Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VEGFA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004009 LIG_NRP_CendR_1 LIG 188 191 -
ELMI004009 LIG_NRP_CendR_1 LIG 188 191 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VEGFA_HUMAN
GO:0042803 protein homodimerization activity 36.8421 4 yes
GO:0043169 cation binding 31.5789 4 no
GO:0046872 metal ion binding 31.5789 5 no
GO:0003723 RNA binding 31.5789 4 no
GO:0044389 ubiquitin-like protein ligase binding 21.0526 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0005125 cytokine activity 10.5263 5 yes
GO:0005126 cytokine receptor binding 10.5263 4 yes
GO:0005161 platelet-derived growth factor receptor binding 10.5263 5 yes
GO:0005172 vascular endothelial growth factor receptor binding 10.5263 5 yes
GO:0008083 growth factor activity 10.5263 5 yes
GO:0019209 kinase activator activity 10.5263 4 yes
GO:0019887 protein kinase regulator activity 10.5263 4 yes
GO:0030295 protein kinase activator activity 10.5263 5 yes
GO:0030296 protein tyrosine kinase activator activity 10.5263 6 yes
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 10.5263 4 yes
GO:0038191 neuropilin binding 10.5263 4 yes
GO:0042056 chemoattractant activity 10.5263 5 yes
GO:0043183 vascular endothelial growth factor receptor 1 binding 10.5263 6 yes
GO:0043184 vascular endothelial growth factor receptor 2 binding 10.5263 6 yes
GO:0048018 receptor ligand activity 10.5263 4 yes
GO:0070851 growth factor receptor binding 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VEGFA_HUMAN
GO:0048522 positive regulation of cellular process 84.2105 4 yes
GO:0031323 regulation of cellular metabolic process 78.9474 4 yes
GO:0060255 regulation of macromolecule metabolic process 78.9474 4 yes
GO:0080090 regulation of primary metabolic process 78.9474 4 yes
GO:0031326 regulation of cellular biosynthetic process 73.6842 5 yes
GO:0009889 regulation of biosynthetic process 73.6842 4 yes
GO:0010468 regulation of gene expression 73.6842 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 73.6842 5 yes
GO:0031325 positive regulation of cellular metabolic process 68.4211 5 yes
GO:0048523 negative regulation of cellular process 68.4211 4 yes
GO:0051246 regulation of protein metabolic process 68.4211 5 yes
GO:0009893 positive regulation of metabolic process 68.4211 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 68.4211 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 63.1579 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 63.1579 6 yes
GO:0009891 positive regulation of biosynthetic process 63.1579 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 63.1579 6 yes
GO:0042127 regulation of cell population proliferation 57.8947 4 yes
GO:0051247 positive regulation of protein metabolic process 57.8947 6 yes
GO:0051252 regulation of RNA metabolic process 57.8947 5 yes
GO:0009966 regulation of signal transduction 57.8947 4 yes
GO:0010628 positive regulation of gene expression 57.8947 7 yes
GO:0010646 regulation of cell communication 57.8947 4 yes
GO:0009894 regulation of catabolic process 52.6316 4 no
GO:0051094 positive regulation of developmental process 52.6316 4 yes
GO:0051128 regulation of cellular component organization 52.6316 4 yes
GO:0009892 negative regulation of metabolic process 52.6316 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 52.6316 5 yes
GO:2001141 regulation of RNA biosynthetic process 47.3684 6 yes
GO:0008104 protein localization 47.3684 4 no
GO:0022607 cellular component assembly 47.3684 4 no
GO:0033365 protein localization to organelle 47.3684 5 no
GO:0048585 negative regulation of response to stimulus 47.3684 4 no
GO:0042981 regulation of apoptotic process 47.3684 5 yes
GO:0043067 regulation of programmed cell death 47.3684 4 yes
GO:0045595 regulation of cell differentiation 47.3684 4 yes
GO:0045597 positive regulation of cell differentiation 47.3684 5 yes
GO:0051049 regulation of transport 47.3684 4 yes
GO:0051240 positive regulation of multicellular organismal process 47.3684 4 yes
GO:0006355 regulation of DNA-templated transcription 47.3684 7 yes
GO:0031324 negative regulation of cellular metabolic process 42.1053 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 42.1053 6 yes
GO:0043066 negative regulation of apoptotic process 42.1053 6 yes
GO:0043069 negative regulation of programmed cell death 42.1053 5 yes
GO:0044087 regulation of cellular component biogenesis 42.1053 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 42.1053 5 yes
GO:0048584 positive regulation of response to stimulus 42.1053 4 yes
GO:0051253 negative regulation of RNA metabolic process 42.1053 6 yes
GO:0009890 negative regulation of biosynthetic process 42.1053 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 42.1053 6 yes
GO:0010629 negative regulation of gene expression 42.1053 7 yes
GO:0019220 regulation of phosphate metabolic process 36.8421 6 yes
GO:0023056 positive regulation of signaling 36.8421 4 yes
GO:2000026 regulation of multicellular organismal development 36.8421 4 yes
GO:0006886 intracellular protein transport 36.8421 4 no
GO:0015031 protein transport 36.8421 4 no
GO:0032101 regulation of response to external stimulus 36.8421 4 yes
GO:0071702 organic substance transport 36.8421 4 no
GO:0071705 nitrogen compound transport 36.8421 4 no
GO:0080134 regulation of response to stress 36.8421 4 no
GO:0040017 positive regulation of locomotion 36.8421 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 36.8421 5 yes
GO:0051050 positive regulation of transport 36.8421 4 yes
GO:0051129 negative regulation of cellular component organization 36.8421 5 yes
GO:0051130 positive regulation of cellular component organization 36.8421 5 yes
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 yes
GO:0060341 regulation of cellular localization 36.8421 4 yes
GO:0008284 positive regulation of cell population proliferation 36.8421 5 yes
GO:0009967 positive regulation of signal transduction 36.8421 5 yes
GO:0010647 positive regulation of cell communication 36.8421 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 31.5789 4 yes
GO:0030334 regulation of cell migration 31.5789 5 yes
GO:2000145 regulation of cell motility 31.5789 4 yes
GO:0030335 positive regulation of cell migration 31.5789 6 yes
GO:2000147 positive regulation of cell motility 31.5789 5 yes
GO:0006996 organelle organization 31.5789 4 no
GO:0031344 regulation of cell projection organization 31.5789 5 yes
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0031399 regulation of protein modification process 31.5789 6 yes
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0032880 regulation of protein localization 31.5789 5 yes
GO:0072594 establishment of protein localization to organelle 31.5789 4 no
GO:0036293 response to decreased oxygen levels 31.5789 4 yes
GO:0009896 positive regulation of catabolic process 31.5789 5 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0065003 protein-containing complex assembly 31.5789 5 no
GO:0043254 regulation of protein-containing complex assembly 31.5789 5 yes
GO:0044089 positive regulation of cellular component biogenesis 31.5789 5 yes
GO:0045892 negative regulation of DNA-templated transcription 31.5789 8 yes
GO:0045893 positive regulation of DNA-templated transcription 31.5789 8 yes
GO:0050678 regulation of epithelial cell proliferation 31.5789 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 31.5789 6 yes
GO:0051248 negative regulation of protein metabolic process 31.5789 6 yes
GO:0051254 positive regulation of RNA metabolic process 31.5789 6 yes
GO:0060284 regulation of cell development 31.5789 5 yes
GO:0001936 regulation of endothelial cell proliferation 31.5789 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 31.5789 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 31.5789 8 yes
GO:0090287 regulation of cellular response to growth factor stimulus 31.5789 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.5789 6 yes
GO:1902531 regulation of intracellular signal transduction 31.5789 5 yes
GO:1902679 negative regulation of RNA biosynthetic process 31.5789 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 31.5789 7 yes
GO:1903829 positive regulation of protein localization 26.3158 5 yes
GO:0030030 cell projection organization 26.3158 4 yes
GO:0030162 regulation of proteolysis 26.3158 6 yes
GO:0031401 positive regulation of protein modification process 26.3158 7 yes
GO:0042176 regulation of protein catabolic process 26.3158 5 no
GO:0009057 macromolecule catabolic process 26.3158 4 no
GO:0009895 negative regulation of catabolic process 26.3158 5 no
GO:0042325 regulation of phosphorylation 26.3158 7 yes
GO:0014070 response to organic cyclic compound 26.3158 4 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 yes
GO:0045765 regulation of angiogenesis 26.3158 5 yes
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 26.3158 9 yes
GO:0051093 negative regulation of developmental process 26.3158 4 yes
GO:0051338 regulation of transferase activity 26.3158 4 yes
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 yes
GO:0001764 neuron migration 26.3158 4 yes
GO:0001932 regulation of protein phosphorylation 26.3158 7 yes
GO:1901342 regulation of vasculature development 26.3158 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 yes
GO:1904018 positive regulation of vasculature development 21.0526 5 yes
GO:2000278 regulation of DNA biosynthetic process 21.0526 6 yes
GO:0031175 neuron projection development 21.0526 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 21.0526 6 yes
GO:0031346 positive regulation of cell projection organization 21.0526 6 yes
GO:0032103 positive regulation of response to external stimulus 21.0526 5 yes
GO:0061024 membrane organization 21.0526 4 no
GO:0072657 protein localization to membrane 21.0526 4 no
GO:0030163 protein catabolic process 21.0526 4 no
GO:0036294 cellular response to decreased oxygen levels 21.0526 5 yes
GO:0031329 regulation of cellular catabolic process 21.0526 5 no
GO:0050821 protein stabilization 21.0526 4 no
GO:1901565 organonitrogen compound catabolic process 21.0526 4 no
GO:0007005 mitochondrion organization 21.0526 5 no
GO:0031347 regulation of defense response 21.0526 5 no
GO:0032102 negative regulation of response to external stimulus 21.0526 5 no
GO:0032386 regulation of intracellular transport 21.0526 5 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0045732 positive regulation of protein catabolic process 21.0526 6 no
GO:0001817 regulation of cytokine production 21.0526 4 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 yes
GO:0001819 positive regulation of cytokine production 21.0526 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0033993 response to lipid 21.0526 4 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0090304 nucleic acid metabolic process 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 yes
GO:0045596 negative regulation of cell differentiation 21.0526 5 yes
GO:0045766 positive regulation of angiogenesis 21.0526 6 yes
GO:0045859 regulation of protein kinase activity 21.0526 6 yes
GO:0048638 regulation of developmental growth 21.0526 4 yes
GO:0050767 regulation of neurogenesis 21.0526 6 yes
GO:0050769 positive regulation of neurogenesis 21.0526 6 yes
GO:0051052 regulation of DNA metabolic process 21.0526 5 yes
GO:0051054 positive regulation of DNA metabolic process 21.0526 6 yes
GO:0051347 positive regulation of transferase activity 21.0526 5 yes
GO:0051960 regulation of nervous system development 21.0526 5 yes
GO:0051962 positive regulation of nervous system development 21.0526 5 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 21.0526 9 yes
GO:0001558 regulation of cell growth 21.0526 4 yes
GO:0001667 ameboidal-type cell migration 21.0526 4 yes
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 yes
GO:0071363 cellular response to growth factor stimulus 21.0526 4 yes
GO:0071453 cellular response to oxygen levels 21.0526 4 yes
GO:0071456 cellular response to hypoxia 21.0526 4 yes
GO:0002684 positive regulation of immune system process 21.0526 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.0526 5 yes
GO:0097485 neuron projection guidance 21.0526 7 yes
GO:0007411 axon guidance 21.0526 8 yes
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 yes
GO:1901888 regulation of cell junction assembly 21.0526 5 yes
GO:0010594 regulation of endothelial cell migration 21.0526 5 yes
GO:0010595 positive regulation of endothelial cell migration 21.0526 6 yes
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 yes
GO:0010632 regulation of epithelial cell migration 21.0526 4 yes
GO:0010634 positive regulation of epithelial cell migration 21.0526 5 yes
GO:0010720 positive regulation of cell development 21.0526 6 yes
GO:0010975 regulation of neuron projection development 21.0526 7 yes
GO:0030100 regulation of endocytosis 15.7895 5 yes
GO:0030155 regulation of cell adhesion 15.7895 4 yes
GO:0030182 neuron differentiation 15.7895 4 yes
GO:0030307 positive regulation of cell growth 15.7895 5 yes
GO:0030516 regulation of axon extension 15.7895 5 yes
GO:2000177 regulation of neural precursor cell proliferation 15.7895 5 yes
GO:2000573 positive regulation of DNA biosynthetic process 15.7895 7 yes
GO:2000628 regulation of miRNA metabolic process 15.7895 6 yes
GO:0031290 retinal ganglion cell axon guidance 15.7895 9 yes
GO:0033674 positive regulation of kinase activity 15.7895 6 yes
GO:0035767 endothelial cell chemotaxis 15.7895 5 yes
GO:0035924 cellular response to vascular endothelial growth factor stimulus 15.7895 5 yes
GO:0038084 vascular endothelial growth factor signaling pathway 15.7895 6 yes
GO:0038189 neuropilin signaling pathway 15.7895 4 yes
GO:0038190 VEGF-activated neuropilin signaling pathway 15.7895 5 yes
GO:0043405 regulation of MAP kinase activity 15.7895 8 yes
GO:0043408 regulation of MAPK cascade 15.7895 6 yes
GO:0043410 positive regulation of MAPK cascade 15.7895 7 yes
GO:0043534 blood vessel endothelial cell migration 15.7895 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 15.7895 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 15.7895 7 yes
GO:0043542 endothelial cell migration 15.7895 6 yes
GO:0045773 positive regulation of axon extension 15.7895 6 yes
GO:0045785 positive regulation of cell adhesion 15.7895 5 yes
GO:0045807 positive regulation of endocytosis 15.7895 5 yes
GO:0045860 positive regulation of protein kinase activity 15.7895 7 yes
GO:0045861 negative regulation of proteolysis 15.7895 7 yes
GO:0045927 positive regulation of growth 15.7895 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 15.7895 6 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 15.7895 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 15.7895 6 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 15.7895 6 yes
GO:0048514 blood vessel morphogenesis 15.7895 4 yes
GO:0048639 positive regulation of developmental growth 15.7895 5 yes
GO:0048754 branching morphogenesis of an epithelial tube 15.7895 4 yes
GO:0048841 regulation of axon extension involved in axon guidance 15.7895 6 yes
GO:0048842 positive regulation of axon extension involved in axon guidance 15.7895 6 yes
GO:0048844 artery morphogenesis 15.7895 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 15.7895 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 15.7895 9 yes
GO:0050770 regulation of axonogenesis 15.7895 5 yes
GO:0050772 positive regulation of axonogenesis 15.7895 6 yes
GO:0050918 positive chemotaxis 15.7895 4 yes
GO:0050920 regulation of chemotaxis 15.7895 4 yes
GO:0050921 positive regulation of chemotaxis 15.7895 5 yes
GO:0051336 regulation of hydrolase activity 15.7895 4 yes
GO:0051893 regulation of focal adhesion assembly 15.7895 7 yes
GO:0051894 positive regulation of focal adhesion assembly 15.7895 7 yes
GO:0052547 regulation of peptidase activity 15.7895 5 yes
GO:0052548 regulation of endopeptidase activity 15.7895 6 yes
GO:0001569 branching involved in blood vessel morphogenesis 15.7895 5 yes
GO:0001570 vasculogenesis 15.7895 4 yes
GO:0060326 cell chemotaxis 15.7895 4 yes
GO:0060977 coronary vasculature morphogenesis 15.7895 5 yes
GO:0060982 coronary artery morphogenesis 15.7895 6 yes
GO:0001952 regulation of cell-matrix adhesion 15.7895 6 yes
GO:0061387 regulation of extent of cell growth 15.7895 5 yes
GO:0001954 positive regulation of cell-matrix adhesion 15.7895 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 15.7895 7 yes
GO:0002009 morphogenesis of an epithelium 15.7895 4 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 15.7895 8 yes
GO:0002040 sprouting angiogenesis 15.7895 4 yes
GO:0002042 cell migration involved in sprouting angiogenesis 15.7895 8 yes
GO:0071679 commissural neuron axon guidance 15.7895 9 yes
GO:0071900 regulation of protein serine/threonine kinase activity 15.7895 7 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 15.7895 7 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 15.7895 8 yes
GO:0090109 regulation of cell-substrate junction assembly 15.7895 6 yes
GO:0097475 motor neuron migration 15.7895 5 yes
GO:0007399 nervous system development 15.7895 4 yes
GO:0150116 regulation of cell-substrate junction organization 15.7895 5 yes
GO:0150117 positive regulation of cell-substrate junction organization 15.7895 6 yes
GO:1901890 positive regulation of cell junction assembly 15.7895 6 yes
GO:0010631 epithelial cell migration 15.7895 5 yes
GO:1902893 regulation of miRNA transcription 15.7895 7 yes
GO:0010721 negative regulation of cell development 15.7895 6 yes
GO:0010810 regulation of cell-substrate adhesion 15.7895 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 15.7895 6 yes
GO:1903670 regulation of sprouting angiogenesis 10.5263 6 yes
GO:1903672 positive regulation of sprouting angiogenesis 10.5263 7 yes
GO:0022407 regulation of cell-cell adhesion 10.5263 5 yes
GO:0022408 negative regulation of cell-cell adhesion 10.5263 6 yes
GO:1905276 regulation of epithelial tube formation 10.5263 5 yes
GO:0022604 regulation of cell morphogenesis 10.5263 5 yes
GO:1905278 positive regulation of epithelial tube formation 10.5263 5 yes
GO:1905330 regulation of morphogenesis of an epithelium 10.5263 5 yes
GO:1905332 positive regulation of morphogenesis of an epithelium 10.5263 5 yes
GO:0030099 myeloid cell differentiation 10.5263 4 yes
GO:1905603 regulation of blood-brain barrier permeability 10.5263 4 yes
GO:1905604 negative regulation of blood-brain barrier permeability 10.5263 5 yes
GO:1905666 regulation of protein localization to endosome 10.5263 6 yes
GO:1905668 positive regulation of protein localization to endosome 10.5263 6 yes
GO:0030218 erythrocyte differentiation 10.5263 5 yes
GO:2000027 regulation of animal organ morphogenesis 10.5263 5 yes
GO:0030224 monocyte differentiation 10.5263 6 yes
GO:2000047 regulation of cell-cell adhesion mediated by cadherin 10.5263 6 yes
GO:0030225 macrophage differentiation 10.5263 6 yes
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin 10.5263 7 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 10.5263 7 yes
GO:0030324 lung development 10.5263 4 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 10.5263 8 yes
GO:0030855 epithelial cell differentiation 10.5263 4 yes
GO:2000179 positive regulation of neural precursor cell proliferation 10.5263 6 yes
GO:0030856 regulation of epithelial cell differentiation 10.5263 5 yes
GO:2000243 positive regulation of reproductive process 10.5263 4 yes
GO:0030857 negative regulation of epithelial cell differentiation 10.5263 6 yes
GO:0031077 post-embryonic camera-type eye development 10.5263 7 yes
GO:2000629 negative regulation of miRNA metabolic process 10.5263 7 yes
GO:2001026 regulation of endothelial cell chemotaxis 10.5263 5 yes
GO:2001028 positive regulation of endothelial cell chemotaxis 10.5263 6 yes
GO:0031952 regulation of protein autophosphorylation 10.5263 8 yes
GO:0031954 positive regulation of protein autophosphorylation 10.5263 9 yes
GO:0032147 activation of protein kinase activity 10.5263 8 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 10.5263 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 10.5263 9 yes
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway 10.5263 7 yes
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 10.5263 7 yes
GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway 10.5263 7 yes
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway 10.5263 7 yes
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 10.5263 6 yes
GO:0042461 photoreceptor cell development 10.5263 5 yes
GO:0042462 eye photoreceptor cell development 10.5263 6 yes
GO:0043009 chordate embryonic development 10.5263 5 yes
GO:0043010 camera-type eye development 10.5263 6 yes
GO:0043086 negative regulation of catalytic activity 10.5263 4 yes
GO:0043116 negative regulation of vascular permeability 10.5263 4 yes
GO:0043117 positive regulation of vascular permeability 10.5263 4 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 10.5263 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 10.5263 7 yes
GO:0043129 surfactant homeostasis 10.5263 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 10.5263 7 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 10.5263 8 yes
GO:0043406 positive regulation of MAP kinase activity 10.5263 8 yes
GO:0045601 regulation of endothelial cell differentiation 10.5263 6 yes
GO:0045602 negative regulation of endothelial cell differentiation 10.5263 7 yes
GO:0046903 secretion 10.5263 4 yes
GO:0048592 eye morphogenesis 10.5263 5 yes
GO:0048593 camera-type eye morphogenesis 10.5263 6 yes
GO:0048666 neuron development 10.5263 4 yes
GO:0048845 venous blood vessel morphogenesis 10.5263 5 yes
GO:0050926 regulation of positive chemotaxis 10.5263 5 yes
GO:0050927 positive regulation of positive chemotaxis 10.5263 6 yes
GO:0050930 induction of positive chemotaxis 10.5263 7 yes
GO:0051302 regulation of cell division 10.5263 4 yes
GO:0051346 negative regulation of hydrolase activity 10.5263 5 yes
GO:0051781 positive regulation of cell division 10.5263 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 10.5263 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 10.5263 7 yes
GO:0055001 muscle cell development 10.5263 4 yes
GO:0055006 cardiac cell development 10.5263 4 yes
GO:0055013 cardiac muscle cell development 10.5263 5 yes
GO:0060055 angiogenesis involved in wound healing 10.5263 4 yes
GO:0060319 primitive erythrocyte differentiation 10.5263 6 yes
GO:0001654 eye development 10.5263 5 yes
GO:0001701 in utero embryonic development 10.5263 6 yes
GO:0060688 regulation of morphogenesis of a branching structure 10.5263 4 yes
GO:0060753 regulation of mast cell chemotaxis 10.5263 6 yes
GO:0001822 kidney development 10.5263 4 yes
GO:0060754 positive regulation of mast cell chemotaxis 10.5263 7 yes
GO:0060948 cardiac vascular smooth muscle cell development 10.5263 5 yes
GO:0061042 vascular wound healing 10.5263 5 yes
GO:0002052 positive regulation of neuroblast proliferation 10.5263 7 yes
GO:0002090 regulation of receptor internalization 10.5263 7 yes
GO:0071542 dopaminergic neuron differentiation 10.5263 5 yes
GO:0002092 positive regulation of receptor internalization 10.5263 7 yes
GO:0071621 granulocyte chemotaxis 10.5263 4 yes
GO:0002521 leukocyte differentiation 10.5263 4 yes
GO:0002573 myeloid leukocyte differentiation 10.5263 5 yes
GO:0002575 basophil chemotaxis 10.5263 5 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 10.5263 8 yes
GO:0002685 regulation of leukocyte migration 10.5263 4 yes
GO:0090036 regulation of protein kinase C signaling 10.5263 6 yes
GO:0002687 positive regulation of leukocyte migration 10.5263 5 yes
GO:0090037 positive regulation of protein kinase C signaling 10.5263 7 yes
GO:0002688 regulation of leukocyte chemotaxis 10.5263 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 10.5263 6 yes
GO:0003007 heart morphogenesis 10.5263 4 yes
GO:0003018 vascular process in circulatory system 10.5263 4 yes
GO:0090183 regulation of kidney development 10.5263 4 yes
GO:0003169 coronary vein morphogenesis 10.5263 6 yes
GO:0090189 regulation of branching involved in ureteric bud morphogenesis 10.5263 5 yes
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 10.5263 5 yes
GO:0007162 negative regulation of cell adhesion 10.5263 5 yes
GO:0090596 sensory organ morphogenesis 10.5263 4 yes
GO:0097084 vascular associated smooth muscle cell development 10.5263 5 yes
GO:0097530 granulocyte migration 10.5263 4 yes
GO:0007423 sensory organ development 10.5263 4 yes
GO:0097533 cellular stress response to acid chemical 10.5263 4 yes
GO:0007498 mesoderm development 10.5263 4 yes
GO:0007589 body fluid secretion 10.5263 4 yes
GO:0007595 lactation 10.5263 5 yes
GO:0120161 regulation of cold-induced thermogenesis 10.5263 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 10.5263 5 yes
GO:0009792 embryo development ending in birth or egg hatching 10.5263 4 yes
GO:1900084 regulation of peptidyl-tyrosine autophosphorylation 10.5263 9 yes
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation 10.5263 10 yes
GO:1900744 regulation of p38MAPK cascade 10.5263 7 yes
GO:1900745 positive regulation of p38MAPK cascade 10.5263 8 yes
GO:1900746 regulation of vascular endothelial growth factor signaling pathway 10.5263 5 yes
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway 10.5263 6 yes
GO:0010466 negative regulation of peptidase activity 10.5263 6 yes
GO:1901163 regulation of trophoblast cell migration 10.5263 6 yes
GO:1901165 positive regulation of trophoblast cell migration 10.5263 5 yes
GO:1901550 regulation of endothelial cell development 10.5263 6 yes
GO:1901551 negative regulation of endothelial cell development 10.5263 7 yes
GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 10.5263 5 yes
GO:1902692 regulation of neuroblast proliferation 10.5263 6 yes
GO:1902894 negative regulation of miRNA transcription 10.5263 8 yes
GO:1902965 regulation of protein localization to early endosome 10.5263 7 yes
GO:1902966 positive regulation of protein localization to early endosome 10.5263 7 yes
GO:1903131 mononuclear cell differentiation 10.5263 5 yes
GO:1903140 regulation of establishment of endothelial barrier 10.5263 7 yes
GO:0010749 regulation of nitric oxide mediated signal transduction 10.5263 6 yes
GO:1903141 negative regulation of establishment of endothelial barrier 10.5263 8 yes
GO:1903391 regulation of adherens junction organization 10.5263 5 yes
GO:1903392 negative regulation of adherens junction organization 10.5263 6 yes
GO:0010951 negative regulation of endopeptidase activity 10.5263 7 yes
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 10.5263 7 yes
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 10.5263 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR2_HUMAN [view interactions] Low throughput no no
VGFR1_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
PLGF_HUMAN [view interactions] Low throughput no no
UBIA1_HUMAN [view interactions] Low throughput no no
ATS1_HUMAN [view interactions] Low throughput no no
CCN2_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
HNRPD_HUMAN [view entry] [view interactions] Low throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR3_HUMAN [view interactions] Low throughput no yes
HNRPL_HUMAN [view interactions] Low throughput no yes
ILF3_HUMAN [view interactions] Low throughput no yes
PTPRB_HUMAN [view interactions] Low throughput no yes
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
FINC_HUMAN [view interactions] Low throughput no yes
IBP7_HUMAN [view interactions] Low throughput no no
VTNC_HUMAN [view interactions] Low throughput no no
GPC1_HUMAN [view entry] [view interactions] Low throughput yes no
LYVE1_HUMAN [view interactions] Low throughput no yes
NRP2_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1A_HUMAN [view interactions] Low throughput no no
SP1_HUMAN [view interactions] Low throughput no yes
SP3_HUMAN [view interactions] Low throughput no no
AP2A_HUMAN [view interactions] Low throughput no no
SPRC_HUMAN [view interactions] Low throughput no yes
USF2_HUMAN [view interactions] Low throughput no no
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
EPAS1_HUMAN [view interactions] Low throughput no no
FOS_HUMAN [view interactions] Low throughput no yes
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
LCN1_HUMAN [view interactions] Low throughput no no
NCBP3_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
VEGFB_HUMAN [view interactions] High throughput no no
S35C2_HUMAN [view interactions] High throughput no yes
MOT8_HUMAN [view interactions] High throughput no no
TM237_HUMAN [view interactions] High throughput no no
CXB1_HUMAN [view interactions] High throughput no yes
ACTBL_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes