Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MVP_HUMAN

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MVP_HUMAN
GO:0017076 purine nucleotide binding 32.0000 5 no
GO:0019900 kinase binding 32.0000 4 yes
GO:0000166 nucleotide binding 32.0000 4 no
GO:0043168 anion binding 30.0000 4 no
GO:0019901 protein kinase binding 30.0000 5 yes
GO:0030554 adenyl nucleotide binding 28.0000 6 no
GO:0032555 purine ribonucleotide binding 28.0000 4 no
GO:0003723 RNA binding 28.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0000 4 no
GO:0044389 ubiquitin-like protein ligase binding 26.0000 4 no
GO:0032559 adenyl ribonucleotide binding 24.0000 5 no
GO:0031625 ubiquitin protein ligase binding 24.0000 5 no
GO:0005524 ATP binding 22.0000 5 no
GO:0019902 phosphatase binding 10.0000 4 yes
GO:0019903 protein phosphatase binding 10.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MVP_HUMAN
GO:0060255 regulation of macromolecule metabolic process 72.0000 4 yes
GO:0080090 regulation of primary metabolic process 70.0000 4 yes
GO:0031323 regulation of cellular metabolic process 68.0000 4 yes
GO:0048523 negative regulation of cellular process 64.0000 4 yes
GO:0048522 positive regulation of cellular process 58.0000 4 no
GO:0009892 negative regulation of metabolic process 54.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 52.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 52.0000 5 yes
GO:0009889 regulation of biosynthetic process 52.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 52.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 52.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 46.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 46.0000 5 no
GO:0006996 organelle organization 44.0000 4 no
GO:0009966 regulation of signal transduction 42.0000 4 yes
GO:0022607 cellular component assembly 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0008104 protein localization 38.0000 4 yes
GO:0031399 regulation of protein modification process 38.0000 6 yes
GO:0009890 negative regulation of biosynthetic process 38.0000 5 no
GO:0009894 regulation of catabolic process 38.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 38.0000 6 no
GO:0051247 positive regulation of protein metabolic process 36.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.0000 5 no
GO:0042981 regulation of apoptotic process 36.0000 5 no
GO:0043067 regulation of programmed cell death 36.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 34.0000 4 no
GO:0036211 protein modification process 34.0000 4 no
GO:0043412 macromolecule modification 34.0000 4 no
GO:0051252 regulation of RNA metabolic process 32.0000 5 no
GO:0045595 regulation of cell differentiation 32.0000 4 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0009891 positive regulation of biosynthetic process 30.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.0000 6 no
GO:0043933 protein-containing complex organization 30.0000 4 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 yes
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 30.0000 6 yes
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0051049 regulation of transport 28.0000 4 no
GO:0051094 positive regulation of developmental process 28.0000 4 no
GO:0071310 cellular response to organic substance 28.0000 4 no
GO:0001932 regulation of protein phosphorylation 28.0000 7 yes
GO:0042325 regulation of phosphorylation 28.0000 7 yes
GO:0009967 positive regulation of signal transduction 28.0000 5 no
GO:0051726 regulation of cell cycle 26.0000 4 no
GO:0031401 positive regulation of protein modification process 26.0000 7 no
GO:1902531 regulation of intracellular signal transduction 26.0000 5 no
GO:0044087 regulation of cellular component biogenesis 26.0000 4 no
GO:0006355 regulation of DNA-templated transcription 26.0000 7 no
GO:0045597 positive regulation of cell differentiation 26.0000 5 no
GO:0060284 regulation of cell development 26.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 26.0000 6 no
GO:0010648 negative regulation of cell communication 26.0000 5 yes
GO:0023057 negative regulation of signaling 26.0000 4 yes
GO:0048585 negative regulation of response to stimulus 26.0000 4 yes
GO:0009896 positive regulation of catabolic process 26.0000 5 no
GO:0033043 regulation of organelle organization 24.0000 5 no
GO:2000026 regulation of multicellular organismal development 24.0000 4 no
GO:0009968 negative regulation of signal transduction 24.0000 5 yes
GO:0071702 organic substance transport 24.0000 4 yes
GO:0071705 nitrogen compound transport 24.0000 4 yes
GO:0010629 negative regulation of gene expression 24.0000 7 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 22.0000 7 no
GO:0051240 positive regulation of multicellular organismal process 22.0000 4 no
GO:0080134 regulation of response to stress 22.0000 4 no
GO:0009057 macromolecule catabolic process 22.0000 4 no
GO:0032880 regulation of protein localization 22.0000 5 no
GO:0060341 regulation of cellular localization 22.0000 4 no
GO:0030162 regulation of proteolysis 22.0000 6 no
GO:0042127 regulation of cell population proliferation 22.0000 4 no
GO:0043066 negative regulation of apoptotic process 22.0000 6 no
GO:0043069 negative regulation of programmed cell death 22.0000 5 no
GO:0015031 protein transport 20.0000 4 yes
GO:0031400 negative regulation of protein modification process 18.0000 7 yes
GO:0051338 regulation of transferase activity 18.0000 4 yes
GO:0043549 regulation of kinase activity 16.0000 5 yes
GO:0045859 regulation of protein kinase activity 16.0000 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 14.0000 6 yes
GO:0043086 negative regulation of catalytic activity 14.0000 4 yes
GO:0045936 negative regulation of phosphate metabolic process 14.0000 7 yes
GO:0001933 negative regulation of protein phosphorylation 12.0000 8 yes
GO:0042326 negative regulation of phosphorylation 12.0000 8 yes
GO:0051348 negative regulation of transferase activity 12.0000 5 yes
GO:0006469 negative regulation of protein kinase activity 10.0000 7 yes
GO:0033673 negative regulation of kinase activity 10.0000 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 8.0000 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 8.0000 5 yes
GO:0015931 nucleobase-containing compound transport 6.0000 5 yes
GO:0050657 nucleic acid transport 6.0000 6 yes
GO:0050658 RNA transport 6.0000 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 6.0000 8 yes
GO:0051028 mRNA transport 6.0000 5 yes
GO:0061097 regulation of protein tyrosine kinase activity 6.0000 7 yes
GO:0031952 regulation of protein autophosphorylation 4.0000 8 yes
GO:0031953 negative regulation of protein autophosphorylation 4.0000 9 yes
GO:0038127 ERBB signaling pathway 4.0000 6 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 4.0000 6 yes
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 4.0000 7 yes
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 4.0000 9 yes
GO:0061099 negative regulation of protein tyrosine kinase activity 4.0000 8 yes
GO:1901184 regulation of ERBB signaling pathway 4.0000 5 yes
GO:1901185 negative regulation of ERBB signaling pathway 4.0000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
CD276_HUMAN [view interactions] Low throughput no yes
XIAP_HUMAN [view interactions] Low throughput no yes
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
MVP_HUMAN [view entry] [view interactions] Low throughput yes yes
PARP4_HUMAN [view interactions] Low throughput no yes
COP1_HUMAN [view interactions] Low throughput no no
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
TEP1_HUMAN [view interactions] Low throughput no no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
RCOR3_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNT1_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
CMTR1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
EMC4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
F16P1_HUMAN [view interactions] High throughput no no
EIF3H_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
STX17_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
2ABB_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
COLQ_HUMAN [view interactions] High throughput no no
CO8A2_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
ERCC8_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
IF2B3_HUMAN [view interactions] High throughput no no
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
MEN1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
GSDME_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
TNIP1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
NCBP1_HUMAN [view interactions] High throughput no yes
VAT1_HUMAN [view entry] [view interactions] High throughput yes no
SAP_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CDC16_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
UTP25_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
H2B2F_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
TLE2_HUMAN [view interactions] High throughput no yes
HYES_HUMAN [view interactions] High throughput no no
HPT_HUMAN [view interactions] High throughput no no
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
CYB_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
GIT2_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
POTE1_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
TBE_HUMAN [view interactions] High throughput no yes
CEP78_HUMAN [view interactions] High throughput no yes
STA5B_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
TGM2_HUMAN [view interactions] High throughput no no
FBW1B_HUMAN [view interactions] High throughput no yes
MAP9_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
LG3BP_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
DOK2_HUMAN [view interactions] High throughput no no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
MSPD2_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
H2BFS_HUMAN [view interactions] High throughput no yes
H2B1D_HUMAN [view interactions] High throughput no yes
CO1A1_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
STAM2_HUMAN [view interactions] High throughput no yes
STAT2_HUMAN [view interactions] High throughput no yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
DTX2_HUMAN [view interactions] High throughput no yes
UBTD2_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP13_HUMAN [view interactions] High throughput no yes
RIMB1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DLX2_HUMAN [view interactions] High throughput no no
ATL4_HUMAN [view interactions] High throughput no yes
TLE5_HUMAN [view interactions] High throughput no no
BANP_HUMAN [view interactions] High throughput no yes
CA094_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
IHO1_HUMAN [view interactions] High throughput no no
SAXO1_HUMAN [view interactions] High throughput no no
TET5C_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD9_HUMAN [view interactions] High throughput no no
IMA4_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
MEOX1_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
TRIM1_HUMAN [view interactions] High throughput no no
MRTFA_HUMAN [view entry] [view interactions] High throughput yes yes
NT2NA_HUMAN [view interactions] High throughput no no
STN1_HUMAN [view interactions] High throughput no no
PIHD2_HUMAN [view interactions] High throughput no no
PPIP1_HUMAN [view interactions] High throughput no no
RAB3I_HUMAN [view interactions] High throughput no no
RBPMS_HUMAN [view interactions] High throughput no no
REL_HUMAN [view interactions] High throughput no yes
RHXF2_HUMAN [view interactions] High throughput no no
RIM3A_HUMAN [view interactions] High throughput no no
RN111_HUMAN [view interactions] High throughput no yes
SRTD1_HUMAN [view interactions] High throughput no no
SKIL_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
TRAF2_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
TRI42_HUMAN [view interactions] High throughput no no
PCH2_HUMAN [view interactions] High throughput no no
TRIP6_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT32_HUMAN [view interactions] High throughput no yes
ZMIZ2_HUMAN [view interactions] High throughput no yes
FND3B_HUMAN [view interactions] High throughput no no
NRF1_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
MERL_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
NKX21_HUMAN [view interactions] High throughput no no