Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRZ_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRZ_HUMAN
GO:0019900 kinase binding 39.2857 4 no
GO:0016301 kinase activity 32.1429 4 no
GO:0019901 protein kinase binding 32.1429 5 no
GO:0043169 cation binding 32.1429 4 no
GO:0046872 metal ion binding 32.1429 5 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0016791 phosphatase activity 14.2857 5 yes
GO:0042578 phosphoric ester hydrolase activity 14.2857 4 yes
GO:0004725 protein tyrosine phosphatase activity 10.7143 4 yes
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 10.7143 5 yes
GO:0019198 transmembrane receptor protein phosphatase activity 10.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRZ_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0048523 negative regulation of cellular process 78.5714 4 yes
GO:0051128 regulation of cellular component organization 71.4286 4 no
GO:0060255 regulation of macromolecule metabolic process 67.8571 4 no
GO:0010646 regulation of cell communication 64.2857 4 no
GO:0031323 regulation of cellular metabolic process 64.2857 4 no
GO:0009889 regulation of biosynthetic process 57.1429 4 no
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0010468 regulation of gene expression 57.1429 6 no
GO:0010556 regulation of macromolecule biosynthetic process 57.1429 5 no
GO:0031326 regulation of cellular biosynthetic process 57.1429 5 no
GO:0080090 regulation of primary metabolic process 53.5714 4 no
GO:0030030 cell projection organization 53.5714 4 yes
GO:0042981 regulation of apoptotic process 53.5714 5 yes
GO:0043067 regulation of programmed cell death 53.5714 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0042127 regulation of cell population proliferation 50.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 46.4286 5 no
GO:0048584 positive regulation of response to stimulus 46.4286 4 no
GO:0051246 regulation of protein metabolic process 46.4286 5 no
GO:0006796 phosphate-containing compound metabolic process 46.4286 4 yes
GO:0051240 positive regulation of multicellular organismal process 46.4286 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 42.8571 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0031344 regulation of cell projection organization 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0036211 protein modification process 42.8571 4 yes
GO:0043066 negative regulation of apoptotic process 42.8571 6 yes
GO:0043069 negative regulation of programmed cell death 42.8571 5 yes
GO:0043412 macromolecule modification 42.8571 4 yes
GO:0045595 regulation of cell differentiation 42.8571 4 yes
GO:2000026 regulation of multicellular organismal development 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 39.2857 5 no
GO:0010605 negative regulation of macromolecule metabolic process 39.2857 5 no
GO:0030155 regulation of cell adhesion 39.2857 4 no
GO:0031175 neuron projection development 39.2857 6 no
GO:0031324 negative regulation of cellular metabolic process 39.2857 5 no
GO:0032880 regulation of protein localization 39.2857 5 no
GO:0042325 regulation of phosphorylation 39.2857 7 no
GO:0051130 positive regulation of cellular component organization 39.2857 5 no
GO:0060341 regulation of cellular localization 39.2857 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 39.2857 6 no
GO:0050890 cognition 39.2857 4 yes
GO:0051094 positive regulation of developmental process 39.2857 4 yes
GO:0001932 regulation of protein phosphorylation 39.2857 7 no
GO:0008284 positive regulation of cell population proliferation 35.7143 5 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0009891 positive regulation of biosynthetic process 32.1429 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 32.1429 6 no
GO:0010975 regulation of neuron projection development 32.1429 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.1429 5 no
GO:0022603 regulation of anatomical structure morphogenesis 32.1429 4 no
GO:0031328 positive regulation of cellular biosynthetic process 32.1429 6 no
GO:0051129 negative regulation of cellular component organization 32.1429 5 no
GO:1902533 positive regulation of intracellular signal transduction 32.1429 6 no
GO:0016310 phosphorylation 32.1429 5 no
GO:0008104 protein localization 32.1429 4 no
GO:0022607 cellular component assembly 32.1429 4 no
GO:0034330 cell junction organization 32.1429 4 no
GO:0060284 regulation of cell development 32.1429 5 yes
GO:0002684 positive regulation of immune system process 32.1429 4 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010628 positive regulation of gene expression 28.5714 7 no
GO:0022407 regulation of cell-cell adhesion 28.5714 5 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0032101 regulation of response to external stimulus 28.5714 4 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0006996 organelle organization 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0050808 synapse organization 28.5714 5 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:1905475 regulation of protein localization to membrane 25.0000 6 no
GO:0002694 regulation of leukocyte activation 25.0000 4 no
GO:0050863 regulation of T cell activation 25.0000 6 no
GO:0050865 regulation of cell activation 25.0000 4 no
GO:0051249 regulation of lymphocyte activation 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0010720 positive regulation of cell development 25.0000 6 yes
GO:0043523 regulation of neuron apoptotic process 25.0000 6 yes
GO:0045597 positive regulation of cell differentiation 25.0000 5 yes
GO:0048812 neuron projection morphogenesis 25.0000 5 yes
GO:0050767 regulation of neurogenesis 25.0000 6 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 4 yes
GO:0007162 negative regulation of cell adhesion 21.4286 5 no
GO:0007411 axon guidance 21.4286 8 no
GO:0030182 neuron differentiation 21.4286 4 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0045596 negative regulation of cell differentiation 21.4286 5 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.4286 9 no
GO:0051093 negative regulation of developmental process 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0071363 cellular response to growth factor stimulus 21.4286 4 no
GO:0097485 neuron projection guidance 21.4286 7 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1903037 regulation of leukocyte cell-cell adhesion 21.4286 6 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0007612 learning 21.4286 4 no
GO:0050769 positive regulation of neurogenesis 21.4286 6 yes
GO:0051962 positive regulation of nervous system development 21.4286 5 yes
GO:0043524 negative regulation of neuron apoptotic process 17.8571 7 yes
GO:2000177 regulation of neural precursor cell proliferation 17.8571 5 yes
GO:0010001 glial cell differentiation 14.2857 4 yes
GO:0014013 regulation of gliogenesis 14.2857 7 yes
GO:0031641 regulation of myelination 14.2857 4 yes
GO:0045685 regulation of glial cell differentiation 14.2857 5 yes
GO:0048709 oligodendrocyte differentiation 14.2857 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 14.2857 6 yes
GO:0006470 protein dephosphorylation 10.7143 5 yes
GO:0007409 axonogenesis 10.7143 6 yes
GO:0014015 positive regulation of gliogenesis 10.7143 7 yes
GO:0016311 dephosphorylation 10.7143 5 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 10.7143 6 yes
GO:0045687 positive regulation of glial cell differentiation 10.7143 6 yes
GO:0048714 positive regulation of oligodendrocyte differentiation 10.7143 7 yes
GO:0002244 hematopoietic progenitor cell differentiation 7.1429 4 yes
GO:0007417 central nervous system development 7.1429 4 yes
GO:0070445 regulation of oligodendrocyte progenitor proliferation 7.1429 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTN_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
NUCL_HUMAN [view interactions] Low throughput no yes
IL34_HUMAN [view interactions] Low throughput no no
CNTP1_HUMAN [view entry] [view interactions] Low throughput yes yes
LEG1_HUMAN [view interactions] Low throughput no yes
SCN1B_HUMAN [view interactions] Low throughput no no
SCN1A_HUMAN [view interactions] Low throughput no no
SCN2B_HUMAN [view interactions] Low throughput no no
CD5R1_HUMAN [view entry] [view interactions] Low throughput yes no
TENR_HUMAN [view entry] [view interactions] Low throughput yes no
HMGB1_HUMAN [view interactions] Low throughput no yes
MK_HUMAN [view interactions] Low throughput no no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
MGT5B_HUMAN [view interactions] Low throughput no no
SMAL1_HUMAN [view interactions] Low throughput no no
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
ALK_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
ITAV_HUMAN [view interactions] Low throughput no yes
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
LEG3_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
SELH_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
ACTA_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
MOT6_HUMAN [view interactions] High throughput no no
PK3CD_HUMAN [view interactions] High throughput no no
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SYEP_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
PTPRA_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SMD2_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
WASP_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
P2RX7_HUMAN [view interactions] High throughput no yes