Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CACB4_HUMAN

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CACB4_HUMAN
GO:0005216 ion channel activity 70.0000 4 yes
GO:0005244 voltage-gated ion channel activity 70.0000 4 yes
GO:0005245 voltage-gated calcium channel activity 70.0000 6 yes
GO:0005261 cation channel activity 70.0000 5 yes
GO:0005262 calcium channel activity 70.0000 6 yes
GO:0008324 cation transmembrane transporter activity 70.0000 4 yes
GO:0015085 calcium ion transmembrane transporter activity 70.0000 6 yes
GO:0015267 channel activity 70.0000 4 yes
GO:0022832 voltage-gated channel activity 70.0000 6 yes
GO:0022836 gated channel activity 70.0000 5 yes
GO:0022843 voltage-gated cation channel activity 70.0000 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 70.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 70.0000 5 yes
GO:0046872 metal ion binding 35.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CACB4_HUMAN
GO:0051049 regulation of transport 85.0000 4 yes
GO:0043269 regulation of ion transport 80.0000 5 yes
GO:0034762 regulation of transmembrane transport 75.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 75.0000 5 yes
GO:0048522 positive regulation of cellular process 70.0000 4 no
GO:1904062 regulation of cation transmembrane transport 55.0000 6 yes
GO:0022898 regulation of transmembrane transporter activity 50.0000 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 50.0000 5 yes
GO:2001257 regulation of cation channel activity 50.0000 6 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 45.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 45.0000 4 no
GO:0010647 positive regulation of cell communication 45.0000 5 no
GO:0023056 positive regulation of signaling 45.0000 4 no
GO:0006811 ion transport 40.0000 4 no
GO:0006812 cation transport 40.0000 5 no
GO:0006816 calcium ion transport 40.0000 7 no
GO:0008104 protein localization 40.0000 4 no
GO:0030001 metal ion transport 40.0000 6 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0050806 positive regulation of synaptic transmission 40.0000 5 no
GO:0016192 vesicle-mediated transport 35.0000 4 no
GO:0010959 regulation of metal ion transport 30.0000 6 yes
GO:0051924 regulation of calcium ion transport 30.0000 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 30.0000 7 yes
GO:0043270 positive regulation of ion transport 30.0000 5 no
GO:0072657 protein localization to membrane 30.0000 4 no
GO:0006897 endocytosis 30.0000 5 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 30.0000 6 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0007268 chemical synaptic transmission 25.0000 6 yes
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 yes
GO:0099537 trans-synaptic signaling 25.0000 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 25.0000 6 yes
GO:1901385 regulation of voltage-gated calcium channel activity 25.0000 7 yes
GO:0032411 positive regulation of transporter activity 25.0000 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0034764 positive regulation of transmembrane transport 25.0000 5 no
GO:0034767 positive regulation of ion transmembrane transport 25.0000 6 no
GO:1904064 positive regulation of cation transmembrane transport 25.0000 7 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:2001259 positive regulation of cation channel activity 25.0000 6 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0006898 receptor-mediated endocytosis 25.0000 6 no
GO:0007034 vacuolar transport 25.0000 4 no
GO:0007041 lysosomal transport 25.0000 5 no
GO:0008333 endosome to lysosome transport 25.0000 5 no
GO:0015031 protein transport 25.0000 4 no
GO:0031623 receptor internalization 25.0000 7 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 25.0000 6 no
GO:0061462 protein localization to lysosome 25.0000 7 no
GO:0072594 establishment of protein localization to organelle 25.0000 4 no
GO:0072665 protein localization to vacuole 25.0000 6 no
GO:0072666 establishment of protein localization to vacuole 25.0000 5 no
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 25.0000 4 no
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 25.0000 4 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:0099628 neurotransmitter receptor diffusion trapping 25.0000 4 no
GO:2000311 regulation of AMPA receptor activity 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0007528 neuromuscular junction development 20.0000 6 yes
GO:0034330 cell junction organization 20.0000 4 yes
GO:0050808 synapse organization 20.0000 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
THA_HUMAN [view interactions] Low throughput no yes
CBX3_HUMAN [view interactions] Low throughput no yes
H4_HUMAN [view interactions] Low throughput no yes
PP2AB_HUMAN [view interactions] Low throughput no yes
CACB4_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1A_HUMAN [view interactions] Low throughput no no
CAC1B_HUMAN [view interactions] Low throughput no yes
RIMS3_HUMAN [view entry] [view interactions] Low throughput yes no
TNFL6_HUMAN [view interactions] High throughput no yes
GT252_HUMAN [view interactions] High throughput no yes
CACB3_HUMAN [view entry] [view interactions] High throughput yes no
ACTS_HUMAN [view interactions] High throughput no no
TBA1C_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
CAC1D_HUMAN [view interactions] High throughput no yes
CAC1E_HUMAN [view entry] [view interactions] High throughput yes no
TBB4A_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
C102B_HUMAN [view interactions] High throughput no yes
EFHC2_HUMAN [view interactions] High throughput no no
MED31_HUMAN [view interactions] High throughput no yes
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
TBL3_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CACB2_HUMAN [view interactions] High throughput no yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
CCG8_HUMAN [view entry] [view interactions] Computational yes no
CA2D1_HUMAN [view entry] [view interactions] Computational yes yes
CA2D3_HUMAN [view entry] [view interactions] Computational yes no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
CTSR3_HUMAN [view interactions] Computational no no
CCG4_HUMAN [view entry] [view interactions] Computational yes no
CAC1S_HUMAN [view interactions] Computational no no
CCG6_HUMAN [view interactions] Computational no no
CAC1F_HUMAN [view interactions] Computational no no
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
CTSR1_HUMAN [view interactions] Computational no no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
CAC1G_HUMAN [view interactions] Computational no no
CCG1_HUMAN [view interactions] Computational no no
CA2D4_HUMAN [view interactions] Computational no no
CCG7_HUMAN [view entry] [view interactions] Computational yes no