PLCE_HUMAN
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed). Activity toward lysophosphatidylglycerol not detectable (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLCE_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
GO:0008374 | O-acyltransferase activity | 16.6667 | 5 | yes |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 16.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLCE_HUMAN |
---|---|---|---|---|
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 41.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
GO:0030030 | cell projection organization | 41.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 41.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 25.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0034329 | cell junction assembly | 25.0000 | 5 | no |
GO:0034330 | cell junction organization | 25.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 25.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
GO:0006644 | phospholipid metabolic process | 25.0000 | 4 | yes |
GO:0045017 | glycerolipid biosynthetic process | 16.6667 | 4 | yes |
GO:0046473 | phosphatidic acid metabolic process | 16.6667 | 6 | yes |
GO:0046474 | glycerophospholipid biosynthetic process | 16.6667 | 5 | yes |
GO:0046486 | glycerolipid metabolic process | 16.6667 | 4 | yes |
GO:0090407 | organophosphate biosynthetic process | 16.6667 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 16.6667 | 5 | yes |
GO:0006654 | phosphatidic acid biosynthetic process | 16.6667 | 6 | yes |
GO:0008610 | lipid biosynthetic process | 16.6667 | 4 | yes |
GO:0008654 | phospholipid biosynthetic process | 16.6667 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CD70_HUMAN | [view interactions] | High throughput | no | no |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
CAD13_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
CYAC3_HUMAN | [view interactions] | High throughput | no | no |
SCN3B_HUMAN | [view interactions] | High throughput | no | no |
TMX2_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TXD15_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
TMCO3_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
RAMP2_HUMAN | [view interactions] | High throughput | no | no |
CTLA4_HUMAN | [view interactions] | High throughput | no | no |
S22A4_HUMAN | [view interactions] | High throughput | no | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
RAMP3_HUMAN | [view interactions] | High throughput | no | no |
HCST_HUMAN | [view interactions] | High throughput | no | no |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
NKG2A_HUMAN | [view interactions] | High throughput | no | no |
OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
KLK1_HUMAN | [view interactions] | High throughput | no | yes |
GPBAR_HUMAN | [view interactions] | High throughput | no | no |
TNR9_HUMAN | [view interactions] | High throughput | no | no |
LRC25_HUMAN | [view interactions] | High throughput | no | yes |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GHITM_HUMAN | [view interactions] | High throughput | no | yes |
IMDH1_HUMAN | [view interactions] | High throughput | no | yes |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
PRND_HUMAN | [view interactions] | High throughput | no | no |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
TNFL8_HUMAN | [view interactions] | High throughput | no | no |
GPR35_HUMAN | [view interactions] | High throughput | no | no |
T184A_HUMAN | [view interactions] | High throughput | no | no |
P2RY8_HUMAN | [view interactions] | High throughput | no | no |
HM13_HUMAN | [view interactions] | High throughput | no | yes |
STR3N_HUMAN | [view interactions] | High throughput | no | yes |
TECTB_HUMAN | [view interactions] | High throughput | no | no |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMO2_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPAT1_HUMAN | [view interactions] | Computational | no | no |
GPAT3_HUMAN | [view interactions] | Computational | no | yes |
CDS1_HUMAN | [view interactions] | Computational | no | yes |
PLCB_HUMAN | [view interactions] | Computational | no | yes |
PLCD_HUMAN | [view interactions] | Computational | no | yes |
PLPR4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PLPP2_HUMAN | [view interactions] | Computational | no | yes |
MBOA1_HUMAN | [view interactions] | Computational | no | no |
PLPR2_HUMAN | [view interactions] | Computational | no | yes |
GNPAT_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GPAT2_HUMAN | [view interactions] | Computational | no | no |
PLPR3_HUMAN | [view interactions] | Computational | no | no |
PLCC_HUMAN | [view interactions] | Computational | no | no |
GPAT4_HUMAN | [view interactions] | Computational | no | yes |
LCLT1_HUMAN | [view interactions] | Computational | no | no |
GPDM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLPP1_HUMAN | [view interactions] | Computational | no | no |
PLPP3_HUMAN | [view interactions] | Computational | no | no |
CDS2_HUMAN | [view interactions] | Computational | no | yes |
MBOA2_HUMAN | [view interactions] | Computational | no | yes |
PLPP4_HUMAN | [view interactions] | Computational | no | yes |
PLCA_HUMAN | [view interactions] | Computational | no | yes |