GPX4_HUMAN
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins . Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide . Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation . Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis . The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures . May be required to protect cells from the toxicity of ingested lipid hydroperoxides . Required for normal sperm development and male fertility . Essential for maturation and survival of photoreceptor cells . Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion . Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GPX4_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 26.6667 | 4 | no |
GO:0003723 | RNA binding | 23.3333 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GPX4_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0010941 | regulation of cell death | 40.0000 | 4 | yes |
GO:0019752 | carboxylic acid metabolic process | 40.0000 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 40.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
GO:0032787 | monocarboxylic acid metabolic process | 36.6667 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 36.6667 | 5 | yes |
GO:0060548 | negative regulation of cell death | 36.6667 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 36.6667 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 36.6667 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 36.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
GO:0043069 | negative regulation of programmed cell death | 33.3333 | 6 | yes |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
GO:0010648 | negative regulation of cell communication | 30.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 30.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 30.0000 | 7 | no |
GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 26.6667 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 26.6667 | 4 | no |
GO:0051128 | regulation of cellular component organization | 26.6667 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 26.6667 | 5 | no |
GO:0033993 | response to lipid | 23.3333 | 4 | yes |
GO:0080134 | regulation of response to stress | 23.3333 | 4 | yes |
GO:0006996 | organelle organization | 23.3333 | 4 | no |
GO:0006753 | nucleoside phosphate metabolic process | 23.3333 | 4 | no |
GO:0009117 | nucleotide metabolic process | 23.3333 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 23.3333 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 23.3333 | 5 | no |
GO:1902532 | negative regulation of intracellular signal transduction | 23.3333 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 23.3333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 23.3333 | 6 | no |
GO:0071310 | cellular response to organic substance | 23.3333 | 4 | no |
GO:0006518 | peptide metabolic process | 20.0000 | 4 | yes |
GO:0006749 | glutathione metabolic process | 20.0000 | 4 | yes |
GO:0014070 | response to organic cyclic compound | 20.0000 | 4 | yes |
GO:0022607 | cellular component assembly | 20.0000 | 4 | yes |
GO:0043603 | cellular amide metabolic process | 20.0000 | 4 | yes |
GO:0043933 | protein-containing complex organization | 16.6667 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 16.6667 | 5 | yes |
GO:0006631 | fatty acid metabolic process | 13.3333 | 4 | yes |
GO:0008610 | lipid biosynthetic process | 13.3333 | 4 | yes |
GO:0016053 | organic acid biosynthetic process | 13.3333 | 4 | yes |
GO:0032101 | regulation of response to external stimulus | 13.3333 | 4 | yes |
GO:0032355 | response to estradiol | 13.3333 | 4 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 13.3333 | 5 | yes |
GO:0072330 | monocarboxylic acid biosynthetic process | 13.3333 | 6 | yes |
GO:0006644 | phospholipid metabolic process | 10.0000 | 4 | yes |
GO:0031347 | regulation of defense response | 10.0000 | 5 | yes |
GO:0050727 | regulation of inflammatory response | 10.0000 | 5 | yes |
GO:0001676 | long-chain fatty acid metabolic process | 6.6667 | 5 | yes |
GO:0006633 | fatty acid biosynthetic process | 6.6667 | 5 | yes |
GO:0006690 | icosanoid metabolic process | 6.6667 | 6 | yes |
GO:0033559 | unsaturated fatty acid metabolic process | 6.6667 | 5 | yes |
GO:0042759 | long-chain fatty acid biosynthetic process | 6.6667 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MIB2_HUMAN | [view interactions] | Low throughput | no | yes |
PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
SDHF4_HUMAN | [view interactions] | High throughput | no | yes |
LACTB_HUMAN | [view interactions] | High throughput | no | yes |
ZP2_HUMAN | [view interactions] | High throughput | no | no |
ZP3_HUMAN | [view interactions] | High throughput | no | no |
ZP4_HUMAN | [view interactions] | High throughput | no | no |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
MK13_HUMAN | [view interactions] | High throughput | no | yes |
CE170_HUMAN | [view interactions] | High throughput | no | yes |
SNR48_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
GSTO2_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EYA4_HUMAN | [view interactions] | High throughput | no | yes |
MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN12_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
IL18_HUMAN | [view interactions] | High throughput | no | yes |
LHPL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RPE_HUMAN | [view interactions] | High throughput | no | yes |
VCY1_HUMAN | [view interactions] | High throughput | no | no |
DBLOH_HUMAN | [view interactions] | High throughput | no | no |
OMP_HUMAN | [view interactions] | High throughput | no | no |
FLOWR_HUMAN | [view interactions] | High throughput | no | no |
CDD_HUMAN | [view interactions] | High throughput | no | no |
CY561_HUMAN | [view interactions] | High throughput | no | yes |
CYTM_HUMAN | [view interactions] | High throughput | no | no |
GPA33_HUMAN | [view interactions] | High throughput | no | no |
SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
ALDR_HUMAN | [view interactions] | High throughput | no | no |
ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUT_HUMAN | [view interactions] | High throughput | no | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
ERO1B_HUMAN | [view interactions] | High throughput | no | yes |
ETFA_HUMAN | [view interactions] | High throughput | no | yes |
ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
HINT1_HUMAN | [view interactions] | High throughput | no | yes |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMPA2_HUMAN | [view interactions] | High throughput | no | no |
NTF2_HUMAN | [view interactions] | High throughput | no | yes |
PGAM4_HUMAN | [view interactions] | High throughput | no | no |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CH10_HUMAN | [view interactions] | High throughput | no | yes |
MAOX_HUMAN | [view interactions] | High throughput | no | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIF_HUMAN | [view interactions] | High throughput | no | no |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPA34_HUMAN | [view interactions] | High throughput | no | yes |
COIL_HUMAN | [view interactions] | High throughput | no | yes |
THIO_HUMAN | [view interactions] | Computational | no | yes |
CATA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GSTA1_HUMAN | [view interactions] | Computational | no | no |
GSTM5_HUMAN | [view interactions] | Computational | no | yes |
GSTP1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GGT7_HUMAN | [view interactions] | Computational | no | yes |
GSTM1_HUMAN | [view interactions] | Computational | no | yes |
GGT1_HUMAN | [view interactions] | Computational | no | no |
PRDX3_HUMAN | [view interactions] | Computational | no | yes |
SEPP1_HUMAN | [view interactions] | Computational | no | yes |
GSTA3_HUMAN | [view interactions] | Computational | no | no |
CHAC2_HUMAN | [view interactions] | Computational | no | no |
TRXR2_HUMAN | [view interactions] | Computational | no | yes |
TRXR1_HUMAN | [view interactions] | Computational | no | yes |
GRSF1_HUMAN | [view interactions] | Computational | no | yes |
GSTO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GSTM3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HPGDS_HUMAN | [view interactions] | Computational | no | no |
GSHR_HUMAN | [view interactions] | Computational | no | yes |
GGT5_HUMAN | [view interactions] | Computational | no | yes |