GP179_HUMAN
Evidence for PS localization
Functions
Orphan receptor involved in vision (PubMed, PubMed). Required for signal transduction through retinal depolarizing bipolar cells (PubMed). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GP179_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 50.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GP179_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0007600 | sensory perception | 50.0000 | 4 | yes |
| GO:0007601 | visual perception | 50.0000 | 6 | yes |
| GO:0050953 | sensory perception of light stimulus | 50.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFLA_HUMAN | [view interactions] | Low throughput | no | no |
| GP179_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |