NED4L_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed, PubMed, PubMed). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed, PubMed). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed, PubMed). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed). Plays a role in dendrite formation by melanocytes (PubMed). Involved in the regulation of TOR signaling (PubMed). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed). Plays a role in antiviral innate immunity by catalyzing Lys-29-linked cysteine ubiquitination of TRAF3, resulting in enhanced Lys-48 and Lys-63-linked ubiquitination of TRAF3 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003042 | LIG_14-3-3_CanoR_1 | LIG | 339 | 344 | - |
| ELMI003012 | LIG_14-3-3_CanoR_1 | LIG | 443 | 448 | - |
| ELMI003042 | LIG_14-3-3_CanoR_1 | LIG | 339 | 344 | - |
| ELMI003012 | LIG_14-3-3_CanoR_1 | LIG | 443 | 448 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NED4L_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.4872 | 4 | no |
| GO:0043169 | cation binding | 28.2051 | 4 | no |
| GO:0000166 | nucleotide binding | 26.9231 | 4 | no |
| GO:0046872 | metal ion binding | 26.9231 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.6410 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.6410 | 4 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7949 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.7949 | 4 | no |
| GO:0005524 | ATP binding | 20.5128 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.5128 | 5 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 8.9744 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 8.9744 | 4 | yes |
| GO:0099106 | ion channel regulator activity | 8.9744 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 7.6923 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 7.6923 | 4 | yes |
| GO:0015459 | potassium channel regulator activity | 6.4103 | 5 | yes |
| GO:0017080 | sodium channel regulator activity | 5.1282 | 5 | yes |
| GO:0008200 | ion channel inhibitor activity | 3.8462 | 5 | yes |
| GO:0016248 | channel inhibitor activity | 3.8462 | 4 | yes |
| GO:0019871 | sodium channel inhibitor activity | 3.8462 | 6 | yes |
| GO:0019870 | potassium channel inhibitor activity | 2.5641 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NED4L_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 65.3846 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 65.3846 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 61.5385 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.2564 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 48.7179 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.7179 | 4 | yes |
| GO:0051049 | regulation of transport | 47.4359 | 4 | yes |
| GO:0008104 | protein localization | 47.4359 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 47.4359 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.1538 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.1538 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.1538 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.8718 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.8718 | 6 | no |
| GO:0022607 | cellular component assembly | 41.0256 | 4 | no |
| GO:0006996 | organelle organization | 39.7436 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0031399 | regulation of protein modification process | 35.8974 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.8974 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.8974 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.8974 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 35.8974 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.6154 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 34.6154 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.6154 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.0513 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.0513 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 32.0513 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 32.0513 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.4872 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 29.4872 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.4872 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 29.4872 | 5 | no |
| GO:0023057 | negative regulation of signaling | 29.4872 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.4872 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.4872 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.4872 | 4 | no |
| GO:0043412 | macromolecule modification | 28.2051 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.2051 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.2051 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.2051 | 4 | no |
| GO:0036211 | protein modification process | 28.2051 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 26.9231 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.9231 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.9231 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.9231 | 7 | no |
| GO:0032880 | regulation of protein localization | 26.9231 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.6410 | 7 | no |
| GO:0009968 | negative regulation of signal transduction | 25.6410 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.6410 | 5 | no |
| GO:0071702 | organic substance transport | 25.6410 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.6410 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.6410 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.6410 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.6410 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.6410 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 25.6410 | 4 | yes |
| GO:0051050 | positive regulation of transport | 24.3590 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.3590 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 24.3590 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.3590 | 5 | no |
| GO:0043933 | protein-containing complex organization | 24.3590 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.3590 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.3590 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.3590 | 6 | no |
| GO:0051051 | negative regulation of transport | 23.0769 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0015031 | protein transport | 23.0769 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.0769 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 21.7949 | 5 | yes |
| GO:0030030 | cell projection organization | 21.7949 | 4 | no |
| GO:2000145 | regulation of cell motility | 21.7949 | 4 | no |
| GO:0033993 | response to lipid | 21.7949 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.7949 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 21.7949 | 7 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5128 | 4 | yes |
| GO:0016310 | phosphorylation | 20.5128 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.5128 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.5128 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 20.5128 | 7 | no |
| GO:0030334 | regulation of cell migration | 20.5128 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 20.5128 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 19.2308 | 6 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 19.2308 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 16.6667 | 6 | yes |
| GO:0006508 | proteolysis | 16.6667 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 16.6667 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 15.3846 | 4 | yes |
| GO:0043687 | post-translational protein modification | 14.1026 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 14.1026 | 4 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 14.1026 | 6 | yes |
| GO:0016567 | protein ubiquitination | 14.1026 | 8 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 14.1026 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 14.1026 | 7 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 12.8205 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 12.8205 | 5 | yes |
| GO:0001558 | regulation of cell growth | 12.8205 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 12.8205 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 12.8205 | 5 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 12.8205 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 11.5385 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 11.5385 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 10.2564 | 7 | yes |
| GO:0009896 | positive regulation of catabolic process | 10.2564 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 10.2564 | 5 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 8.9744 | 5 | yes |
| GO:0045927 | positive regulation of growth | 8.9744 | 4 | yes |
| GO:0050773 | regulation of dendrite development | 8.9744 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 8.9744 | 4 | yes |
| GO:0000209 | protein polyubiquitination | 8.9744 | 9 | yes |
| GO:0002028 | regulation of sodium ion transport | 8.9744 | 7 | yes |
| GO:0030163 | protein catabolic process | 8.9744 | 4 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 8.9744 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 8.9744 | 7 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 7.6923 | 5 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 7.6923 | 7 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 7.6923 | 7 | yes |
| GO:0001508 | action potential | 7.6923 | 4 | yes |
| GO:0010498 | proteasomal protein catabolic process | 7.6923 | 5 | yes |
| GO:0030307 | positive regulation of cell growth | 7.6923 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 7.6923 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 6.4103 | 6 | yes |
| GO:0048639 | positive regulation of developmental growth | 6.4103 | 5 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 6.4103 | 6 | yes |
| GO:2000008 | regulation of protein localization to cell surface | 6.4103 | 6 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 6.4103 | 6 | yes |
| GO:0032410 | negative regulation of transporter activity | 6.4103 | 4 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 6.4103 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 5.1282 | 5 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 5.1282 | 7 | yes |
| GO:0010766 | negative regulation of sodium ion transport | 5.1282 | 6 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 5.1282 | 5 | yes |
| GO:0070936 | protein K48-linked ubiquitination | 3.8462 | 10 | yes |
| GO:0086001 | cardiac muscle cell action potential | 3.8462 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 3.8462 | 6 | yes |
| GO:1902306 | negative regulation of sodium ion transmembrane transport | 3.8462 | 7 | yes |
| GO:1903859 | regulation of dendrite extension | 3.8462 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 3.8462 | 6 | yes |
| GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 3.8462 | 6 | yes |
| GO:0003254 | regulation of membrane depolarization | 3.8462 | 4 | yes |
| GO:0043267 | negative regulation of potassium ion transport | 3.8462 | 6 | yes |
| GO:0086005 | ventricular cardiac muscle cell action potential | 2.5641 | 7 | yes |
| GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 2.5641 | 6 | yes |
| GO:1901380 | negative regulation of potassium ion transmembrane transport | 2.5641 | 7 | yes |
| GO:2000009 | negative regulation of protein localization to cell surface | 2.5641 | 6 | yes |
| GO:2001286 | regulation of caveolin-mediated endocytosis | 2.5641 | 6 | yes |
| GO:2001288 | positive regulation of caveolin-mediated endocytosis | 2.5641 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| T22D3_HUMAN | [view interactions] | Low throughput | no | yes |
| WNK4_HUMAN | [view interactions] | Low throughput | no | yes |
| NRAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCNNA_HUMAN | [view interactions] | Low throughput | no | yes |
| NPC2_HUMAN | [view interactions] | Low throughput | no | yes |
| MT2_HUMAN | [view interactions] | Low throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CYBR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| YLAT1_HUMAN | [view interactions] | Low throughput | no | no |
| PBX1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACY3_HUMAN | [view interactions] | Low throughput | no | no |
| HAX1_HUMAN | [view interactions] | Low throughput | no | no |
| KIF3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NFIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | Low throughput | no | no |
| APBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD7_HUMAN | [view interactions] | Low throughput | no | yes |
| AMOL1_HUMAN | [view interactions] | Low throughput | no | no |
| SCNNG_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| NFIP2_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNH2_HUMAN | [view interactions] | Low throughput | no | no |
| CAV3_HUMAN | [view interactions] | Low throughput | no | no |
| KCNQ1_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK3_HUMAN | [view interactions] | Low throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SL9A3_HUMAN | [view interactions] | Low throughput | no | yes |
| WNK3_HUMAN | [view interactions] | Low throughput | no | no |
| LITAF_HUMAN | [view interactions] | Low throughput | no | yes |
| S22AB_HUMAN | [view interactions] | Low throughput | no | no |
| S22A8_HUMAN | [view interactions] | Low throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRYAB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ULK1_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
| S22A6_HUMAN | [view interactions] | Low throughput | no | no |
| IL2RG_HUMAN | [view interactions] | Low throughput | no | no |
| IL4RA_HUMAN | [view interactions] | Low throughput | no | no |
| PKHD1_HUMAN | [view interactions] | Low throughput | no | no |
| CRTC3_HUMAN | [view interactions] | Low throughput | no | no |
| BEST1_HUMAN | [view interactions] | Low throughput | no | no |
| FOXO1_HUMAN | [view interactions] | Low throughput | no | yes |
| PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| OGG1_HUMAN | [view interactions] | Low throughput | no | yes |
| STK35_HUMAN | [view interactions] | Low throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLIRP_HUMAN | [view interactions] | Low throughput | no | yes |
| SG1D2_HUMAN | [view interactions] | Low throughput | no | no |
| YMEL1_HUMAN | [view interactions] | Low throughput | no | yes |
| TMED8_HUMAN | [view interactions] | Low throughput | no | no |
| TRFL_HUMAN | [view interactions] | Low throughput | no | no |
| H2A1A_HUMAN | [view interactions] | Low throughput | no | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| CSRP2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP7_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
| SPHK2_HUMAN | [view interactions] | Low throughput | no | no |
| COPT1_HUMAN | [view interactions] | Low throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CPNE1_HUMAN | [view interactions] | Low throughput | no | no |
| CRCM1_HUMAN | [view interactions] | Low throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | Low throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTBP1_HUMAN | [view interactions] | Low throughput | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K2_HUMAN | [view interactions] | Low throughput | no | yes |
| PHF8_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WNT3_HUMAN | [view interactions] | Low throughput | no | no |
| GPX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2K_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P4K2A_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L6_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NED4L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSMD4_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | Low throughput | no | no |
| AMOT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCNNB_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PYM1_HUMAN | [view interactions] | High throughput | no | yes |
| SGK2_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRMS_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PEDF_HUMAN | [view interactions] | High throughput | no | no |
| TMG2_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK3_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CACB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACV1B_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD6_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| TMG3_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD6_HUMAN | [view interactions] | High throughput | no | yes |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM92_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| ILDR1_HUMAN | [view interactions] | High throughput | no | no |
| TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR19_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| HAVR1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH3_HUMAN | [view interactions] | High throughput | no | no |
| RN128_HUMAN | [view interactions] | High throughput | no | yes |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| XIRP2_HUMAN | [view interactions] | High throughput | no | no |
| LRP3_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| T255A_HUMAN | [view interactions] | High throughput | no | yes |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF5_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| M4A10_HUMAN | [view interactions] | High throughput | no | no |
| TM174_HUMAN | [view interactions] | High throughput | no | no |
| TMG1_HUMAN | [view interactions] | High throughput | no | no |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| TM101_HUMAN | [view interactions] | High throughput | no | no |
| PMEPA_HUMAN | [view interactions] | High throughput | no | no |
| TM252_HUMAN | [view interactions] | High throughput | no | no |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| CYYR1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| IFRD2_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROBO3_HUMAN | [view interactions] | High throughput | no | no |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF1B_HUMAN | [view interactions] | High throughput | no | no |
| SPAG8_HUMAN | [view interactions] | High throughput | no | no |
| STAC_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC2_HUMAN | [view interactions] | High throughput | no | yes |
| H10_HUMAN | [view interactions] | High throughput | no | yes |
| ADAP2_HUMAN | [view interactions] | High throughput | no | no |
| LARGN_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK3_HUMAN | [view interactions] | High throughput | no | no |
| FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX2_HUMAN | [view interactions] | High throughput | no | no |
| RM19_HUMAN | [view interactions] | High throughput | no | yes |
| TGFI1_HUMAN | [view interactions] | High throughput | no | no |
| TBCD7_HUMAN | [view interactions] | High throughput | no | no |
| NHP2_HUMAN | [view interactions] | High throughput | no | yes |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| PP4P2_HUMAN | [view interactions] | High throughput | no | yes |
| CP26B_HUMAN | [view interactions] | High throughput | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SENP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIVA_HUMAN | [view interactions] | High throughput | no | no |
| RSLBB_HUMAN | [view interactions] | High throughput | no | no |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK40_HUMAN | [view interactions] | High throughput | no | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| TIRR_HUMAN | [view interactions] | High throughput | no | no |
| CG050_HUMAN | [view interactions] | High throughput | no | yes |
| TCAL2_HUMAN | [view interactions] | High throughput | no | no |
| ZCCHL_HUMAN | [view interactions] | High throughput | no | no |
| MOB3A_HUMAN | [view interactions] | High throughput | no | no |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KCAB1_HUMAN | [view interactions] | High throughput | no | no |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2J2_HUMAN | [view interactions] | High throughput | no | no |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| MAPK3_HUMAN | [view interactions] | High throughput | no | no |
| FBLN4_HUMAN | [view interactions] | High throughput | no | no |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC3_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC1D_HUMAN | [view interactions] | High throughput | no | yes |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGB1_HUMAN | [view interactions] | High throughput | no | no |
| LAPM5_HUMAN | [view interactions] | High throughput | no | yes |
| DEMA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| EREP1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| FXL15_HUMAN | [view interactions] | High throughput | no | no |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD4_HUMAN | [view interactions] | High throughput | no | yes |
| KCAB3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BBX_HUMAN | [view interactions] | High throughput | no | no |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |