CACB4_HUMAN
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CACB4_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 70.0000 | 4 | yes |
GO:0005244 | voltage-gated ion channel activity | 70.0000 | 4 | yes |
GO:0005245 | voltage-gated calcium channel activity | 70.0000 | 6 | yes |
GO:0005261 | cation channel activity | 70.0000 | 5 | yes |
GO:0005262 | calcium channel activity | 70.0000 | 6 | yes |
GO:0008324 | cation transmembrane transporter activity | 70.0000 | 4 | yes |
GO:0015085 | calcium ion transmembrane transporter activity | 70.0000 | 6 | yes |
GO:0015267 | channel activity | 70.0000 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 70.0000 | 6 | yes |
GO:0022836 | gated channel activity | 70.0000 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 70.0000 | 5 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 70.0000 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 70.0000 | 5 | yes |
GO:0046872 | metal ion binding | 35.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CACB4_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 85.0000 | 4 | yes |
GO:0043269 | regulation of ion transport | 80.0000 | 5 | yes |
GO:0034762 | regulation of transmembrane transport | 75.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 75.0000 | 5 | yes |
GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 55.0000 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 50.0000 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 50.0000 | 5 | yes |
GO:2001257 | regulation of cation channel activity | 50.0000 | 6 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 45.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 45.0000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 45.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 45.0000 | 4 | no |
GO:0006811 | ion transport | 40.0000 | 4 | no |
GO:0006812 | cation transport | 40.0000 | 5 | no |
GO:0006816 | calcium ion transport | 40.0000 | 7 | no |
GO:0008104 | protein localization | 40.0000 | 4 | no |
GO:0030001 | metal ion transport | 40.0000 | 6 | no |
GO:0051050 | positive regulation of transport | 40.0000 | 4 | no |
GO:0050806 | positive regulation of synaptic transmission | 40.0000 | 5 | no |
GO:0016192 | vesicle-mediated transport | 35.0000 | 4 | no |
GO:0010959 | regulation of metal ion transport | 30.0000 | 6 | yes |
GO:0051924 | regulation of calcium ion transport | 30.0000 | 7 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 30.0000 | 7 | yes |
GO:0043270 | positive regulation of ion transport | 30.0000 | 5 | no |
GO:0072657 | protein localization to membrane | 30.0000 | 4 | no |
GO:0006897 | endocytosis | 30.0000 | 5 | no |
GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 30.0000 | 6 | no |
GO:0071702 | organic substance transport | 30.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
GO:0007268 | chemical synaptic transmission | 25.0000 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 25.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | yes |
GO:1901019 | regulation of calcium ion transmembrane transporter activity | 25.0000 | 6 | yes |
GO:1901385 | regulation of voltage-gated calcium channel activity | 25.0000 | 7 | yes |
GO:0032411 | positive regulation of transporter activity | 25.0000 | 4 | no |
GO:0032414 | positive regulation of ion transmembrane transporter activity | 25.0000 | 5 | no |
GO:0034764 | positive regulation of transmembrane transport | 25.0000 | 5 | no |
GO:0034767 | positive regulation of ion transmembrane transport | 25.0000 | 6 | no |
GO:1904064 | positive regulation of cation transmembrane transport | 25.0000 | 7 | no |
GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | no |
GO:2001259 | positive regulation of cation channel activity | 25.0000 | 6 | no |
GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
GO:0006898 | receptor-mediated endocytosis | 25.0000 | 6 | no |
GO:0007034 | vacuolar transport | 25.0000 | 4 | no |
GO:0007041 | lysosomal transport | 25.0000 | 5 | no |
GO:0008333 | endosome to lysosome transport | 25.0000 | 5 | no |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0031623 | receptor internalization | 25.0000 | 7 | no |
GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
GO:0061462 | protein localization to lysosome | 25.0000 | 7 | no |
GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | no |
GO:0072665 | protein localization to vacuole | 25.0000 | 6 | no |
GO:0072666 | establishment of protein localization to vacuole | 25.0000 | 5 | no |
GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 25.0000 | 4 | no |
GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
GO:0099601 | regulation of neurotransmitter receptor activity | 25.0000 | 4 | no |
GO:0099628 | neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
GO:2000311 | regulation of AMPA receptor activity | 25.0000 | 5 | no |
GO:0044057 | regulation of system process | 25.0000 | 4 | no |
GO:0007528 | neuromuscular junction development | 20.0000 | 6 | yes |
GO:0034330 | cell junction organization | 20.0000 | 4 | yes |
GO:0050808 | synapse organization | 20.0000 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
THA_HUMAN | [view interactions] | Low throughput | no | yes |
CBX3_HUMAN | [view interactions] | Low throughput | no | yes |
H4_HUMAN | [view interactions] | Low throughput | no | yes |
PP2AB_HUMAN | [view interactions] | Low throughput | no | yes |
CACB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
RIMS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
GT252_HUMAN | [view interactions] | High throughput | no | yes |
CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
CAC1D_HUMAN | [view interactions] | High throughput | no | yes |
CAC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C102B_HUMAN | [view interactions] | High throughput | no | yes |
EFHC2_HUMAN | [view interactions] | High throughput | no | no |
MED31_HUMAN | [view interactions] | High throughput | no | yes |
PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBL3_HUMAN | [view interactions] | High throughput | no | yes |
CTBP2_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
IDE_HUMAN | [view interactions] | High throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CACB2_HUMAN | [view interactions] | High throughput | no | yes |
CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CA2D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CA2D3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CTSR3_HUMAN | [view interactions] | Computational | no | no |
CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CAC1S_HUMAN | [view interactions] | Computational | no | no |
CCG6_HUMAN | [view interactions] | Computational | no | no |
CAC1F_HUMAN | [view interactions] | Computational | no | no |
2A5D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CTSR1_HUMAN | [view interactions] | Computational | no | no |
CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CAC1G_HUMAN | [view interactions] | Computational | no | no |
CCG1_HUMAN | [view interactions] | Computational | no | no |
CA2D4_HUMAN | [view interactions] | Computational | no | no |
CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |