Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAD13_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CAD13_HUMAN
GO:0043169 cation binding 35.7143 4 yes
GO:0046872 metal ion binding 35.7143 5 yes
GO:0019900 kinase binding 35.7143 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0045296 cadherin binding 21.4286 4 yes
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0000166 nucleotide binding 21.4286 4 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0043168 anion binding 21.4286 4 no
GO:0005509 calcium ion binding 14.2857 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CAD13_HUMAN
GO:0048522 positive regulation of cellular process 64.2857 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 yes
GO:0010647 positive regulation of cell communication 42.8571 5 yes
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0023056 positive regulation of signaling 42.8571 4 yes
GO:0030030 cell projection organization 42.8571 4 yes
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 yes
GO:0048584 positive regulation of response to stimulus 42.8571 4 yes
GO:0051049 regulation of transport 42.8571 4 yes
GO:0006996 organelle organization 42.8571 4 no
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0009889 regulation of biosynthetic process 35.7143 4 yes
GO:0010468 regulation of gene expression 35.7143 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 yes
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 yes
GO:0120036 plasma membrane bounded cell projection organization 35.7143 5 yes
GO:1902533 positive regulation of intracellular signal transduction 35.7143 6 yes
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0009894 regulation of catabolic process 35.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0007010 cytoskeleton organization 35.7143 5 no
GO:0043066 negative regulation of apoptotic process 35.7143 6 no
GO:0043069 negative regulation of programmed cell death 35.7143 5 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 yes
GO:0009891 positive regulation of biosynthetic process 28.5714 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 yes
GO:0034329 cell junction assembly 28.5714 5 yes
GO:0034330 cell junction organization 28.5714 4 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051726 regulation of cell cycle 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 yes
GO:0030100 regulation of endocytosis 21.4286 5 yes
GO:0030334 regulation of cell migration 21.4286 5 yes
GO:0030335 positive regulation of cell migration 21.4286 6 yes
GO:0040017 positive regulation of locomotion 21.4286 4 yes
GO:0051252 regulation of RNA metabolic process 21.4286 5 yes
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 yes
GO:2000145 regulation of cell motility 21.4286 4 yes
GO:2000147 positive regulation of cell motility 21.4286 5 yes
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 yes
GO:0008104 protein localization 21.4286 4 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043269 regulation of monoatomic ion transport 21.4286 5 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0050808 synapse organization 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0090287 regulation of cellular response to growth factor stimulus 21.4286 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 21.4286 6 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0043065 positive regulation of apoptotic process 21.4286 6 no
GO:0043068 positive regulation of programmed cell death 21.4286 5 no
GO:0048812 neuron projection morphogenesis 21.4286 5 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.4286 4 no
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:1902850 microtubule cytoskeleton organization involved in mitosis 21.4286 4 no
GO:0001667 ameboidal-type cell migration 14.2857 4 yes
GO:0001936 regulation of endothelial cell proliferation 14.2857 6 yes
GO:0001938 positive regulation of endothelial cell proliferation 14.2857 7 yes
GO:0001952 regulation of cell-matrix adhesion 14.2857 6 yes
GO:0001954 positive regulation of cell-matrix adhesion 14.2857 7 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 14.2857 5 yes
GO:0010631 epithelial cell migration 14.2857 5 yes
GO:0010810 regulation of cell-substrate adhesion 14.2857 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 14.2857 6 yes
GO:0030031 cell projection assembly 14.2857 5 yes
GO:0030032 lamellipodium assembly 14.2857 7 yes
GO:0030155 regulation of cell adhesion 14.2857 4 yes
GO:0032101 regulation of response to external stimulus 14.2857 4 yes
GO:0043542 endothelial cell migration 14.2857 6 yes
GO:0045785 positive regulation of cell adhesion 14.2857 5 yes
GO:0045893 positive regulation of DNA-templated transcription 14.2857 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 14.2857 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 14.2857 9 yes
GO:0048660 regulation of smooth muscle cell proliferation 14.2857 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 14.2857 6 yes
GO:0050678 regulation of epithelial cell proliferation 14.2857 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 14.2857 6 yes
GO:0050848 regulation of calcium-mediated signaling 14.2857 6 yes
GO:0051254 positive regulation of RNA metabolic process 14.2857 6 yes
GO:0097581 lamellipodium organization 14.2857 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 14.2857 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 14.2857 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 14.2857 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADIPO_HUMAN [view interactions] Low throughput no no
MK06_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
INSI1_HUMAN [view interactions] High throughput no no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
ERMP1_HUMAN [view interactions] High throughput no no
CHPT1_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
TMX4_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
PLCE_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
CASP8_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
S14L1_HUMAN [view interactions] High throughput no yes
DUSTY_HUMAN [view interactions] High throughput no yes
RRAGB_HUMAN [view interactions] High throughput no yes
UQCC1_HUMAN [view interactions] High throughput no yes
PIGU_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SIK2_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes