PRPS1_HUMAN
Evidence for PS localization
Functions
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 114 | Asn | Ser | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 183 | Asp | His | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 52 | Asp | His | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 129 | Leu | Ile | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 190 | Ala | Val | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 193 | His | Gln | Phosphoribosylpyrophosphatesynthetasesuperactivity(PRPS1superactivity) | - |
| 43 | Glu | Asp | Charcot-Marie-Toothdisease,X-linkedrecessive,5(CMTX5) | - |
| 115 | Met | Thr | Charcot-Marie-Toothdisease,X-linkedrecessive,5(CMTX5) | - |
| 133 | Gln | Pro | ARTSsyndrome(ARTS) | - |
| 152 | Leu | Pro | ARTSsyndrome(ARTS) | - |
| 65 | Asp | Asn | Deafness,X-linked,1(DFNX1) | - |
| 87 | Ala | Thr | Deafness,X-linked,1(DFNX1) | - |
| 290 | Ile | Thr | Deafness,X-linked,1(DFNX1) | - |
| 306 | Gly | Arg | Deafness,X-linked,1(DFNX1) | - |
| 16 | Ser | Pro | - | - |
| 142 | Val | Leu | - | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PRPS1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
| GO:0005524 | ATP binding | 24.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.0000 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 22.0000 | 4 | yes |
| GO:0016301 | kinase activity | 18.0000 | 4 | yes |
| GO:0000287 | magnesium ion binding | 10.0000 | 5 | yes |
| GO:0004749 | ribose phosphate diphosphokinase activity | 4.0000 | 5 | yes |
| GO:0016778 | diphosphotransferase activity | 4.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PRPS1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 38.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 38.0000 | 5 | no |
| GO:0036211 | protein modification process | 38.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 38.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 34.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.0000 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.0000 | 5 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0051049 | regulation of transport | 28.0000 | 4 | no |
| GO:0060548 | negative regulation of cell death | 28.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 28.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.0000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0000 | 6 | no |
| GO:0009894 | regulation of catabolic process | 26.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0000 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 24.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.0000 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 24.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.0000 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.0000 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.0000 | 6 | no |
| GO:0016310 | phosphorylation | 22.0000 | 5 | no |
| GO:0030162 | regulation of proteolysis | 22.0000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.0000 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 22.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.0000 | 5 | no |
| GO:0018130 | heterocycle biosynthetic process | 14.0000 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 14.0000 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 14.0000 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 14.0000 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 14.0000 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 10.0000 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 10.0000 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 10.0000 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 8.0000 | 5 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 8.0000 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 8.0000 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 8.0000 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 8.0000 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 6.0000 | 6 | yes |
| GO:0007399 | nervous system development | 6.0000 | 4 | yes |
| GO:0009165 | nucleotide biosynthetic process | 6.0000 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 6.0000 | 5 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 6.0000 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 6.0000 | 4 | yes |
| GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process | 4.0000 | 6 | yes |
| GO:0006144 | purine nucleobase metabolic process | 4.0000 | 5 | yes |
| GO:0006220 | pyrimidine nucleotide metabolic process | 4.0000 | 5 | yes |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | 4.0000 | 6 | yes |
| GO:0009112 | nucleobase metabolic process | 4.0000 | 4 | yes |
| GO:0009113 | purine nucleobase biosynthetic process | 4.0000 | 6 | yes |
| GO:0009116 | nucleoside metabolic process | 4.0000 | 4 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 4.0000 | 5 | yes |
| GO:0009124 | nucleoside monophosphate biosynthetic process | 4.0000 | 6 | yes |
| GO:0009156 | ribonucleoside monophosphate biosynthetic process | 4.0000 | 7 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 4.0000 | 6 | yes |
| GO:0034418 | urate biosynthetic process | 4.0000 | 4 | yes |
| GO:0046100 | hypoxanthine metabolic process | 4.0000 | 6 | yes |
| GO:0046101 | hypoxanthine biosynthetic process | 4.0000 | 7 | yes |
| GO:0046112 | nucleobase biosynthetic process | 4.0000 | 5 | yes |
| GO:0046391 | 5-phosphoribose 1-diphosphate metabolic process | 4.0000 | 5 | yes |
| GO:0072527 | pyrimidine-containing compound metabolic process | 4.0000 | 4 | yes |
| GO:0072528 | pyrimidine-containing compound biosynthetic process | 4.0000 | 5 | yes |
| GO:1901657 | glycosyl compound metabolic process | 4.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PRPS1_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 8.0000 | 3 | yes |
| DOID:0050563 | nonsyndromic deafness | 6.0000 | 5 | yes |
| DOID:0060038 | specific developmental disorder | 6.0000 | 3 | yes |
| DOID:1059 | intellectual disability | 6.0000 | 4 | yes |
| DOID:2742 | auditory system disease | 6.0000 | 4 | yes |
| DOID:0050542 | Charcot-Marie-Tooth disease type X | 4.0000 | 7 | yes |
| DOID:0050566 | X-linked nonsyndromic deafness | 4.0000 | 6 | yes |
| DOID:0050647 | Arts syndrome | 4.0000 | 7 | yes |
| DOID:0050888 | syndromic intellectual disability | 4.0000 | 5 | yes |
| DOID:0060309 | syndromic X-linked intellectual disability | 4.0000 | 6 | yes |
| DOID:0110210 | Charcot-Marie-Tooth disease X-linked recessive 5 | 4.0000 | 8 | yes |
| DOID:0111260 | phosphoribosylpyrophosphate synthetase superactivity | 4.0000 | 3 | yes |
| DOID:0111739 | X-linked deafness 1 | 4.0000 | 7 | yes |
| DOID:10595 | Charcot-Marie-Tooth disease | 4.0000 | 6 | yes |
| DOID:440 | neuromuscular disease | 4.0000 | 5 | yes |
| DOID:574 | peripheral nervous system disease | 4.0000 | 3 | yes |
| DOID:870 | neuropathy | 4.0000 | 4 | yes |
| DOID:110 | lens disease | 4.0000 | 5 | no |
| DOID:5614 | eye disease | 4.0000 | 4 | no |
| DOID:83 | cataract | 4.0000 | 6 | no |
| DOID:612 | primary immunodeficiency disease | 4.0000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KPRA_HUMAN | [view interactions] | Low throughput | no | no |
| PRPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRMS1_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL4_HUMAN | [view interactions] | High throughput | no | yes |
| H90B4_HUMAN | [view interactions] | High throughput | no | no |
| ELF2_HUMAN | [view interactions] | High throughput | no | yes |
| PLSI_HUMAN | [view interactions] | High throughput | no | no |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS3_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELK4_HUMAN | [view interactions] | High throughput | no | yes |
| CAV2_HUMAN | [view interactions] | High throughput | no | no |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDG_HUMAN | [view interactions] | High throughput | no | yes |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| KT33B_HUMAN | [view interactions] | High throughput | no | no |
| HXK3_HUMAN | [view interactions] | High throughput | no | no |
| FANCG_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| TEN1L_HUMAN | [view interactions] | High throughput | no | no |
| AQP8_HUMAN | [view interactions] | High throughput | no | no |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| CITE2_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FEZ2_HUMAN | [view interactions] | High throughput | no | yes |
| F16P2_HUMAN | [view interactions] | High throughput | no | no |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC9_HUMAN | [view interactions] | High throughput | no | yes |
| ZKSC8_HUMAN | [view interactions] | High throughput | no | yes |
| SPY4_HUMAN | [view interactions] | High throughput | no | yes |
| ZXDC_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TASO2_HUMAN | [view interactions] | High throughput | no | yes |
| PLPR1_HUMAN | [view interactions] | High throughput | no | no |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| PELO_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| CRLF3_HUMAN | [view interactions] | High throughput | no | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RAI2_HUMAN | [view interactions] | High throughput | no | no |
| RPC6_HUMAN | [view interactions] | High throughput | no | yes |
| BATF_HUMAN | [view interactions] | High throughput | no | no |
| UB2E3_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| LENG8_HUMAN | [view interactions] | High throughput | no | yes |
| PGRP3_HUMAN | [view interactions] | High throughput | no | no |
| MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
| MPND_HUMAN | [view interactions] | High throughput | no | yes |
| PHF5A_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| ASCL4_HUMAN | [view interactions] | High throughput | no | no |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| IQCF2_HUMAN | [view interactions] | High throughput | no | no |
| VSX2_HUMAN | [view interactions] | High throughput | no | no |
| CC141_HUMAN | [view interactions] | High throughput | no | no |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| SPRE2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN366_HUMAN | [view interactions] | High throughput | no | yes |
| ZN296_HUMAN | [view interactions] | High throughput | no | no |
| ZN497_HUMAN | [view interactions] | High throughput | no | no |
| CH048_HUMAN | [view interactions] | High throughput | no | no |
| MET27_HUMAN | [view interactions] | High throughput | no | yes |
| F117B_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| VP37A_HUMAN | [view interactions] | High throughput | no | yes |
| CG031_HUMAN | [view interactions] | High throughput | no | no |
| ZNF57_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB11_HUMAN | [view interactions] | High throughput | no | no |
| ASB18_HUMAN | [view interactions] | High throughput | no | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH13_HUMAN | [view interactions] | High throughput | no | no |
| TOP1M_HUMAN | [view interactions] | High throughput | no | yes |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| CRBN_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| LPD6B_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WN10A_HUMAN | [view interactions] | High throughput | no | no |
| DTWD2_HUMAN | [view interactions] | High throughput | no | no |
| DCA16_HUMAN | [view interactions] | High throughput | no | no |
| MGAP_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESQ1_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H1BP3_HUMAN | [view interactions] | High throughput | no | yes |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| LHPL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOH1B_HUMAN | [view interactions] | High throughput | no | no |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| PHYD1_HUMAN | [view interactions] | High throughput | no | no |
| IL25_HUMAN | [view interactions] | High throughput | no | no |
| TF2H1_HUMAN | [view interactions] | High throughput | no | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THTPA_HUMAN | [view interactions] | High throughput | no | yes |
| AQ12B_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNC_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| PUR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DKC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX47_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH1_HUMAN | [view interactions] | High throughput | no | yes |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| TRM11_HUMAN | [view interactions] | High throughput | no | no |
| TRM6_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DNJA4_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP3_HUMAN | [view interactions] | High throughput | no | yes |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| FBX31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPIA_HUMAN | [view interactions] | Computational | no | yes |
| UMPS_HUMAN | [view interactions] | Computational | no | no |
| TKTL1_HUMAN | [view interactions] | Computational | no | no |
| TKTL2_HUMAN | [view interactions] | Computational | no | no |
| NUDT9_HUMAN | [view interactions] | Computational | no | yes |
| ADPRM_HUMAN | [view interactions] | Computational | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGM2_HUMAN | [view interactions] | Computational | no | no |
| RBSK_HUMAN | [view interactions] | Computational | no | yes |
| NUDT5_HUMAN | [view interactions] | Computational | no | no |