Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DEMA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DEMA_HUMAN
GO:0003779 actin binding 40.9091 4 yes
GO:0019900 kinase binding 36.3636 4 no
GO:0019901 protein kinase binding 31.8182 5 no
GO:0045296 cadherin binding 31.8182 4 no
GO:0003723 RNA binding 27.2727 4 no
GO:0046982 protein heterodimerization activity 22.7273 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DEMA_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 72.7273 4 yes
GO:0060255 regulation of macromolecule metabolic process 72.7273 4 yes
GO:0080090 regulation of primary metabolic process 72.7273 4 yes
GO:0031323 regulation of cellular metabolic process 72.7273 4 yes
GO:0048523 negative regulation of cellular process 72.7273 4 yes
GO:0051128 regulation of cellular component organization 63.6364 4 yes
GO:0022607 cellular component assembly 63.6364 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0051246 regulation of protein metabolic process 59.0909 5 yes
GO:0008104 protein localization 59.0909 4 yes
GO:0006996 organelle organization 54.5455 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 45.4545 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 yes
GO:0010646 regulation of cell communication 45.4545 4 yes
GO:0031399 regulation of protein modification process 45.4545 6 yes
GO:0051174 regulation of phosphorus metabolic process 40.9091 5 yes
GO:0071702 organic substance transport 40.9091 4 yes
GO:0071705 nitrogen compound transport 40.9091 4 yes
GO:0009966 regulation of signal transduction 40.9091 4 yes
GO:0019220 regulation of phosphate metabolic process 40.9091 6 yes
GO:0044087 regulation of cellular component biogenesis 40.9091 4 yes
GO:0071310 cellular response to organic substance 36.3636 4 yes
GO:0007010 cytoskeleton organization 36.3636 5 yes
GO:0015031 protein transport 36.3636 4 yes
GO:0033043 regulation of organelle organization 36.3636 5 yes
GO:0043933 protein-containing complex organization 36.3636 4 yes
GO:0045595 regulation of cell differentiation 36.3636 4 yes
GO:0051049 regulation of transport 36.3636 4 yes
GO:0051129 negative regulation of cellular component organization 31.8182 5 yes
GO:0051248 negative regulation of protein metabolic process 31.8182 6 yes
GO:0051493 regulation of cytoskeleton organization 31.8182 6 yes
GO:0060341 regulation of cellular localization 31.8182 4 yes
GO:0065003 protein-containing complex assembly 31.8182 5 yes
GO:0071417 cellular response to organonitrogen compound 31.8182 4 yes
GO:0097435 supramolecular fiber organization 31.8182 4 yes
GO:1901699 cellular response to nitrogen compound 31.8182 4 yes
GO:1901701 cellular response to oxygen-containing compound 31.8182 4 yes
GO:1902903 regulation of supramolecular fiber organization 31.8182 5 yes
GO:0050804 modulation of chemical synaptic transmission 31.8182 5 no
GO:0099177 regulation of trans-synaptic signaling 31.8182 4 no
GO:0009889 regulation of biosynthetic process 31.8182 4 no
GO:0010468 regulation of gene expression 31.8182 5 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8182 5 no
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 no
GO:0043393 regulation of protein binding 31.8182 4 no
GO:0001932 regulation of protein phosphorylation 31.8182 7 yes
GO:0010243 response to organonitrogen compound 31.8182 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 31.8182 6 yes
GO:0031400 negative regulation of protein modification process 31.8182 7 yes
GO:0032880 regulation of protein localization 31.8182 5 yes
GO:0042325 regulation of phosphorylation 31.8182 7 yes
GO:0045936 negative regulation of phosphate metabolic process 31.8182 7 yes
GO:0071407 cellular response to organic cyclic compound 27.2727 5 yes
GO:0006886 intracellular protein transport 27.2727 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0034330 cell junction organization 27.2727 4 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 no
GO:0036211 protein modification process 27.2727 4 no
GO:0043412 macromolecule modification 27.2727 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.2727 5 no
GO:0022898 regulation of transmembrane transporter activity 27.2727 4 no
GO:0034762 regulation of transmembrane transport 27.2727 4 no
GO:0043269 regulation of ion transport 27.2727 5 no
GO:0051050 positive regulation of transport 27.2727 4 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0010639 negative regulation of organelle organization 27.2727 6 yes
GO:0014070 response to organic cyclic compound 27.2727 4 yes
GO:0030030 cell projection organization 27.2727 4 yes
GO:0032956 regulation of actin cytoskeleton organization 27.2727 5 yes
GO:0032970 regulation of actin filament-based process 27.2727 4 yes
GO:0043254 regulation of protein-containing complex assembly 27.2727 5 yes
GO:0051094 positive regulation of developmental process 22.7273 4 yes
GO:0051223 regulation of protein transport 22.7273 5 yes
GO:0051494 negative regulation of cytoskeleton organization 22.7273 7 yes
GO:0070201 regulation of establishment of protein localization 22.7273 6 yes
GO:0110053 regulation of actin filament organization 22.7273 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.7273 6 yes
GO:0120036 plasma membrane bounded cell projection organization 22.7273 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 22.7273 6 yes
GO:0006605 protein targeting 22.7273 5 no
GO:0043549 regulation of kinase activity 22.7273 5 no
GO:0045859 regulation of protein kinase activity 22.7273 6 no
GO:0051338 regulation of transferase activity 22.7273 4 no
GO:0006355 regulation of DNA-templated transcription 22.7273 6 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.7273 7 no
GO:2001141 regulation of RNA biosynthetic process 22.7273 6 no
GO:0009894 regulation of catabolic process 22.7273 4 no
GO:0031329 regulation of cellular catabolic process 22.7273 5 no
GO:0030162 regulation of proteolysis 22.7273 6 no
GO:0034765 regulation of ion transmembrane transport 22.7273 5 no
GO:0048878 chemical homeostasis 22.7273 4 no
GO:1903829 positive regulation of protein localization 22.7273 5 no
GO:1904062 regulation of cation transmembrane transport 22.7273 6 no
GO:0007015 actin filament organization 22.7273 5 yes
GO:0031333 negative regulation of protein-containing complex assembly 22.7273 6 yes
GO:0031344 regulation of cell projection organization 22.7273 5 yes
GO:0032271 regulation of protein polymerization 22.7273 6 yes
GO:0032272 negative regulation of protein polymerization 22.7273 7 yes
GO:0045597 positive regulation of cell differentiation 22.7273 5 yes
GO:0048584 positive regulation of response to stimulus 22.7273 4 yes
GO:0051693 actin filament capping 18.1818 8 yes
GO:0060284 regulation of cell development 18.1818 5 yes
GO:0061572 actin filament bundle organization 18.1818 6 yes
GO:0071241 cellular response to inorganic substance 18.1818 4 yes
GO:0071248 cellular response to metal ion 18.1818 5 yes
GO:0080134 regulation of response to stress 18.1818 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 18.1818 6 yes
GO:1901879 regulation of protein depolymerization 18.1818 6 yes
GO:1901880 negative regulation of protein depolymerization 18.1818 7 yes
GO:1901888 regulation of cell junction assembly 18.1818 5 yes
GO:0001933 negative regulation of protein phosphorylation 18.1818 8 yes
GO:0008064 regulation of actin polymerization or depolymerization 18.1818 6 yes
GO:0010038 response to metal ion 18.1818 4 yes
GO:0010647 positive regulation of cell communication 18.1818 5 yes
GO:0019722 calcium-mediated signaling 18.1818 5 yes
GO:0019932 second-messenger-mediated signaling 18.1818 4 yes
GO:0023056 positive regulation of signaling 18.1818 4 yes
GO:0030031 cell projection assembly 18.1818 5 yes
GO:0030832 regulation of actin filament length 18.1818 5 yes
GO:0030833 regulation of actin filament polymerization 18.1818 7 yes
GO:0030834 regulation of actin filament depolymerization 18.1818 7 yes
GO:0030835 negative regulation of actin filament depolymerization 18.1818 7 yes
GO:0030837 negative regulation of actin filament polymerization 18.1818 7 yes
GO:0032386 regulation of intracellular transport 18.1818 5 yes
GO:0032535 regulation of cellular component size 18.1818 4 yes
GO:0033157 regulation of intracellular protein transport 18.1818 6 yes
GO:0042326 negative regulation of phosphorylation 18.1818 8 yes
GO:0043242 negative regulation of protein-containing complex disassembly 18.1818 6 yes
GO:0043244 regulation of protein-containing complex disassembly 18.1818 5 yes
GO:0051017 actin filament bundle assembly 18.1818 5 yes
GO:0051240 positive regulation of multicellular organismal process 13.6364 4 yes
GO:1905475 regulation of protein localization to membrane 13.6364 6 yes
GO:0009967 positive regulation of signal transduction 13.6364 5 yes
GO:0010720 positive regulation of cell development 13.6364 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 13.6364 4 yes
GO:0032101 regulation of response to external stimulus 13.6364 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 13.6364 8 yes
GO:0045596 negative regulation of cell differentiation 13.6364 5 yes
GO:0050865 regulation of cell activation 13.6364 4 yes
GO:0051051 negative regulation of transport 13.6364 4 yes
GO:0051093 negative regulation of developmental process 13.6364 4 yes
GO:0051489 regulation of filopodium assembly 9.0909 7 yes
GO:0051591 response to cAMP 9.0909 4 yes
GO:0051592 response to calcium ion 9.0909 5 yes
GO:0060491 regulation of cell projection assembly 9.0909 5 yes
GO:0061515 myeloid cell development 9.0909 4 yes
GO:0071277 cellular response to calcium ion 9.0909 6 yes
GO:0071320 cellular response to cAMP 9.0909 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 9.0909 6 yes
GO:1902743 regulation of lamellipodium organization 9.0909 7 yes
GO:1903828 negative regulation of protein localization 9.0909 5 yes
GO:2000145 regulation of cell motility 9.0909 4 yes
GO:2000147 positive regulation of cell motility 9.0909 5 yes
GO:0001952 regulation of cell-matrix adhesion 9.0909 6 yes
GO:0010591 regulation of lamellipodium assembly 9.0909 7 yes
GO:0010721 negative regulation of cell development 9.0909 6 yes
GO:0010799 regulation of peptidyl-threonine phosphorylation 9.0909 8 yes
GO:0010810 regulation of cell-substrate adhesion 9.0909 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 9.0909 6 yes
GO:0014074 response to purine-containing compound 9.0909 5 yes
GO:0030155 regulation of cell adhesion 9.0909 4 yes
GO:0030334 regulation of cell migration 9.0909 5 yes
GO:0030335 positive regulation of cell migration 9.0909 6 yes
GO:0035584 calcium-mediated signaling using intracellular calcium source 9.0909 6 yes
GO:0040017 positive regulation of locomotion 9.0909 4 yes
GO:0045785 positive regulation of cell adhesion 9.0909 5 yes
GO:0046683 response to organophosphorus 9.0909 4 yes
GO:0046903 secretion 9.0909 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 9.0909 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VASP_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
UBR1_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
CEP76_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
EPCR_HUMAN [view interactions] High throughput no yes
PTOV1_HUMAN [view interactions] High throughput no yes
SMD2_HUMAN [view interactions] High throughput no yes
TEX11_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
TPC10_HUMAN [view interactions] High throughput no no
NU188_HUMAN [view interactions] High throughput no yes
DPP9_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD2_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
MIB2_HUMAN [view interactions] High throughput no yes
ATE1_HUMAN [view interactions] High throughput no yes
CBPA3_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view interactions] High throughput no yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
ADDA_HUMAN [view entry] [view interactions] Computational yes yes
FSCN1_HUMAN [view entry] [view interactions] Computational yes yes
ADDG_HUMAN [view entry] [view interactions] Computational yes yes