CAD13_HUMAN
Evidence for PS localization
Functions
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAD13_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0045296 | cadherin binding | 30.0000 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 30.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.0000 | 6 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 30.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 30.0000 | 4 | no |
| GO:0005509 | calcium ion binding | 20.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAD13_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 50.0000 | 5 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 50.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 40.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 40.0000 | 6 | yes |
| GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 40.0000 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 5 | no |
| GO:0043069 | negative regulation of programmed cell death | 40.0000 | 6 | no |
| GO:0060548 | negative regulation of cell death | 40.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 40.0000 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 40.0000 | 7 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 40.0000 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 30.0000 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 30.0000 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 30.0000 | 8 | yes |
| GO:0006886 | intracellular protein transport | 30.0000 | 4 | no |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0071702 | organic substance transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 30.0000 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 30.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 30.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 30.0000 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 30.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 30.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 30.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 30.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 30.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 30.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 30.0000 | 4 | no |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 30.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0008284 | positive regulation of cell population proliferation | 30.0000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | yes |
| GO:0030030 | cell projection organization | 30.0000 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 30.0000 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 30.0000 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.0000 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 30.0000 | 8 | yes |
| GO:0051049 | regulation of transport | 30.0000 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 30.0000 | 6 | yes |
| GO:2000145 | regulation of cell motility | 20.0000 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 20.0000 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 20.0000 | 5 | yes |
| GO:0030334 | regulation of cell migration | 20.0000 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 20.0000 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 20.0000 | 4 | yes |
| GO:0048660 | regulation of smooth muscle cell proliferation | 20.0000 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 20.0000 | 5 | yes |
| GO:0050679 | positive regulation of epithelial cell proliferation | 20.0000 | 6 | yes |
| GO:0050848 | regulation of calcium-mediated signaling | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ADIPO_HUMAN | [view interactions] | Low throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| TMX4_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHPT1_HUMAN | [view interactions] | High throughput | no | yes |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| S14L1_HUMAN | [view interactions] | High throughput | no | yes |
| DUSTY_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGU_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAQR1_HUMAN | [view interactions] | Computational | no | no |
| PAQR2_HUMAN | [view interactions] | Computational | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |