interactions] High throughput no yes
DCP1B_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
CREB3_HUMAN [view interactions] High throughput no no
SCP2_HUMAN [view interactions] High throughput no no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
ELF5_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
DKK3_HUMAN [view interactions] High throughput no yes
CADH5_HUMAN [view interactions] High throughput no yes
TMOD4_HUMAN [view interactions] High throughput no no
UBE2O_HUMAN [view interactions] High throughput no yes
EID1_HUMAN [view interactions] High throughput no yes
FEZ1_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
PP6R2_HUMAN [view interactions] High throughput no no
MLRV_HUMAN [view interactions] High throughput no no
LRIQ1_HUMAN [view interactions] High throughput no no
AVIL_HUMAN [view interactions] High throughput no no
FHI2B_HUMAN [view interactions] High throughput no yes
I20RA_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
NUPR1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
MALL_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
DPM2_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
TNNC1_HUMAN [view interactions] High throughput no no
CUL9_HUMAN [view interactions] High throughput no no
KIBRA_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
CX001_HUMAN [view interactions] High throughput no no
CXCL6_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
ML12B_HUMAN [view interactions] High throughput no no
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
GAGE5_HUMAN [view interactions] High throughput no no
LURA1_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
EI2BE_HUMAN [view interactions] High throughput no yes
TRI52_HUMAN [view interactions] High throughput no yes
CASQ2_HUMAN [view interactions] High throughput no no
DTX3_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
COPZ1_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
PLST_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
MYH8_HUMAN [view interactions] High throughput no no
TMF1_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
PEX3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC8_HUMAN [view entry] [view interactions] Computational yes yes
MYO9B_HUMAN [view interactions] Computational no yes
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
IGLL5_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
EXOC7_HUMAN [view entry] [view interactions] Computational yes yes
FCGR1_HUMAN [view interactions] Computational no no
EXOC1_HUMAN [view entry] [view interactions] Computational yes yes
FCG2A_HUMAN [view interactions] Computational no no
RAB10_HUMAN [view entry] [view interactions] Computational yes yes
EXOC2_HUMAN [view entry] [view interactions] Computational yes no
RAB8A_HUMAN [view entry] [view interactions] Computational yes no
STX1A_HUMAN [view entry] [view interactions] Computational yes yes
EXOC5_HUMAN [view entry] [view interactions] Computational yes yes
CD3Z_HUMAN [view interactions] Computational no no
CD3G_HUMAN [view interactions] Computational no no
MYH2_HUMAN [view interactions] Computational no yes
RALA_HUMAN [view entry] [view interactions] Computational yes yes
RAB13_HUMAN [view entry] [view interactions] Computational yes yes
MYRIP_HUMAN [view interactions] Computational no no