Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GPC1_HUMAN

GO
G2C
SynGO

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination . May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GPC1_HUMAN
GO:0003723 RNA binding 37.5000 4 no
GO:0046872 metal ion binding 20.8333 4 yes
GO:0045296 cadherin binding 20.8333 4 no
GO:0046914 transition metal ion binding 3.1250 5 yes
GO:0005507 copper ion binding 2.0833 6 yes
GO:0017134 fibroblast growth factor binding 2.0833 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GPC1_HUMAN
GO:0048522 positive regulation of cellular process 54.1667 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.0833 4 no
GO:0048523 negative regulation of cellular process 47.9167 4 yes
GO:0080090 regulation of primary metabolic process 47.9167 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.8750 4 no
GO:0031323 regulation of cellular metabolic process 45.8333 4 no
GO:0010468 regulation of gene expression 40.6250 5 no
GO:0009893 positive regulation of metabolic process 40.6250 4 no
GO:0010646 regulation of cell communication 39.5833 4 yes
GO:0051128 regulation of cellular component organization 38.5417 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.5417 5 no
GO:0051246 regulation of protein metabolic process 35.4167 5 no
GO:0009966 regulation of signal transduction 34.3750 4 yes
GO:0022607 cellular component assembly 34.3750 4 yes
GO:0009889 regulation of biosynthetic process 34.3750 4 no
GO:0031326 regulation of cellular biosynthetic process 34.3750 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 32.2917 5 no
GO:0010605 negative regulation of macromolecule metabolic process 32.2917 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0051049 regulation of transport 30.2083 4 no
GO:0010941 regulation of cell death 30.2083 4 no
GO:0031324 negative regulation of cellular metabolic process 28.1250 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.1250 5 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:0043067 regulation of programmed cell death 27.0833 5 no
GO:0032880 regulation of protein localization 27.0833 5 yes
GO:0060341 regulation of cellular localization 27.0833 4 yes
GO:0006355 regulation of DNA-templated transcription 27.0833 6 no
GO:1903506 regulation of nucleic acid-templated transcription 27.0833 7 no
GO:2001141 regulation of RNA biosynthetic process 27.0833 6 no
GO:0051247 positive regulation of protein metabolic process 27.0833 6 no
GO:0008104 protein localization 26.0417 4 no
GO:0051130 positive regulation of cellular component organization 26.0417 5 no
GO:1902531 regulation of intracellular signal transduction 26.0417 5 no
GO:0031399 regulation of protein modification process 26.0417 6 no
GO:0042981 regulation of apoptotic process 26.0417 6 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0051094 positive regulation of developmental process 25.0000 4 yes
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 23.9583 4 no
GO:0060548 negative regulation of cell death 23.9583 5 no
GO:2000026 regulation of multicellular organismal development 23.9583 4 no
GO:0043412 macromolecule modification 23.9583 4 no
GO:0006996 organelle organization 23.9583 4 no
GO:0051174 regulation of phosphorus metabolic process 22.9167 5 no
GO:0010648 negative regulation of cell communication 22.9167 5 yes
GO:0023057 negative regulation of signaling 22.9167 4 yes
GO:0045595 regulation of cell differentiation 22.9167 4 yes
GO:0036211 protein modification process 22.9167 4 no
GO:0071310 cellular response to organic substance 22.9167 4 no
GO:0051248 negative regulation of protein metabolic process 22.9167 6 no
GO:0051338 regulation of transferase activity 22.9167 4 no
GO:0048584 positive regulation of response to stimulus 22.9167 4 no
GO:0019220 regulation of phosphate metabolic process 22.9167 6 no
GO:0009968 negative regulation of signal transduction 21.8750 5 yes
GO:0043933 protein-containing complex organization 21.8750 4 no
GO:0042325 regulation of phosphorylation 21.8750 7 no
GO:0043069 negative regulation of programmed cell death 20.8333 6 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:1903829 positive regulation of protein localization 20.8333 5 no
GO:0030334 regulation of cell migration 20.8333 5 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:2000145 regulation of cell motility 20.8333 4 no
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0043066 negative regulation of apoptotic process 20.8333 7 no
GO:0045597 positive regulation of cell differentiation 17.7083 5 yes
GO:1905475 regulation of protein localization to membrane 11.4583 6 yes
GO:0009057 macromolecule catabolic process 8.3333 4 yes
GO:0090287 regulation of cellular response to growth factor stimulus 7.2917 4 yes
GO:0044265 cellular macromolecule catabolic process 6.2500 4 yes
GO:1901565 organonitrogen compound catabolic process 6.2500 4 yes
GO:0030163 protein catabolic process 5.2083 4 yes
GO:0006029 proteoglycan metabolic process 3.1250 5 yes
GO:0009100 glycoprotein metabolic process 3.1250 4 yes
GO:0010001 glial cell differentiation 3.1250 4 yes
GO:0030201 heparan sulfate proteoglycan metabolic process 3.1250 6 yes
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 3.1250 5 yes
GO:0090288 negative regulation of cellular response to growth factor stimulus 3.1250 5 yes
GO:0032288 myelin assembly 2.0833 4 yes
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 2.0833 6 yes
GO:1901136 carbohydrate derivative catabolic process 2.0833 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in GPC1_HUMAN
DOID:0080000 muscular disease 4.1667 3 no
DOID:423 myopathy 4.1667 5 no
DOID:66 muscle tissue disease 4.1667 4 no
DOID:65 connective tissue disease 4.1667 3 no
DOID:0080001 bone disease 3.1250 4 no
DOID:9884 muscular dystrophy 3.1250 6 no
DOID:0080006 bone development disease 2.0833 5 no
DOID:37 skin disease 2.0833 3 no
DOID:0110274 autosomal recessive limb-girdle muscular dystrophy 2.0833 8 no
DOID:11724 limb-girdle muscular dystrophy 2.0833 7 no
DOID:0050557 congenital muscular dystrophy 2.0833 7 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.0833 7 no
DOID:10595 Charcot-Marie-Tooth disease 2.0833 6 no
DOID:440 neuromuscular disease 2.0833 5 no
DOID:574 peripheral nervous system disease 2.0833 3 no
DOID:870 neuropathy 2.0833 4 no
DOID:114 heart disease 2.0833 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FSTL1_HUMAN [view interactions] Low throughput no yes
GP158_HUMAN [view entry] [view interactions] Low throughput yes yes
GP179_HUMAN [view interactions] Low throughput no no
TDGF1_HUMAN [view interactions] Low throughput no no
XYLK_HUMAN [view interactions] Low throughput no yes
PECA1_HUMAN [view interactions] Low throughput no no
SLIT2_HUMAN [view interactions] Low throughput no no
VEGFA_HUMAN [view entry] [view interactions] Low throughput yes yes
DUX4C_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
MD2L1_HUMAN [view interactions] High throughput no no
CBX1_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
ODAPH_HUMAN [view interactions] High throughput no no
GP183_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
UBP3_HUMAN [view interactions] High throughput no no
FANCE_HUMAN [view interactions] High throughput no yes
XYLT2_HUMAN [view interactions] High throughput no no
TM214_HUMAN [view interactions] High throughput no no
SPCS2_HUMAN [view interactions] High throughput no yes
SC11A_HUMAN [view interactions] High throughput no no
FGF1_HUMAN [view interactions] High throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
NCBP3_HUMAN [view interactions] High throughput no yes
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
AKA10_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
TM245_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
CD44_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CADH3_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
DSG2_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
ITA3_HUMAN [view entry] [view interactions] High throughput yes yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
ITB4_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
NHRF1_HUMAN [view interactions] High throughput no no
STRAP_HUMAN [view entry] [view interactions] High throughput yes yes
TACD2_HUMAN [view interactions] High throughput no no
FGFP1_HUMAN [view interactions] High throughput no no
GRN_HUMAN [view interactions] High throughput no no
HBEGF_HUMAN [view interactions] High throughput no no
LAMA3_HUMAN [view interactions] High throughput no no
LAMB3_HUMAN [view interactions] High throughput no yes
LAMC2_HUMAN [view interactions] High throughput no no
PDGFA_HUMAN [view interactions] High throughput no yes
UROK_HUMAN [view interactions] High throughput no no
SAP_HUMAN [view interactions] High throughput no yes
STC2_HUMAN [view interactions] High throughput no no
OAF_HUMAN [view interactions] High throughput no no
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC1_HUMAN [view interactions] High throughput no no
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
ERH_HUMAN [view interactions] High throughput no yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
H13_HUMAN [view interactions] High throughput no no
HMGA1_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPR_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
S10A2_HUMAN [view interactions] High throughput no no
SF3A1_HUMAN [view interactions] High throughput no yes
SRSF2_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SYTC_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
VAS1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
FKB1A_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
RACK1_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
PLIN3_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
GLU2B_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RGAP1_HUMAN [view interactions] High throughput no no
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RL12_HUMAN [view entry] [view interactions] High throughput yes yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
S10AB_HUMAN [view interactions] High throughput no no
S10AE_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
DHSO_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
TPD54_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TXND5_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL3_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
NUPR1_HUMAN [view interactions] High throughput no no
LRRT3_HUMAN [view entry] [view interactions] High throughput yes no
TUB_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
FLVC1_HUMAN [view interactions] High throughput no yes
SPCS1_HUMAN [view interactions] High throughput no yes
FGF4_HUMAN [view interactions] High throughput no no
LRRT4_HUMAN [view entry] [view interactions] High throughput yes no
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
WNT2_HUMAN [view interactions] High throughput no no
CEAM7_HUMAN [view interactions] High throughput no no
DAXX_HUMAN [view interactions] High throughput no yes
RTN4R_HUMAN [view interactions] High throughput no no
SRP14_HUMAN [view interactions] High throughput no no
ERMP1_HUMAN [view interactions] High throughput no no
SPCS3_HUMAN [view interactions] High throughput no yes
CGRF1_HUMAN [view interactions] High throughput no yes
PRG2_HUMAN [view interactions] High throughput no no
CAVN1_HUMAN [view interactions] High throughput no no
RMND1_HUMAN [view interactions] High throughput no yes
ERMAP_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
SRP09_HUMAN [view interactions] High throughput no no
PFD5_HUMAN [view interactions] High throughput no yes
SLIT1_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
FGR_HUMAN [view interactions] Computational no no
EXT1_HUMAN [view interactions] Computational no yes
B4GT7_HUMAN [view interactions] Computational no yes
PGS2_HUMAN [view interactions] Computational no no
HS3S2_HUMAN [view interactions] Computational no yes
HPSE_HUMAN [view interactions] Computational no no
H6ST1_HUMAN [view interactions] Computational no no
HS3SA_HUMAN [view interactions] Computational no yes
NCAN_HUMAN [view entry] [view interactions] Computational yes no
CSPG2_HUMAN [view entry] [view interactions] Computational yes no
CSPG5_HUMAN [view entry] [view interactions] Computational yes yes
B3GA2_HUMAN [view interactions] Computational no no
NDST4_HUMAN [view interactions] Computational no no
PRIO_HUMAN [view entry] [view interactions] Computational yes yes
EXT2_HUMAN [view entry] [view interactions] Computational yes no
PGBM_HUMAN [view interactions] Computational no no
LRP12_HUMAN [view interactions] Computational no yes
HS3S5_HUMAN [view interactions] Computational no yes
HS3S6_HUMAN [view interactions] Computational no no
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
FYN_HUMAN [view entry] [view interactions] Computational yes no
SHH_HUMAN [view interactions] Computational no no
XYLT1_HUMAN [view interactions] Computational no yes
COIA1_HUMAN [view interactions] Computational no no
YES_HUMAN [view entry] [view interactions] Computational yes yes
SLIT3_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LRP8_HUMAN [view entry] [view interactions] Computational yes no
VGFR1_HUMAN [view interactions] Computational no no
GLCE_HUMAN [view interactions] Computational no yes
NRG1_HUMAN [view entry] [view interactions] Computational yes no
NDST2_HUMAN [view interactions] Computational no no
H6ST3_HUMAN [view interactions] Computational no no
HS2ST_HUMAN [view interactions] Computational no yes
H6ST2_HUMAN [view interactions] Computational no no
FGF2_HUMAN [view entry] [view interactions] Computational yes yes
SDC4_HUMAN [view interactions] Computational no yes
PA2GA_HUMAN [view interactions] Computational no no
LYN_HUMAN [view entry] [view interactions] Computational yes no
LRP10_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
SDC2_HUMAN [view interactions] Computational no yes
TGFR1_HUMAN [view interactions] Computational no no
NDST1_HUMAN [view interactions] Computational no yes
B3GT6_HUMAN [view interactions] Computational no no
ANT3_HUMAN [view interactions] Computational no no
SDC3_HUMAN [view interactions] Computational no yes
TGFR2_HUMAN [view interactions] Computational no no
HS3SB_HUMAN [view interactions] Computational no no
HPSE2_HUMAN [view interactions] Computational no yes
BLK_HUMAN [view interactions] Computational no no
B3GA3_HUMAN [view entry] [view interactions] Computational yes yes
PGS1_HUMAN [view interactions] Computational no no
CSPG4_HUMAN [view interactions] Computational no yes
LRP1_HUMAN [view entry] [view interactions] Computational yes yes
SDC1_HUMAN [view interactions] Computational no no
HS3S4_HUMAN [view interactions] Computational no no
PGCB_HUMAN [view entry] [view interactions] Computational yes yes
HS3S1_HUMAN [view interactions] Computational no yes
B3GA1_HUMAN [view interactions] Computational no yes
SMAD2_HUMAN [view interactions] Computational no yes
TGFB3_HUMAN [view interactions] Computational no no
NDST3_HUMAN [view interactions] Computational no yes
A4_HUMAN [view entry] [view interactions] Computational yes yes