GPX4_HUMAN
Evidence for PS localization
Functions
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins . Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide . Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation . Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis . The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures . May be required to protect cells from the toxicity of ingested lipid hydroperoxides . Required for normal sperm development and male fertility . Essential for maturation and survival of photoreceptor cells . Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion . Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPX4_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 36.3636 | 4 | no |
| GO:0046872 | metal ion binding | 30.3030 | 5 | no |
| GO:0003723 | RNA binding | 21.2121 | 4 | no |
| GO:0019900 | kinase binding | 21.2121 | 4 | no |
| GO:0045296 | cadherin binding | 21.2121 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPX4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.4242 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.4242 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.3939 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 30.3030 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 30.3030 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 30.3030 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 30.3030 | 4 | yes |
| GO:0036211 | protein modification process | 30.3030 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.3030 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:1901565 | organonitrogen compound catabolic process | 30.3030 | 4 | no |
| GO:0006996 | organelle organization | 30.3030 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.3030 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 30.3030 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.3030 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.3030 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.3030 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.3030 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 27.2727 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 27.2727 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.2727 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | no |
| GO:0022607 | cellular component assembly | 24.2424 | 4 | yes |
| GO:0051049 | regulation of transport | 24.2424 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2424 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 24.2424 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.2424 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 24.2424 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.2424 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 21.2121 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 21.2121 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.2121 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.2121 | 8 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.2121 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.2121 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.2121 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.2121 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.2121 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2121 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 15.1515 | 4 | yes |
| GO:0033993 | response to lipid | 12.1212 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 9.0909 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 9.0909 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 9.0909 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 9.0909 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 9.0909 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 9.0909 | 6 | yes |
| GO:0032355 | response to estradiol | 6.0606 | 4 | yes |
| GO:0051258 | protein polymerization | 6.0606 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF31_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| NED4L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF4_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| ZP2_HUMAN | [view interactions] | High throughput | no | no |
| ZP3_HUMAN | [view interactions] | High throughput | no | no |
| ZP4_HUMAN | [view interactions] | High throughput | no | no |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| SNR48_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| GSTO2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| IL18_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| VCY1_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| OMP_HUMAN | [view interactions] | High throughput | no | no |
| FLOWR_HUMAN | [view interactions] | High throughput | no | no |
| CDD_HUMAN | [view interactions] | High throughput | no | no |
| CY561_HUMAN | [view interactions] | High throughput | no | yes |
| CYTM_HUMAN | [view interactions] | High throughput | no | no |
| GPA33_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOF1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1B_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPA2_HUMAN | [view interactions] | High throughput | no | no |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM4_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA0_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |