Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADDB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADDB_HUMAN
GO:0017076 purine nucleotide binding 45.9459 4 no
GO:0032555 purine ribonucleotide binding 45.9459 4 no
GO:0035639 purine ribonucleoside triphosphate binding 45.9459 4 no
GO:0019900 kinase binding 35.1351 4 yes
GO:0046872 metal ion binding 35.1351 4 no
GO:0019901 protein kinase binding 32.4324 5 yes
GO:0005524 ATP binding 27.0270 5 no
GO:0030554 adenyl nucleotide binding 27.0270 5 no
GO:0032559 adenyl ribonucleotide binding 27.0270 5 no
GO:0016301 kinase activity 24.3243 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.3243 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.6216 4 no
GO:0003924 GTPase activity 21.6216 7 no
GO:0005525 GTP binding 21.6216 5 no
GO:0016462 pyrophosphatase activity 21.6216 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.6216 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.6216 6 no
GO:0019001 guanyl nucleotide binding 21.6216 5 no
GO:0032561 guanyl ribonucleotide binding 21.6216 5 no
GO:0003779 actin binding 18.9189 4 yes
GO:0042803 protein homodimerization activity 10.8108 4 yes
GO:0046982 protein heterodimerization activity 8.1081 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADDB_HUMAN
GO:0048522 positive regulation of cellular process 78.3784 4 no
GO:0031323 regulation of cellular metabolic process 67.5676 4 no
GO:0048523 negative regulation of cellular process 64.8649 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 64.8649 4 no
GO:0080090 regulation of primary metabolic process 64.8649 4 no
GO:0060255 regulation of macromolecule metabolic process 64.8649 4 no
GO:0010646 regulation of cell communication 56.7568 4 no
GO:0051049 regulation of transport 54.0541 4 no
GO:0009893 positive regulation of metabolic process 54.0541 4 no
GO:0051246 regulation of protein metabolic process 54.0541 5 no
GO:0051128 regulation of cellular component organization 51.3514 4 yes
GO:0009966 regulation of signal transduction 51.3514 4 no
GO:0031325 positive regulation of cellular metabolic process 51.3514 5 no
GO:0010604 positive regulation of macromolecule metabolic process 48.6486 5 no
GO:0019220 regulation of phosphate metabolic process 48.6486 6 no
GO:0031399 regulation of protein modification process 48.6486 6 no
GO:0042325 regulation of phosphorylation 48.6486 7 no
GO:0051174 regulation of phosphorus metabolic process 48.6486 5 no
GO:0022607 cellular component assembly 45.9459 4 yes
GO:0009892 negative regulation of metabolic process 45.9459 4 no
GO:0010468 regulation of gene expression 45.9459 5 no
GO:0010605 negative regulation of macromolecule metabolic process 45.9459 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.9459 5 no
GO:0001932 regulation of protein phosphorylation 45.9459 7 no
GO:0006996 organelle organization 40.5405 4 yes
GO:0031324 negative regulation of cellular metabolic process 40.5405 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 40.5405 5 no
GO:0010562 positive regulation of phosphorus metabolic process 37.8378 6 no
GO:0043085 positive regulation of catalytic activity 37.8378 4 no
GO:0045595 regulation of cell differentiation 37.8378 4 no
GO:0045937 positive regulation of phosphate metabolic process 37.8378 7 no
GO:0051336 regulation of hydrolase activity 37.8378 4 no
GO:1902531 regulation of intracellular signal transduction 37.8378 5 no
GO:0071310 cellular response to organic substance 37.8378 4 no
GO:0044087 regulation of cellular component biogenesis 35.1351 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.1351 5 no
GO:0099177 regulation of trans-synaptic signaling 35.1351 4 no
GO:0008104 protein localization 35.1351 4 no
GO:0010243 response to organonitrogen compound 35.1351 4 no
GO:0030030 cell projection organization 35.1351 4 no
GO:0051248 negative regulation of protein metabolic process 35.1351 6 no
GO:0042327 positive regulation of phosphorylation 35.1351 8 no
GO:0051050 positive regulation of transport 35.1351 4 no
GO:0051247 positive regulation of protein metabolic process 35.1351 6 no
GO:0009889 regulation of biosynthetic process 32.4324 4 no
GO:0010647 positive regulation of cell communication 32.4324 5 no
GO:0023056 positive regulation of signaling 32.4324 4 no
GO:0031326 regulation of cellular biosynthetic process 32.4324 5 no
GO:0031400 negative regulation of protein modification process 32.4324 7 no
GO:0036211 protein modification process 32.4324 4 no
GO:0043412 macromolecule modification 32.4324 4 no
GO:0048584 positive regulation of response to stimulus 32.4324 4 no
GO:0051345 positive regulation of hydrolase activity 32.4324 5 no
GO:0001934 positive regulation of protein phosphorylation 32.4324 8 no
GO:0031401 positive regulation of protein modification process 32.4324 7 no
GO:0043269 regulation of ion transport 32.4324 5 no
GO:0032880 regulation of protein localization 32.4324 5 no
GO:0060341 regulation of cellular localization 32.4324 4 no
GO:1901701 cellular response to oxygen-containing compound 32.4324 4 no
GO:0007010 cytoskeleton organization 29.7297 5 yes
GO:0033043 regulation of organelle organization 29.7297 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 29.7297 6 no
GO:0030334 regulation of cell migration 29.7297 5 no
GO:0045936 negative regulation of phosphate metabolic process 29.7297 7 no
GO:0120036 plasma membrane bounded cell projection organization 29.7297 5 no
GO:2000145 regulation of cell motility 29.7297 4 no
GO:0014070 response to organic cyclic compound 29.7297 4 no
GO:1901699 cellular response to nitrogen compound 29.7297 4 no
GO:0032956 regulation of actin cytoskeleton organization 27.0270 5 yes
GO:0032970 regulation of actin filament-based process 27.0270 4 yes
GO:0051129 negative regulation of cellular component organization 27.0270 5 yes
GO:0051493 regulation of cytoskeleton organization 27.0270 6 yes
GO:0006468 protein phosphorylation 27.0270 5 no
GO:0006796 phosphate-containing compound metabolic process 27.0270 4 no
GO:0009967 positive regulation of signal transduction 27.0270 5 no
GO:0010556 regulation of macromolecule biosynthetic process 27.0270 5 no
GO:0010941 regulation of cell death 27.0270 4 no
GO:0016310 phosphorylation 27.0270 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.0270 5 no
GO:0031175 neuron projection development 27.0270 6 no
GO:0051130 positive regulation of cellular component organization 27.0270 5 no
GO:0051240 positive regulation of multicellular organismal process 27.0270 4 no
GO:0060284 regulation of cell development 27.0270 5 no
GO:0034762 regulation of transmembrane transport 27.0270 4 no
GO:0043549 regulation of kinase activity 27.0270 5 no
GO:0045859 regulation of protein kinase activity 27.0270 6 no
GO:0051338 regulation of transferase activity 27.0270 4 no
GO:0051726 regulation of cell cycle 27.0270 4 no
GO:0071702 organic substance transport 27.0270 4 no
GO:0071705 nitrogen compound transport 27.0270 4 no
GO:0097435 supramolecular fiber organization 24.3243 4 yes
GO:0007264 small GTPase mediated signal transduction 24.3243 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.3243 4 no
GO:0030155 regulation of cell adhesion 24.3243 4 no
GO:0042326 negative regulation of phosphorylation 24.3243 8 no
GO:0042981 regulation of apoptotic process 24.3243 6 no
GO:0043067 regulation of programmed cell death 24.3243 5 no
GO:0043086 negative regulation of catalytic activity 24.3243 4 no
GO:0051093 negative regulation of developmental process 24.3243 4 no
GO:0051252 regulation of RNA metabolic process 24.3243 5 no
GO:0034765 regulation of ion transmembrane transport 24.3243 5 no
GO:1904062 regulation of cation transmembrane transport 24.3243 6 no
GO:0031344 regulation of cell projection organization 24.3243 5 no
GO:0051094 positive regulation of developmental process 24.3243 4 no
GO:0071407 cellular response to organic cyclic compound 24.3243 5 no
GO:0071417 cellular response to organonitrogen compound 24.3243 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.3243 6 no
GO:0042127 regulation of cell population proliferation 24.3243 4 no
GO:0007015 actin filament organization 21.6216 5 yes
GO:0043933 protein-containing complex organization 21.6216 4 yes
GO:1902903 regulation of supramolecular fiber organization 21.6216 5 yes
GO:0051051 negative regulation of transport 21.6216 4 no
GO:0007265 Ras protein signal transduction 21.6216 5 no
GO:0010628 positive regulation of gene expression 21.6216 6 no
GO:0010629 negative regulation of gene expression 21.6216 6 no
GO:0018193 peptidyl-amino acid modification 21.6216 5 no
GO:0044057 regulation of system process 21.6216 4 no
GO:0051241 negative regulation of multicellular organismal process 21.6216 4 no
GO:1901652 response to peptide 21.6216 4 no
GO:1901888 regulation of cell junction assembly 21.6216 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.6216 6 no
GO:0001933 negative regulation of protein phosphorylation 21.6216 8 no
GO:0022898 regulation of transmembrane transporter activity 21.6216 4 no
GO:0033674 positive regulation of kinase activity 21.6216 6 no
GO:0051347 positive regulation of transferase activity 21.6216 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 21.6216 7 no
GO:0045597 positive regulation of cell differentiation 21.6216 5 no
GO:0080134 regulation of response to stress 21.6216 4 no
GO:1905475 regulation of protein localization to membrane 21.6216 6 no
GO:0016192 vesicle-mediated transport 21.6216 4 no
GO:1903829 positive regulation of protein localization 21.6216 5 no
GO:0043393 regulation of protein binding 18.9189 4 yes
GO:0051099 positive regulation of binding 18.9189 4 yes
GO:0110053 regulation of actin filament organization 18.9189 6 yes
GO:0065003 protein-containing complex assembly 16.2162 5 yes
GO:0010639 negative regulation of organelle organization 13.5135 6 yes
GO:0032271 regulation of protein polymerization 13.5135 6 yes
GO:0032535 regulation of cellular component size 13.5135 4 yes
GO:0043254 regulation of protein-containing complex assembly 13.5135 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 10.8108 6 yes
GO:0030832 regulation of actin filament length 10.8108 5 yes
GO:0030833 regulation of actin filament polymerization 10.8108 7 yes
GO:0030834 regulation of actin filament depolymerization 10.8108 7 yes
GO:0030835 negative regulation of actin filament depolymerization 10.8108 7 yes
GO:0030837 negative regulation of actin filament polymerization 10.8108 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 10.8108 6 yes
GO:0032092 positive regulation of protein binding 10.8108 5 yes
GO:0032272 negative regulation of protein polymerization 10.8108 7 yes
GO:0034329 cell junction assembly 10.8108 5 yes
GO:0034330 cell junction organization 10.8108 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 10.8108 6 yes
GO:0043244 regulation of protein-containing complex disassembly 10.8108 5 yes
GO:0051017 actin filament bundle assembly 10.8108 5 yes
GO:0051494 negative regulation of cytoskeleton organization 10.8108 7 yes
GO:0051693 actin filament capping 10.8108 8 yes
GO:0061572 actin filament bundle organization 10.8108 6 yes
GO:1901879 regulation of protein depolymerization 10.8108 6 yes
GO:1901880 negative regulation of protein depolymerization 10.8108 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 10.8108 6 yes
GO:0051016 barbed-end actin filament capping 8.1081 9 yes
GO:0007159 leukocyte cell-cell adhesion 5.4054 4 yes
GO:0007416 synapse assembly 5.4054 6 yes
GO:0050808 synapse organization 5.4054 5 yes
GO:0050901 leukocyte tethering or rolling 5.4054 6 yes
GO:0061756 leukocyte adhesion to vascular endothelial cell 5.4054 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ADDB_HUMAN
DOID:0050700 cardiomyopathy 5.4054 4 no
DOID:0060036 intrinsic cardiomyopathy 5.4054 5 no
DOID:114 heart disease 5.4054 3 no
DOID:2843 long QT syndrome 5.4054 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
VP13A_HUMAN [view interactions] Low throughput no yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
DPPA4_HUMAN [view interactions] High throughput no no
ANR29_HUMAN [view interactions] High throughput no no
DEFI6_HUMAN [view interactions] High throughput no no
NUD12_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
SPB13_HUMAN [view interactions] High throughput no no
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
DUS23_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ABRA_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
CRIS3_HUMAN [view interactions] High throughput no no
FEM1A_HUMAN [view interactions] High throughput no no
CTAG2_HUMAN [view interactions] High throughput no no
NEP_HUMAN [view interactions] High throughput no no
PECA1_HUMAN [view interactions] High throughput no no
INT4_HUMAN [view interactions] High throughput no yes
ESCO2_HUMAN [view interactions] High throughput no no
NOG2_HUMAN [view interactions] High throughput no yes
LBH_HUMAN [view interactions] High throughput no yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
ASTRB_HUMAN [view interactions] High throughput no yes
ZN641_HUMAN [view interactions] High throughput no yes
VPP3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DEMA_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MTPN_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no