LHPL4_HUMAN
Evidence for PS localization
Functions
Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LHPL4_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 42.8571 | 4 | no |
| GO:0046872 | metal ion binding | 42.8571 | 5 | no |
| GO:0000166 | nucleotide binding | 28.5714 | 4 | no |
| GO:0005524 | ATP binding | 28.5714 | 5 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | no |
| GO:0043168 | anion binding | 28.5714 | 4 | no |
| GO:0042803 | protein homodimerization activity | 28.5714 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LHPL4_HUMAN |
|---|---|---|---|---|
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 28.5714 | 4 | no |
| GO:0033993 | response to lipid | 28.5714 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 28.5714 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IFN17_HUMAN | [view interactions] | High throughput | no | no |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| FKRP_HUMAN | [view interactions] | High throughput | no | yes |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| CP054_HUMAN | [view interactions] | High throughput | no | no |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFC4B_HUMAN | [view interactions] | High throughput | no | no |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NJMU_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| HM20B_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| RET7_HUMAN | [view interactions] | High throughput | no | yes |
| SL9A1_HUMAN | [view interactions] | High throughput | no | no |
| PTER_HUMAN | [view interactions] | High throughput | no | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| GAMT_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |