Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RP3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays an essential role in docking and fusion steps of regulated exocytosis . At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release . In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RP3A_HUMAN
GO:0043168 anion binding 37.5000 4 yes
GO:0043169 cation binding 37.5000 4 yes
GO:0046872 metal ion binding 37.5000 5 yes
GO:0019900 kinase binding 34.3750 4 no
GO:0000166 nucleotide binding 31.2500 4 no
GO:0017076 purine nucleotide binding 31.2500 5 no
GO:0032555 purine ribonucleotide binding 31.2500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.1250 4 no
GO:0019901 protein kinase binding 28.1250 5 no
GO:0005509 calcium ion binding 18.7500 6 yes
GO:0031267 small GTPase binding 15.6250 5 yes
GO:0046914 transition metal ion binding 15.6250 6 yes
GO:0051020 GTPase binding 15.6250 4 yes
GO:0008270 zinc ion binding 12.5000 7 yes
GO:0035091 phosphatidylinositol binding 12.5000 4 yes
GO:0005544 calcium-dependent phospholipid binding 9.3750 4 yes
GO:1901981 phosphatidylinositol phosphate binding 9.3750 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 9.3750 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6.2500 5 yes
GO:0042301 phosphate ion binding 6.2500 5 yes
GO:0070679 inositol 1,4,5 trisphosphate binding 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RP3A_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0010646 regulation of cell communication 71.8750 4 no
GO:0051049 regulation of transport 68.7500 4 yes
GO:0051128 regulation of cellular component organization 56.2500 4 no
GO:0099177 regulation of trans-synaptic signaling 53.1250 4 no
GO:0048523 negative regulation of cellular process 53.1250 4 no
GO:0031323 regulation of cellular metabolic process 53.1250 4 no
GO:0060255 regulation of macromolecule metabolic process 53.1250 4 no
GO:0050804 modulation of chemical synaptic transmission 53.1250 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0009966 regulation of signal transduction 46.8750 4 no
GO:0008104 protein localization 46.8750 4 yes
GO:0031325 positive regulation of cellular metabolic process 46.8750 5 no
GO:0060627 regulation of vesicle-mediated transport 43.7500 4 yes
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0022607 cellular component assembly 40.6250 4 yes
GO:0071702 organic substance transport 40.6250 4 yes
GO:0071705 nitrogen compound transport 40.6250 4 yes
GO:0051046 regulation of secretion 37.5000 5 yes
GO:1903530 regulation of secretion by cell 37.5000 4 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0051246 regulation of protein metabolic process 34.3750 5 no
GO:0051247 positive regulation of protein metabolic process 34.3750 6 no
GO:0015031 protein transport 34.3750 4 yes
GO:0043933 protein-containing complex organization 34.3750 4 yes
GO:0065003 protein-containing complex assembly 34.3750 5 yes
GO:0006996 organelle organization 34.3750 4 no
GO:0010468 regulation of gene expression 34.3750 6 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0017157 regulation of exocytosis 31.2500 5 yes
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0050890 cognition 31.2500 4 no
GO:0048584 positive regulation of response to stimulus 28.1250 4 no
GO:0009892 negative regulation of metabolic process 28.1250 4 no
GO:0010038 response to metal ion 28.1250 4 no
GO:0010243 response to organonitrogen compound 28.1250 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.1250 5 no
GO:0019220 regulation of phosphate metabolic process 28.1250 6 no
GO:0031401 positive regulation of protein modification process 28.1250 7 no
GO:0034762 regulation of transmembrane transport 28.1250 4 no
GO:0042325 regulation of phosphorylation 28.1250 7 no
GO:0051129 negative regulation of cellular component organization 28.1250 5 no
GO:0051174 regulation of phosphorus metabolic process 28.1250 5 no
GO:0071310 cellular response to organic substance 28.1250 4 no
GO:1901701 cellular response to oxygen-containing compound 28.1250 4 no
GO:1902531 regulation of intracellular signal transduction 28.1250 5 no
GO:0046903 secretion 28.1250 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.1250 4 no
GO:0009891 positive regulation of biosynthetic process 28.1250 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.1250 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.1250 6 no
GO:0036211 protein modification process 28.1250 4 no
GO:0043412 macromolecule modification 28.1250 4 no
GO:0051130 positive regulation of cellular component organization 28.1250 5 no
GO:0010647 positive regulation of cell communication 28.1250 5 no
GO:0031344 regulation of cell projection organization 28.1250 5 no
GO:0032880 regulation of protein localization 28.1250 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0098657 import into cell 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0070201 regulation of establishment of protein localization 21.8750 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.8750 6 no
GO:0001934 positive regulation of protein phosphorylation 21.8750 8 no
GO:0010563 negative regulation of phosphorus metabolic process 21.8750 6 no
GO:0031400 negative regulation of protein modification process 21.8750 7 no
GO:0042326 negative regulation of phosphorylation 21.8750 8 no
GO:0043549 regulation of kinase activity 21.8750 5 no
GO:0045936 negative regulation of phosphate metabolic process 21.8750 7 no
GO:0051347 positive regulation of transferase activity 21.8750 5 no
GO:0071417 cellular response to organonitrogen compound 21.8750 4 no
GO:1901699 cellular response to nitrogen compound 21.8750 4 no
GO:0045595 regulation of cell differentiation 21.8750 4 no
GO:0006886 intracellular protein transport 21.8750 4 yes
GO:0006355 regulation of DNA-templated transcription 21.8750 7 no
GO:0044087 regulation of cellular component biogenesis 21.8750 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.8750 5 no
GO:0051252 regulation of RNA metabolic process 21.8750 5 no
GO:2001141 regulation of RNA biosynthetic process 21.8750 6 no
GO:0034330 cell junction organization 21.8750 4 no
GO:0044057 regulation of system process 21.8750 4 no
GO:0072657 protein localization to membrane 21.8750 4 no
GO:1990778 protein localization to cell periphery 21.8750 5 no
GO:0006836 neurotransmitter transport 18.7500 4 yes
GO:1903305 regulation of regulated secretory pathway 18.7500 6 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 15.6250 7 yes
GO:0023061 signal release 15.6250 4 yes
GO:0099643 signal release from synapse 15.6250 5 yes
GO:0007269 neurotransmitter secretion 9.3750 4 yes
GO:0061669 spontaneous neurotransmitter secretion 6.2500 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RB27A_HUMAN [view interactions] Low throughput no yes
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
GCH1_HUMAN [view interactions] Low throughput no no
RAB3B_HUMAN [view interactions] Low throughput no no
CAND1_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADDB_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CF298_HUMAN [view interactions] High throughput no yes
RB27B_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3D_HUMAN [view interactions] High throughput no yes
PALS1_HUMAN [view interactions] High throughput no no
DOC2B_HUMAN [view interactions] High throughput no no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
P63_HUMAN [view interactions] High throughput no no
LX15B_HUMAN [view interactions] High throughput no no
TIA1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SYDE1_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes