Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RP3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays an essential role in docking and fusion steps of regulated exocytosis . At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release . In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RP3A_HUMAN
GO:0046872 metal ion binding 32.1429 4 yes
GO:0019900 kinase binding 32.1429 4 no
GO:0017076 purine nucleotide binding 32.1429 4 no
GO:0032555 purine ribonucleotide binding 32.1429 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0005509 calcium ion binding 25.0000 5 yes
GO:0031267 small GTPase binding 14.2857 5 yes
GO:0035091 phosphatidylinositol binding 14.2857 4 yes
GO:0046914 transition metal ion binding 14.2857 5 yes
GO:0051020 GTPase binding 14.2857 4 yes
GO:0005544 calcium-dependent phospholipid binding 10.7143 4 yes
GO:0008270 zinc ion binding 10.7143 6 yes
GO:1901981 phosphatidylinositol phosphate binding 10.7143 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 10.7143 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7.1429 4 yes
GO:0042301 phosphate ion binding 7.1429 4 yes
GO:0070679 inositol 1,4,5 trisphosphate binding 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RP3A_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 no
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0051049 regulation of transport 67.8571 4 no
GO:0008104 protein localization 53.5714 4 yes
GO:0048523 negative regulation of cellular process 53.5714 4 no
GO:0051128 regulation of cellular component organization 53.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 53.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 53.5714 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0043269 regulation of ion transport 46.4286 5 no
GO:0031323 regulation of cellular metabolic process 46.4286 4 no
GO:0071702 organic substance transport 42.8571 4 yes
GO:0071705 nitrogen compound transport 42.8571 4 yes
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0051171 regulation of nitrogen compound metabolic process 42.8571 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.8571 5 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0015031 protein transport 39.2857 4 yes
GO:0009966 regulation of signal transduction 39.2857 4 no
GO:0051050 positive regulation of transport 39.2857 4 no
GO:0060627 regulation of vesicle-mediated transport 39.2857 4 no
GO:0006996 organelle organization 39.2857 4 no
GO:0010243 response to organonitrogen compound 35.7143 4 no
GO:0071310 cellular response to organic substance 35.7143 4 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0051046 regulation of secretion 35.7143 5 no
GO:1903530 regulation of secretion by cell 35.7143 4 no
GO:0043085 positive regulation of catalytic activity 32.1429 4 no
GO:0051246 regulation of protein metabolic process 32.1429 5 no
GO:0051247 positive regulation of protein metabolic process 32.1429 6 no
GO:1901701 cellular response to oxygen-containing compound 32.1429 4 no
GO:0072657 protein localization to membrane 32.1429 4 no
GO:0046903 secretion 32.1429 4 yes
GO:0010468 regulation of gene expression 32.1429 5 no
GO:0034762 regulation of transmembrane transport 32.1429 4 no
GO:0060341 regulation of cellular localization 32.1429 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0034765 regulation of ion transmembrane transport 28.5714 5 no
GO:0017157 regulation of exocytosis 28.5714 5 no
GO:0071417 cellular response to organonitrogen compound 28.5714 4 no
GO:1901699 cellular response to nitrogen compound 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0050890 cognition 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:0006886 intracellular protein transport 25.0000 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0051093 negative regulation of developmental process 21.4286 4 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0032412 regulation of ion transmembrane transporter activity 21.4286 5 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:1904062 regulation of cation transmembrane transport 21.4286 6 no
GO:0006811 ion transport 21.4286 4 no
GO:0006812 cation transport 21.4286 5 no
GO:0030001 metal ion transport 21.4286 6 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0016050 vesicle organization 21.4286 5 no
GO:0048278 vesicle docking 21.4286 4 no
GO:0061024 membrane organization 21.4286 4 no
GO:0070201 regulation of establishment of protein localization 21.4286 6 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0006836 neurotransmitter transport 17.8571 4 yes
GO:0023061 signal release 17.8571 4 yes
GO:0099643 signal release from synapse 17.8571 5 yes
GO:0007269 neurotransmitter secretion 10.7143 4 yes
GO:0061669 spontaneous neurotransmitter secretion 7.1429 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in RP3A_HUMAN
DOID:0050700 cardiomyopathy 7.1429 4 no
DOID:0060036 intrinsic cardiomyopathy 7.1429 5 no
DOID:114 heart disease 7.1429 3 no
DOID:2843 long QT syndrome 7.1429 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAND1_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADDB_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RB27A_HUMAN [view interactions] Low throughput no yes
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view interactions] Low throughput no yes
GCH1_HUMAN [view interactions] Low throughput no no
RAB3B_HUMAN [view interactions] Low throughput no no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
P63_HUMAN [view interactions] High throughput no no
LX15B_HUMAN [view interactions] High throughput no no
TIA1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SYDE1_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
RB27B_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3D_HUMAN [view interactions] High throughput no yes
PALS1_HUMAN [view interactions] High throughput no no
DOC2B_HUMAN [view interactions] High throughput no no