SAHH_HUMAN
Evidence for PS localization
Functions
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAHH_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 24.4898 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.4898 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.4898 | 4 | no |
| GO:0046872 | metal ion binding | 24.4898 | 4 | no |
| GO:0003723 | RNA binding | 20.4082 | 4 | no |
| GO:0019900 | kinase binding | 20.4082 | 4 | no |
| GO:0019901 | protein kinase binding | 20.4082 | 5 | no |
| GO:0004013 | adenosylhomocysteinase activity | 4.0816 | 5 | yes |
| GO:0016802 | trialkylsulfonium hydrolase activity | 4.0816 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAHH_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.1429 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 55.1020 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.0204 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.8980 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.8980 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 40.8163 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.8163 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.8163 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.8163 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.7755 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.7347 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 36.7347 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.7347 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6939 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.6939 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.6939 | 4 | no |
| GO:0008104 | protein localization | 32.6531 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 32.6531 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 32.6531 | 6 | no |
| GO:0036211 | protein modification process | 32.6531 | 4 | no |
| GO:0043412 | macromolecule modification | 32.6531 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.6531 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6531 | 5 | no |
| GO:0010941 | regulation of cell death | 32.6531 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.6122 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 30.6122 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.6122 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.6122 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 26.5306 | 4 | no |
| GO:0051049 | regulation of transport | 26.5306 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.5306 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5306 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.4898 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.4898 | 6 | no |
| GO:0060341 | regulation of cellular localization | 24.4898 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.4490 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.4490 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.4490 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.4490 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
| GO:0060548 | negative regulation of cell death | 22.4490 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.4082 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.4082 | 6 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.4082 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.4082 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.4082 | 7 | no |
| GO:0080134 | regulation of response to stress | 20.4082 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.4082 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.4082 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.4082 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.4082 | 6 | no |
| GO:0033353 | S-adenosylmethionine cycle | 6.1224 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SAHH_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.1224 | 4 | no |
| DOID:331 | central nervous system disease | 6.1224 | 3 | no |
| DOID:231 | motor neuron disease | 4.0816 | 5 | no |
| DOID:574 | peripheral nervous system disease | 4.0816 | 3 | no |
| DOID:870 | neuropathy | 4.0816 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SAHH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| CA050_HUMAN | [view interactions] | High throughput | no | yes |
| ANR40_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| LMBL4_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| LBN_HUMAN | [view interactions] | High throughput | no | yes |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB16_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN217_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC2_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| SPB6_HUMAN | [view interactions] | High throughput | no | yes |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIC_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AV_HUMAN | [view interactions] | High throughput | no | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| MSHR_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALAT2_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | Computational | no | yes |
| SDSL_HUMAN | [view interactions] | Computational | no | yes |
| CGL_HUMAN | [view interactions] | Computational | no | yes |
| KAT3_HUMAN | [view interactions] | Computational | no | yes |
| SDHL_HUMAN | [view interactions] | Computational | no | yes |
| METK1_HUMAN | [view interactions] | Computational | no | no |
| MTHR_HUMAN | [view interactions] | Computational | no | yes |
| CBS_HUMAN | [view interactions] | Computational | no | yes |
| DNMT1_HUMAN | [view interactions] | Computational | no | no |
| METK2_HUMAN | [view interactions] | Computational | no | no |
| DNM3A_HUMAN | [view interactions] | Computational | no | yes |
| DNM3B_HUMAN | [view interactions] | Computational | no | yes |
| GLYC_HUMAN | [view interactions] | Computational | no | no |
| SBP1_HUMAN | [view interactions] | Computational | no | no |
| LDHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNMT_HUMAN | [view interactions] | Computational | no | no |
| BHMT1_HUMAN | [view interactions] | Computational | no | no |
| BHMT2_HUMAN | [view interactions] | Computational | no | no |
| ADHX_HUMAN | [view interactions] | Computational | no | yes |