GPC1_HUMAN
Evidence for PS localization
Functions
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination . May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPC1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 42.3529 | 4 | no |
| GO:0045296 | cadherin binding | 22.3529 | 4 | no |
| GO:0043168 | anion binding | 21.1765 | 4 | no |
| GO:0043169 | cation binding | 12.9412 | 4 | yes |
| GO:0046872 | metal ion binding | 12.9412 | 5 | yes |
| GO:0017134 | fibroblast growth factor binding | 2.3529 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.7647 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.2353 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.8824 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.8824 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.5294 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.3529 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.1765 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.1765 | 5 | no |
| GO:0010646 | regulation of cell communication | 38.8235 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.8235 | 6 | no |
| GO:0022607 | cellular component assembly | 34.1176 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 32.9412 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.9412 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.9412 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.7647 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7647 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.5882 | 5 | no |
| GO:0006996 | organelle organization | 28.2353 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.2353 | 5 | no |
| GO:0008104 | protein localization | 28.2353 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.0588 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.0588 | 5 | no |
| GO:0051049 | regulation of transport | 27.0588 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.0588 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.8824 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 25.8824 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 25.8824 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 24.7059 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.7059 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.3529 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.3529 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.3529 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.3529 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.3529 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.3529 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.3529 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.3529 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.3529 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.1765 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 21.1765 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.1765 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 18.8235 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 18.8235 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 17.6471 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.9412 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 10.5882 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 10.5882 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 10.5882 | 6 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 9.4118 | 4 | yes |
| GO:0030163 | protein catabolic process | 7.0588 | 4 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 4.7059 | 4 | yes |
| GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 3.5294 | 5 | yes |
| GO:0010001 | glial cell differentiation | 2.3529 | 4 | yes |
| GO:0032288 | myelin assembly | 2.3529 | 4 | yes |
| GO:0090288 | negative regulation of cellular response to growth factor stimulus | 2.3529 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FSTL1_HUMAN | [view interactions] | Low throughput | no | yes |
| MGLYR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GP179_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TDGF1_HUMAN | [view interactions] | Low throughput | no | no |
| XYLK_HUMAN | [view interactions] | Low throughput | no | yes |
| PECA1_HUMAN | [view interactions] | Low throughput | no | no |
| SLIT2_HUMAN | [view interactions] | Low throughput | no | no |
| VEGFA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DUX4C_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODAPH_HUMAN | [view interactions] | High throughput | no | no |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC11A_HUMAN | [view interactions] | High throughput | no | no |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| TM214_HUMAN | [view interactions] | High throughput | no | no |
| XYLT2_HUMAN | [view interactions] | High throughput | no | no |
| FANCE_HUMAN | [view interactions] | High throughput | no | yes |
| UBP3_HUMAN | [view interactions] | High throughput | no | no |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM245_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH3_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| ITA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| FGFP1_HUMAN | [view interactions] | High throughput | no | no |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| HBEGF_HUMAN | [view interactions] | High throughput | no | no |
| LAMA3_HUMAN | [view interactions] | High throughput | no | no |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC2_HUMAN | [view interactions] | High throughput | no | no |
| PDGFA_HUMAN | [view interactions] | High throughput | no | yes |
| UROK_HUMAN | [view interactions] | High throughput | no | no |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| STC2_HUMAN | [view interactions] | High throughput | no | no |
| OAF_HUMAN | [view interactions] | High throughput | no | no |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERH_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA0_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| S10AE_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| LRRT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TUB_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLVC1_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| FGF4_HUMAN | [view interactions] | High throughput | no | no |
| LRRT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT2_HUMAN | [view interactions] | High throughput | no | no |
| CEAM7_HUMAN | [view interactions] | High throughput | no | no |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| ERMAP_HUMAN | [view interactions] | High throughput | no | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| FOLR1_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| SLIT1_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |