Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADDB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADDB_HUMAN
GO:0043168 anion binding 50.0000 4 no
GO:0000166 nucleotide binding 47.6190 4 no
GO:0017076 purine nucleotide binding 47.6190 5 no
GO:0032555 purine ribonucleotide binding 47.6190 4 no
GO:0035639 purine ribonucleoside triphosphate binding 45.2381 4 no
GO:0019900 kinase binding 35.7143 4 yes
GO:0043169 cation binding 35.7143 4 no
GO:0046872 metal ion binding 35.7143 5 no
GO:0019901 protein kinase binding 33.3333 5 yes
GO:0030554 adenyl nucleotide binding 30.9524 6 no
GO:0032559 adenyl ribonucleotide binding 30.9524 5 no
GO:0005524 ATP binding 28.5714 5 no
GO:0016301 kinase activity 26.1905 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 26.1905 4 no
GO:0003779 actin binding 19.0476 4 yes
GO:0042803 protein homodimerization activity 9.5238 4 yes
GO:0046982 protein heterodimerization activity 4.7619 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADDB_HUMAN
GO:0048522 positive regulation of cellular process 80.9524 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048523 negative regulation of cellular process 64.2857 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 no
GO:0080090 regulation of primary metabolic process 64.2857 4 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0051128 regulation of cellular component organization 54.7619 4 yes
GO:0031325 positive regulation of cellular metabolic process 54.7619 5 no
GO:0051246 regulation of protein metabolic process 54.7619 5 no
GO:0010646 regulation of cell communication 52.3810 4 no
GO:0019220 regulation of phosphate metabolic process 52.3810 6 no
GO:0051174 regulation of phosphorus metabolic process 52.3810 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0022607 cellular component assembly 47.6190 4 yes
GO:0001932 regulation of protein phosphorylation 47.6190 7 no
GO:0009966 regulation of signal transduction 47.6190 4 no
GO:0009889 regulation of biosynthetic process 45.2381 4 no
GO:0009892 negative regulation of metabolic process 45.2381 4 no
GO:0010468 regulation of gene expression 45.2381 6 no
GO:0010556 regulation of macromolecule biosynthetic process 45.2381 5 no
GO:0031324 negative regulation of cellular metabolic process 45.2381 5 no
GO:0031326 regulation of cellular biosynthetic process 45.2381 5 no
GO:0006996 organelle organization 42.8571 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0141124 intracellular signaling cassette 40.4762 4 no
GO:0048584 positive regulation of response to stimulus 40.4762 4 no
GO:0071310 cellular response to organic substance 40.4762 4 no
GO:1902531 regulation of intracellular signal transduction 40.4762 5 no
GO:0010647 positive regulation of cell communication 38.0952 5 no
GO:0023056 positive regulation of signaling 38.0952 4 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:0044087 regulation of cellular component biogenesis 35.7143 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 35.7143 6 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0045937 positive regulation of phosphate metabolic process 35.7143 7 no
GO:0008104 protein localization 33.3333 4 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 30.9524 5 no
GO:1901699 cellular response to nitrogen compound 30.9524 4 no
GO:0033043 regulation of organelle organization 30.9524 5 yes
GO:0009967 positive regulation of signal transduction 30.9524 5 no
GO:0030030 cell projection organization 30.9524 4 no
GO:0051130 positive regulation of cellular component organization 30.9524 5 no
GO:0051248 negative regulation of protein metabolic process 30.9524 6 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0051336 regulation of hydrolase activity 28.5714 4 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.1905 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.1905 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.1905 5 no
GO:0032880 regulation of protein localization 26.1905 5 no
GO:0051726 regulation of cell cycle 26.1905 4 no
GO:0071417 cellular response to organonitrogen compound 26.1905 4 no
GO:0032956 regulation of actin cytoskeleton organization 26.1905 5 yes
GO:0032970 regulation of actin filament-based process 26.1905 4 yes
GO:0043933 protein-containing complex organization 26.1905 4 yes
GO:0051493 regulation of cytoskeleton organization 26.1905 6 yes
GO:0006796 phosphate-containing compound metabolic process 26.1905 4 no
GO:0016310 phosphorylation 26.1905 5 no
GO:0042127 regulation of cell population proliferation 26.1905 4 no
GO:0042981 regulation of apoptotic process 26.1905 5 no
GO:0043067 regulation of programmed cell death 26.1905 4 no
GO:0045859 regulation of protein kinase activity 26.1905 6 no
GO:0051345 positive regulation of hydrolase activity 26.1905 5 no
GO:0071702 organic substance transport 26.1905 4 no
GO:0071705 nitrogen compound transport 26.1905 4 no
GO:0080134 regulation of response to stress 26.1905 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.1905 5 no
GO:1902533 positive regulation of intracellular signal transduction 26.1905 6 no
GO:0007264 small GTPase-mediated signal transduction 23.8095 5 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.8095 6 no
GO:0044057 regulation of system process 23.8095 4 no
GO:0051252 regulation of RNA metabolic process 23.8095 5 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 yes
GO:0097435 supramolecular fiber organization 23.8095 4 yes
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0006468 protein phosphorylation 23.8095 5 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0030155 regulation of cell adhesion 23.8095 4 no
GO:0031175 neuron projection development 23.8095 6 no
GO:0034762 regulation of transmembrane transport 23.8095 4 no
GO:0042326 negative regulation of phosphorylation 23.8095 8 no
GO:0051093 negative regulation of developmental process 23.8095 4 no
GO:0060284 regulation of cell development 23.8095 5 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0010628 positive regulation of gene expression 21.4286 7 no
GO:0071407 cellular response to organic cyclic compound 21.4286 5 no
GO:1905475 regulation of protein localization to membrane 21.4286 6 no
GO:1902903 regulation of supramolecular fiber organization 21.4286 5 yes
GO:0001933 negative regulation of protein phosphorylation 21.4286 8 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0043269 regulation of monoatomic ion transport 21.4286 5 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0051046 regulation of secretion 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:1903530 regulation of secretion by cell 21.4286 4 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:0007015 actin filament organization 19.0476 5 yes
GO:0043393 regulation of protein binding 19.0476 4 yes
GO:0065003 protein-containing complex assembly 19.0476 5 yes
GO:0110053 regulation of actin filament organization 19.0476 6 yes
GO:0043254 regulation of protein-containing complex assembly 14.2857 5 yes
GO:0010639 negative regulation of organelle organization 11.9048 6 yes
GO:0032092 positive regulation of protein binding 11.9048 5 yes
GO:0032271 regulation of protein polymerization 11.9048 6 yes
GO:0032535 regulation of cellular component size 11.9048 4 yes
GO:0051099 positive regulation of binding 11.9048 4 yes
GO:0051494 negative regulation of cytoskeleton organization 11.9048 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 11.9048 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 9.5238 6 yes
GO:0030832 regulation of actin filament length 9.5238 5 yes
GO:0030833 regulation of actin filament polymerization 9.5238 7 yes
GO:0030834 regulation of actin filament depolymerization 9.5238 7 yes
GO:0030835 negative regulation of actin filament depolymerization 9.5238 7 yes
GO:0030837 negative regulation of actin filament polymerization 9.5238 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 9.5238 6 yes
GO:0032272 negative regulation of protein polymerization 9.5238 7 yes
GO:0034329 cell junction assembly 9.5238 5 yes
GO:0034330 cell junction organization 9.5238 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 9.5238 6 yes
GO:0043244 regulation of protein-containing complex disassembly 9.5238 5 yes
GO:0051017 actin filament bundle assembly 9.5238 5 yes
GO:0051693 actin filament capping 9.5238 8 yes
GO:0061572 actin filament bundle organization 9.5238 6 yes
GO:1901879 regulation of protein depolymerization 9.5238 6 yes
GO:1901880 negative regulation of protein depolymerization 9.5238 7 yes
GO:0030097 hemopoiesis 7.1429 4 yes
GO:0051016 barbed-end actin filament capping 7.1429 9 yes
GO:0007159 leukocyte cell-cell adhesion 4.7619 4 yes
GO:0007416 synapse assembly 4.7619 6 yes
GO:0050808 synapse organization 4.7619 5 yes
GO:0050901 leukocyte tethering or rolling 4.7619 6 yes
GO:0061756 leukocyte adhesion to vascular endothelial cell 4.7619 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VP13A_HUMAN [view interactions] Low throughput no yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
DUS23_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF23_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ABRA_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
CRIS3_HUMAN [view interactions] High throughput no no
FEM1A_HUMAN [view interactions] High throughput no no
CTAG2_HUMAN [view interactions] High throughput no no
NEP_HUMAN [view interactions] High throughput no no
PECA1_HUMAN [view interactions] High throughput no no
INT4_HUMAN [view interactions] High throughput no yes
ESCO2_HUMAN [view interactions] High throughput no no
NOG2_HUMAN [view interactions] High throughput no yes
LBH_HUMAN [view interactions] High throughput no yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
ASTRB_HUMAN [view interactions] High throughput no yes
ZN641_HUMAN [view interactions] High throughput no yes
VPP3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DEMA_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MTPN_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
DPPA4_HUMAN [view interactions] High throughput no no
ANR29_HUMAN [view interactions] High throughput no no
DEFI6_HUMAN [view interactions] High throughput no no
NUD12_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
SPB13_HUMAN [view interactions] High throughput no no