Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CACB4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CACB4_HUMAN
GO:0005216 monoatomic ion channel activity 50.0000 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 50.0000 5 yes
GO:0005245 voltage-gated calcium channel activity 50.0000 7 yes
GO:0005261 monoatomic cation channel activity 50.0000 5 yes
GO:0005262 calcium channel activity 50.0000 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 50.0000 4 yes
GO:0015085 calcium ion transmembrane transporter activity 50.0000 6 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0022832 voltage-gated channel activity 50.0000 6 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 50.0000 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 yes
GO:0043169 cation binding 35.7143 4 no
GO:0046872 metal ion binding 35.7143 5 no
GO:0008331 high voltage-gated calcium channel activity 28.5714 8 no
GO:0019900 kinase binding 21.4286 4 yes
GO:0019901 protein kinase binding 21.4286 5 yes
GO:0019905 syntaxin binding 21.4286 4 no
GO:0043168 anion binding 21.4286 4 no
GO:0099511 voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels 14.2857 8 yes
GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels 14.2857 9 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CACB4_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0099177 regulation of trans-synaptic signaling 64.2857 4 yes
GO:0048522 positive regulation of cellular process 64.2857 4 yes
GO:0050804 modulation of chemical synaptic transmission 64.2857 5 yes
GO:0051049 regulation of transport 64.2857 4 yes
GO:0098916 anterograde trans-synaptic signaling 42.8571 6 yes
GO:0099536 synaptic signaling 42.8571 4 yes
GO:0099537 trans-synaptic signaling 42.8571 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 42.8571 6 yes
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0007268 chemical synaptic transmission 42.8571 7 yes
GO:0010959 regulation of metal ion transport 42.8571 6 yes
GO:0034762 regulation of transmembrane transport 42.8571 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 42.8571 5 yes
GO:0043269 regulation of monoatomic ion transport 42.8571 5 yes
GO:0051924 regulation of calcium ion transport 42.8571 7 yes
GO:0060627 regulation of vesicle-mediated transport 42.8571 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 35.7143 7 yes
GO:1903305 regulation of regulated secretory pathway 35.7143 6 yes
GO:1903530 regulation of secretion by cell 35.7143 4 yes
GO:2000300 regulation of synaptic vesicle exocytosis 35.7143 6 yes
GO:0006811 monoatomic ion transport 35.7143 4 no
GO:0006812 monoatomic cation transport 35.7143 5 no
GO:0006816 calcium ion transport 35.7143 7 no
GO:0030001 metal ion transport 35.7143 6 no
GO:0070588 calcium ion transmembrane transport 35.7143 5 no
GO:0097553 calcium ion transmembrane import into cytosol 35.7143 6 no
GO:0098655 monoatomic cation transmembrane transport 35.7143 4 no
GO:0098657 import into cell 35.7143 4 no
GO:0098662 inorganic cation transmembrane transport 35.7143 4 no
GO:0017157 regulation of exocytosis 35.7143 5 yes
GO:0022898 regulation of transmembrane transporter activity 35.7143 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 35.7143 5 yes
GO:0046928 regulation of neurotransmitter secretion 35.7143 5 yes
GO:0048523 negative regulation of cellular process 35.7143 4 yes
GO:0048584 positive regulation of response to stimulus 35.7143 4 yes
GO:0051046 regulation of secretion 35.7143 5 yes
GO:0051588 regulation of neurotransmitter transport 35.7143 5 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 28.5714 6 yes
GO:1901385 regulation of voltage-gated calcium channel activity 28.5714 7 yes
GO:2001257 regulation of cation channel activity 28.5714 6 yes
GO:0070509 calcium ion import 28.5714 8 no
GO:0098659 inorganic cation import across plasma membrane 28.5714 5 no
GO:0098703 calcium ion import across plasma membrane 28.5714 6 no
GO:0099587 inorganic ion import across plasma membrane 28.5714 4 no
GO:1902656 calcium ion import into cytosol 28.5714 8 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0001508 action potential 28.5714 4 yes
GO:0002684 positive regulation of immune system process 28.5714 4 yes
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 yes
GO:0046903 secretion 28.5714 4 yes
GO:0071702 organic substance transport 21.4286 4 yes
GO:0071705 nitrogen compound transport 21.4286 4 yes
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0006996 organelle organization 21.4286 4 no
GO:0008104 protein localization 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0050773 regulation of dendrite development 21.4286 4 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0050806 positive regulation of synaptic transmission 21.4286 5 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 21.4286 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 21.4286 4 yes
GO:0007528 neuromuscular junction development 21.4286 6 yes
GO:0008285 negative regulation of cell population proliferation 21.4286 5 yes
GO:0034330 cell junction organization 21.4286 4 yes
GO:0042127 regulation of cell population proliferation 21.4286 4 yes
GO:0050776 regulation of immune response 21.4286 4 yes
GO:0050778 positive regulation of immune response 21.4286 5 yes
GO:0050808 synapse organization 21.4286 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 21.4286 5 yes
GO:0050852 T cell receptor signaling pathway 21.4286 6 yes
GO:0071310 cellular response to organic substance 21.4286 4 yes
GO:0071345 cellular response to cytokine stimulus 14.2857 5 yes
GO:0072521 purine-containing compound metabolic process 14.2857 4 yes
GO:0090659 walking behavior 14.2857 4 yes
GO:0098870 action potential propagation 14.2857 5 yes
GO:1900180 regulation of protein localization to nucleus 14.2857 6 yes
GO:1900182 positive regulation of protein localization to nucleus 14.2857 6 yes
GO:1901987 regulation of cell cycle phase transition 14.2857 6 yes
GO:1901988 negative regulation of cell cycle phase transition 14.2857 7 yes
GO:1901990 regulation of mitotic cell cycle phase transition 14.2857 6 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 14.2857 7 yes
GO:1902806 regulation of cell cycle G1/S phase transition 14.2857 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 14.2857 8 yes
GO:1903829 positive regulation of protein localization 14.2857 5 yes
GO:1904749 regulation of protein localization to nucleolus 14.2857 7 yes
GO:1904751 positive regulation of protein localization to nucleolus 14.2857 7 yes
GO:1990823 response to leukemia inhibitory factor 14.2857 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 14.2857 6 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 14.2857 7 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 14.2857 8 yes
GO:0006163 purine nucleotide metabolic process 14.2857 5 yes
GO:0006753 nucleoside phosphate metabolic process 14.2857 4 yes
GO:0006865 amino acid transport 14.2857 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 14.2857 4 yes
GO:0007346 regulation of mitotic cell cycle 14.2857 5 yes
GO:0007628 adult walking behavior 14.2857 5 yes
GO:0008344 adult locomotory behavior 14.2857 4 yes
GO:0009117 nucleotide metabolic process 14.2857 5 yes
GO:0009150 purine ribonucleotide metabolic process 14.2857 6 yes
GO:0009187 cyclic nucleotide metabolic process 14.2857 6 yes
GO:0009259 ribonucleotide metabolic process 14.2857 5 yes
GO:0009416 response to light stimulus 14.2857 4 yes
GO:0009583 detection of light stimulus 14.2857 4 yes
GO:0009584 detection of visible light 14.2857 5 yes
GO:0010564 regulation of cell cycle process 14.2857 5 yes
GO:0010948 negative regulation of cell cycle process 14.2857 6 yes
GO:0014051 gamma-aminobutyric acid secretion 14.2857 6 yes
GO:0015711 organic anion transport 14.2857 5 yes
GO:0015812 gamma-aminobutyric acid transport 14.2857 5 yes
GO:0015849 organic acid transport 14.2857 5 yes
GO:0019227 neuronal action potential propagation 14.2857 4 yes
GO:0019693 ribose phosphate metabolic process 14.2857 4 yes
GO:0032880 regulation of protein localization 14.2857 5 yes
GO:0034097 response to cytokine 14.2857 4 yes
GO:0035249 synaptic transmission, glutamatergic 14.2857 8 yes
GO:0045786 negative regulation of cell cycle 14.2857 5 yes
GO:0045930 negative regulation of mitotic cell cycle 14.2857 6 yes
GO:0046058 cAMP metabolic process 14.2857 7 yes
GO:0046717 acid secretion 14.2857 5 yes
GO:0046942 carboxylic acid transport 14.2857 6 yes
GO:0048534 hematopoietic or lymphoid organ development 14.2857 4 yes
GO:0048536 spleen development 14.2857 5 yes
GO:0048537 mucosa-associated lymphoid tissue development 14.2857 4 yes
GO:0048538 thymus development 14.2857 5 yes
GO:0048541 Peyers patch development 14.2857 5 yes
GO:0048732 gland development 14.2857 4 yes
GO:0050908 detection of light stimulus involved in visual perception 14.2857 5 yes
GO:0050962 detection of light stimulus involved in sensory perception 14.2857 4 yes
GO:0051726 regulation of cell cycle 14.2857 4 yes
GO:0052652 cyclic purine nucleotide metabolic process 14.2857 6 yes
GO:0055001 muscle cell development 14.2857 4 yes
GO:0060341 regulation of cellular localization 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAC1A_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1B_HUMAN [view interactions] Low throughput no yes
RIMS3_HUMAN [view entry] [view interactions] Low throughput yes no
THA_HUMAN [view interactions] Low throughput no yes
CBX3_HUMAN [view interactions] Low throughput no yes
H4_HUMAN [view interactions] Low throughput no yes
PP2AB_HUMAN [view interactions] Low throughput no yes
CACB4_HUMAN [view entry] [view interactions] Low throughput yes yes
TBL3_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
CACB2_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
TNFL6_HUMAN [view interactions] High throughput no yes
CACB3_HUMAN [view entry] [view interactions] High throughput yes no
GT252_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
CAC1E_HUMAN [view entry] [view interactions] High throughput yes no
CAC1D_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
C102B_HUMAN [view interactions] High throughput no yes
EFHC2_HUMAN [view interactions] High throughput no no
MED31_HUMAN [view interactions] High throughput no yes
PTN_HUMAN [view entry] [view interactions] High throughput yes yes