Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VEGFA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004009 LIG_NRP_CendR_1 LIG 188 191 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VEGFA_HUMAN
GO:0042803 protein homodimerization activity 38.8889 4 yes
GO:0003723 RNA binding 27.7778 4 no
GO:0046872 metal ion binding 27.7778 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0005125 cytokine activity 11.1111 5 yes
GO:0005126 cytokine receptor binding 11.1111 4 yes
GO:0005161 platelet-derived growth factor receptor binding 11.1111 5 yes
GO:0005172 vascular endothelial growth factor receptor binding 11.1111 5 yes
GO:0008083 growth factor activity 11.1111 5 yes
GO:0038191 neuropilin binding 11.1111 4 yes
GO:0042056 chemoattractant activity 11.1111 5 yes
GO:0043183 vascular endothelial growth factor receptor 1 binding 11.1111 6 yes
GO:0043184 vascular endothelial growth factor receptor 2 binding 11.1111 6 yes
GO:0048018 receptor ligand activity 11.1111 4 yes
GO:0070851 growth factor receptor binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VEGFA_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0031323 regulation of cellular metabolic process 77.7778 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 77.7778 4 yes
GO:0010468 regulation of gene expression 72.2222 5 yes
GO:0048523 negative regulation of cellular process 72.2222 4 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0009889 regulation of biosynthetic process 61.1111 4 yes
GO:0009966 regulation of signal transduction 61.1111 4 yes
GO:0010646 regulation of cell communication 61.1111 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 61.1111 5 yes
GO:0031325 positive regulation of cellular metabolic process 61.1111 5 yes
GO:0031326 regulation of cellular biosynthetic process 61.1111 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 61.1111 5 yes
GO:0051252 regulation of RNA metabolic process 55.5556 5 yes
GO:0009891 positive regulation of biosynthetic process 55.5556 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 yes
GO:0010628 positive regulation of gene expression 55.5556 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 55.5556 6 yes
GO:0042127 regulation of cell population proliferation 55.5556 4 yes
GO:0051247 positive regulation of protein metabolic process 55.5556 6 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010941 regulation of cell death 50.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0060548 negative regulation of cell death 44.4444 5 yes
GO:0006355 regulation of DNA-templated transcription 44.4444 6 yes
GO:0009967 positive regulation of signal transduction 44.4444 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 44.4444 6 yes
GO:0010629 negative regulation of gene expression 44.4444 6 yes
GO:0010647 positive regulation of cell communication 44.4444 5 yes
GO:0019220 regulation of phosphate metabolic process 44.4444 6 yes
GO:0023056 positive regulation of signaling 44.4444 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 44.4444 7 yes
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 yes
GO:2001141 regulation of RNA biosynthetic process 44.4444 6 yes
GO:0008104 protein localization 44.4444 4 no
GO:0042325 regulation of phosphorylation 44.4444 7 yes
GO:0033365 protein localization to organelle 44.4444 5 no
GO:0042981 regulation of apoptotic process 44.4444 6 yes
GO:0043067 regulation of programmed cell death 44.4444 5 yes
GO:0009894 regulation of catabolic process 44.4444 4 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 yes
GO:0045595 regulation of cell differentiation 44.4444 4 yes
GO:0045597 positive regulation of cell differentiation 44.4444 5 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 yes
GO:0051253 negative regulation of RNA metabolic process 38.8889 6 yes
GO:0031399 regulation of protein modification process 38.8889 6 yes
GO:2000026 regulation of multicellular organismal development 38.8889 4 yes
GO:0006886 intracellular protein transport 38.8889 4 no
GO:0006996 organelle organization 38.8889 4 no
GO:0015031 protein transport 38.8889 4 no
GO:0071702 organic substance transport 38.8889 4 no
GO:0071705 nitrogen compound transport 38.8889 4 no
GO:0043066 negative regulation of apoptotic process 38.8889 7 yes
GO:0043069 negative regulation of programmed cell death 38.8889 6 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 38.8889 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 38.8889 6 yes
GO:0051049 regulation of transport 38.8889 4 yes
GO:0051130 positive regulation of cellular component organization 38.8889 5 yes
GO:0051248 negative regulation of protein metabolic process 33.3333 6 yes
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0001936 regulation of endothelial cell proliferation 33.3333 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 33.3333 7 yes
GO:0060341 regulation of cellular localization 33.3333 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 7 yes
GO:0008284 positive regulation of cell population proliferation 33.3333 5 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0009890 negative regulation of biosynthetic process 33.3333 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 yes
GO:0030030 cell projection organization 33.3333 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 33.3333 8 yes
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0040017 positive regulation of locomotion 33.3333 4 yes
GO:0042327 positive regulation of phosphorylation 33.3333 8 yes
GO:0072594 establishment of protein localization to organelle 33.3333 4 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 yes
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 yes
GO:0045893 positive regulation of DNA-templated transcription 33.3333 7 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0050678 regulation of epithelial cell proliferation 33.3333 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 33.3333 6 yes
GO:0051129 negative regulation of cellular component organization 33.3333 5 yes
GO:0051347 positive regulation of transferase activity 27.7778 5 yes
GO:0001934 positive regulation of protein phosphorylation 27.7778 8 yes
GO:0060627 regulation of vesicle-mediated transport 27.7778 4 yes
GO:0080134 regulation of response to stress 27.7778 4 yes
GO:1901342 regulation of vasculature development 27.7778 5 yes
GO:0030162 regulation of proteolysis 27.7778 6 yes
GO:1902531 regulation of intracellular signal transduction 27.7778 5 yes
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 27.7778 7 yes
GO:0030334 regulation of cell migration 27.7778 5 yes
GO:0030335 positive regulation of cell migration 27.7778 6 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 27.7778 8 yes
GO:0032101 regulation of response to external stimulus 27.7778 4 yes
GO:0032880 regulation of protein localization 27.7778 5 yes
GO:2000145 regulation of cell motility 27.7778 4 yes
GO:2000147 positive regulation of cell motility 27.7778 5 yes
GO:0043933 protein-containing complex organization 27.7778 4 no
GO:0065003 protein-containing complex assembly 27.7778 5 no
GO:0009968 negative regulation of signal transduction 27.7778 5 no
GO:0010648 negative regulation of cell communication 27.7778 5 no
GO:0023057 negative regulation of signaling 27.7778 4 no
GO:0009896 positive regulation of catabolic process 27.7778 5 no
GO:0043549 regulation of kinase activity 27.7778 5 yes
GO:0045765 regulation of angiogenesis 27.7778 5 yes
GO:0045859 regulation of protein kinase activity 27.7778 6 yes
GO:0045892 negative regulation of DNA-templated transcription 27.7778 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 27.7778 8 yes
GO:0051050 positive regulation of transport 27.7778 4 yes
GO:0051093 negative regulation of developmental process 27.7778 4 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 8 yes
GO:0001558 regulation of cell growth 22.2222 4 yes
GO:0051336 regulation of hydrolase activity 22.2222 4 yes
GO:0001667 ameboidal-type cell migration 22.2222 4 yes
GO:0001764 neuron migration 22.2222 4 yes
GO:0051960 regulation of nervous system development 22.2222 5 yes
GO:0051962 positive regulation of nervous system development 22.2222 5 yes
GO:0052547 regulation of peptidase activity 22.2222 5 yes
GO:0052548 regulation of endopeptidase activity 22.2222 6 yes
GO:0060284 regulation of cell development 22.2222 5 yes
GO:0002684 positive regulation of immune system process 22.2222 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 22.2222 5 yes
GO:0007411 axon guidance 22.2222 8 yes
GO:0010594 regulation of endothelial cell migration 22.2222 5 yes
GO:0010595 positive regulation of endothelial cell migration 22.2222 6 yes
GO:0010632 regulation of epithelial cell migration 22.2222 4 yes
GO:0010634 positive regulation of epithelial cell migration 22.2222 5 yes
GO:0010720 positive regulation of cell development 22.2222 6 yes
GO:0097485 neuron projection guidance 22.2222 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 yes
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 yes
GO:1901888 regulation of cell junction assembly 22.2222 5 yes
GO:0031175 neuron projection development 22.2222 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 22.2222 6 yes
GO:0031344 regulation of cell projection organization 22.2222 5 yes
GO:1904018 positive regulation of vasculature development 22.2222 5 yes
GO:0032103 positive regulation of response to external stimulus 22.2222 5 yes
GO:0033674 positive regulation of kinase activity 22.2222 6 yes
GO:0036293 response to decreased oxygen levels 22.2222 4 yes
GO:2000278 regulation of DNA biosynthetic process 22.2222 6 yes
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0007005 mitochondrion organization 22.2222 5 no
GO:0061024 membrane organization 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0001819 positive regulation of cytokine production 22.2222 5 no
GO:0050821 protein stabilization 22.2222 4 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 22.2222 5 yes
GO:0043620 regulation of DNA-templated transcription in response to stress 22.2222 4 yes
GO:0045596 negative regulation of cell differentiation 22.2222 5 yes
GO:0045766 positive regulation of angiogenesis 22.2222 6 yes
GO:0045860 positive regulation of protein kinase activity 22.2222 7 yes
GO:0048638 regulation of developmental growth 22.2222 4 yes
GO:0050767 regulation of neurogenesis 22.2222 6 yes
GO:0050769 positive regulation of neurogenesis 22.2222 6 yes
GO:0051052 regulation of DNA metabolic process 22.2222 5 yes
GO:0051054 positive regulation of DNA metabolic process 22.2222 6 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 22.2222 4 yes
GO:0001569 branching involved in blood vessel morphogenesis 16.6667 5 yes
GO:0051345 positive regulation of hydrolase activity 16.6667 5 yes
GO:0051346 negative regulation of hydrolase activity 16.6667 5 yes
GO:0051893 regulation of focal adhesion assembly 16.6667 7 yes
GO:0051894 positive regulation of focal adhesion assembly 16.6667 7 yes
GO:0051896 regulation of protein kinase B signaling 16.6667 6 yes
GO:0051897 positive regulation of protein kinase B signaling 16.6667 7 yes
GO:0001952 regulation of cell-matrix adhesion 16.6667 6 yes
GO:0001954 positive regulation of cell-matrix adhesion 16.6667 7 yes
GO:0002009 morphogenesis of an epithelium 16.6667 4 yes
GO:0002040 sprouting angiogenesis 16.6667 4 yes
GO:0002042 cell migration involved in sprouting angiogenesis 16.6667 8 yes
GO:0060326 cell chemotaxis 16.6667 4 yes
GO:0060977 coronary vasculature morphogenesis 16.6667 5 yes
GO:0060982 coronary artery morphogenesis 16.6667 6 yes
GO:0061387 regulation of extent of cell growth 16.6667 5 yes
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 16.6667 6 yes
GO:0007399 nervous system development 16.6667 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 16.6667 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 16.6667 8 yes
GO:0070848 response to growth factor 16.6667 4 yes
GO:0071363 cellular response to growth factor stimulus 16.6667 5 yes
GO:0071679 commissural neuron axon guidance 16.6667 9 yes
GO:0071900 regulation of protein serine/threonine kinase activity 16.6667 7 yes
GO:0010466 negative regulation of peptidase activity 16.6667 6 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 16.6667 7 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 16.6667 8 yes
GO:0090109 regulation of cell-substrate junction assembly 16.6667 6 yes
GO:0090259 regulation of retinal ganglion cell axon guidance 16.6667 6 yes
GO:0010631 epithelial cell migration 16.6667 5 yes
GO:0097475 motor neuron migration 16.6667 5 yes
GO:0010721 negative regulation of cell development 16.6667 6 yes
GO:0010810 regulation of cell-substrate adhesion 16.6667 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 16.6667 6 yes
GO:0010951 negative regulation of endopeptidase activity 16.6667 7 yes
GO:0010975 regulation of neuron projection development 16.6667 7 yes
GO:0150116 regulation of cell-substrate junction organization 16.6667 5 yes
GO:0010976 positive regulation of neuron projection development 16.6667 7 yes
GO:0150117 positive regulation of cell-substrate junction organization 16.6667 6 yes
GO:0022604 regulation of cell morphogenesis 16.6667 5 yes
GO:0030100 regulation of endocytosis 16.6667 5 yes
GO:0030155 regulation of cell adhesion 16.6667 4 yes
GO:1901890 positive regulation of cell junction assembly 16.6667 6 yes
GO:0030182 neuron differentiation 16.6667 4 yes
GO:1902336 positive regulation of retinal ganglion cell axon guidance 16.6667 7 yes
GO:1902667 regulation of axon guidance 16.6667 5 yes
GO:0030307 positive regulation of cell growth 16.6667 5 yes
GO:1902669 positive regulation of axon guidance 16.6667 6 yes
GO:0030516 regulation of axon extension 16.6667 5 yes
GO:1903829 positive regulation of protein localization 16.6667 5 yes
GO:0031346 positive regulation of cell projection organization 16.6667 6 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 16.6667 8 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 16.6667 7 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 16.6667 9 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 16.6667 8 yes
GO:0035767 endothelial cell chemotaxis 16.6667 5 yes
GO:0035924 cellular response to vascular endothelial growth factor stimulus 16.6667 6 yes
GO:2000177 regulation of neural precursor cell proliferation 16.6667 5 yes
GO:2000573 positive regulation of DNA biosynthetic process 16.6667 7 yes
GO:0038084 vascular endothelial growth factor signaling pathway 16.6667 6 yes
GO:0038189 neuropilin signaling pathway 16.6667 4 yes
GO:0038190 VEGF-activated neuropilin signaling pathway 16.6667 5 yes
GO:0043086 negative regulation of catalytic activity 16.6667 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 16.6667 8 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 16.6667 8 yes
GO:0043405 regulation of MAP kinase activity 16.6667 8 yes
GO:0043408 regulation of MAPK cascade 16.6667 6 yes
GO:0043410 positive regulation of MAPK cascade 16.6667 7 yes
GO:0043534 blood vessel endothelial cell migration 16.6667 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 16.6667 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 16.6667 7 yes
GO:0043542 endothelial cell migration 16.6667 6 yes
GO:0045773 positive regulation of axon extension 16.6667 6 yes
GO:0045785 positive regulation of cell adhesion 16.6667 5 yes
GO:0045807 positive regulation of endocytosis 16.6667 5 yes
GO:0045861 negative regulation of proteolysis 16.6667 7 yes
GO:0045927 positive regulation of growth 16.6667 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 16.6667 6 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 16.6667 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 16.6667 6 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 16.6667 6 yes
GO:0048514 blood vessel morphogenesis 16.6667 4 yes
GO:0048639 positive regulation of developmental growth 16.6667 5 yes
GO:0048754 branching morphogenesis of an epithelial tube 16.6667 4 yes
GO:0048841 regulation of axon extension involved in axon guidance 16.6667 6 yes
GO:0048842 positive regulation of axon extension involved in axon guidance 16.6667 6 yes
GO:0048844 artery morphogenesis 16.6667 5 yes
GO:0048878 chemical homeostasis 16.6667 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 16.6667 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 16.6667 9 yes
GO:0050770 regulation of axonogenesis 16.6667 5 yes
GO:0050772 positive regulation of axonogenesis 16.6667 6 yes
GO:0050918 positive chemotaxis 16.6667 4 yes
GO:0050920 regulation of chemotaxis 16.6667 4 yes
GO:0050921 positive regulation of chemotaxis 16.6667 5 yes
GO:0051302 regulation of cell division 11.1111 4 yes
GO:0001570 vasculogenesis 11.1111 4 yes
GO:0001654 eye development 11.1111 5 yes
GO:0001701 in utero embryonic development 11.1111 6 yes
GO:0001822 kidney development 11.1111 4 yes
GO:0051781 positive regulation of cell division 11.1111 5 yes
GO:0001894 tissue homeostasis 11.1111 5 yes
GO:0055001 muscle cell development 11.1111 4 yes
GO:0055006 cardiac cell development 11.1111 4 yes
GO:0002052 positive regulation of neuroblast proliferation 11.1111 7 yes
GO:0055013 cardiac muscle cell development 11.1111 5 yes
GO:0002090 regulation of receptor internalization 11.1111 7 yes
GO:0060055 angiogenesis involved in wound healing 11.1111 4 yes
GO:0002092 positive regulation of receptor internalization 11.1111 7 yes
GO:0060249 anatomical structure homeostasis 11.1111 4 yes
GO:0002521 leukocyte differentiation 11.1111 4 yes
GO:0002573 myeloid leukocyte differentiation 11.1111 5 yes
GO:0002575 basophil chemotaxis 11.1111 5 yes
GO:0060319 primitive erythrocyte differentiation 11.1111 6 yes
GO:0002685 regulation of leukocyte migration 11.1111 4 yes
GO:0002687 positive regulation of leukocyte migration 11.1111 5 yes
GO:0002688 regulation of leukocyte chemotaxis 11.1111 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 11.1111 6 yes
GO:0060688 regulation of morphogenesis of a branching structure 11.1111 4 yes
GO:0003007 heart morphogenesis 11.1111 4 yes
GO:0060753 regulation of mast cell chemotaxis 11.1111 6 yes
GO:0003018 vascular process in circulatory system 11.1111 4 yes
GO:0060754 positive regulation of mast cell chemotaxis 11.1111 7 yes
GO:0003169 coronary vein morphogenesis 11.1111 6 yes
GO:0060948 cardiac vascular smooth muscle cell development 11.1111 5 yes
GO:0007162 negative regulation of cell adhesion 11.1111 5 yes
GO:0061042 vascular wound healing 11.1111 5 yes
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia 11.1111 7 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 11.1111 5 yes
GO:0007423 sensory organ development 11.1111 4 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11.1111 6 yes
GO:0007498 mesoderm development 11.1111 4 yes
GO:0007589 body fluid secretion 11.1111 4 yes
GO:0007595 lactation 11.1111 5 yes
GO:0008360 regulation of cell shape 11.1111 6 yes
GO:0009792 embryo development ending in birth or egg hatching 11.1111 4 yes
GO:0071453 cellular response to oxygen levels 11.1111 4 yes
GO:0071456 cellular response to hypoxia 11.1111 4 yes
GO:0071542 dopaminergic neuron differentiation 11.1111 5 yes
GO:0071621 granulocyte chemotaxis 11.1111 4 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 11.1111 8 yes
GO:0090036 regulation of protein kinase C signaling 11.1111 6 yes
GO:0090037 positive regulation of protein kinase C signaling 11.1111 7 yes
GO:0090045 positive regulation of deacetylase activity 11.1111 6 yes
GO:0090183 regulation of kidney development 11.1111 4 yes
GO:0090189 regulation of branching involved in ureteric bud morphogenesis 11.1111 5 yes
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 11.1111 5 yes
GO:0090311 regulation of protein deacetylation 11.1111 7 yes
GO:0090312 positive regulation of protein deacetylation 11.1111 8 yes
GO:0090596 sensory organ morphogenesis 11.1111 4 yes
GO:0097084 vascular associated smooth muscle cell development 11.1111 5 yes
GO:0097530 granulocyte migration 11.1111 4 yes
GO:0010749 regulation of nitric oxide mediated signal transduction 11.1111 6 yes
GO:0097533 cellular stress response to acid chemical 11.1111 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 11.1111 4 yes
GO:0150065 regulation of deacetylase activity 11.1111 5 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 11.1111 6 yes
GO:1900084 regulation of peptidyl-tyrosine autophosphorylation 11.1111 9 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 11.1111 7 yes
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation 11.1111 10 yes
GO:1900744 regulation of p38MAPK cascade 11.1111 7 yes
GO:1900745 positive regulation of p38MAPK cascade 11.1111 8 yes
GO:0022407 regulation of cell-cell adhesion 11.1111 5 yes
GO:1901163 regulation of trophoblast cell migration 11.1111 4 yes
GO:0022408 negative regulation of cell-cell adhesion 11.1111 6 yes
GO:1901165 positive regulation of trophoblast cell migration 11.1111 5 yes
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 11.1111 9 yes
GO:1901550 regulation of endothelial cell development 11.1111 6 yes
GO:1901551 negative regulation of endothelial cell development 11.1111 7 yes
GO:0030099 myeloid cell differentiation 11.1111 4 yes
GO:1901725 regulation of histone deacetylase activity 11.1111 6 yes
GO:1901727 positive regulation of histone deacetylase activity 11.1111 7 yes
GO:0030218 erythrocyte differentiation 11.1111 5 yes
GO:0030224 monocyte differentiation 11.1111 6 yes
GO:0030225 macrophage differentiation 11.1111 6 yes
GO:0030324 lung development 11.1111 4 yes
GO:1902692 regulation of neuroblast proliferation 11.1111 6 yes
GO:1902965 regulation of protein localization to early endosome 11.1111 7 yes
GO:0030855 epithelial cell differentiation 11.1111 4 yes
GO:1902966 positive regulation of protein localization to early endosome 11.1111 7 yes
GO:0030856 regulation of epithelial cell differentiation 11.1111 5 yes
GO:1903131 mononuclear cell differentiation 11.1111 5 yes
GO:0030857 negative regulation of epithelial cell differentiation 11.1111 6 yes
GO:1903140 regulation of establishment of endothelial barrier 11.1111 7 yes
GO:0031056 regulation of histone modification 11.1111 7 yes
GO:1903141 negative regulation of establishment of endothelial barrier 11.1111 8 yes
GO:0031058 positive regulation of histone modification 11.1111 8 yes
GO:1903391 regulation of adherens junction organization 11.1111 5 yes
GO:0031063 regulation of histone deacetylation 11.1111 8 yes
GO:1903392 negative regulation of adherens junction organization 11.1111 6 yes
GO:0031065 positive regulation of histone deacetylation 11.1111 9 yes
GO:0031077 post-embryonic camera-type eye development 11.1111 5 yes
GO:1903570 regulation of protein kinase D signaling 11.1111 6 yes
GO:1903572 positive regulation of protein kinase D signaling 11.1111 7 yes
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 11.1111 7 yes
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 11.1111 8 yes
GO:1903670 regulation of sprouting angiogenesis 11.1111 6 yes
GO:1903672 positive regulation of sprouting angiogenesis 11.1111 7 yes
GO:1905276 regulation of epithelial tube formation 11.1111 5 yes
GO:1905278 positive regulation of epithelial tube formation 11.1111 5 yes
GO:1905330 regulation of morphogenesis of an epithelium 11.1111 5 yes
GO:0031952 regulation of protein autophosphorylation 11.1111 8 yes
GO:1905332 positive regulation of morphogenesis of an epithelium 11.1111 5 yes
GO:0031954 positive regulation of protein autophosphorylation 11.1111 9 yes
GO:1905603 regulation of blood-brain barrier permeability 11.1111 4 yes
GO:1905604 negative regulation of blood-brain barrier permeability 11.1111 5 yes
GO:1905666 regulation of protein localization to endosome 11.1111 6 yes
GO:0032147 activation of protein kinase activity 11.1111 8 yes
GO:1905668 positive regulation of protein localization to endosome 11.1111 6 yes
GO:0032793 positive regulation of CREB transcription factor activity 11.1111 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 11.1111 6 yes
GO:2000027 regulation of animal organ morphogenesis 11.1111 5 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 11.1111 7 yes
GO:2000047 regulation of cell-cell adhesion mediated by cadherin 11.1111 6 yes
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin 11.1111 7 yes
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 11.1111 6 yes
GO:2000179 positive regulation of neural precursor cell proliferation 11.1111 6 yes
GO:2000243 positive regulation of reproductive process 11.1111 4 yes
GO:0036294 cellular response to decreased oxygen levels 11.1111 5 yes
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway 11.1111 7 yes
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 11.1111 7 yes
GO:2001026 regulation of endothelial cell chemotaxis 11.1111 5 yes
GO:2001028 positive regulation of endothelial cell chemotaxis 11.1111 6 yes
GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway 11.1111 7 yes
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway 11.1111 7 yes
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 11.1111 6 yes
GO:0042461 photoreceptor cell development 11.1111 5 yes
GO:0042462 eye photoreceptor cell development 11.1111 6 yes
GO:0043009 chordate embryonic development 11.1111 5 yes
GO:0043010 camera-type eye development 11.1111 6 yes
GO:0043116 negative regulation of vascular permeability 11.1111 4 yes
GO:0043117 positive regulation of vascular permeability 11.1111 4 yes
GO:0043129 surfactant homeostasis 11.1111 6 yes
GO:0043406 positive regulation of MAP kinase activity 11.1111 8 yes
GO:0045601 regulation of endothelial cell differentiation 11.1111 6 yes
GO:0045602 negative regulation of endothelial cell differentiation 11.1111 7 yes
GO:0046903 secretion 11.1111 4 yes
GO:0048569 post-embryonic animal organ development 11.1111 4 yes
GO:0048592 eye morphogenesis 11.1111 5 yes
GO:0048593 camera-type eye morphogenesis 11.1111 6 yes
GO:0048666 neuron development 11.1111 4 yes
GO:0048845 venous blood vessel morphogenesis 11.1111 5 yes
GO:0048875 chemical homeostasis within a tissue 11.1111 5 yes
GO:0050926 regulation of positive chemotaxis 11.1111 5 yes
GO:0050927 positive regulation of positive chemotaxis 11.1111 6 yes
GO:0050930 induction of positive chemotaxis 11.1111 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR2_HUMAN [view interactions] Low throughput no no
VGFR1_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
PLGF_HUMAN [view interactions] Low throughput no no
UBIA1_HUMAN [view interactions] Low throughput no no
ATS1_HUMAN [view interactions] Low throughput no no
CCN2_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
HNRPD_HUMAN [view entry] [view interactions] Low throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR3_HUMAN [view interactions] Low throughput no yes
HNRPL_HUMAN [view interactions] Low throughput no yes
ILF3_HUMAN [view interactions] Low throughput no yes
PTPRB_HUMAN [view interactions] Low throughput no yes
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view interactions] Low throughput no yes
FINC_HUMAN [view interactions] Low throughput no yes
IBP7_HUMAN [view interactions] Low throughput no no
VTNC_HUMAN [view interactions] Low throughput no no
GPC1_HUMAN [view entry] [view interactions] Low throughput yes no
LYVE1_HUMAN [view interactions] Low throughput no yes
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1A_HUMAN [view interactions] Low throughput no no
SP1_HUMAN [view interactions] Low throughput no yes
SP3_HUMAN [view interactions] Low throughput no no
AP2A_HUMAN [view interactions] Low throughput no no
SPRC_HUMAN [view interactions] Low throughput no yes
USF2_HUMAN [view interactions] Low throughput no no
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
EPAS1_HUMAN [view interactions] Low throughput no no
FOS_HUMAN [view interactions] Low throughput no yes
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
LCN1_HUMAN [view interactions] Low throughput no no
NCBP3_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
VEGFB_HUMAN [view interactions] High throughput no no
S35C2_HUMAN [view interactions] High throughput no yes
MOT8_HUMAN [view interactions] High throughput no no
TM237_HUMAN [view interactions] High throughput no no
CXB1_HUMAN [view interactions] High throughput no yes
ACTBL_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes