MVP_HUMAN
Evidence for PS localization
Functions
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MVP_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 30.9524 | 4 | yes |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | yes |
| GO:0003723 | RNA binding | 26.1905 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.8095 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.4286 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
| GO:0019902 | phosphatase binding | 9.5238 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 9.5238 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MVP_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 64.2857 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 64.2857 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.9048 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.5238 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.7619 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 45.2381 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.2381 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.2381 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.4762 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 40.4762 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 40.4762 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.4762 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4762 | 5 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.0952 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.0952 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | yes |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.9524 | 4 | yes |
| GO:0006996 | organelle organization | 30.9524 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.9524 | 5 | no |
| GO:0036211 | protein modification process | 30.9524 | 4 | no |
| GO:0043412 | macromolecule modification | 30.9524 | 4 | no |
| GO:0051049 | regulation of transport | 30.9524 | 4 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
| GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 26.1905 | 7 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.1905 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 26.1905 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.1905 | 4 | no |
| GO:0010941 | regulation of cell death | 26.1905 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.8095 | 7 | yes |
| GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.8095 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 23.8095 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.8095 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.8095 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.8095 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8095 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.8095 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.8095 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.8095 | 6 | no |
| GO:0071310 | cellular response to organic substance | 23.8095 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.4286 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 21.4286 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:0051338 | regulation of transferase activity | 16.6667 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 14.2857 | 5 | yes |
| GO:0043549 | regulation of kinase activity | 14.2857 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 14.2857 | 4 | yes |
| GO:0031400 | negative regulation of protein modification process | 11.9048 | 7 | yes |
| GO:0045859 | regulation of protein kinase activity | 11.9048 | 6 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 9.5238 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 9.5238 | 4 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 9.5238 | 7 | yes |
| GO:0051348 | negative regulation of transferase activity | 9.5238 | 5 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 7.1429 | 8 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 7.1429 | 7 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 7.1429 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7.1429 | 5 | yes |
| GO:0015931 | nucleobase-containing compound transport | 7.1429 | 5 | yes |
| GO:0033673 | negative regulation of kinase activity | 7.1429 | 6 | yes |
| GO:0042326 | negative regulation of phosphorylation | 7.1429 | 8 | yes |
| GO:0050657 | nucleic acid transport | 7.1429 | 6 | yes |
| GO:0050658 | RNA transport | 7.1429 | 4 | yes |
| GO:0051028 | mRNA transport | 7.1429 | 5 | yes |
| GO:0031952 | regulation of protein autophosphorylation | 4.7619 | 8 | yes |
| GO:0031953 | negative regulation of protein autophosphorylation | 4.7619 | 9 | yes |
| GO:0038127 | ERBB signaling pathway | 4.7619 | 6 | yes |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 4.7619 | 6 | yes |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 4.7619 | 7 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 4.7619 | 8 | yes |
| GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation | 4.7619 | 9 | yes |
| GO:0061097 | regulation of protein tyrosine kinase activity | 4.7619 | 7 | yes |
| GO:0061099 | negative regulation of protein tyrosine kinase activity | 4.7619 | 8 | yes |
| GO:1901184 | regulation of ERBB signaling pathway | 4.7619 | 5 | yes |
| GO:1901185 | negative regulation of ERBB signaling pathway | 4.7619 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| TEP1_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| CD276_HUMAN | [view interactions] | Low throughput | no | yes |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MVP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARP4_HUMAN | [view interactions] | Low throughput | no | yes |
| COP1_HUMAN | [view interactions] | Low throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRTFA_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| STN1_HUMAN | [view interactions] | High throughput | no | no |
| PIHD2_HUMAN | [view interactions] | High throughput | no | no |
| PPIP1_HUMAN | [view interactions] | High throughput | no | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| RHXF2_HUMAN | [view interactions] | High throughput | no | no |
| RIM3A_HUMAN | [view interactions] | High throughput | no | no |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| SRTD1_HUMAN | [view interactions] | High throughput | no | no |
| SKIL_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| TRI42_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT32_HUMAN | [view interactions] | High throughput | no | yes |
| ZMIZ2_HUMAN | [view interactions] | High throughput | no | yes |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| NRF1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| NKX21_HUMAN | [view interactions] | High throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCOR3_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| COLQ_HUMAN | [view interactions] | High throughput | no | no |
| CO8A2_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| HYES_HUMAN | [view interactions] | High throughput | no | no |
| HPT_HUMAN | [view interactions] | High throughput | no | no |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TBE_HUMAN | [view interactions] | High throughput | no | yes |
| CEP78_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H2BFS_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1D_HUMAN | [view interactions] | High throughput | no | yes |
| CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| UBTD2_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIMB1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLX2_HUMAN | [view interactions] | High throughput | no | no |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IHO1_HUMAN | [view interactions] | High throughput | no | no |
| SAXO1_HUMAN | [view interactions] | High throughput | no | no |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| IMA4_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |