Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYO5A_HUMAN

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MYO5A_HUMAN
GO:0043168 anion binding 34.0206 4 yes
GO:0000166 nucleotide binding 29.8969 4 yes
GO:0017076 purine nucleotide binding 29.8969 5 yes
GO:0043169 cation binding 28.8660 4 no
GO:0046872 metal ion binding 28.8660 5 no
GO:0032555 purine ribonucleotide binding 27.8351 4 yes
GO:0003779 actin binding 25.7732 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.7732 4 yes
GO:0030554 adenyl nucleotide binding 24.7423 6 yes
GO:0032559 adenyl ribonucleotide binding 22.6804 5 yes
GO:0005524 ATP binding 20.6186 5 yes
GO:0019900 kinase binding 20.6186 4 no
GO:0051020 GTPase binding 15.4639 4 yes
GO:0003723 RNA binding 13.4021 4 yes
GO:0031267 small GTPase binding 13.4021 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYO5A_HUMAN
GO:0048522 positive regulation of cellular process 64.9485 4 no
GO:0010646 regulation of cell communication 55.6701 4 no
GO:0060255 regulation of macromolecule metabolic process 52.5773 4 no
GO:0048523 negative regulation of cellular process 50.5155 4 no
GO:0031323 regulation of cellular metabolic process 50.5155 4 no
GO:0051128 regulation of cellular component organization 44.3299 4 no
GO:0080090 regulation of primary metabolic process 44.3299 4 no
GO:0006996 organelle organization 43.2990 4 no
GO:0009966 regulation of signal transduction 42.2680 4 no
GO:0008104 protein localization 41.2371 4 yes
GO:0051049 regulation of transport 37.1134 4 no
GO:0022607 cellular component assembly 37.1134 4 no
GO:0009889 regulation of biosynthetic process 35.0515 4 no
GO:0010647 positive regulation of cell communication 35.0515 5 no
GO:0023056 positive regulation of signaling 35.0515 4 no
GO:0051246 regulation of protein metabolic process 34.0206 5 no
GO:0010468 regulation of gene expression 34.0206 6 no
GO:0010556 regulation of macromolecule biosynthetic process 34.0206 5 no
GO:0031326 regulation of cellular biosynthetic process 34.0206 5 no
GO:0048584 positive regulation of response to stimulus 32.9897 4 no
GO:0009893 positive regulation of metabolic process 30.9278 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.8969 5 no
GO:0071702 organic substance transport 28.8660 4 yes
GO:0071705 nitrogen compound transport 27.8351 4 yes
GO:0050804 modulation of chemical synaptic transmission 25.7732 5 no
GO:0099177 regulation of trans-synaptic signaling 25.7732 4 no
GO:0009967 positive regulation of signal transduction 25.7732 5 no
GO:0030030 cell projection organization 25.7732 4 no
GO:0031325 positive regulation of cellular metabolic process 25.7732 5 no
GO:0009892 negative regulation of metabolic process 24.7423 4 no
GO:0051050 positive regulation of transport 24.7423 4 no
GO:0015031 protein transport 24.7423 4 yes
GO:0007010 cytoskeleton organization 24.7423 5 no
GO:0031324 negative regulation of cellular metabolic process 23.7113 5 no
GO:0044087 regulation of cellular component biogenesis 23.7113 4 no
GO:0060341 regulation of cellular localization 23.7113 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.6804 5 no
GO:0031399 regulation of protein modification process 22.6804 6 no
GO:0051174 regulation of phosphorus metabolic process 21.6495 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.6495 5 no
GO:0033043 regulation of organelle organization 21.6495 5 no
GO:0019220 regulation of phosphate metabolic process 21.6495 6 no
GO:0036211 protein modification process 21.6495 4 no
GO:0042325 regulation of phosphorylation 21.6495 7 no
GO:0043412 macromolecule modification 21.6495 4 no
GO:0051247 positive regulation of protein metabolic process 20.6186 6 no
GO:1902531 regulation of intracellular signal transduction 20.6186 5 no
GO:0051130 positive regulation of cellular component organization 20.6186 5 no
GO:0001932 regulation of protein phosphorylation 20.6186 7 no
GO:0097435 supramolecular fiber organization 17.5258 4 yes
GO:0071310 cellular response to organic substance 16.4948 4 yes
GO:0072657 protein localization to membrane 14.4330 4 yes
GO:0010243 response to organonitrogen compound 13.4021 4 yes
GO:0007015 actin filament organization 12.3711 5 yes
GO:1901701 cellular response to oxygen-containing compound 12.3711 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 11.3402 4 yes
GO:0051650 establishment of vesicle localization 11.3402 4 yes
GO:1901699 cellular response to nitrogen compound 10.3093 4 yes
GO:1990778 protein localization to cell periphery 10.3093 5 yes
GO:0071417 cellular response to organonitrogen compound 9.2784 4 yes
GO:0072659 protein localization to plasma membrane 9.2784 5 yes
GO:0099518 vesicle cytoskeletal trafficking 8.2474 5 yes
GO:0043434 response to peptide hormone 6.1856 4 yes
GO:0006892 post-Golgi vesicle-mediated transport 5.1546 4 yes
GO:0030050 vesicle transport along actin filament 5.1546 4 yes
GO:0032870 cellular response to hormone stimulus 5.1546 4 yes
GO:0071375 cellular response to peptide hormone stimulus 5.1546 5 yes
GO:0099515 actin filament-based transport 5.1546 5 yes
GO:0032868 response to insulin 4.1237 5 yes
GO:0032869 cellular response to insulin stimulus 4.1237 6 yes
GO:0032400 melanosome localization 3.0928 5 yes
GO:0032401 establishment of melanosome localization 3.0928 6 yes
GO:0032402 melanosome transport 3.0928 5 yes
GO:0051875 pigment granule localization 3.0928 4 yes
GO:0051904 pigment granule transport 3.0928 4 yes
GO:0051905 establishment of pigment granule localization 3.0928 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
RIPL2_HUMAN [view interactions] Low throughput no yes
SPIR2_HUMAN [view interactions] Low throughput no yes
MICA1_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
S17A9_HUMAN [view interactions] Low throughput no no
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DYL2_HUMAN [view entry] [view interactions] Low throughput yes no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
MELPH_HUMAN [view interactions] Low throughput no yes
RB27A_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
GFAP_HUMAN [view entry] [view interactions] Low throughput yes no
BMF_HUMAN [view interactions] Low throughput no yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
PEX3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NPHP4_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
WRP73_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
KPCD1_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CSF1_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
MK07_HUMAN [view interactions] High throughput no yes
CDK13_HUMAN [view interactions] High throughput no no
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
PKN3_HUMAN [view interactions] High throughput no yes
TBCK_HUMAN [view interactions] High throughput no yes
PSKH2_HUMAN [view interactions] High throughput no no
RPKL1_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
ERG_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
DCP1A_HUMAN [view interactions] High throughput no yes
DCP1B_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
CREB3_HUMAN [view interactions] High throughput no no
SCP2_HUMAN [view interactions] High throughput no no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
ELF5_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
DKK3_HUMAN [view interactions] High throughput no yes
CADH5_HUMAN [view interactions] High throughput no yes
TMOD4_HUMAN [view interactions] High throughput no no
UBE2O_HUMAN [view interactions] High throughput no yes
EID1_HUMAN [view interactions] High throughput no yes
FEZ1_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
PP6R2_HUMAN [view interactions] High throughput no no
MLRV_HUMAN [view interactions] High throughput no no
LRIQ1_HUMAN [view interactions] High throughput no no
AVIL_HUMAN [view interactions] High throughput no no
FHI2B_HUMAN [view interactions] High throughput no yes
I20RA_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
NUPR1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
MALL_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
DPM2_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
TNNC1_HUMAN [view interactions] High throughput no no
CUL9_HUMAN [view interactions] High throughput no no
KIBRA_HUMAN [view entry] [view interactions] High throughput yes yes
SH3L1_HUMAN [view interactions] High throughput no yes
CX001_HUMAN [view interactions] High throughput no no
CXCL6_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
ML12B_HUMAN [view interactions] High throughput no no
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
GAGE5_HUMAN [view interactions] High throughput no no
LURA1_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
EI2BE_HUMAN [view interactions] High throughput no yes
TRI52_HUMAN [view interactions] High throughput no yes
CASQ2_HUMAN [view interactions] High throughput no no
DTX3_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
COPZ1_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RNF38_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
HDAC6_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
INKA2_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
PLST_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
MYH8_HUMAN [view interactions] High throughput no no
TMF1_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes