Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLCE_HUMAN

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed). Activity toward lysophosphatidylglycerol not detectable (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PLCE_HUMAN
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0008374 O-acyltransferase activity 16.6667 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLCE_HUMAN
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0010468 regulation of gene expression 41.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0030030 cell projection organization 41.6667 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0006796 phosphate-containing compound metabolic process 41.6667 4 yes
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0006644 phospholipid metabolic process 25.0000 4 yes
GO:0045017 glycerolipid biosynthetic process 16.6667 4 yes
GO:0046473 phosphatidic acid metabolic process 16.6667 6 yes
GO:0046474 glycerophospholipid biosynthetic process 16.6667 5 yes
GO:0046486 glycerolipid metabolic process 16.6667 4 yes
GO:0090407 organophosphate biosynthetic process 16.6667 4 yes
GO:0006650 glycerophospholipid metabolic process 16.6667 5 yes
GO:0006654 phosphatidic acid biosynthetic process 16.6667 6 yes
GO:0008610 lipid biosynthetic process 16.6667 4 yes
GO:0008654 phospholipid biosynthetic process 16.6667 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CD70_HUMAN [view interactions] High throughput no no
APJ_HUMAN [view interactions] High throughput no yes
CAD13_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
CR3L1_HUMAN [view interactions] High throughput no yes
CYAC3_HUMAN [view interactions] High throughput no no
SCN3B_HUMAN [view interactions] High throughput no no
TMX2_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TXD15_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
TMCO3_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
RAMP2_HUMAN [view interactions] High throughput no no
CTLA4_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
RAMP3_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
OSTM1_HUMAN [view interactions] High throughput no yes
KLK1_HUMAN [view interactions] High throughput no yes
GPBAR_HUMAN [view interactions] High throughput no no
TNR9_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
GHITM_HUMAN [view interactions] High throughput no yes
IMDH1_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
PRND_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
PPTC7_HUMAN [view interactions] High throughput no yes
TNFL8_HUMAN [view interactions] High throughput no no
GPR35_HUMAN [view interactions] High throughput no no
T184A_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
HM13_HUMAN [view interactions] High throughput no yes
STR3N_HUMAN [view interactions] High throughput no yes
TECTB_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
HS2ST_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBP2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FMO2_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
GPAT1_HUMAN [view interactions] Computational no no
GPAT3_HUMAN [view interactions] Computational no yes
CDS1_HUMAN [view interactions] Computational no yes
PLCB_HUMAN [view interactions] Computational no yes
PLCD_HUMAN [view interactions] Computational no yes
PLPR4_HUMAN [view entry] [view interactions] Computational yes no
PLPP2_HUMAN [view interactions] Computational no yes
MBOA1_HUMAN [view interactions] Computational no no
PLPR2_HUMAN [view interactions] Computational no yes
GNPAT_HUMAN [view entry] [view interactions] Computational yes no
GPAT2_HUMAN [view interactions] Computational no no
PLPR3_HUMAN [view interactions] Computational no no
PLCC_HUMAN [view interactions] Computational no no
GPAT4_HUMAN [view interactions] Computational no yes
LCLT1_HUMAN [view interactions] Computational no no
GPDM_HUMAN [view entry] [view interactions] Computational yes yes
PLPP1_HUMAN [view interactions] Computational no no
PLPP3_HUMAN [view interactions] Computational no no
CDS2_HUMAN [view interactions] Computational no yes
MBOA2_HUMAN [view interactions] Computational no yes
PLPP4_HUMAN [view interactions] Computational no yes
PLCA_HUMAN [view interactions] Computational no yes