Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRZ_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRZ_HUMAN
GO:0016301 kinase activity 27.5862 4 no
GO:0019900 kinase binding 27.5862 4 no
GO:0046872 metal ion binding 27.5862 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.1379 4 no
GO:0019901 protein kinase binding 24.1379 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.6897 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 20.6897 4 no
GO:0005524 ATP binding 20.6897 5 no
GO:0017076 purine nucleotide binding 20.6897 4 no
GO:0030554 adenyl nucleotide binding 20.6897 5 no
GO:0032555 purine ribonucleotide binding 20.6897 4 no
GO:0032559 adenyl ribonucleotide binding 20.6897 5 no
GO:0016791 phosphatase activity 13.7931 5 yes
GO:0042578 phosphoric ester hydrolase activity 13.7931 4 yes
GO:0004725 protein tyrosine phosphatase activity 10.3448 4 yes
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 10.3448 5 yes
GO:0019198 transmembrane receptor protein phosphatase activity 10.3448 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRZ_HUMAN
GO:0048522 positive regulation of cellular process 75.8621 4 yes
GO:0048523 negative regulation of cellular process 68.9655 4 yes
GO:0051128 regulation of cellular component organization 58.6207 4 no
GO:0010646 regulation of cell communication 58.6207 4 no
GO:0030030 cell projection organization 55.1724 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.1724 4 no
GO:0060255 regulation of macromolecule metabolic process 55.1724 4 no
GO:0080090 regulation of primary metabolic process 55.1724 4 no
GO:0009893 positive regulation of metabolic process 51.7241 4 no
GO:0009966 regulation of signal transduction 51.7241 4 no
GO:0031323 regulation of cellular metabolic process 48.2759 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.2759 5 no
GO:0051246 regulation of protein metabolic process 48.2759 5 no
GO:0042325 regulation of phosphorylation 44.8276 7 no
GO:0051049 regulation of transport 44.8276 4 no
GO:0051174 regulation of phosphorus metabolic process 44.8276 5 no
GO:0120036 plasma membrane bounded cell projection organization 44.8276 5 no
GO:0010941 regulation of cell death 44.8276 4 yes
GO:0045595 regulation of cell differentiation 44.8276 4 yes
GO:0019220 regulation of phosphate metabolic process 44.8276 6 no
GO:0031175 neuron projection development 41.3793 6 no
GO:0031325 positive regulation of cellular metabolic process 41.3793 5 no
GO:0031344 regulation of cell projection organization 41.3793 5 no
GO:0031399 regulation of protein modification process 41.3793 6 no
GO:0043085 positive regulation of catalytic activity 41.3793 4 no
GO:0048584 positive regulation of response to stimulus 41.3793 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.3793 5 no
GO:0051247 positive regulation of protein metabolic process 41.3793 6 no
GO:0042981 regulation of apoptotic process 41.3793 6 yes
GO:0043067 regulation of programmed cell death 41.3793 5 yes
GO:0050890 cognition 41.3793 4 yes
GO:0010468 regulation of gene expression 41.3793 5 no
GO:0010647 positive regulation of cell communication 41.3793 5 no
GO:0023056 positive regulation of signaling 41.3793 4 no
GO:0031401 positive regulation of protein modification process 37.9310 7 no
GO:0042327 positive regulation of phosphorylation 37.9310 8 no
GO:0045937 positive regulation of phosphate metabolic process 37.9310 7 no
GO:0051338 regulation of transferase activity 37.9310 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.9310 6 no
GO:0006796 phosphate-containing compound metabolic process 37.9310 4 yes
GO:0036211 protein modification process 37.9310 4 yes
GO:0042127 regulation of cell population proliferation 37.9310 4 yes
GO:0043412 macromolecule modification 37.9310 4 yes
GO:0051094 positive regulation of developmental process 37.9310 4 yes
GO:2000026 regulation of multicellular organismal development 37.9310 4 yes
GO:0009892 negative regulation of metabolic process 37.9310 4 no
GO:0001932 regulation of protein phosphorylation 37.9310 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 37.9310 4 no
GO:0009967 positive regulation of signal transduction 37.9310 5 no
GO:0010562 positive regulation of phosphorus metabolic process 37.9310 6 no
GO:0032880 regulation of protein localization 34.4828 5 no
GO:0043549 regulation of kinase activity 34.4828 5 no
GO:0051130 positive regulation of cellular component organization 34.4828 5 no
GO:0051347 positive regulation of transferase activity 34.4828 5 no
GO:0060341 regulation of cellular localization 34.4828 4 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0060548 negative regulation of cell death 34.4828 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 34.4828 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.4828 5 no
GO:0001934 positive regulation of protein phosphorylation 34.4828 8 no
GO:0010975 regulation of neuron projection development 34.4828 7 no
GO:0031324 negative regulation of cellular metabolic process 31.0345 5 no
GO:0031326 regulation of cellular biosynthetic process 31.0345 5 no
GO:0033674 positive regulation of kinase activity 31.0345 6 no
GO:0051050 positive regulation of transport 31.0345 4 no
GO:0051129 negative regulation of cellular component organization 31.0345 5 no
GO:0043066 negative regulation of apoptotic process 31.0345 7 yes
GO:0043069 negative regulation of programmed cell death 31.0345 6 yes
GO:0051240 positive regulation of multicellular organismal process 31.0345 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 31.0345 5 no
GO:0009889 regulation of biosynthetic process 31.0345 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.0345 5 no
GO:0045859 regulation of protein kinase activity 27.5862 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 27.5862 8 no
GO:0051252 regulation of RNA metabolic process 27.5862 5 no
GO:0071310 cellular response to organic substance 27.5862 4 no
GO:0097485 neuron projection guidance 27.5862 7 no
GO:1902533 positive regulation of intracellular signal transduction 27.5862 6 no
GO:1903506 regulation of nucleic acid-templated transcription 27.5862 7 no
GO:1903829 positive regulation of protein localization 27.5862 5 no
GO:2001141 regulation of RNA biosynthetic process 27.5862 6 no
GO:0043269 regulation of ion transport 27.5862 5 no
GO:0034330 cell junction organization 27.5862 4 no
GO:0050808 synapse organization 27.5862 5 no
GO:0008104 protein localization 27.5862 4 no
GO:0022607 cellular component assembly 27.5862 4 no
GO:0050804 modulation of chemical synaptic transmission 27.5862 5 no
GO:0099177 regulation of trans-synaptic signaling 27.5862 4 no
GO:0032990 cell part morphogenesis 27.5862 4 yes
GO:0045597 positive regulation of cell differentiation 27.5862 5 yes
GO:0048812 neuron projection morphogenesis 27.5862 7 yes
GO:0048858 cell projection morphogenesis 27.5862 5 yes
GO:0050767 regulation of neurogenesis 27.5862 6 yes
GO:0051960 regulation of nervous system development 27.5862 5 yes
GO:0060284 regulation of cell development 27.5862 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.5862 6 yes
GO:1901214 regulation of neuron death 27.5862 5 yes
GO:0016310 phosphorylation 27.5862 5 no
GO:0051248 negative regulation of protein metabolic process 27.5862 6 no
GO:0006355 regulation of DNA-templated transcription 27.5862 6 no
GO:0007411 axon guidance 27.5862 8 no
GO:0010556 regulation of macromolecule biosynthetic process 27.5862 5 no
GO:0022603 regulation of anatomical structure morphogenesis 27.5862 4 no
GO:0030155 regulation of cell adhesion 24.1379 4 no
GO:0045596 negative regulation of cell differentiation 24.1379 5 no
GO:0045860 positive regulation of protein kinase activity 24.1379 7 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 24.1379 9 no
GO:0051093 negative regulation of developmental process 24.1379 4 no
GO:0080134 regulation of response to stress 24.1379 4 no
GO:0006468 protein phosphorylation 24.1379 5 no
GO:0051241 negative regulation of multicellular organismal process 24.1379 4 no
GO:0043523 regulation of neuron apoptotic process 24.1379 6 yes
GO:0051336 regulation of hydrolase activity 24.1379 4 no
GO:0008284 positive regulation of cell population proliferation 24.1379 5 no
GO:0022407 regulation of cell-cell adhesion 24.1379 5 no
GO:0030182 neuron differentiation 20.6897 4 no
GO:0031346 positive regulation of cell projection organization 20.6897 6 no
GO:0032101 regulation of response to external stimulus 20.6897 4 no
GO:0043408 regulation of MAPK cascade 20.6897 6 no
GO:0043410 positive regulation of MAPK cascade 20.6897 7 no
GO:0051345 positive regulation of hydrolase activity 20.6897 5 no
GO:0080135 regulation of cellular response to stress 20.6897 4 no
GO:0006996 organelle organization 20.6897 4 no
GO:0018193 peptidyl-amino acid modification 20.6897 5 no
GO:1905475 regulation of protein localization to membrane 20.6897 6 no
GO:0007612 learning 20.6897 4 no
GO:0048585 negative regulation of response to stimulus 20.6897 4 no
GO:0002694 regulation of leukocyte activation 20.6897 4 no
GO:0050863 regulation of T cell activation 20.6897 6 no
GO:0050865 regulation of cell activation 20.6897 4 no
GO:0051249 regulation of lymphocyte activation 20.6897 5 no
GO:0010720 positive regulation of cell development 20.6897 6 yes
GO:0050769 positive regulation of neurogenesis 20.6897 6 yes
GO:0051962 positive regulation of nervous system development 20.6897 5 yes
GO:0002684 positive regulation of immune system process 20.6897 4 no
GO:0010628 positive regulation of gene expression 20.6897 6 no
GO:0030334 regulation of cell migration 20.6897 5 no
GO:2000145 regulation of cell motility 20.6897 4 no
GO:0001764 neuron migration 20.6897 4 no
GO:0007417 central nervous system development 17.2414 4 yes
GO:1901215 negative regulation of neuron death 17.2414 6 yes
GO:2000177 regulation of neural precursor cell proliferation 17.2414 5 yes
GO:0007409 axonogenesis 13.7931 8 yes
GO:0014013 regulation of gliogenesis 13.7931 7 yes
GO:0031641 regulation of myelination 13.7931 4 yes
GO:0043524 negative regulation of neuron apoptotic process 13.7931 7 yes
GO:0045685 regulation of glial cell differentiation 13.7931 5 yes
GO:0048713 regulation of oligodendrocyte differentiation 13.7931 6 yes
GO:0006470 protein dephosphorylation 10.3448 5 yes
GO:0010001 glial cell differentiation 10.3448 4 yes
GO:0014015 positive regulation of gliogenesis 10.3448 7 yes
GO:0016311 dephosphorylation 10.3448 5 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 10.3448 6 yes
GO:0045687 positive regulation of glial cell differentiation 10.3448 6 yes
GO:0048709 oligodendrocyte differentiation 10.3448 5 yes
GO:0048714 positive regulation of oligodendrocyte differentiation 10.3448 7 yes
GO:0002244 hematopoietic progenitor cell differentiation 6.8966 4 yes
GO:0070445 regulation of oligodendrocyte progenitor proliferation 6.8966 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALK_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITAV_HUMAN [view interactions] Low throughput no yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
PTN_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
NUCL_HUMAN [view interactions] Low throughput no yes
IL34_HUMAN [view interactions] Low throughput no no
CNTP1_HUMAN [view entry] [view interactions] Low throughput yes yes
LEG1_HUMAN [view interactions] Low throughput no yes
SCN1B_HUMAN [view interactions] Low throughput no no
SCN1A_HUMAN [view interactions] Low throughput no no
SCN2B_HUMAN [view interactions] Low throughput no no
CD5R1_HUMAN [view entry] [view interactions] Low throughput yes no
TENR_HUMAN [view entry] [view interactions] Low throughput yes no
HMGB1_HUMAN [view interactions] Low throughput no yes
MK_HUMAN [view interactions] Low throughput no no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
MGT5B_HUMAN [view interactions] Low throughput no no
SMAL1_HUMAN [view interactions] Low throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SMD2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
WASP_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
P2RX7_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
SELH_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
ACTA_HUMAN [view interactions] High throughput no no
MOT6_HUMAN [view interactions] High throughput no no
PK3CD_HUMAN [view interactions] High throughput no no
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SYEP_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
PTPRA_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
NCHL1_HUMAN [view entry] [view interactions] Computational yes yes
PGCB_HUMAN [view entry] [view interactions] Computational yes yes
NCAN_HUMAN [view entry] [view interactions] Computational yes no
NRCAM_HUMAN [view entry] [view interactions] Computational yes no