Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBB2B_HUMAN

Tubulin is the major constituent of microtubules (PubMed, PubMed, PubMed). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain . Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed). Implicated in neuronal migration (PubMed). [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TBB2B_HUMAN
GO:0043168 anion binding 34.7826 4 yes
GO:0000166 nucleotide binding 33.6957 4 yes
GO:0017076 purine nucleotide binding 32.6087 5 yes
GO:0032555 purine ribonucleotide binding 31.5217 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.4348 4 yes
GO:0043169 cation binding 27.1739 4 yes
GO:0046872 metal ion binding 27.1739 5 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 22.8261 6 no
GO:0003723 RNA binding 22.8261 4 no
GO:0016462 pyrophosphatase activity 21.7391 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.7391 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.7391 6 yes
GO:0032559 adenyl ribonucleotide binding 21.7391 5 no
GO:0019901 protein kinase binding 21.7391 5 no
GO:0005524 ATP binding 20.6522 5 no
GO:0005525 GTP binding 10.8696 5 yes
GO:0019001 guanyl nucleotide binding 10.8696 6 yes
GO:0032561 guanyl ribonucleotide binding 10.8696 5 yes
GO:0003924 GTPase activity 9.7826 7 yes
GO:0046982 protein heterodimerization activity 5.4348 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBB2B_HUMAN
GO:0048522 positive regulation of cellular process 57.6087 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.1739 4 no
GO:0031323 regulation of cellular metabolic process 47.8261 4 no
GO:0080090 regulation of primary metabolic process 47.8261 4 no
GO:0051128 regulation of cellular component organization 46.7391 4 yes
GO:0006996 organelle organization 44.5652 4 yes
GO:0048523 negative regulation of cellular process 44.5652 4 no
GO:0010646 regulation of cell communication 43.4783 4 yes
GO:0008104 protein localization 39.1304 4 no
GO:0009889 regulation of biosynthetic process 38.0435 4 no
GO:0009893 positive regulation of metabolic process 35.8696 4 no
GO:0022607 cellular component assembly 35.8696 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.8696 5 no
GO:0031326 regulation of cellular biosynthetic process 35.8696 5 no
GO:0010604 positive regulation of macromolecule metabolic process 34.7826 5 no
GO:0051246 regulation of protein metabolic process 33.6957 5 no
GO:0009966 regulation of signal transduction 31.5217 4 no
GO:0060341 regulation of cellular localization 30.4348 4 no
GO:0010468 regulation of gene expression 29.3478 6 no
GO:0032880 regulation of protein localization 29.3478 5 no
GO:0007010 cytoskeleton organization 28.2609 5 yes
GO:0036211 protein modification process 28.2609 4 no
GO:0043412 macromolecule modification 28.2609 4 no
GO:0009892 negative regulation of metabolic process 28.2609 4 no
GO:0031324 negative regulation of cellular metabolic process 28.2609 5 no
GO:0051049 regulation of transport 27.1739 4 no
GO:0051130 positive regulation of cellular component organization 27.1739 5 yes
GO:0023056 positive regulation of signaling 27.1739 4 no
GO:0043933 protein-containing complex organization 27.1739 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0870 5 no
GO:0010647 positive regulation of cell communication 26.0870 5 no
GO:0031325 positive regulation of cellular metabolic process 26.0870 5 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0051247 positive regulation of protein metabolic process 26.0870 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 23.9130 4 no
GO:0033043 regulation of organelle organization 22.8261 5 no
GO:0044087 regulation of cellular component biogenesis 22.8261 4 no
GO:0019220 regulation of phosphate metabolic process 22.8261 6 no
GO:0051174 regulation of phosphorus metabolic process 22.8261 5 no
GO:0031344 regulation of cell projection organization 21.7391 5 yes
GO:0030030 cell projection organization 21.7391 4 no
GO:0010648 negative regulation of cell communication 20.6522 5 no
GO:0023057 negative regulation of signaling 20.6522 4 no
GO:0048585 negative regulation of response to stimulus 20.6522 4 no
GO:0071310 cellular response to organic substance 20.6522 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6522 6 yes
GO:0071702 organic substance transport 20.6522 4 no
GO:0071705 nitrogen compound transport 20.6522 4 no
GO:0009890 negative regulation of biosynthetic process 20.6522 5 no
GO:0050804 modulation of chemical synaptic transmission 19.5652 5 yes
GO:0099177 regulation of trans-synaptic signaling 19.5652 4 yes
GO:0010975 regulation of neuron projection development 15.2174 7 yes
GO:0032101 regulation of response to external stimulus 15.2174 4 yes
GO:0031346 positive regulation of cell projection organization 10.8696 6 yes
GO:0001764 neuron migration 8.6957 4 yes
GO:0010976 positive regulation of neuron projection development 4.3478 7 yes
GO:0050920 regulation of chemotaxis 4.3478 4 yes
GO:0048568 embryonic organ development 2.1739 4 yes
GO:1902667 regulation of axon guidance 2.1739 5 yes
GO:1902669 positive regulation of axon guidance 2.1739 6 yes
GO:1990403 embryonic brain development 2.1739 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TBB2A_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
TBA1C_HUMAN [view interactions] Low throughput no yes
TBA4A_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
TBB2B_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO10_HUMAN [view interactions] Low throughput no no
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
ZNRF1_HUMAN [view interactions] Low throughput no yes
MK_HUMAN [view interactions] Low throughput no no
ZC21B_HUMAN [view interactions] High throughput no no
GP107_HUMAN [view interactions] High throughput no yes
CPXCR_HUMAN [view interactions] High throughput no no
LAD1_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
MOGT3_HUMAN [view interactions] High throughput no yes
PRDM7_HUMAN [view interactions] High throughput no no
ARMX6_HUMAN [view interactions] High throughput no yes
SACA9_HUMAN [view interactions] High throughput no no
MICB_HUMAN [view interactions] High throughput no no
BORG5_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
GMPPB_HUMAN [view interactions] High throughput no yes
NDST3_HUMAN [view interactions] High throughput no yes
ZMYM4_HUMAN [view interactions] High throughput no yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
POTEF_HUMAN [view interactions] High throughput no no
L2HDH_HUMAN [view interactions] High throughput no yes
RFFL_HUMAN [view interactions] High throughput no yes
CD1A_HUMAN [view interactions] High throughput no no
EMAL3_HUMAN [view interactions] High throughput no no
ABRX2_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
ZN333_HUMAN [view interactions] High throughput no no
F177A_HUMAN [view interactions] High throughput no no
FBLN7_HUMAN [view interactions] High throughput no no
CND3_HUMAN [view interactions] High throughput no yes
NEUR1_HUMAN [view interactions] High throughput no yes
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
PRD14_HUMAN [view interactions] High throughput no no
CBCO1_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR46_HUMAN [view interactions] High throughput no yes
GRPL2_HUMAN [view interactions] High throughput no no
RBSK_HUMAN [view interactions] High throughput no yes
CLP1_HUMAN [view interactions] High throughput no yes
BACD1_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ZN363_HUMAN [view interactions] High throughput no yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI31_HUMAN [view interactions] High throughput no no
PLD2_HUMAN [view interactions] High throughput no yes
PLD3_HUMAN [view entry] [view interactions] High throughput yes yes
PLD5_HUMAN [view interactions] High throughput no no
PLD6_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
KCTD9_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
MK08_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
EFNA3_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3E_HUMAN [view interactions] High throughput no no
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ATG4B_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CEP76_HUMAN [view interactions] High throughput no yes
BID_HUMAN [view interactions] High throughput no no
SCG1_HUMAN [view interactions] High throughput no no
CH033_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CENPU_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
RGS2_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI1_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
DIRA3_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
FTM_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
NPHP4_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
COP1_HUMAN [view interactions] High throughput no no
TRPM7_HUMAN [view interactions] High throughput no no
SMU1_HUMAN [view interactions] High throughput no yes
PR15A_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
LRP1_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
TRYB2_HUMAN [view interactions] High throughput no no
EMAL2_HUMAN [view interactions] High throughput no yes
ARL2_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
CAYP1_HUMAN [view interactions] High throughput no no
TBB8_HUMAN [view interactions] High throughput no no
EMAL6_HUMAN [view interactions] High throughput no no
TTC5_HUMAN [view interactions] High throughput no yes
TBB1_HUMAN [view interactions] High throughput no yes
EMAL4_HUMAN [view interactions] High throughput no yes
T11L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
CNR2_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
SIM26_HUMAN [view interactions] High throughput no no
CLC4G_HUMAN [view interactions] High throughput no no
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
PPE1_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
MIPT3_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
LN28A_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
IKKB_HUMAN [view interactions] High throughput no yes
M3K1_HUMAN [view interactions] High throughput no yes
M3K3_HUMAN [view interactions] High throughput no no
M3K14_HUMAN [view interactions] High throughput no yes
RIPK2_HUMAN [view interactions] High throughput no yes
RIPK3_HUMAN [view interactions] High throughput no no
TAB1_HUMAN [view interactions] High throughput no yes
TNR1A_HUMAN [view interactions] High throughput no yes
TNR1B_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LMBL1_HUMAN [view interactions] High throughput no no
B9D1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RSPH1_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
RPGR_HUMAN [view interactions] High throughput no yes
CG025_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
NANP8_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
ATX3_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
MET22_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
ASB17_HUMAN [view interactions] High throughput no no
CP250_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
OZF_HUMAN [view interactions] High throughput no yes
SEN2_HUMAN [view interactions] High throughput no yes
EMAL1_HUMAN [view interactions] High throughput no no
C42S2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
PODO_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
MCM5_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
PO5F1_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
INADL_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CBAR1_HUMAN [view interactions] High throughput no no
TEDC2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
APC4_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
TFE3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT7B_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR76_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
OSTM1_HUMAN [view interactions] High throughput no yes