KCC2B_HUMAN
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCC2B_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 28.9720 | 4 | no |
GO:0017076 | purine nucleotide binding | 27.1028 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 27.1028 | 4 | yes |
GO:0019900 | kinase binding | 26.1682 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.2336 | 4 | yes |
GO:0019901 | protein kinase binding | 25.2336 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 20.5607 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 20.5607 | 5 | yes |
GO:0005524 | ATP binding | 18.6916 | 5 | yes |
GO:0003779 | actin binding | 14.9533 | 4 | yes |
GO:0042803 | protein homodimerization activity | 14.9533 | 4 | yes |
GO:0016301 | kinase activity | 14.0187 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 14.0187 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 13.0841 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 11.2150 | 4 | yes |
GO:0106310 | protein serine kinase activity | 10.2804 | 4 | yes |
GO:0004683 | calmodulin-dependent protein kinase activity | 8.4112 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCC2B_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 68.2243 | 4 | yes |
GO:0010646 | regulation of cell communication | 61.6822 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 58.8785 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 57.0093 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 56.0748 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 54.2056 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.4673 | 4 | no |
GO:0009966 | regulation of signal transduction | 49.5327 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 45.7944 | 4 | no |
GO:0051049 | regulation of transport | 43.9252 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 43.9252 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.9907 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.0561 | 5 | no |
GO:0010468 | regulation of gene expression | 41.1215 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.1869 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 39.2523 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 39.2523 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 39.2523 | 4 | yes |
GO:0031399 | regulation of protein modification process | 37.3832 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 34.5794 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.5794 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.5794 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 34.5794 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.6449 | 5 | no |
GO:0010647 | positive regulation of cell communication | 33.6449 | 5 | no |
GO:0023056 | positive regulation of signaling | 33.6449 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 32.7103 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.7757 | 5 | no |
GO:0042325 | regulation of phosphorylation | 31.7757 | 7 | no |
GO:0043269 | regulation of ion transport | 30.8411 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 29.9065 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.9065 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 29.9065 | 7 | no |
GO:0022607 | cellular component assembly | 29.9065 | 4 | no |
GO:0008104 | protein localization | 28.9720 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 28.9720 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.9720 | 5 | no |
GO:0006996 | organelle organization | 28.9720 | 4 | no |
GO:0010941 | regulation of cell death | 28.9720 | 4 | no |
GO:0051050 | positive regulation of transport | 28.0374 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 28.0374 | 7 | no |
GO:0036211 | protein modification process | 27.1028 | 4 | yes |
GO:0043412 | macromolecule modification | 27.1028 | 4 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.1028 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 27.1028 | 5 | no |
GO:0010243 | response to organonitrogen compound | 26.1682 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.1682 | 6 | no |
GO:0034762 | regulation of transmembrane transport | 26.1682 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 26.1682 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 26.1682 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.1682 | 7 | no |
GO:0043067 | regulation of programmed cell death | 26.1682 | 5 | no |
GO:0031344 | regulation of cell projection organization | 25.2336 | 5 | yes |
GO:0071310 | cellular response to organic substance | 25.2336 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.2336 | 8 | no |
GO:0034765 | regulation of ion transmembrane transport | 25.2336 | 5 | no |
GO:0042981 | regulation of apoptotic process | 25.2336 | 6 | no |
GO:0044057 | regulation of system process | 24.2991 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.2991 | 6 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 24.2991 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.2991 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 24.2991 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.2991 | 6 | no |
GO:0045595 | regulation of cell differentiation | 23.3645 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 23.3645 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 23.3645 | 6 | no |
GO:0071702 | organic substance transport | 23.3645 | 4 | no |
GO:0071705 | nitrogen compound transport | 23.3645 | 4 | no |
GO:0051338 | regulation of transferase activity | 23.3645 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 23.3645 | 6 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.4299 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 22.4299 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 22.4299 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.4299 | 6 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.4299 | 4 | no |
GO:0022898 | regulation of transmembrane transporter activity | 22.4299 | 4 | no |
GO:0043549 | regulation of kinase activity | 22.4299 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 22.4299 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.4953 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 21.4953 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.4953 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 21.4953 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.4953 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.4953 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5607 | 6 | no |
GO:0032880 | regulation of protein localization | 20.5607 | 5 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 20.5607 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 20.5607 | 4 | no |
GO:0010959 | regulation of metal ion transport | 19.6262 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 15.8879 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 15.8879 | 5 | yes |
GO:0051924 | regulation of calcium ion transport | 15.8879 | 7 | yes |
GO:2000026 | regulation of multicellular organismal development | 15.8879 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 14.9533 | 7 | yes |
GO:0006468 | protein phosphorylation | 14.0187 | 5 | yes |
GO:0016310 | phosphorylation | 14.0187 | 5 | yes |
GO:0060284 | regulation of cell development | 14.0187 | 5 | yes |
GO:0030334 | regulation of cell migration | 13.0841 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 13.0841 | 6 | yes |
GO:2000145 | regulation of cell motility | 13.0841 | 4 | yes |
GO:0048168 | regulation of neuronal synaptic plasticity | 12.1495 | 4 | yes |
GO:0050807 | regulation of synapse organization | 11.2150 | 5 | yes |
GO:0051960 | regulation of nervous system development | 11.2150 | 5 | yes |
GO:0090257 | regulation of muscle system process | 11.2150 | 5 | yes |
GO:0010720 | positive regulation of cell development | 10.2804 | 6 | yes |
GO:0046777 | protein autophosphorylation | 10.2804 | 6 | yes |
GO:0050767 | regulation of neurogenesis | 10.2804 | 6 | yes |
GO:0022604 | regulation of cell morphogenesis | 9.3458 | 5 | yes |
GO:0048169 | regulation of long-term neuronal synaptic plasticity | 9.3458 | 5 | yes |
GO:0051962 | positive regulation of nervous system development | 9.3458 | 5 | yes |
GO:0050769 | positive regulation of neurogenesis | 8.4112 | 6 | yes |
GO:0043502 | regulation of muscle adaptation | 6.5421 | 4 | yes |
GO:0099175 | regulation of postsynapse organization | 6.5421 | 6 | yes |
GO:0010976 | positive regulation of neuron projection development | 5.6075 | 7 | yes |
GO:0010769 | regulation of cell morphogenesis involved in differentiation | 4.6729 | 6 | yes |
GO:0050773 | regulation of dendrite development | 4.6729 | 4 | yes |
GO:0060998 | regulation of dendritic spine development | 4.6729 | 4 | yes |
GO:0060999 | positive regulation of dendritic spine development | 4.6729 | 5 | yes |
GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 3.7383 | 7 | yes |
GO:0014733 | regulation of skeletal muscle adaptation | 3.7383 | 5 | yes |
GO:0048814 | regulation of dendrite morphogenesis | 3.7383 | 5 | yes |
GO:0061001 | regulation of dendritic spine morphogenesis | 3.7383 | 5 | yes |
GO:0090128 | regulation of synapse maturation | 3.7383 | 4 | yes |
GO:0051823 | regulation of synapse structural plasticity | 2.8037 | 6 | yes |
GO:0090129 | positive regulation of synapse maturation | 2.8037 | 5 | yes |
GO:2001222 | regulation of neuron migration | 2.8037 | 6 | yes |
GO:0050775 | positive regulation of dendrite morphogenesis | 1.8692 | 6 | yes |
GO:0061003 | positive regulation of dendritic spine morphogenesis | 1.8692 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCC2B_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 6.5421 | 3 | no |
DOID:0050700 | cardiomyopathy | 5.6075 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 5.6075 | 5 | no |
DOID:331 | central nervous system disease | 4.6729 | 3 | no |
DOID:2843 | long QT syndrome | 2.8037 | 6 | no |
DOID:1289 | neurodegenerative disease | 2.8037 | 4 | no |
DOID:0050753 | cerebellar ataxia | 1.8692 | 6 | no |
DOID:0050950 | autosomal recessive cerebellar ataxia | 1.8692 | 7 | no |
DOID:0050951 | hereditary ataxia | 1.8692 | 5 | no |
DOID:0060038 | specific developmental disorder | 1.8692 | 3 | no |
DOID:1059 | intellectual disability | 1.8692 | 4 | no |
DOID:0060674 | catecholaminergic polymorphic ventricular tachycardia | 1.8692 | 5 | no |
DOID:10273 | heart conduction disease | 1.8692 | 4 | no |
DOID:936 | brain disease | 1.8692 | 4 | no |
DOID:0080000 | muscular disease | 1.8692 | 3 | no |
DOID:423 | myopathy | 1.8692 | 5 | no |
DOID:65 | connective tissue disease | 1.8692 | 3 | no |
DOID:66 | muscle tissue disease | 1.8692 | 4 | no |
DOID:9884 | muscular dystrophy | 1.8692 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FLII_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDC20_HUMAN | [view interactions] | Low throughput | no | no |
PTPRR_HUMAN | [view interactions] | Low throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGR_HUMAN | [view interactions] | High throughput | no | no |
PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN3_HUMAN | [view interactions] | High throughput | no | yes |
ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
PDE4A_HUMAN | [view interactions] | High throughput | no | no |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKN3_HUMAN | [view interactions] | High throughput | no | yes |
M3K2_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEUL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
SMYD3_HUMAN | [view interactions] | High throughput | no | yes |
BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
KR10B_HUMAN | [view interactions] | High throughput | no | no |
RAP2B_HUMAN | [view interactions] | High throughput | no | no |
RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
KR195_HUMAN | [view interactions] | High throughput | no | no |
KR197_HUMAN | [view interactions] | High throughput | no | no |
SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
TTC5_HUMAN | [view interactions] | High throughput | no | yes |
RBPMS_HUMAN | [view interactions] | High throughput | no | no |
KPBB_HUMAN | [view interactions] | High throughput | no | no |
POP5_HUMAN | [view interactions] | High throughput | no | no |
MED18_HUMAN | [view interactions] | High throughput | no | yes |
MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
RM11_HUMAN | [view interactions] | High throughput | no | yes |
FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
NINL_HUMAN | [view interactions] | High throughput | no | yes |
TANK_HUMAN | [view interactions] | High throughput | no | yes |
THB_HUMAN | [view interactions] | High throughput | no | no |
RXRG_HUMAN | [view interactions] | High throughput | no | no |
MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
CCM2L_HUMAN | [view interactions] | High throughput | no | no |
MGT5B_HUMAN | [view interactions] | High throughput | no | no |
F1712_HUMAN | [view interactions] | High throughput | no | no |
ZBT32_HUMAN | [view interactions] | High throughput | no | yes |
PNKP_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
ARSA_HUMAN | [view interactions] | High throughput | no | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
MO4L2_HUMAN | [view interactions] | High throughput | no | yes |
ZMYM5_HUMAN | [view interactions] | High throughput | no | yes |
DUS1L_HUMAN | [view interactions] | High throughput | no | yes |
KRT86_HUMAN | [view interactions] | High throughput | no | no |
RPC3_HUMAN | [view interactions] | High throughput | no | yes |
KRA62_HUMAN | [view interactions] | High throughput | no | no |
KRA11_HUMAN | [view interactions] | High throughput | no | no |
KR193_HUMAN | [view interactions] | High throughput | no | no |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STB5L_HUMAN | [view interactions] | High throughput | no | no |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
LIPH_HUMAN | [view interactions] | High throughput | no | no |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM42_HUMAN | [view interactions] | High throughput | no | yes |
CF141_HUMAN | [view interactions] | High throughput | no | no |
ZN843_HUMAN | [view interactions] | High throughput | no | yes |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INADL_HUMAN | [view interactions] | High throughput | no | no |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
DNAL4_HUMAN | [view interactions] | High throughput | no | yes |
P121A_HUMAN | [view interactions] | High throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
E41LB_HUMAN | [view interactions] | High throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCM5_HUMAN | [view interactions] | High throughput | no | no |
TCPQM_HUMAN | [view interactions] | High throughput | no | no |
RDH8_HUMAN | [view interactions] | High throughput | no | no |
F163B_HUMAN | [view interactions] | High throughput | no | yes |
EFMT2_HUMAN | [view interactions] | High throughput | no | yes |
NAA11_HUMAN | [view interactions] | High throughput | no | no |
VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRC2_HUMAN | [view interactions] | High throughput | no | no |
MAGA9_HUMAN | [view interactions] | High throughput | no | no |
SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAP10_HUMAN | [view interactions] | High throughput | no | no |
WDR5B_HUMAN | [view interactions] | High throughput | no | yes |
CT096_HUMAN | [view interactions] | High throughput | no | yes |
TRAT1_HUMAN | [view interactions] | High throughput | no | no |
PIGH_HUMAN | [view interactions] | High throughput | no | yes |
DUS4L_HUMAN | [view interactions] | High throughput | no | yes |
F170A_HUMAN | [view interactions] | High throughput | no | no |
ZN397_HUMAN | [view interactions] | High throughput | no | yes |
NUP43_HUMAN | [view interactions] | High throughput | no | yes |
ZN764_HUMAN | [view interactions] | High throughput | no | no |
TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PALD_HUMAN | [view interactions] | High throughput | no | yes |
ZSCA1_HUMAN | [view interactions] | High throughput | no | yes |
SYQ_HUMAN | [view interactions] | High throughput | no | yes |
ELP3_HUMAN | [view interactions] | High throughput | no | no |
TTLL1_HUMAN | [view interactions] | High throughput | no | yes |
PADI4_HUMAN | [view interactions] | High throughput | no | no |
ANGL7_HUMAN | [view interactions] | High throughput | no | no |
MECP2_HUMAN | [view interactions] | High throughput | no | yes |
CD22_HUMAN | [view interactions] | High throughput | no | no |
ACY1_HUMAN | [view interactions] | High throughput | no | no |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CREB1_HUMAN | [view interactions] | Computational | no | yes |
AGGF1_HUMAN | [view interactions] | Computational | no | no |
HSF1_HUMAN | [view interactions] | Computational | no | yes |
NOS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PPM1F_HUMAN | [view interactions] | Computational | no | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPIP3_HUMAN | [view interactions] | Computational | no | yes |
CK2N2_HUMAN | [view interactions] | Computational | no | yes |
F1142_HUMAN | [view interactions] | Computational | no | yes |
EP300_HUMAN | [view interactions] | Computational | no | yes |
RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KKCC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MEF2C_HUMAN | [view interactions] | Computational | no | yes |
CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
E41L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATRAP_HUMAN | [view interactions] | Computational | no | yes |
MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
JAK1_HUMAN | [view interactions] | Computational | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CLCN6_HUMAN | [view interactions] | Computational | no | yes |
ZCCHV_HUMAN | [view interactions] | Computational | no | yes |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CY24B_HUMAN | [view interactions] | Computational | no | no |
F131B_HUMAN | [view interactions] | Computational | no | no |
HDAC9_HUMAN | [view interactions] | Computational | no | yes |
CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ESRP1_HUMAN | [view interactions] | Computational | no | yes |
SC6A3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PP2BB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PP2BC_HUMAN | [view interactions] | Computational | no | yes |
MEF2D_HUMAN | [view interactions] | Computational | no | yes |
HDAC5_HUMAN | [view interactions] | Computational | no | yes |
TIF1A_HUMAN | [view interactions] | Computational | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KDM7A_HUMAN | [view interactions] | Computational | no | yes |
KKCC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IFNG_HUMAN | [view interactions] | Computational | no | no |
PLCG2_HUMAN | [view interactions] | Computational | no | yes |
GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FLNC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CABIN_HUMAN | [view interactions] | Computational | no | yes |
TRAK1_HUMAN | [view interactions] | Computational | no | yes |
RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
B2L11_HUMAN | [view interactions] | Computational | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CAV1_HUMAN | [view interactions] | Computational | no | no |
MP2K3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AKAP9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MARK3_HUMAN | [view interactions] | Computational | no | yes |
MYLK_HUMAN | [view interactions] | Computational | no | no |
NOS3_HUMAN | [view interactions] | Computational | no | no |
FAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPRIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RIPK3_HUMAN | [view interactions] | Computational | no | no |
INGR2_HUMAN | [view interactions] | Computational | no | yes |
GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PP2BA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ADCY3_HUMAN | [view interactions] | Computational | no | yes |
RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
INGR1_HUMAN | [view interactions] | Computational | no | no |
MEF2A_HUMAN | [view interactions] | Computational | no | yes |
FBX43_HUMAN | [view interactions] | Computational | no | no |
HDAC1_HUMAN | [view interactions] | Computational | no | no |
QKI_HUMAN | [view interactions] | Computational | no | no |
GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PAPS1_HUMAN | [view interactions] | Computational | no | yes |
ATG7_HUMAN | [view interactions] | Computational | no | yes |
STMN1_HUMAN | [view interactions] | Computational | no | yes |
M3K5_HUMAN | [view interactions] | Computational | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KSR1_HUMAN | [view interactions] | Computational | no | yes |
MP2K6_HUMAN | [view interactions] | Computational | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SND1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MDM2_HUMAN | [view interactions] | Computational | no | yes |
FLNB_HUMAN | [view interactions] | Computational | no | no |
PP1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HDAC2_HUMAN | [view interactions] | Computational | no | yes |
K1549_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TRPV1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PK3C3_HUMAN | [view interactions] | Computational | no | yes |
STAT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RYR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CBP_HUMAN | [view interactions] | Computational | no | yes |