VAT1_HUMAN
Evidence for PS localization
Functions
Possesses ATPase activity . Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VAT1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.5000 | 4 | no |
| GO:0000166 | nucleotide binding | 35.4167 | 4 | no |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 31.2500 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.2500 | 4 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 22.9167 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.9167 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.9167 | 6 | no |
| GO:0003723 | RNA binding | 22.9167 | 4 | no |
| GO:0008270 | zinc ion binding | 8.3333 | 7 | yes |
| GO:0046914 | transition metal ion binding | 8.3333 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VAT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 54.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.0833 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.9167 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.7500 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 39.5833 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.5833 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.4167 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.2500 | 5 | yes |
| GO:0006996 | organelle organization | 31.2500 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.2500 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 31.2500 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.2500 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.1667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.1667 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.1667 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0008104 | protein localization | 27.0833 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.0833 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.0833 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.0833 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.0833 | 5 | no |
| GO:0051338 | regulation of transferase activity | 27.0833 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.0833 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.0833 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.0833 | 6 | no |
| GO:0060341 | regulation of cellular localization | 27.0833 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.9167 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.9167 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.9167 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.9167 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.9167 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.9167 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.9167 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.9167 | 4 | no |
| GO:0006915 | apoptotic process | 20.8333 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.8333 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 20.8333 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.8333 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 20.8333 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.8333 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.8333 | 7 | no |
| GO:0010628 | positive regulation of gene expression | 20.8333 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.8333 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.7500 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.5833 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 12.5000 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 10.4167 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 10.4167 | 4 | yes |
| GO:0010635 | regulation of mitochondrial fusion | 8.3333 | 5 | yes |
| GO:0010637 | negative regulation of mitochondrial fusion | 6.2500 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PHLP2_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| DHRS6_HUMAN | [view interactions] | High throughput | no | no |
| GMFG_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| WDR12_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY21_HUMAN | [view interactions] | High throughput | no | yes |
| WDR74_HUMAN | [view interactions] | High throughput | no | no |
| MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AD_HUMAN | [view interactions] | High throughput | no | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| SETLP_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| RO60_HUMAN | [view interactions] | High throughput | no | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| SYCC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| SSH3_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |