LHPL4_HUMAN
Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LHPL4_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 37.5000 | 4 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
GO:0042803 | protein homodimerization activity | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LHPL4_HUMAN |
---|---|---|---|---|
GO:0044087 | regulation of cellular component biogenesis | 37.5000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | yes |
GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
GO:0032880 | regulation of protein localization | 37.5000 | 5 | no |
GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
GO:0051049 | regulation of transport | 37.5000 | 4 | no |
GO:0051223 | regulation of protein transport | 37.5000 | 5 | no |
GO:0060341 | regulation of cellular localization | 37.5000 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 37.5000 | 6 | no |
GO:0007600 | sensory perception | 25.0000 | 4 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | yes |
GO:0043113 | receptor clustering | 25.0000 | 5 | yes |
GO:0050807 | regulation of synapse organization | 25.0000 | 5 | yes |
GO:0051963 | regulation of synapse assembly | 25.0000 | 6 | yes |
GO:0072578 | neurotransmitter-gated ion channel clustering | 25.0000 | 6 | yes |
GO:0072657 | protein localization to membrane | 25.0000 | 4 | yes |
GO:1901888 | regulation of cell junction assembly | 25.0000 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0033993 | response to lipid | 25.0000 | 4 | no |
GO:0022898 | regulation of transmembrane transporter activity | 25.0000 | 4 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 25.0000 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | no |
GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0051222 | positive regulation of protein transport | 25.0000 | 5 | no |
GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | no |
GO:1904062 | regulation of cation transmembrane transport | 25.0000 | 6 | no |
GO:1904951 | positive regulation of establishment of protein localization | 25.0000 | 6 | no |
GO:1905475 | regulation of protein localization to membrane | 25.0000 | 6 | no |
GO:1905477 | positive regulation of protein localization to membrane | 25.0000 | 6 | no |
GO:2001257 | regulation of cation channel activity | 25.0000 | 6 | no |
GO:0032386 | regulation of intracellular transport | 25.0000 | 5 | no |
GO:0033157 | regulation of intracellular protein transport | 25.0000 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FKRP_HUMAN | [view interactions] | High throughput | no | yes |
MSS4_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
IFN17_HUMAN | [view interactions] | High throughput | no | no |
TX264_HUMAN | [view interactions] | High throughput | no | no |
CP054_HUMAN | [view interactions] | High throughput | no | no |
PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EFC4B_HUMAN | [view interactions] | High throughput | no | no |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NJMU_HUMAN | [view interactions] | High throughput | no | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
TP4A1_HUMAN | [view interactions] | High throughput | no | no |
PEBB_HUMAN | [view interactions] | High throughput | no | no |
RN114_HUMAN | [view interactions] | High throughput | no | no |
ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
HM20B_HUMAN | [view interactions] | High throughput | no | yes |
GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
F91A1_HUMAN | [view interactions] | High throughput | no | yes |
RABL3_HUMAN | [view interactions] | High throughput | no | yes |
RET7_HUMAN | [view interactions] | High throughput | no | yes |
SL9A1_HUMAN | [view interactions] | High throughput | no | no |
PTER_HUMAN | [view interactions] | High throughput | no | yes |
PPAL_HUMAN | [view interactions] | High throughput | no | no |
GAMT_HUMAN | [view interactions] | High throughput | no | no |
NLGN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |