PTN_HUMAN
Evidence for PS localization
Functions
Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed, PubMed, PubMed). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (PubMed, PubMed). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation . Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed, PubMed, PubMed, PubMed, PubMed). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed, PubMed). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 Tyr-773 phosphorylation (PubMed). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway . Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion . Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition . Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (PubMed). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway . Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration . In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTN_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.5714 | 4 | yes |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | yes |
| GO:0046872 | metal ion binding | 21.4286 | 4 | no |
| GO:0004864 | protein phosphatase inhibitor activity | 7.1429 | 5 | yes |
| GO:0008083 | growth factor activity | 7.1429 | 5 | yes |
| GO:0019212 | phosphatase inhibitor activity | 7.1429 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 7.1429 | 4 | yes |
| GO:0048018 | receptor ligand activity | 7.1429 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.7143 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.4286 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 39.2857 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.2857 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.2857 | 5 | no |
| GO:0043412 | macromolecule modification | 39.2857 | 4 | no |
| GO:0022607 | cellular component assembly | 39.2857 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0036211 | protein modification process | 35.7143 | 4 | no |
| GO:0008104 | protein localization | 35.7143 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 32.1429 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.1429 | 5 | yes |
| GO:0080134 | regulation of response to stress | 32.1429 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.1429 | 5 | no |
| GO:0010941 | regulation of cell death | 32.1429 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 28.5714 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 28.5714 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 28.5714 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.5714 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 28.5714 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 28.5714 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0051338 | regulation of transferase activity | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.5714 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 25.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | yes |
| GO:0060284 | regulation of cell development | 25.0000 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 6 | no |
| GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 21.4286 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 21.4286 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 21.4286 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 21.4286 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 21.4286 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | yes |
| GO:0001558 | regulation of cell growth | 21.4286 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.4286 | 7 | no |
| GO:0043549 | regulation of kinase activity | 21.4286 | 5 | no |
| GO:0051347 | positive regulation of transferase activity | 21.4286 | 5 | no |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 21.4286 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.4286 | 5 | no |
| GO:0034330 | cell junction organization | 21.4286 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.4286 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
| GO:0051049 | regulation of transport | 21.4286 | 4 | no |
| GO:0010721 | negative regulation of cell development | 17.8571 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 17.8571 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 17.8571 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 17.8571 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 17.8571 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 17.8571 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 17.8571 | 6 | yes |
| GO:0014013 | regulation of gliogenesis | 14.2857 | 7 | yes |
| GO:0030334 | regulation of cell migration | 14.2857 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 14.2857 | 6 | yes |
| GO:0031175 | neuron projection development | 14.2857 | 6 | yes |
| GO:0031641 | regulation of myelination | 14.2857 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 14.2857 | 4 | yes |
| GO:0040017 | positive regulation of locomotion | 14.2857 | 4 | yes |
| GO:0045685 | regulation of glial cell differentiation | 14.2857 | 5 | yes |
| GO:0048713 | regulation of oligodendrocyte differentiation | 14.2857 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 14.2857 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 14.2857 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 14.2857 | 5 | yes |
| GO:0050679 | positive regulation of epithelial cell proliferation | 14.2857 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 14.2857 | 6 | yes |
| GO:0050773 | regulation of dendrite development | 14.2857 | 4 | yes |
| GO:0050890 | cognition | 14.2857 | 4 | yes |
| GO:0051961 | negative regulation of nervous system development | 14.2857 | 5 | yes |
| GO:0072657 | protein localization to membrane | 14.2857 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 14.2857 | 6 | yes |
| GO:2000145 | regulation of cell motility | 14.2857 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 14.2857 | 5 | yes |
| GO:2000177 | regulation of neural precursor cell proliferation | 14.2857 | 5 | yes |
| GO:0002684 | positive regulation of immune system process | 14.2857 | 4 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 14.2857 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 14.2857 | 5 | yes |
| GO:0010632 | regulation of epithelial cell migration | 14.2857 | 4 | yes |
| GO:0010976 | positive regulation of neuron projection development | 10.7143 | 7 | yes |
| GO:0014015 | positive regulation of gliogenesis | 10.7143 | 7 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 10.7143 | 5 | yes |
| GO:0045687 | positive regulation of glial cell differentiation | 10.7143 | 6 | yes |
| GO:0048477 | oogenesis | 10.7143 | 4 | yes |
| GO:0048679 | regulation of axon regeneration | 10.7143 | 5 | yes |
| GO:0048714 | positive regulation of oligodendrocyte differentiation | 10.7143 | 7 | yes |
| GO:0070570 | regulation of neuron projection regeneration | 10.7143 | 4 | yes |
| GO:1900006 | positive regulation of dendrite development | 10.7143 | 5 | yes |
| GO:1900271 | regulation of long-term synaptic potentiation | 10.7143 | 4 | yes |
| GO:1902692 | regulation of neuroblast proliferation | 10.7143 | 6 | yes |
| GO:1903034 | regulation of response to wounding | 10.7143 | 5 | yes |
| GO:1903706 | regulation of hemopoiesis | 10.7143 | 4 | yes |
| GO:2000736 | regulation of stem cell differentiation | 10.7143 | 5 | yes |
| GO:0007292 | female gamete generation | 10.7143 | 4 | yes |
| GO:0007613 | memory | 10.7143 | 4 | yes |
| GO:0010594 | regulation of endothelial cell migration | 10.7143 | 5 | yes |
| GO:0010996 | response to auditory stimulus | 7.1429 | 4 | yes |
| GO:0030278 | regulation of ossification | 7.1429 | 4 | yes |
| GO:0030500 | regulation of bone mineralization | 7.1429 | 5 | yes |
| GO:0030501 | positive regulation of bone mineralization | 7.1429 | 6 | yes |
| GO:0031102 | neuron projection regeneration | 7.1429 | 4 | yes |
| GO:0031104 | dendrite regeneration | 7.1429 | 4 | yes |
| GO:0043113 | receptor clustering | 7.1429 | 5 | yes |
| GO:0045778 | positive regulation of ossification | 7.1429 | 5 | yes |
| GO:0048680 | positive regulation of axon regeneration | 7.1429 | 6 | yes |
| GO:0048813 | dendrite morphogenesis | 7.1429 | 8 | yes |
| GO:0050920 | regulation of chemotaxis | 7.1429 | 4 | yes |
| GO:0050921 | positive regulation of chemotaxis | 7.1429 | 5 | yes |
| GO:0051302 | regulation of cell division | 7.1429 | 4 | yes |
| GO:0051781 | positive regulation of cell division | 7.1429 | 5 | yes |
| GO:0060326 | cell chemotaxis | 7.1429 | 4 | yes |
| GO:0070167 | regulation of biomineral tissue development | 7.1429 | 4 | yes |
| GO:0070169 | positive regulation of biomineral tissue development | 7.1429 | 5 | yes |
| GO:0070572 | positive regulation of neuron projection regeneration | 7.1429 | 5 | yes |
| GO:0110151 | positive regulation of biomineralization | 7.1429 | 4 | yes |
| GO:0140058 | neuron projection arborization | 7.1429 | 8 | yes |
| GO:0140059 | dendrite arborization | 7.1429 | 9 | yes |
| GO:1900272 | negative regulation of long-term synaptic potentiation | 7.1429 | 4 | yes |
| GO:1903036 | positive regulation of response to wounding | 7.1429 | 5 | yes |
| GO:2000036 | regulation of stem cell population maintenance | 7.1429 | 4 | yes |
| GO:2000178 | negative regulation of neural precursor cell proliferation | 7.1429 | 6 | yes |
| GO:2000345 | regulation of hepatocyte proliferation | 7.1429 | 6 | yes |
| GO:2000347 | positive regulation of hepatocyte proliferation | 7.1429 | 7 | yes |
| GO:2000738 | positive regulation of stem cell differentiation | 7.1429 | 6 | yes |
| GO:0002232 | leukocyte chemotaxis involved in inflammatory response | 7.1429 | 4 | yes |
| GO:0002685 | regulation of leukocyte migration | 7.1429 | 4 | yes |
| GO:0002687 | positive regulation of leukocyte migration | 7.1429 | 5 | yes |
| GO:0002688 | regulation of leukocyte chemotaxis | 7.1429 | 5 | yes |
| GO:0002690 | positive regulation of leukocyte chemotaxis | 7.1429 | 6 | yes |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 7.1429 | 5 | yes |
| GO:0007399 | nervous system development | 7.1429 | 4 | yes |
| GO:0007406 | negative regulation of neuroblast proliferation | 7.1429 | 7 | yes |
| GO:0007612 | learning | 7.1429 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITAM_HUMAN | [view interactions] | Low throughput | no | no |
| NEK6_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITAV_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRB_HUMAN | [view interactions] | Low throughput | no | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GA45G_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| CP2E1_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| CG025_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| GA45A_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1D_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| GIPC2_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGSM2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| S2536_HUMAN | [view interactions] | High throughput | no | yes |
| GPDA_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMA4_HUMAN | [view interactions] | High throughput | no | no |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| SAS10_HUMAN | [view interactions] | High throughput | no | yes |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTBD2_HUMAN | [view interactions] | High throughput | no | no |
| CAAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| EVA1A_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S1_HUMAN | [view interactions] | High throughput | no | yes |
| GLYAT_HUMAN | [view interactions] | High throughput | no | no |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| CRCT1_HUMAN | [view interactions] | High throughput | no | no |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNCAP_HUMAN | [view interactions] | High throughput | no | no |
| STC2_HUMAN | [view interactions] | High throughput | no | no |
| TKNK_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| ABC3G_HUMAN | [view interactions] | High throughput | no | no |
| GLHA_HUMAN | [view interactions] | High throughput | no | no |
| GSDME_HUMAN | [view interactions] | High throughput | no | yes |
| HBAP1_HUMAN | [view interactions] | High throughput | no | yes |
| MKKS_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| ST65G_HUMAN | [view interactions] | High throughput | no | yes |
| WFDC2_HUMAN | [view interactions] | High throughput | no | yes |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| SPIN1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| HGH1_HUMAN | [view interactions] | High throughput | no | no |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDC1_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |