Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VAT1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Possesses ATPase activity . Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VAT1_HUMAN
GO:0046872 metal ion binding 39.2857 4 yes
GO:0019900 kinase binding 39.2857 4 no
GO:0019901 protein kinase binding 35.7143 5 no
GO:0017076 purine nucleotide binding 35.7143 4 no
GO:0032555 purine ribonucleotide binding 35.7143 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.7143 4 no
GO:0008270 zinc ion binding 14.2857 6 yes
GO:0046914 transition metal ion binding 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VAT1_HUMAN
GO:0048522 positive regulation of cellular process 67.8571 4 no
GO:0060255 regulation of macromolecule metabolic process 53.5714 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.4286 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0010604 positive regulation of macromolecule metabolic process 39.2857 5 no
GO:0031325 positive regulation of cellular metabolic process 39.2857 5 no
GO:0051049 regulation of transport 39.2857 4 no
GO:0033043 regulation of organelle organization 35.7143 5 yes
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0006996 organelle organization 35.7143 4 no
GO:0051338 regulation of transferase activity 32.1429 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0008104 protein localization 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0010038 response to metal ion 21.4286 4 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of ion transmembrane transport 21.4286 5 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 21.4286 7 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0008284 positive regulation of cell population proliferation 21.4286 5 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0051493 regulation of cytoskeleton organization 21.4286 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0048878 chemical homeostasis 21.4286 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0010821 regulation of mitochondrion organization 17.8571 6 yes
GO:0010635 regulation of mitochondrial fusion 14.2857 5 yes
GO:0051093 negative regulation of developmental process 14.2857 4 yes
GO:0010637 negative regulation of mitochondrial fusion 10.7143 5 yes
GO:0010639 negative regulation of organelle organization 10.7143 6 yes
GO:0010823 negative regulation of mitochondrion organization 10.7143 7 yes
GO:0051129 negative regulation of cellular component organization 10.7143 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in VAT1_HUMAN
DOID:0050700 cardiomyopathy 7.1429 4 no
DOID:0060036 intrinsic cardiomyopathy 7.1429 5 no
DOID:114 heart disease 7.1429 3 no
DOID:2843 long QT syndrome 7.1429 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAT1_HUMAN [view entry] [view interactions] Low throughput yes no
PHLP2_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP3_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
TM216_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RET_HUMAN [view interactions] High throughput no yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
IF2B_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
BDH2_HUMAN [view interactions] High throughput no no
GMFG_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
SAR1B_HUMAN [view interactions] High throughput no yes
WDR12_HUMAN [view interactions] High throughput no yes
ZFY21_HUMAN [view interactions] High throughput no yes
WDR74_HUMAN [view interactions] High throughput no no
MVP_HUMAN [view entry] [view interactions] High throughput yes yes
S10AD_HUMAN [view interactions] High throughput no yes
TTC1_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
SETLP_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
PLIN3_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CAH9_HUMAN [view interactions] High throughput no no
OTULL_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes