CAC1A_HUMAN
Evidence for PS localization
Functions
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the high-voltage activated (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) . They are however insensitive to dihydropyridines (DHP). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAC1A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 42.8571 | 4 | yes |
| GO:0046872 | metal ion binding | 42.8571 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 16.3265 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 14.2857 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0015267 | channel activity | 14.2857 | 4 | yes |
| GO:0022836 | gated channel activity | 14.2857 | 5 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 12.2449 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 12.2449 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 12.2449 | 5 | yes |
| GO:0005262 | calcium channel activity | 12.2449 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 12.2449 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 12.2449 | 6 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 12.2449 | 6 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 12.2449 | 5 | yes |
| GO:0008331 | high voltage-gated calcium channel activity | 8.1633 | 8 | yes |
| GO:0019905 | syntaxin binding | 6.1224 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAC1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 44.8980 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.8163 | 4 | yes |
| GO:0051049 | regulation of transport | 36.7347 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.6939 | 4 | no |
| GO:0022607 | cellular component assembly | 30.6122 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.6122 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 24.4898 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 24.4898 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 24.4898 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.4490 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 22.4490 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 20.4082 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.4082 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.4082 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 20.4082 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 20.4082 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 18.3673 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 18.3673 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 16.3265 | 7 | yes |
| GO:0010243 | response to organonitrogen compound | 16.3265 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 16.3265 | 6 | yes |
| GO:0099536 | synaptic signaling | 16.3265 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 16.3265 | 5 | yes |
| GO:0098657 | import into cell | 14.2857 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 12.2449 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 12.2449 | 5 | yes |
| GO:0006816 | calcium ion transport | 12.2449 | 7 | yes |
| GO:0030001 | metal ion transport | 12.2449 | 6 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 12.2449 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 12.2449 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 12.2449 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 10.2041 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 10.2041 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 10.2041 | 4 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 8.1633 | 6 | yes |
| GO:0070509 | calcium ion import | 6.1224 | 8 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 6.1224 | 5 | yes |
| GO:0098703 | calcium ion import across plasma membrane | 6.1224 | 6 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 6.1224 | 4 | yes |
| GO:1902656 | calcium ion import into cytosol | 6.1224 | 8 | yes |
| GO:1904645 | response to amyloid-beta | 6.1224 | 4 | yes |
| GO:1904646 | cellular response to amyloid-beta | 6.1224 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CABP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN138_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLHL1_HUMAN | [view interactions] | Low throughput | no | no |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CACB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CACB2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
| BCL6_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTBP1_HUMAN | [view interactions] | High throughput | no | no |
| LTBP3_HUMAN | [view interactions] | High throughput | no | no |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NALCN_HUMAN | [view interactions] | High throughput | no | no |
| SCNAA_HUMAN | [view interactions] | High throughput | no | no |
| SCNBA_HUMAN | [view interactions] | High throughput | no | no |
| SCN5A_HUMAN | [view interactions] | High throughput | no | no |
| SCN9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| GET3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMGO2_HUMAN | [view interactions] | High throughput | no | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIMB1_HUMAN | [view interactions] | High throughput | no | yes |
| C1QT1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIM1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| FBLN4_HUMAN | [view interactions] | High throughput | no | no |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBLN1_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| HHATL_HUMAN | [view interactions] | High throughput | no | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAG2_HUMAN | [view interactions] | High throughput | no | yes |
| IP6K1_HUMAN | [view interactions] | High throughput | no | yes |
| PGBM_HUMAN | [view interactions] | High throughput | no | no |
| HECW1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZEP1_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR3_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL1_HUMAN | [view interactions] | High throughput | no | no |
| L2GL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRM4_HUMAN | [view interactions] | High throughput | no | no |
| P33MX_HUMAN | [view interactions] | High throughput | no | yes |
| TELO2_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTBP4_HUMAN | [view interactions] | High throughput | no | yes |
| MANBL_HUMAN | [view interactions] | High throughput | no | yes |
| MATK_HUMAN | [view interactions] | High throughput | no | yes |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| MEGF6_HUMAN | [view interactions] | High throughput | no | yes |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| MEGF8_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NELL1_HUMAN | [view interactions] | High throughput | no | yes |
| NELL2_HUMAN | [view interactions] | High throughput | no | no |
| NOXA1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLIG1_HUMAN | [view interactions] | High throughput | no | no |
| PP12C_HUMAN | [view interactions] | High throughput | no | yes |
| PPIG_HUMAN | [view interactions] | High throughput | no | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCSK6_HUMAN | [view interactions] | High throughput | no | yes |
| PCSK5_HUMAN | [view interactions] | High throughput | no | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB12B_HUMAN | [view interactions] | High throughput | no | yes |
| PTGDS_HUMAN | [view interactions] | High throughput | no | yes |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| RBP56_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF2_HUMAN | [view interactions] | High throughput | no | yes |
| SPY1_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| TSN7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VWF_HUMAN | [view interactions] | High throughput | no | no |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN233_HUMAN | [view interactions] | High throughput | no | no |
| ZCC17_HUMAN | [view interactions] | High throughput | no | yes |
| YLPM1_HUMAN | [view interactions] | High throughput | no | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |